JPWO2018190432A1 - ソフトカプセル集合体の製造方法及びソフトカプセル集合体 - Google Patents
ソフトカプセル集合体の製造方法及びソフトカプセル集合体 Download PDFInfo
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- JPWO2018190432A1 JPWO2018190432A1 JP2019512586A JP2019512586A JPWO2018190432A1 JP WO2018190432 A1 JPWO2018190432 A1 JP WO2018190432A1 JP 2019512586 A JP2019512586 A JP 2019512586A JP 2019512586 A JP2019512586 A JP 2019512586A JP WO2018190432 A1 JPWO2018190432 A1 JP WO2018190432A1
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Abstract
Description
(1)内側ノズル、前記内側ノズルの外側の中間ノズル及び前記中間ノズルの外側の外側ノズルからなる三重ノズルを用い、前記内側ノズルから内容液を、前記中間ノズルから皮膜液を、前記外側ノズルからキャリア液を吐出して液滴を形成し、前記液滴の前記皮膜液を硬化させることを特徴とする平均粒子径が800μm以下のソフトカプセル集合体の製造方法。
(2)内容液の吐出速度が0.1〜7.5ml/hrであり、皮膜液の吐出速度が0.1〜13.0ml/hrであり、キャリア液の吐出速度が0.1〜6.0ml/minであることを特徴とする上記(1)記載のソフトカプセル集合体の製造方法。
(3)キャリア液が中鎖脂肪酸トリグリセリドを含むことを特徴とする上記(1)又は(2)記載のソフトカプセル集合体の製造方法。
(4)皮膜液がゼラチンを含むことを特徴とする上記(1)〜(3)のいずれか記載のソフトカプセル集合体の製造方法。
(5)皮膜液がカラギナン類を含むことを特徴とする上記(1)〜(4)のいずれか記載のソフトカプセル集合体の製造方法。
(6)皮膜液を硬化させた後、洗浄及び乾燥を行うことを特徴とする上記(1)〜(5)のいずれか記載のソフトカプセル集合体の製造方法。
(7)ゼラチンを含む皮膜で内容物が被包されたソフトカプセルの集合体であり、平均粒子径が800μm以下であることを特徴とするソフトカプセル集合体。
(8)皮膜がカラギナン類を含むことを特徴とする上記(7)記載のソフトカプセル集合体。
図1に記載の同心三重ノズルを用い、内側ノズルからは合成着色料sudanIIIを0.1%含有するMCT溶液からなる内容液(液温:20℃)を、中間ノズルからは表1〜3に示す組成からなる皮膜液(液温:80℃)を、外側ノズルからはMCT(液温:20℃)を吐出させて三層液滴とし、かかる三層液滴をMCT液中(液温:20℃)に滴下した。得られたカプセルを凍結乾燥、洗浄してソフトカプセルを得た。内容液の吐出速度は、実施例1〜10では1.0ml/hr、実施例11では0.2ml/hr、皮膜液の吐出速度は、実施例1〜10では10.0ml/hr、実施例11では0.2ml/hr、キャリア液の吐出速度は、実施例1〜10では3.0ml/min、実施例11では0.3ml/minとした。内側ノズルの吐出口の内径は250μm、中間ノズルの吐出口の内径は800μm、外側ノズルの吐出口の内径は1800μmであった。ゼラチン、κカラギナン及びMCTは、以下のものを使用した。また、各配合の皮膜液の粘度は、コーンプレート型粘度計(DV2T、英弘精機株式会社)を用いて測定した。皮膜液の吐出速度に対するキャリア液の吐出速度の比は、実施例1〜10では18、実施例11では90であった。
ゼラチン(豚皮ゼラチン、ゼライス社製)
κカラギナン(三菱商事フードテック社製)
MCT(花王社製)
実施例1〜11で使用したものと同じ同心三重ノズルを用いて、内側ノズルからは合成着色料sudanIIIを0.1%含有するMCT溶液からなる内容液(液温:20℃)を、中間ノズルからは表4〜7に示す組成からなる皮膜液(液温:80℃)を、外側ノズルからはMCT(液温:20℃)を吐出させて三層液滴とし、かかる三層液滴をMCT液中(液温:20℃)に滴下した。得られたカプセルを凍結乾燥、洗浄してソフトカプセルを得た。内容液の吐出速度及び皮膜液の吐出速度は0.2ml/hrとし、キャリア液の吐出速度は表4〜7に示す速度とした。皮膜液の吐出速度に対するキャリア液の吐出速度の比は、キャリア液の吐出速度が0.3ml/min、1.1ml/min、1.9ml/minの場合、それぞれ90、330、570であった。
(表面形状の観察)
得られたソフトカプセルの表面形状を走査型電子顕微鏡(SEM)により観察した。観察結果を図3〜5に示す。図3は実施例5で得られたソフトカプセル、図4は実施例6で得られたソフトカプセル、図5は実施例7で得られたソフトカプセルのSEM画像である。皮膜にカラギナンを加えることにより粒子表面が滑らかなソフトカプセルが得られた(図4及び5)。
実施例で得られたソフトカプセルを顕微鏡デジタルカメラ(DP010、オリンパス光学工業)により撮影した画像を、画像解析ソフト(WinROOF、三谷産業株式会社)を用いて解析し、平均粒子径を求めた。結果を表8及び9に示す。表8及び9に示されるように、いずれの実施例においても平均粒子径が400μm以下のソフトカプセル集合体が得られ、条件を調整することにより平均粒子径が300μm以下、200μm以下、あるいは100μm以下のソフトカプセル集合体を得ることができた。実施例11で得られたソフトカプセルを顕微鏡デジタルカメラ(DP010、オリンパス光学工業)により撮影した画像を画像解析ソフトImageJ(登録商標)1.46rを用いて画像から造粒物の粒子径を測定した。その結果に基づき粒度分布を作成した。粒度分布を図6に示す。また、表9におけるスパンファクターとは、(累積分布90%における粒子径(d90)−累積分布10%における粒子径(d10))/メジアン径(d50)で表される指標である。
得られたソフトカプセルの硬度を粒子硬度測定装置(GRANO Win Ver4.0)を用いて測定し、粒子硬度を求めた。結果を表10に示す。表10に示されるように、いずれの実施例においてもカプセル内容物を保護するのに充分な硬度を有するソフトカプセルが得られた。
1 内側ノズル
2 中間ノズル
3 外側ノズル
4 内容液
5 皮膜液
6 キャリア液
7 捕集容器
8 硬化液
9 顕微鏡対物レンズ
10 CCDカメラ
11 モニター
12 ライト
13 ポンプ
Claims (8)
- 内側ノズル、前記内側ノズルの外側の中間ノズル及び前記中間ノズルの外側の外側ノズルからなる三重ノズルを用い、前記内側ノズルから内容液を、前記中間ノズルから皮膜液を、前記外側ノズルからキャリア液を吐出して液滴を形成し、前記液滴の前記皮膜液を硬化させることを特徴とする平均粒子径が800μm以下のソフトカプセル集合体の製造方法。
- 内容液の吐出速度が0.1〜7.5ml/hrであり、皮膜液の吐出速度が0.1〜13.0ml/hrであり、キャリア液の吐出速度が0.1〜6.0ml/minであることを特徴とする請求項1記載のソフトカプセル集合体の製造方法。
- キャリア液が中鎖脂肪酸トリグリセリドを含むことを特徴とする請求項1又は2記載のソフトカプセル集合体の製造方法。
- 皮膜液がゼラチンを含むことを特徴とする請求項1〜3のいずれか記載のソフトカプセル集合体の製造方法。
- 皮膜液がカラギナン類を含むことを特徴とする請求項1〜4のいずれか記載のソフトカプセル集合体の製造方法。
- 皮膜液を硬化させた後、洗浄及び乾燥を行うことを特徴とする請求項1〜5のいずれか記載のソフトカプセル集合体の製造方法。
- ゼラチンを含む皮膜で内容物が被包されたソフトカプセルの集合体であり、平均粒子径が800μm以下であることを特徴とするソフトカプセル集合体。
- 皮膜がカラギナン類を含むことを特徴とする請求項7記載のソフトカプセル集合体。
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