JPWO2008001672A1 - 漢方エキス含有錠剤組成物 - Google Patents
漢方エキス含有錠剤組成物 Download PDFInfo
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- JPWO2008001672A1 JPWO2008001672A1 JP2008522513A JP2008522513A JPWO2008001672A1 JP WO2008001672 A1 JPWO2008001672 A1 JP WO2008001672A1 JP 2008522513 A JP2008522513 A JP 2008522513A JP 2008522513 A JP2008522513 A JP 2008522513A JP WO2008001672 A1 JPWO2008001672 A1 JP WO2008001672A1
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- JAWMENYCRQKKJY-UHFFFAOYSA-N [3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-ylmethyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-en-8-yl]-[2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidin-5-yl]methanone Chemical compound N1N=NC=2CN(CCC=21)CC1=NOC2(C1)CCN(CC2)C(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F JAWMENYCRQKKJY-UHFFFAOYSA-N 0.000 description 1
- YKTSYUJCYHOUJP-UHFFFAOYSA-N [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] Chemical compound [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] YKTSYUJCYHOUJP-UHFFFAOYSA-N 0.000 description 1
- VJHCJDRQFCCTHL-UHFFFAOYSA-N acetic acid 2,3,4,5,6-pentahydroxyhexanal Chemical compound CC(O)=O.OCC(O)C(O)C(O)C(O)C=O VJHCJDRQFCCTHL-UHFFFAOYSA-N 0.000 description 1
- 239000003125 aqueous solvent Substances 0.000 description 1
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- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
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- 235000019359 magnesium stearate Nutrition 0.000 description 1
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- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
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- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A—HUMAN NECESSITIES
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
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- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Epidemiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Inorganic Chemistry (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
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- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
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- Medicines Containing Plant Substances (AREA)
Abstract
Description
さらに、炭酸水素ナトリウムを組成物中に多量に配合すると、炭酸水素ナトリウムのアルカリ性がエキス粉末の安定性に影響を与える可能性があることも危惧された。
本発明における漢方エキス粉末とは、通常の漢方処方から煎出した煎出液を濃縮および乾燥して得られるもので、例えば、葛根湯、葛根湯加川きゅう辛夷、小青竜湯、当帰芍薬散、加味逍遥散、桂枝茯苓丸、補中益気湯、防風通聖散、牛車腎気丸、麻黄附子細辛湯、桂枝加朮附湯、十全大補湯、疎経活血湯、芍薬甘草湯、桂枝人参湯、桃核承気湯、抑肝散、五苓湯および越婢加朮湯等のエキス粉末を挙げることができるが、これに制限されるものではない。また、その他1種または2種以上の生薬から煎出し、煎出液を濃縮乾燥して得られる生薬エキス粉末も含む。
(実施例1−1,1−2、比較例1−1〜1−12)
下記の表1,2に示す配合処方に従い、混合したものを打錠用混合末とし、これを打錠機により打錠し、錠剤重量540mgの供試錠剤を得た。
試験液 :精製水
試験液量 :900mL
液温 :37℃
パドル回転速度 :50min-1
検出器 :UV(紫外線)
下記の表3に示す配合処方に従い、混合したものを打錠用混合末とし、これを打錠機により打錠し、錠剤重量540mgの供試錠剤を得た。
下記の表4に示す配合処方に従い、混合したものを打錠用混合末とし、これを打錠機により打錠し、錠剤重量540mgの供試錠剤を得た。
下記の表5に示す配合処方に従い、混合したものを打錠用混合末とし、これを打錠機により打錠し、錠剤重量540mgの供試錠剤を得た。
下記の表6に示す配合処方に従い、混合したものを打錠用混合末とし、これを打錠機により打錠し、錠剤重量540mgの供試錠剤を得た。
下記の表7に示す配合処方に従い、混合したものを打錠用混合末とし、これを打錠機により打錠し、錠剤重量540mgの供試錠剤を得た。
下記の表8に示す配合処方に従い、混合したものを打錠用混合末とし、これを打錠機により打錠し、錠剤重量540mgの供試錠剤を得た。
下記の表9に示す処方に従い、混合したものを打錠用混合末とし、これを打錠機により打錠し、錠剤重量540mgの供試錠剤を得た。
下記の表10〜13に示す処方に従い、混合したものを打錠用混合末とし、これを打錠機により打錠し、錠剤重量540mgの供試錠剤を得た。
下記の表14〜16に示す処方に従い、混合したものを打錠用混合末とし、これを打錠機により打錠し、錠剤重量540mgの供試錠剤を得た。
Claims (4)
- 漢方エキス粉末、クロスカルメロースナトリウムおよび炭酸水素ナトリウムが配合されてなることを特徴とする漢方エキス含有錠剤組成物。
- 前記クロスカルメロースナトリウムの配合量が、前記漢方エキス粉末100重量部に対し5〜30重量部である請求項1記載の漢方エキス含有錠剤組成物。
- 前記炭酸水素ナトリウムの配合量が、前記漢方エキス粉末100重量部に対し5〜30重量部である請求項1記載の漢方エキス含有錠剤組成物。
- 前記漢方エキス粉末が、葛根湯、葛根湯加川きゅう辛夷、小青竜湯、当帰芍薬散、加味逍遥散、桂枝茯苓丸、補中益気湯、防風通聖散、牛車腎気丸、麻黄附子細辛湯、桂枝加朮附湯、十全大補湯、疎経活血湯、芍薬甘草湯、桂枝人参湯、桃核承気湯、抑肝散、五苓湯および越婢加朮湯からなる群から選択される少なくとも1種のエキス粉末である請求項1記載の漢方エキス含有錠剤組成物。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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JP2008522513A JP5344289B2 (ja) | 2006-06-29 | 2007-06-21 | 漢方エキス含有錠剤組成物 |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
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JP2006179341 | 2006-06-29 | ||
JP2006179341 | 2006-06-29 | ||
JP2008522513A JP5344289B2 (ja) | 2006-06-29 | 2007-06-21 | 漢方エキス含有錠剤組成物 |
PCT/JP2007/062515 WO2008001672A1 (fr) | 2006-06-29 | 2007-06-21 | Composition de comprimé contenant un extrait d'herbe chinoise |
Publications (2)
Publication Number | Publication Date |
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JPWO2008001672A1 true JPWO2008001672A1 (ja) | 2009-11-26 |
JP5344289B2 JP5344289B2 (ja) | 2013-11-20 |
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JP2008522513A Expired - Fee Related JP5344289B2 (ja) | 2006-06-29 | 2007-06-21 | 漢方エキス含有錠剤組成物 |
Country Status (5)
Country | Link |
---|---|
US (1) | US8980337B2 (ja) |
JP (1) | JP5344289B2 (ja) |
KR (1) | KR101426754B1 (ja) |
CN (1) | CN101478979B (ja) |
WO (1) | WO2008001672A1 (ja) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
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JP5224834B2 (ja) * | 2008-01-25 | 2013-07-03 | 小林製薬株式会社 | 植物加工物およびパンテチン類を含有する錠剤 |
JP5339761B2 (ja) * | 2008-03-31 | 2013-11-13 | 小林製薬株式会社 | 防風通聖散配合製剤 |
CN101810842B (zh) * | 2010-03-08 | 2013-03-13 | 瑞阳制药有限公司 | 葛根汤颗粒的制备方法 |
JP5759113B2 (ja) * | 2010-06-16 | 2015-08-05 | 旭化成ケミカルズ株式会社 | エキス末配合錠剤 |
JP6379700B2 (ja) * | 2013-06-20 | 2018-08-29 | 大正製薬株式会社 | 錠剤 |
JP6347956B2 (ja) * | 2014-01-17 | 2018-06-27 | ポーラ化成工業株式会社 | 経口用組成物 |
CN103976962A (zh) * | 2014-04-25 | 2014-08-13 | 南昌济顺制药有限公司 | 一种中药提取物片剂的制备方法 |
KR20220077979A (ko) * | 2020-12-02 | 2022-06-10 | 경희대학교 산학협력단 | 우차신기환을 함유하는 암성 악액질 예방, 개선 또는 치료용 조성물 |
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JPH01258625A (ja) * | 1988-04-08 | 1989-10-16 | Kanebo Ltd | 漢方エキス錠剤の製造法 |
JP4122544B2 (ja) * | 1997-08-18 | 2008-07-23 | 株式会社ツムラ | 錠剤組成物 |
SE9802973D0 (sv) * | 1998-09-03 | 1998-09-03 | Astra Ab | Immediate release tablet |
US6413546B1 (en) * | 1999-03-18 | 2002-07-02 | Indena, S.P.A. | Tablets incorporating isoflavone plant extracts and methods of manufacturing them |
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WO2008001672A1 (fr) | 2008-01-03 |
KR101426754B1 (ko) | 2014-08-07 |
CN101478979B (zh) | 2012-07-25 |
US8980337B2 (en) | 2015-03-17 |
JP5344289B2 (ja) | 2013-11-20 |
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