JPWO2007066557A1 - ホスフィン遷移金属錯体、その製造方法およびそれを含有する抗癌剤 - Google Patents
ホスフィン遷移金属錯体、その製造方法およびそれを含有する抗癌剤 Download PDFInfo
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- JPWO2007066557A1 JPWO2007066557A1 JP2007549088A JP2007549088A JPWO2007066557A1 JP WO2007066557 A1 JPWO2007066557 A1 JP WO2007066557A1 JP 2007549088 A JP2007549088 A JP 2007549088A JP 2007549088 A JP2007549088 A JP 2007549088A JP WO2007066557 A1 JPWO2007066557 A1 JP WO2007066557A1
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- Prior art keywords
- group
- bis
- gold
- transition metal
- metal complex
- Prior art date
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- 229910052723 transition metal Inorganic materials 0.000 title claims abstract description 43
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- PNGLEYLFMHGIQO-UHFFFAOYSA-M sodium;3-(n-ethyl-3-methoxyanilino)-2-hydroxypropane-1-sulfonate;dihydrate Chemical compound O.O.[Na+].[O-]S(=O)(=O)CC(O)CN(CC)C1=CC=CC(OC)=C1 PNGLEYLFMHGIQO-UHFFFAOYSA-M 0.000 description 1
- XEGKKGGYSCPDQK-UHFFFAOYSA-J sodium;tetrachloroplatinum Chemical compound [Na].[Na].Cl[Pt](Cl)(Cl)Cl XEGKKGGYSCPDQK-UHFFFAOYSA-J 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
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- 229910052623 talc Inorganic materials 0.000 description 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
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- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
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- 230000007704 transition Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6568—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus atoms as the only ring hetero atoms
- C07F9/65683—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus atoms as the only ring hetero atoms the ring phosphorus atom being part of a phosphine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0086—Platinum compounds
- C07F15/0093—Platinum compounds without a metal-carbon linkage
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
ビス((+)−1,2−ビス((2R, 5R)−2, 5−ジメチルホスホラノ)エタン)金(I)クロリドの合成
1H NMR(CDCl3 );δ=1.0−1.3(m,24H),1.2−1.4(m
,4H),1.3−1.5(m,4H),1.5−1.7(m,4H),1.9−2.1(m,8H),2.1−2.3(m,8H),2.2−2.4(m,4H)
13C NMR;δ=13.78(s),21.3(m),25.1(m),34.1,34.7,36.5(m),36.9(m)
31P NMR(1H decoupled, CDCl3 );δ=37.2(s)
IR(KBr);2927,2865,1454,1407,1375cm-1
MS(FAB,POS);m/z 713.(M+ −Cl- )
ビス((−)−1,2−ビス((2S, 5S)−2, 5−ジメチルホスホラノ)エタン)金(I)クロリド
1H NMR(CDCl3 );δ=1.0−1.3(m,24H),1.2−1.4(m
,4H),1.3−1.5(m,4H),1.5−1.7(m,4H),1.9−2.1(m,8H),2.1−2.3(m,8H),2.2−2.4(m,4H)
13C NMR;δ=13.78(s),21.3(m),25.1(m),34.1,34.7,36.5(m),36.9(m)
31P NMR(1H decoupled, CDCl3 );δ=37.2(s)
IR(KBr);2927,2865,1454,1407,1375cm−1
MS(FAB,POS);m/z 713.(M+ −Cl- )
ビス(1,2−ビス((2S,5S)−2,5−(ジメチルホスホラノ)ベンゼン))金(I)クロリド
1H NMR(300.4MHz,CDCl3 );δ=0.74−0.81(m,12H),1.16−1.25(m,12H),1.52−1.63(m,4H),1.74−1.88(m,4H),2.21−2.34(m,8H),2.54−2.68(m,8H),7.58−7.62(m,4H),7.71−7.74(m,4H)
13C NMR(75.5MHz,CDCl3 );δ=14.4(s),21.3(m),35.7(s),35.9(s),37.5(m),40.3(m),130.6(s),133.2(m),142.2(s)
31P NMR(121.5MHz,CDCl3 )δ=38.9(s)
Mass(FAB,POS);m/z 809.(M+ −Cl- )
ビス(1,2−ビス((2R,5R)−2,5−(ジメチルホスホラノ)ベンゼン))金(I)クロリド
Mass(FAB, POS);m/z 809.(M+ −Cl- )
抗癌性の評価
毒性試験
Claims (8)
- D1 およびD2 はテトラメチレン基であり、R1 、R2 、R3 およびR4 はそれぞれ低級アルキル基である、請求項2に記載のホスフィン遷移金属錯体。
- Mは金原子である請求項1〜3のいずれか1項に記載のホスフィン遷移金属錯体。
- ビス(1,2−ビス(2,5−ジメチルホスホラノ)エタン)金(I)クロリド、ビス(1,2−ビス(2,5−ジエチルホスホラノ)エタン)金(I)クロリド、ビス(1,2−ビス(2,5−ジイソプロピルホスホラノ)エタン)金(I)クロリド、ビス(1,2−ビス(2,5−(ジメチルホスホラノ)ベンゼン))金(I)クロリド、ビス(1,2−ビス(2,5−(ジエチルホスホラノ)ベンゼン))金(I)クロリド、ビス(1,2−ビス(2,5−(ジイソプロピルホスホラノ)ベンゼン))金(I)クロリド、ビス(1,2−ビス(2,5−(ジメチル)−3,4−(ジヒドロキシ)ホスホラノ)ベンゼン))金(I)クロリドまたはビス(1,2−ビス(2,5−(ジメチル)−3,4−(ジベンジルオキシ)ホスホラノ)ベンゼン))金(I)クロリドである請求項1〜4のいずれか1項に記載のホスフィン遷移金属錯体。
- 請求項1〜5のいずれか1項に記載のホスフィン遷移金属錯体の光学活性体。
Priority Applications (1)
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JP2007549088A JP5090180B2 (ja) | 2005-12-06 | 2006-11-30 | ホスフィン遷移金属錯体、その製造方法およびそれを含有する抗癌剤 |
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JP2005352466 | 2005-12-06 | ||
JP2005352466 | 2005-12-06 | ||
PCT/JP2006/323886 WO2007066557A1 (ja) | 2005-12-06 | 2006-11-30 | ホスフィン遷移金属錯体、その製造方法およびそれを含有する抗癌剤 |
JP2007549088A JP5090180B2 (ja) | 2005-12-06 | 2006-11-30 | ホスフィン遷移金属錯体、その製造方法およびそれを含有する抗癌剤 |
Publications (2)
Publication Number | Publication Date |
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JPWO2007066557A1 true JPWO2007066557A1 (ja) | 2009-05-14 |
JP5090180B2 JP5090180B2 (ja) | 2012-12-05 |
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Country Status (6)
Country | Link |
---|---|
US (1) | US7655810B2 (ja) |
EP (1) | EP1958951A4 (ja) |
JP (1) | JP5090180B2 (ja) |
CN (1) | CN101326191B (ja) |
TW (1) | TW200728315A (ja) |
WO (1) | WO2007066557A1 (ja) |
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WO2011078121A1 (ja) * | 2009-12-21 | 2011-06-30 | 日本化学工業株式会社 | 抗がん剤 |
US10111892B2 (en) * | 2009-12-21 | 2018-10-30 | Nippon Chemical Industrial Co., Ltd. | Anti-cancer agent |
WO2013024324A1 (en) | 2011-08-16 | 2013-02-21 | Università Degli Studi Di Padova | [Cu(thp)4]n[X]-n COMPOUNDS FOR THE TREATMENT OF A BROAD RANGE OF HUMAN SOLID TUMORS, INCLUDING REFRACTORY TUMORS |
SG11201610306RA (en) | 2014-06-11 | 2017-01-27 | Univ Texas | Texaphyrin-pt(iv) conjugates and compositions for use in overcoming platinum resistance |
US11564394B2 (en) * | 2019-12-10 | 2023-01-31 | University Of Kentucky Research Foundation | Distorted gold (I)-phosphine complexes and and methods for use as antifungal agents |
CN113861226B (zh) * | 2021-10-11 | 2022-08-19 | 清华大学 | 一种超碳金簇离子型化合物及其制备方法和应用 |
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JPS6110594A (ja) | 1984-06-04 | 1986-01-18 | スミスクライン・ベツクマン・コーポレイシヨン | ホスフイノ‐炭化水素‐金、銀または銅錯体含有腫瘍細胞成長抑制医薬組成物 |
US5171892A (en) | 1991-07-02 | 1992-12-15 | E. I. Du Pont De Nemours And Company | Chiral phospholanes via chiral 1,4-diol cyclic sulfates |
JPH10509957A (ja) | 1994-12-09 | 1998-09-29 | グリフィス ユニヴァーシティ | 抗癌剤 |
JPH10114782A (ja) | 1996-10-08 | 1998-05-06 | Nippon Chem Ind Co Ltd | 第四級ホスホニウム有機酸塩及びその製造方法 |
JPH10147590A (ja) | 1996-11-19 | 1998-06-02 | Nippon Chem Ind Co Ltd | 第四級ホスホニウム無機酸塩及びその製造方法 |
US6727377B2 (en) | 1998-08-21 | 2004-04-27 | The Penn State Research Foundation | Asymmetric catalysis based on chiral phospholanes and hydroxyl phospholanes |
EP1105400A1 (en) * | 1998-08-21 | 2001-06-13 | The Penn State Research Foundation | Asymmetric catalysis based on chiral phospholanes |
FR2807433B1 (fr) * | 2000-04-06 | 2002-09-20 | Centre Nat Rech Scient | Molecules duales contenant un derives peroxydique, leur synthese et leurs applications therapeutiques |
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US7655810B2 (en) | 2010-02-02 |
EP1958951A4 (en) | 2011-05-04 |
TWI370134B (ja) | 2012-08-11 |
TW200728315A (en) | 2007-08-01 |
CN101326191A (zh) | 2008-12-17 |
CN101326191B (zh) | 2012-09-19 |
US20090156850A1 (en) | 2009-06-18 |
WO2007066557A1 (ja) | 2007-06-14 |
JP5090180B2 (ja) | 2012-12-05 |
EP1958951A1 (en) | 2008-08-20 |
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