JPWO2013172339A1 - 腹圧性尿失禁予防剤及び/又は治療剤 - Google Patents
腹圧性尿失禁予防剤及び/又は治療剤 Download PDFInfo
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- JPWO2013172339A1 JPWO2013172339A1 JP2014515634A JP2014515634A JPWO2013172339A1 JP WO2013172339 A1 JPWO2013172339 A1 JP WO2013172339A1 JP 2014515634 A JP2014515634 A JP 2014515634A JP 2014515634 A JP2014515634 A JP 2014515634A JP WO2013172339 A1 JPWO2013172339 A1 JP WO2013172339A1
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- Prior art keywords
- urinary incontinence
- stress urinary
- acid
- present
- compound
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4465—Non condensed piperidines, e.g. piperocaine only substituted in position 4
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- A—HUMAN NECESSITIES
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- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A—HUMAN NECESSITIES
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- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
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Abstract
Description
本出願は、2012年5月15日に出願された、日本国特許出願第特願2012−111843号明細書(その開示全体が参照により本明細書中に援用される)に基づく優先権を主張する。本発明は、優れた腹圧性尿失禁の予防効果及び/又は治療効果を示すピペリジン化合物に関し、特に4-ピペリジルジフェニルプロポキシアセテート又はその塩に関するものである。
ボツリヌスA毒素を筋肉内投与した雌ラット1群あたり8例を使用し、腹部皮下を電気刺激することで腹圧を上昇させ尿失禁を発現させた。モデルラットに、本発明化合物(30 mg/kg)を、また対照群及びボツリヌスA毒素を処置しない正常群には蒸留水を2 mL/kgにて経口投与した。投与前、投与から30分後、及び2時間後の尿失禁の回数をカウントし、結果を表1に示した。
ラット漏出時圧(LPP)試験は、腹圧性尿失禁の治療効果を評価するin vivo試験として一般的に用いられる(Am J Physiol Renal Physiol 293: F920-F926, 2007)。
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PCT/JP2013/063409 WO2013172339A1 (ja) | 2012-05-15 | 2013-05-14 | 腹圧性尿失禁予防剤及び/又は治療剤 |
JP2014515634A JP5908072B2 (ja) | 2012-05-15 | 2013-05-14 | 腹圧性尿失禁予防剤及び/又は治療剤 |
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WO2020101586A1 (en) | 2018-11-16 | 2020-05-22 | Santa Farma İlaç Sanayi̇ A.Ş. | Controlled release propiverine formulations |
EP4251154A1 (en) | 2020-11-27 | 2023-10-04 | Santa Farma Ilac Sanayii A.S. | Sustained release formulation compositions comprising propiverine |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
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JPS6239567A (ja) * | 1985-08-14 | 1987-02-20 | Taiho Yakuhin Kogyo Kk | ベンジル酸−4−ピペリジルエステル誘導体 |
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DD139212A1 (de) | 1978-10-09 | 1979-12-19 | Christian Starke | Verfahren zur herstellung eines neuen arzneimittels aus alpha,alpha-diphenyl-alpha-alkoxyessigsaeure-1-methylpiperidyl-4-ester-derivaten |
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Publication number | Priority date | Publication date | Assignee | Title |
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JPS6239567A (ja) * | 1985-08-14 | 1987-02-20 | Taiho Yakuhin Kogyo Kk | ベンジル酸−4−ピペリジルエステル誘導体 |
Non-Patent Citations (1)
Title |
---|
JPN6013039341; OKADA,H. et al: 'Clinical effect of propiverine in patients with urge or stress incontinence. Kobe University Inconti' Hinyokika Kiyo(Acta Urol. Jpn.)) Vol.44, No.1, 1998, p.65-9 * |
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PL2851073T3 (pl) | 2017-06-30 |
ES2612827T3 (es) | 2017-05-18 |
HK1203159A1 (en) | 2015-10-23 |
EP2851073A4 (en) | 2015-10-28 |
US20150051250A1 (en) | 2015-02-19 |
US9603845B2 (en) | 2017-03-28 |
CN104302293A (zh) | 2015-01-21 |
WO2013172339A1 (ja) | 2013-11-21 |
TWI544925B (zh) | 2016-08-11 |
EP2851073B1 (en) | 2016-11-09 |
EP2851073A1 (en) | 2015-03-25 |
CN104302293B (zh) | 2017-03-15 |
TW201350118A (zh) | 2013-12-16 |
JP5908072B2 (ja) | 2016-04-26 |
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