CS274910B2 - Method of 2-(aminoalkylthio) carbapeneme preparation - Google Patents
Method of 2-(aminoalkylthio) carbapeneme preparationInfo
- Publication number
- CS274910B2 CS274910B2 CS645989A CS645989A CS274910B2 CS 274910 B2 CS274910 B2 CS 274910B2 CS 645989 A CS645989 A CS 645989A CS 645989 A CS645989 A CS 645989A CS 274910 B2 CS274910 B2 CS 274910B2
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- compound
- preparation
- antibiotics
- alkyl
- possibly substituted
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 239000003242 anti bacterial agent Substances 0.000 abstract 2
- 229940088710 antibiotic agent Drugs 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- 150000003335 secondary amines Chemical class 0.000 abstract 1
- 150000003512 tertiary amines Chemical class 0.000 abstract 1
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
The solution concerns a method of production of compound of general formula I, where R<1> and R<2> always mean hydrogen, C1-4-alkyl, possibly substituted in position 1, or C1-4-fluoroalkyl, provided that at least one of the R<1> and R<2> symbols mean hydrogen, R<3> is C1-4-alkyl, or possibly substituted benzyl and the value of n is from 2 to 6, and their pharmaceutically applicable addition salt with acids, characteristic by the fact that the mixture of tertiary amine or sterically protected secondary amine and compound reacts with phosphorohalogenidate and the originated intermediary enol-phosphate is treated by thioalkylamine and the resulting compound is isolated in free form or in the form of salts. The produced compounds can be used as antibiotics or as intermediary products for preparation of other carbapenemic antibiotics.<IMAGE>
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CS896459A CS645989A2 (en) | 1989-11-15 | 1989-11-15 | Method of 2-(aminoalkylthio) carbapenemes preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CS896459A CS645989A2 (en) | 1989-11-15 | 1989-11-15 | Method of 2-(aminoalkylthio) carbapenemes preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CS274910B2 true CS274910B2 (en) | 1991-12-17 |
| CS645989A2 CS645989A2 (en) | 1991-12-17 |
Family
ID=5411677
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS896459A CS645989A2 (en) | 1989-11-15 | 1989-11-15 | Method of 2-(aminoalkylthio) carbapenemes preparation |
Country Status (1)
| Country | Link |
|---|---|
| CS (1) | CS645989A2 (en) |
-
1989
- 1989-11-15 CS CS896459A patent/CS645989A2/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CS645989A2 (en) | 1991-12-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| IF00 | In force as of 2000-06-30 in czech republic | ||
| MM4A | Patent lapsed due to non-payment of fee |
Effective date: 20071115 |