JPWO2017145415A1 - 免疫発達促進剤 - Google Patents
免疫発達促進剤 Download PDFInfo
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- JPWO2017145415A1 JPWO2017145415A1 JP2018500972A JP2018500972A JPWO2017145415A1 JP WO2017145415 A1 JPWO2017145415 A1 JP WO2017145415A1 JP 2018500972 A JP2018500972 A JP 2018500972A JP 2018500972 A JP2018500972 A JP 2018500972A JP WO2017145415 A1 JPWO2017145415 A1 JP WO2017145415A1
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- Prior art keywords
- immune development
- raffinose
- food
- bifidobacterium breve
- lactulose
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Abstract
Description
プロバイオティクスについては、ビフィドバクテリウム・ブレーベ(Bifidobacterium breve)及びラクトバチルス・ラムノサス(Lactobacillus rhamnosus)が、慢性ぜんそくのモデルマウスにおける炎症に有効であることが報告されている(非特許文献1)。また、ビフィドバクテリウム・ロンガムATCC BAA-999、及び/又はビフィドバクテリウム・ブレーベLMG23729が、乳幼児のアレルギー疾患を予防できることが報告されている(特許文献1)。
前記免疫発達促進剤は、免疫発達促進がT細胞数の増加促進であることを好ましい態様としている。
また前記免疫発達促進剤は、前記細菌がビフィドバクテリウム・ブレーベM−16V(LMG23729)であることを好ましい態様としている。
また前記免疫発達促進剤は、ラクチュロース、ラフィノース、及びガラクトオリゴ糖の重量比が、1〜9:1〜9:1〜9であることを好ましい態様としている。
また前記免疫発達促進剤は、前記細菌の量が、ラクチュロース、ラフィノース、及びガラクトオリゴ糖の合計量1gに対して1×106〜1×1012cfuであることを好ましい態様としている。
本発明はまた、ビフィドバクテリウム・ブレーベに属する細菌と、ラクチュロース、ラフィノース、及びガラクトオリゴ糖を有効成分とする、免疫発達促進用の飲食品組成物を提供する。
また、前記飲食品組成物は、飲食品組成物が保健機能食品であることを好ましい態様としている。
本発明の免疫発達促進剤は、ビフィドバクテリウム・ブレーベに属する細菌と、ラクチュロース、ラフィノース、及びガラクトオリゴ糖の三種のオリゴ糖を含む。
また、ラクチュロース、ラフィノース、及びガラクトオリゴ糖の重量比は、1〜9:1〜9:1〜9、好ましくは2〜8:2〜8:2〜8、より好ましくは3〜7:3〜7:3〜7であることが好ましい。
具体的には、本発明の飲食品に係る商品又は商品の包装に上記用途を記載する行為、商品又は商品の包装に上記用途を記載したものを譲渡し、引渡し、譲渡若しくは引渡しのために展示し、輸入する行為、商品に関する広告、価格表若しくは取引書類に上記用途を記載して展示し、若しくは頒布し、又はこれらを内容とする情報に上記用途を記載して電磁気的(インターネット等)方法により提供する行為等が例示でき、特に包装、容器、カタログ、パンフレット、POP等の販売現場における宣伝材、その他の書類等への表示が好ましい。
生後2日齢のC57BL/6J雄マウスを母獣とともに日本エスエルシーより購入した。乳仔マウスには母獣の母乳を自由摂餌させた。乳仔マウスを体重に偏りが生じないように2群に分け、一群は生後14日齢で、他の群は21日齢で、各々解剖を行い、大腸、及び腸間膜リンパ節(mesenteric lymph node。以下「MLN」と記載することがある。)を採取した。
また、MLNL中の総細胞数、Foxp3陽性細胞、及びRORgt陽性細胞の個数(平均値、単位:×106)を、表5〜7に示す。日齢の増加に伴っていずれの細胞数も増加した。
澱粉に倍散したビフィドバクテリウム・ブレーベM-16Vの菌体粉末(2.4×1011cfu/g、森永乳業社製)を生理食塩水に懸濁し、2.5×109cfu/mlのビフィズス菌液を調製した。
B:ビフィズス菌群(ビフィズス菌液希釈液を投与)
C:オリゴ糖+ビフィズス菌群(オリゴ糖とビフィズス菌の混合液を投与)
一方、表10、11に示されるように、生後14日時点において、M-16Vとオリゴ糖の混合投与は、LPL及びMLNL中のCD4陽性細胞におけるRORgt陽性細胞の割合に影響しなかった。
実施例2と同様にして、各投与物を投与した乳仔マウスを14日齢で解剖を行い、MLNL中のCD4陽性細胞のFoxp3陽性細胞及びRORgt陽性細胞の個数を調べた。結果を表12〜14(平均値、単位:×106)に示す。生後14日時点において、ビフィドバクテリウム・ブレーベM-16Vとオリゴ糖の混合投与により、MLNL中の総細胞数、CD4陽性Foxp3陽性細胞、及びCD4陽性RORgt陽性細胞の個数が増加した。
な難消化性オリゴ糖が、慢性ぜんそくのモデルマウスにおける気道炎症を抑制することが報告されている(非特許文献4)。また、ビフィドバクテリウム・ブレーベM-16V、及び
、ガラクトオリゴ糖又はフラクトオリゴ糖が、腸間膜リンパ節におけるFoxp3のmRNAを増
加させることが報告されている(非特許文献5)。
Claims (8)
- ビフィドバクテリウム・ブレーベに属する細菌と、ラクチュロース、ラフィノース、及びガラクトオリゴ糖を含む、免疫発達促進剤。
- 免疫発達促進がT細胞数の増加促進である、請求項1に記載の免疫発達促進剤。
- 前記細菌がビフィドバクテリウム・ブレーベM−16V(LMG23729)である、請求項1又は2に記載の免疫発達促進剤。
- ラクチュロース、ラフィノース、及びガラクトオリゴ糖の重量比が、1〜9:1〜9:1〜9である、請求項1〜3のいずれか一項に記載の免疫発達促進剤。
- 前記細菌の量が、ラクチュロース、ラフィノース、及びガラクトオリゴ糖の合計量1gに対して1×106〜1×1012cfuである、請求項1〜4のいずれか一項に記載の免疫発達促進剤。
- 請求項1〜5のいずれか一項に記載の免疫発達促進剤を含む飼料。
- ビフィドバクテリウム・ブレーベに属する細菌と、ラクチュロース、ラフィノース、及びガラクトオリゴ糖を有効成分とする、免疫発達促進用の飲食品組成物。
- 飲食品組成物が保健機能食品である、請求項7に記載の飲食品組成物。
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BR112019028006A2 (pt) * | 2017-06-30 | 2020-07-07 | N.V. Nutricia | composição nutricional, uso de uma combinação de bifidobacterium breve e oligossacarídeos não digeríveis, e método para prevenir e/ou reduzir o risco de ocorrência de hipercolesterolemia e/ou aterosclerose |
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JPH10175867A (ja) * | 1996-12-12 | 1998-06-30 | Morinaga Milk Ind Co Ltd | ビフィズス菌増殖促進組成物及びその用途 |
JP2014065669A (ja) * | 2012-09-25 | 2014-04-17 | Nihon Kenko Zoshin Shien Kiko | 乳幼児用アレルギー疾患予防剤 |
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JPH10175867A (ja) * | 1996-12-12 | 1998-06-30 | Morinaga Milk Ind Co Ltd | ビフィズス菌増殖促進組成物及びその用途 |
JP2014065669A (ja) * | 2012-09-25 | 2014-04-17 | Nihon Kenko Zoshin Shien Kiko | 乳幼児用アレルギー疾患予防剤 |
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