JPS6470429A - Reduction of ester compound - Google Patents

Reduction of ester compound

Info

Publication number
JPS6470429A
JPS6470429A JP63106199A JP10619988A JPS6470429A JP S6470429 A JPS6470429 A JP S6470429A JP 63106199 A JP63106199 A JP 63106199A JP 10619988 A JP10619988 A JP 10619988A JP S6470429 A JPS6470429 A JP S6470429A
Authority
JP
Japan
Prior art keywords
ester compound
sodium borohydride
formula
aluminum chloride
reduction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP63106199A
Other languages
Japanese (ja)
Other versions
JP2570806B2 (en
Inventor
Taiichi Okada
Yasuaki Abe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Priority to JP63106199A priority Critical patent/JP2570806B2/en
Publication of JPS6470429A publication Critical patent/JPS6470429A/en
Application granted granted Critical
Publication of JP2570806B2 publication Critical patent/JP2570806B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE:To obtain an ester compound useful as an intermediate for pharmaceuticals, using an easily available reagent without causing safety problem, by using sodium borohydride and aluminum chloride as reducing agents in the reduction of a specific ester compound used as a raw material. CONSTITUTION:The objective compound of formula II can be produced by reducing an ester compound of formula I [R<1>, R<2> and R<3> are lower alkyl n is 0-21; X is H or (protected) hydroxy; Y is (protected) hydroxy] with a reducing agent consisting of a mixture of sodium borohydride and aluminum chloride preferably in the presence of water usually at 0-140 deg.C, preferably 10-40 deg.C. The amount of the sodium borohydride is usually >=1.5mol., preferably about 2mol. per 1mol. of the starting compound of formula I and the molar ratio of aluminum chloride to sodium borohydride is preferably about 1:3.
JP63106199A 1987-04-27 1988-04-27 Method for reducing ester compound Expired - Lifetime JP2570806B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP63106199A JP2570806B2 (en) 1987-04-27 1988-04-27 Method for reducing ester compound

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP10579587 1987-04-27
JP62-105795 1987-04-29
JP63106199A JP2570806B2 (en) 1987-04-27 1988-04-27 Method for reducing ester compound

Publications (2)

Publication Number Publication Date
JPS6470429A true JPS6470429A (en) 1989-03-15
JP2570806B2 JP2570806B2 (en) 1997-01-16

Family

ID=26446027

Family Applications (1)

Application Number Title Priority Date Filing Date
JP63106199A Expired - Lifetime JP2570806B2 (en) 1987-04-27 1988-04-27 Method for reducing ester compound

Country Status (1)

Country Link
JP (1) JP2570806B2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102384285A (en) * 2010-08-30 2012-03-21 李殿治 Water distribution type valve

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51128932A (en) * 1975-04-30 1976-11-10 Takeda Chem Ind Ltd Organic compounds
JPS5293729A (en) * 1976-01-28 1977-08-06 Ici Ltd Process for preparing 33 hydroxymethyl diphenyl ether

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51128932A (en) * 1975-04-30 1976-11-10 Takeda Chem Ind Ltd Organic compounds
JPS5293729A (en) * 1976-01-28 1977-08-06 Ici Ltd Process for preparing 33 hydroxymethyl diphenyl ether

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102384285A (en) * 2010-08-30 2012-03-21 李殿治 Water distribution type valve

Also Published As

Publication number Publication date
JP2570806B2 (en) 1997-01-16

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