JPWO2018134962A1 - Frequent urine improving agent - Google Patents
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- 210000002700 urine Anatomy 0.000 title description 4
- 240000001717 Vaccinium macrocarpon Species 0.000 claims abstract description 37
- 235000012545 Vaccinium macrocarpon Nutrition 0.000 claims abstract description 36
- 235000004634 cranberry Nutrition 0.000 claims abstract description 35
- 235000002118 Vaccinium oxycoccus Nutrition 0.000 claims abstract description 29
- 230000027939 micturition Effects 0.000 claims abstract description 26
- 230000007958 sleep Effects 0.000 claims abstract description 19
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims abstract description 17
- 239000003795 chemical substances by application Substances 0.000 description 17
- 230000000694 effects Effects 0.000 description 5
- 206010022437 insomnia Diseases 0.000 description 5
- 244000291414 Vaccinium oxycoccus Species 0.000 description 4
- 235000013399 edible fruits Nutrition 0.000 description 4
- 230000004622 sleep time Effects 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 3
- 235000015872 dietary supplement Nutrition 0.000 description 3
- 230000037406 food intake Effects 0.000 description 3
- 235000015203 fruit juice Nutrition 0.000 description 3
- 239000004129 EU approved improving agent Substances 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 208000000921 Urge Urinary Incontinence Diseases 0.000 description 2
- 235000002724 Vaccinium microcarpum Nutrition 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 235000019441 ethanol Nutrition 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 239000003326 hypnotic agent Substances 0.000 description 2
- 230000000147 hypnotic effect Effects 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 230000037393 skin firmness Effects 0.000 description 2
- 230000036548 skin texture Effects 0.000 description 2
- 230000003860 sleep quality Effects 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 206010020853 Hypertonic bladder Diseases 0.000 description 1
- 208000009722 Overactive Urinary Bladder Diseases 0.000 description 1
- 206010036018 Pollakiuria Diseases 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- 238000001793 Wilcoxon signed-rank test Methods 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 235000021019 cranberries Nutrition 0.000 description 1
- 235000011850 desserts Nutrition 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 235000013376 functional food Nutrition 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 208000020629 overactive bladder Diseases 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 239000002798 polar solvent Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 208000020016 psychiatric disease Diseases 0.000 description 1
- 235000021067 refined food Nutrition 0.000 description 1
- 235000014214 soft drink Nutrition 0.000 description 1
- 238000002562 urinalysis Methods 0.000 description 1
- 208000022934 urinary frequency Diseases 0.000 description 1
- 208000019206 urinary tract infection Diseases 0.000 description 1
- 230000036318 urination frequency Effects 0.000 description 1
- 235000015192 vegetable juice Nutrition 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 230000002618 waking effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/45—Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
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Abstract
本発明は、クランベリー果汁を含む、女性の頻尿の改善剤、クランベリー果汁を含む、女性の睡眠改善剤、又はクランベリー果汁を含む、女性の肌状態の改善剤に関する。 The present invention relates to an improvement agent for female frequent urination including cranberry juice, a female sleep improvement agent including cranberry juice, or an improvement agent for female skin condition including cranberry juice.
Description
本発明は、クランベリー果汁を含む、女性の頻尿の改善剤、クランベリー果汁を含む、女性の睡眠改善剤、又はクランベリー果汁を含む、女性の肌状態の改善剤に関する。 The present invention relates to an improvement agent for female frequent urination including cranberry juice, a female sleep improvement agent including cranberry juice, or an improvement agent for female skin condition including cranberry juice.
クランベリーのヒトでの有効性については、尿路感染症に対してのみ有効性が示唆されている（非特許文献１）。 The effectiveness of cranberries in humans has been suggested only for urinary tract infections (Non-patent Document 1).
一方、副作用のないサプリメント等として、天然物の本来有する機能を利用した機能的飲食品の開発が待たれている。 On the other hand, the development of functional foods and drinks that utilize the natural functions of natural products is awaited as supplements with no side effects.
本発明は、新規の女性の頻尿の改善剤、女性の睡眠改善剤、又は女性の肌状態の改善剤を提供する。 The present invention provides a novel female urinary frequency improving agent, female sleep improving agent, or female skin condition improving agent.
本発明者は、鋭意研究の結果、驚くべきことに、クランベリー果汁に新規の女性の頻尿の改善効果、女性の睡眠改善効果、及び女性の肌状態の改善効果があることを見出し、本発明を完成させた。すなわち、本発明は、以下のとおりである。
［１］クランベリー果汁を含む、女性の頻尿の改善剤、
［２］頻尿が、２４時間の総排尿回数及び尿意切迫感の回数である、［１］に記載の女性の頻尿の改善剤、
［３］クランベリーが、バクシニウム・マクロカルポン（Ｖａｃｃｉｎｉｕｍ ｍａｃｒｏｃａｒｐｏｎ）である、［１］又は［２］に記載の女性の頻尿の改善剤、
［４］クランベリー果汁を含む、女性の睡眠改善剤、
［５］クランベリーが、バクシニウム・マクロカルポン（Ｖａｃｃｉｎｉｕｍ ｍａｃｒｏｃａｒｐｏｎ）である、［４］に記載の女性の睡眠改善剤、
［６］クランベリー果汁を含む、女性の肌状態の改善剤、
［７］肌状態が、肌のうるおい、肌のキメ、肌のハリ及び肌の透明感である、［６］に記載の女性の肌状態の改善剤、
［８］クランベリーが、バクシニウム・マクロカルポン（Ｖａｃｃｉｎｉｕｍ ｍａｃｒｏｃａｒｐｏｎ）である、［６］又は［７］に記載の女性の肌状態の改善剤。As a result of diligent research, the present inventor has surprisingly found that cranberry juice has a novel effect of improving female frequent urination, a female sleep improvement effect, and a female skin condition, and the present invention. Was completed. That is, the present invention is as follows.
[1] An agent for improving female frequent urination, including cranberry juice,
[2] The agent for improving frequent urination in women according to [1], wherein the frequent urination is the total number of urinations and the number of urgency in 24 hours,
[3] The improvement agent of female frequent urination according to [1] or [2], wherein the cranberry is Vaccinium macrocarpon.
[4] A sleep improvement agent for women, including cranberry juice,
[5] The female sleep improving agent according to [4], wherein the cranberry is Vaccinium macrocarpon.
[6] An improving agent for skin condition of women, including cranberry juice,
[7] The skin condition improving agent for women according to [6], wherein the skin condition is moisture, skin texture, skin firmness, and skin transparency.
[8] The agent for improving the skin condition of a woman according to [6] or [7], wherein the cranberry is Vaccinium macrocarpon.
本発明は、女性の頻尿の改善効果、女性の睡眠改善効果、及び女性の肌状態の改善効果を奏する。 The present invention has the effect of improving female frequent urination, the effect of improving female sleep, and the effect of improving the skin condition of females.
クランベリーは、ツツジ科スノキ属ツルコケモモ亜属に属する常緑低木の総称である。好ましくは、バクシニウム・オキシコッコス（Vaccinium oxycoccos、ツルコケモモ）、バクシニウム・ミクロカプルム（Vaccinium microcarpum、ヒメツルコケモモ）、バクニニウム・マクロカルポン（Vaccinium macrocarpon、オオミノツルコケモモ）及びバクシニウム・エリトロカルプム（Vaccinium erythrocarpum、アクシバ）である。より好ましくは、バクニニウム・マクロカルポン（Vaccinium macrocarpon、オオミノツルコケモモ）である。 Cranberry is a general term for an evergreen shrub belonging to the subfamily Genus Vulgaria. Preferred are Vaccinium oxycoccos (Vaccinium oxycoccos), Vaccinium microcarpum (Vaccinium microcarpum), Vaccinium macrocarpon (Vaccinium macrocarpon) and Vaccinium macrocarpum More preferably, it is Vaccinium macrocarpon (Vaccinium macrocarpon).
本発明ではクランベリーの果実成分を用いる。具体的には、果実の圧搾液（果汁）、果実の抽出液、果汁若しくは抽出液の濃縮液又は乾燥物などを用いることができる。果実の抽出には水、アルコール（たとえば、エチルアルコール）、グリコール、グリセリン等の極性溶媒を用いることができる。 In the present invention, a fruit component of cranberry is used. Specifically, a fruit pressing solution (fruit juice), a fruit extract, a fruit juice or a concentrated concentrate of the extract, or a dried product can be used. For the extraction of fruits, polar solvents such as water, alcohol (for example, ethyl alcohol), glycol, and glycerin can be used.
本発明は、女性の頻尿の改善、女性の睡眠改善剤、又は女性の肌状態の改善のために有用である。 The present invention is useful for improving female frequent urination, female sleep improving agents, or female skin condition.
睡眠改善とは、「寝つきが悪い」、「眠りが浅い」といった一時的な不眠症状を緩和することをいう。一時的な不眠とは、「精神疾患等病的な原因のない人が経験する一過性の不眠」のことをいう。 Sleep improvement refers to alleviating temporary insomnia symptoms such as “bad sleep” and “slow sleep”. Temporary insomnia refers to “transient insomnia experienced by people who have no pathological cause such as mental illness”.
本発明の女性の頻尿の改善剤、女性の睡眠改善剤、又は女性の肌状態の改善剤を食品や栄養補助食品などに含有させることも可能である。食品の例としては、穀類、野菜、食肉、各種加工食品、菓子・デザート類、牛乳、清涼飲料水、果汁飲料、珈琲飲料、野菜汁飲料を挙げることができる。また、栄養補助食品の例としては、サプリメント、栄養ドリンクを挙げることができる。栄養補助食品の場合、粉末、顆粒末、タブレット、ペースト、ジュース等の液体等の形状で提供することができる。ジュースの形態で提供することによって、本発明における有効成分を日常的に摂取したり、継続的に摂取したりすることが容易となる。 The female frequent urination improving agent, the female sleep improving agent, or the female skin condition improving agent of the present invention may be contained in a food or a nutritional supplement. Examples of foods include cereals, vegetables, meat, various processed foods, confectionery / desserts, milk, soft drinks, fruit juice drinks, grape drinks, and vegetable juice drinks. Examples of nutritional supplements include supplements and nutritional drinks. In the case of a dietary supplement, it can be provided in the form of a liquid such as powder, granule powder, tablet, paste, juice or the like. By providing it in the form of juice, it becomes easy to ingest the active ingredient in the present invention on a daily basis or continuously.
頻尿傾向のある２０歳以上８０歳未満の女性１６名（年齢４７．９±１３．０５歳）に、一日一回１００ｍｌのクランベリージュース（マルカイ 順造選クランベリー１００）を１２週間摂取させ、以下の項目について検討した。 16 women (age 47.9 ± 13.05 years) who have a tendency to urinate frequently who are 20 years old and younger than 80 years old take 100 ml of cranberry juice (Marukai Cranberry 100) for 12 weeks. The items of were examined.
１．頻尿
過活動膀胱症状質問票（ＯＡＢＳＳ）を用いて、日中（昼間）の排尿回数、夜間排尿回数、尿意切迫感及び切迫性尿失禁について調査した。合計得点は、全被験者が５点以下であり、軽症と判断された。基準となる摂取前の値が３．２±０．２６であるのに対し、１２週間後の値は、１．８±０．２８であり、有意な減少が認められた（ｐ＜０．０１、摂取前とのＷｉｌｃｏｘｏｎ符号付順位検定による。以下同様である。）。より具体的には、日中の排尿回数及び切迫性尿失禁では、有意な減少が認められたが、夜間排尿回数及び尿意切迫感では、有意な減少は認められなかった。
排尿日誌を用いた２４時間の総排尿回数は、摂取前の１０．３±０．６４から１２週間後には、８．４±０．６５に有意に減少していた（ｐ＜０．０５）。一方、２４時間尿量（ｍｌ）は、摂取前の１，４７７．８±８６．２２と１２週間後の、１，５７５．０±１７３．５２には、有意差は認められなかった。すなわち、クランベリージュースの摂取によって、尿量の減少は認められないが、排尿回数が有意に減少した。また尿意切迫感の回数も、摂取前２．８±０．７９から１２週後には、１．０±０．３２に有意に減少していた（ｐ＜０．０５）。
夜間排尿回数及び夜間尿量には、有意な変化は認められなかった。1. Frequent urination Using the Overactive Bladder Symptom Questionnaire (OABSS), the number of urinations during the day (daytime), the number of urinations at night, urgency, and urge urinary incontinence were investigated. The total score was 5 points or less for all subjects, and it was judged as mild. The reference value before ingestion was 3.2 ± 0.26, whereas the value after 12 weeks was 1.8 ± 0.28, indicating a significant decrease (p <0. 01, by Wilcoxon signed rank test before ingestion, and so on.) More specifically, a significant decrease was observed in the number of urination during the day and urge urinary incontinence, but no significant decrease was observed in the number of urination at night and urgency.
The total number of urinations for 24 hours using a urination diary was significantly reduced from 10.3 ± 0.64 before intake to 8.4 ± 0.65 after 12 weeks (p <0.05). . On the other hand, there was no significant difference in 24-hour urine volume (ml) between 1,477.8 ± 86.22 before ingestion and 1,575.0 ± 173.52 after 12 weeks. In other words, the intake of cranberry juice did not reduce the urine volume, but significantly decreased the number of urinations. In addition, the number of urgency was significantly decreased from 2.8 ± 0.79 before intake to 1.0 ± 0.32 after 12 weeks (p <0.05).
No significant changes were observed in the number of night urinations and night urine output.
２．睡眠改善
ピッツバーグ睡眠質問票日本語版を用いて、睡眠の質、入眠時間、睡眠時間、睡眠効率、睡眠困難、眠剤の使用、日中覚醒困難の７点について調査した。総合得点は、基準となる摂取前の値が６．０±０．７５であるのに対し、１２週間後の値は、４．０±０．７９であり、有意な減少が認められた（ｐ＜０．０１）。より具体的には、睡眠時間、睡眠困難、日中覚醒困難では、有意な減少が認められたが、睡眠の質、入眠時間、睡眠効率、眠剤の使用では、有意な減少は認められなかった。2. Sleep Improvement Using the Japanese version of the Pittsburgh Sleep Questionnaire, we investigated seven points: sleep quality, sleep time, sleep time, sleep efficiency, difficulty sleeping, use of hypnotics, and difficulty in waking up during the day. The total score was 6.0 ± 0.75 before the standard intake, whereas the value after 12 weeks was 4.0 ± 0.79, indicating a significant decrease ( p <0.01). More specifically, there was a significant decrease in sleep time, difficulty sleeping, and difficulty in awakening during the day, but no significant decrease was observed in sleep quality, sleep time, sleep efficiency, and the use of hypnotics. It was.
３．肌状態
肌のうるおい、肌のかさつき、肌のやわらかさ、肌のなめらかさ、肌荒れ、肌のキメ、化粧のり、肌のハリ、肌のシワ、肌の透明感、肌色、洗顔後のツッパリ感、肌のべたつきについて調査した。その結果、肌のうるおい及び肌のキメ（ｐ＜０．０５）、肌のハリ及び肌の透明感（ｐ＜０．０１）について、有意な増加（改善）が認められた。3. Skin condition Moisture of the skin, softness of the skin, softness of the skin, smoothness of the skin, rough skin, texture of the skin, makeup paste, firmness of the skin, wrinkles of the skin, skin transparency, skin color, smoothness after washing the face, The skin stickiness was investigated. As a result, significant increases (improvements) were observed in the moisture and skin texture (p <0.05), skin firmness and skin transparency (p <0.01).
試験を通じて特段の有害事象は認められなかった。また、体重や血圧、尿検査、血液学的検査においても有意な変化は認められなかった。 There were no particular adverse events throughout the study. There were no significant changes in body weight, blood pressure, urinalysis, or hematology.
本発明は、女性の頻尿の改善、女性の睡眠改善剤、又は女性の肌状態の改善のために有用である。 The present invention is useful for improving female frequent urination, female sleep improving agents, or female skin condition.
Claims (8)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/JP2017/001904 WO2018134962A1 (en) | 2017-01-20 | 2017-01-20 | Improving agent for frequent urination |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018181829A Division JP6738388B2 (en) | 2018-09-27 | 2018-09-27 | Urinary frequency improving agent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP6412291B1 JP6412291B1 (en) | 2018-10-24 |
| JPWO2018134962A1 true JPWO2018134962A1 (en) | 2019-02-28 |
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| WO2021106856A1 (en) * | 2019-11-29 | 2021-06-03 | 小林製薬株式会社 | Composition for improving urinary tract function and composition for improving blood flow in bladder |
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