JPWO2018206635A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2018206635A5 JPWO2018206635A5 JP2019561911A JP2019561911A JPWO2018206635A5 JP WO2018206635 A5 JPWO2018206635 A5 JP WO2018206635A5 JP 2019561911 A JP2019561911 A JP 2019561911A JP 2019561911 A JP2019561911 A JP 2019561911A JP WO2018206635 A5 JPWO2018206635 A5 JP WO2018206635A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl
- formula
- och
- groups
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023061810A JP2023085475A (ja) | 2017-05-10 | 2023-04-06 | 治療において有用な、ペプチド性リンカーおよびクリプトフィシンコンジュゲート、ならびにこれらの製造 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17305531 | 2017-05-10 | ||
| EP17305531.0 | 2017-05-10 | ||
| PCT/EP2018/061989 WO2018206635A1 (en) | 2017-05-10 | 2018-05-09 | Peptidic linkers and cryptophycin conjugates, useful in therapy, and their preparation |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023061810A Division JP2023085475A (ja) | 2017-05-10 | 2023-04-06 | 治療において有用な、ペプチド性リンカーおよびクリプトフィシンコンジュゲート、ならびにこれらの製造 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020519610A JP2020519610A (ja) | 2020-07-02 |
| JP2020519610A5 JP2020519610A5 (https=) | 2022-08-12 |
| JPWO2018206635A5 true JPWO2018206635A5 (https=) | 2022-08-12 |
Family
ID=58873750
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019561911A Pending JP2020519610A (ja) | 2017-05-10 | 2018-05-09 | 治療において有用な、ペプチド性リンカーおよびクリプトフィシンコンジュゲート、ならびにこれらの製造 |
| JP2023061810A Pending JP2023085475A (ja) | 2017-05-10 | 2023-04-06 | 治療において有用な、ペプチド性リンカーおよびクリプトフィシンコンジュゲート、ならびにこれらの製造 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023061810A Pending JP2023085475A (ja) | 2017-05-10 | 2023-04-06 | 治療において有用な、ペプチド性リンカーおよびクリプトフィシンコンジュゲート、ならびにこれらの製造 |
Country Status (21)
| Country | Link |
|---|---|
| US (5) | US20180369401A1 (https=) |
| EP (1) | EP3621658A1 (https=) |
| JP (2) | JP2020519610A (https=) |
| KR (1) | KR102722886B1 (https=) |
| CN (1) | CN110831633A (https=) |
| AR (1) | AR111781A1 (https=) |
| AU (2) | AU2018265333C1 (https=) |
| BR (1) | BR112019023336A2 (https=) |
| CA (1) | CA3062977A1 (https=) |
| CO (1) | CO2019012108A2 (https=) |
| EA (1) | EA201992667A1 (https=) |
| EC (1) | ECSP19078277A (https=) |
| IL (1) | IL270507B2 (https=) |
| MA (1) | MA50764A (https=) |
| MX (1) | MX2019013421A (https=) |
| MY (1) | MY204075A (https=) |
| PH (1) | PH12019550230A1 (https=) |
| TN (1) | TN2019000303A1 (https=) |
| TW (1) | TWI778059B (https=) |
| UY (1) | UY37728A (https=) |
| WO (1) | WO2018206635A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11951165B2 (en) | 2016-12-30 | 2024-04-09 | Vaxcyte, Inc. | Conjugated vaccine carrier proteins |
| ES3024474T3 (en) | 2016-12-30 | 2025-06-04 | Vaxcyte Inc | Polypeptide-antigen conjugates with non-natural amino acids |
| EP3621658A1 (en) | 2017-05-10 | 2020-03-18 | Sanofi | Peptidic linkers and cryptophycin conjugates, useful in therapy, and their preparation |
| CN111154133B (zh) * | 2020-01-03 | 2022-07-12 | 万华化学集团股份有限公司 | 一种环氧树脂发泡剂，环氧树脂组合物及环氧发泡材料的制备方法和用途 |
| CN114053426B (zh) * | 2020-07-30 | 2024-06-18 | 成都科岭源医药技术有限公司 | 一种双药链接组装单元及双药靶向接头-药物偶联物 |
| CN115105607B (zh) * | 2021-03-22 | 2024-12-20 | 成都科岭源医药技术有限公司 | 一种用于adc的双药-接头的制备方法及其用途 |
| KR20240150807A (ko) | 2022-02-22 | 2024-10-16 | 아라리스 바이오테크 아게 | 2개 이상의 페이로드를 포함하는 펩티드 링커 |
| CN115212315A (zh) * | 2022-08-03 | 2022-10-21 | 联宁（苏州）生物制药有限公司 | 一种抗体偶联药物中间体及含有其的抗体偶联药物 |
| WO2025082990A1 (en) | 2023-10-15 | 2025-04-24 | Araris Biotech Ag | Antibody-drug conjugates using two different types of topoisomerase i inhibitors |
| WO2026013234A1 (en) | 2024-07-10 | 2026-01-15 | Araris Biotech Ag | Triple-payload antibody-drug conjugates (adcs) |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4040907A (en) * | 1974-06-20 | 1977-08-09 | Syva Company | Iodothyronine enzyme conjugates |
| WO1995017093A1 (en) | 1993-12-21 | 1995-06-29 | University Of Hawaii | New cryptophycins |
| PT934065E (pt) * | 1996-08-30 | 2006-10-31 | Univ Hawaii | Compostos farmaceuticos |
| US20020128185A1 (en) | 1998-02-25 | 2002-09-12 | Chuan Shih | Pharmaceutical compounds |
| US7230101B1 (en) | 2002-08-28 | 2007-06-12 | Gpc Biotech, Inc. | Synthesis of methotrexate-containing heterodimeric molecules |
| US20050175619A1 (en) | 2004-02-05 | 2005-08-11 | Robert Duffy | Methods of producing antibody conjugates |
| EP2010475A2 (en) | 2006-04-27 | 2009-01-07 | Intezyne Technologies Incorporated | Heterofunctional poly(ethylene glycol) containing acid-labile amino protecting groups and uses thereof |
| ES2673822T3 (es) | 2006-07-18 | 2018-06-25 | Sanofi | Anticuerpo antagonista contra EphA2 para el tratamiento de cáncer |
| BRPI0812970A2 (pt) * | 2007-06-25 | 2019-09-24 | Endocyte Inc | conjugados contendo espaçadores hidrofílicos |
| FR2947269B1 (fr) * | 2009-06-29 | 2013-01-18 | Sanofi Aventis | Nouveaux composes anticancereux |
| US8953557B2 (en) | 2009-06-30 | 2015-02-10 | Alcatel Lucent | Roaming method for a mobile terminal in WLAN, related access controller and access point device |
| TW201116297A (en) | 2009-10-02 | 2011-05-16 | Sanofi Aventis | Antibodies that specifically bind to the EphA2 receptor |
| WO2015057876A1 (en) * | 2013-10-15 | 2015-04-23 | Sorrento Therapeutics Inc. | Drug-conjugates with a targeting molecule and two different drugs |
| ES2826398T3 (es) | 2013-10-15 | 2021-05-18 | Seagen Inc | Enlazadores-fármacos pegilados para una mejor farmacocinética de los conjugados ligando-fármaco |
| EP3068443B1 (en) * | 2013-11-12 | 2019-04-10 | Centre for Probe Development and Commercialization | Residualizing linkers and uses thereof |
| US10736974B2 (en) | 2014-10-22 | 2020-08-11 | The Johns Hopkins University | Scaffolds and multifunctional intermediates for imaging PSMA and cancer therapy |
| JP2018506509A (ja) * | 2014-12-09 | 2018-03-08 | アッヴィ・インコーポレイテッド | 細胞透過性Ｂｃｌ−ｘＬ阻害剤との抗体薬物コンジュゲート |
| JP2018515457A (ja) * | 2015-04-21 | 2018-06-14 | アッヴィ・ステムセントルクス・エル・エル・シー | カリケアマイシン構築物および使用方法 |
| TWI714661B (zh) | 2015-11-05 | 2021-01-01 | 法商賽諾菲公司 | 新穎念珠藻素化合物及接合物、其製備與其治療用途 |
| CN108066772B (zh) * | 2016-11-14 | 2021-07-13 | 中国科学院上海药物研究所 | 靶向tacstd2的抗体与药物偶联体(adc)分子 |
| EP3621658A1 (en) | 2017-05-10 | 2020-03-18 | Sanofi | Peptidic linkers and cryptophycin conjugates, useful in therapy, and their preparation |
-
2018
- 2018-05-09 EP EP18722557.8A patent/EP3621658A1/en active Pending
- 2018-05-09 BR BR112019023336-9A patent/BR112019023336A2/pt unknown
- 2018-05-09 CA CA3062977A patent/CA3062977A1/en active Pending
- 2018-05-09 MA MA050764A patent/MA50764A/fr unknown
- 2018-05-09 AU AU2018265333A patent/AU2018265333C1/en active Active
- 2018-05-09 KR KR1020197035740A patent/KR102722886B1/ko active Active
- 2018-05-09 MY MYPI2019006354A patent/MY204075A/en unknown
- 2018-05-09 TN TNP/2019/000303A patent/TN2019000303A1/en unknown
- 2018-05-09 UY UY0001037728A patent/UY37728A/es not_active Application Discontinuation
- 2018-05-09 US US15/975,423 patent/US20180369401A1/en not_active Abandoned
- 2018-05-09 TW TW107115718A patent/TWI778059B/zh active
- 2018-05-09 AR ARP180101213A patent/AR111781A1/es not_active Application Discontinuation
- 2018-05-09 WO PCT/EP2018/061989 patent/WO2018206635A1/en not_active Ceased
- 2018-05-09 CN CN201880044816.0A patent/CN110831633A/zh active Pending
- 2018-05-09 US US16/612,090 patent/US20200093934A1/en active Pending
- 2018-05-09 MX MX2019013421A patent/MX2019013421A/es unknown
- 2018-05-09 EA EA201992667A patent/EA201992667A1/ru unknown
- 2018-05-09 JP JP2019561911A patent/JP2020519610A/ja active Pending
-
2019
- 2019-10-29 CO CONC2019/0012108A patent/CO2019012108A2/es unknown
- 2019-10-31 EC ECSENADI201978277A patent/ECSP19078277A/es unknown
- 2019-11-04 US US16/673,367 patent/US11007275B2/en active Active
- 2019-11-05 PH PH12019550230A patent/PH12019550230A1/en unknown
- 2019-11-07 IL IL270507A patent/IL270507B2/en unknown
-
2021
- 2021-03-23 US US17/210,072 patent/US11998611B2/en active Active
-
2022
- 2022-06-30 AU AU2022204711A patent/AU2022204711C1/en active Active
-
2023
- 2023-04-06 JP JP2023061810A patent/JP2023085475A/ja active Pending
-
2024
- 2024-04-10 US US18/631,600 patent/US20250205348A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2374964C (en) | Process for producing an injectable medicament preparation | |
| EP2549276B1 (en) | Reversible covalent linkage of functional molecules | |
| Lattuada et al. | The synthesis and application of polyamino polycarboxylic bifunctional chelating agents | |
| JP5309141B2 (ja) | 癌の画像化と処置 | |
| JP6207509B2 (ja) | 固形腫瘍を治療するためのｆａｐ活性化プロテアソーム阻害剤 | |
| AU2007227202B2 (en) | Peptide-peptidase inhibitor conjugates and methods of using same | |
| US20150031861A1 (en) | Chemical Modification of Antibodies | |
| HRP20191729T1 (hr) | Novi spojevi i konjugati kriptoficina, njihova priprava i njihova terapeutska uporaba | |
| US20250099632A1 (en) | Cleavable radioligands for targeting cell surface receptors and uses thereof | |
| JP2011528360A5 (https=) | ||
| JP2018535255A5 (https=) | ||
| RU2019105549A (ru) | Гидрофильные саморазрушающиеся линкеры и их конъюгаты | |
| EP0941120A1 (en) | Branched peptide linkers | |
| EP3288593A1 (en) | Conjugate of monomethyl auristatin f and trastuzumab and its use for the treatment of cancer | |
| JPWO2018206635A5 (https=) | ||
| JP2015500287A (ja) | 抗体−薬物のコンジュゲート、ならびに関連する化合物、組成物および方法 | |
| JPH0770175A (ja) | リソゾーム酵素開裂性抗腫瘍剤結合体 | |
| JP2020500148A (ja) | 新規細胞傷害性剤およびそのコンジュゲート | |
| US20250082768A1 (en) | Conjugating reagents and conjugates thereof | |
| US20040038871A1 (en) | Conjugates of aminodrugs | |
| US20170112943A1 (en) | Conjugate of monomethyl auristatin f and trastuzumab and its use for the treatment of cancer | |
| JPWO2020065408A5 (https=) | ||
| WO2025206033A1 (ja) | ｕＰＡＲ結合性ＨＬＨペプチド、ペプチド－薬物複合体および組成物 | |
| CN121586588A (zh) | 靶向药物复合体及包含靶向药物复合体的药品以及化合物 | |
| CZ2006815A3 (cs) | Využití inteligentních trífunkcních makrokonjugátu |