JPS6360931A - 血液または血液製剤保存液およびこれを用いた血液または血液製剤の保存方法 - Google Patents
血液または血液製剤保存液およびこれを用いた血液または血液製剤の保存方法Info
- Publication number
- JPS6360931A JPS6360931A JP61204269A JP20426986A JPS6360931A JP S6360931 A JPS6360931 A JP S6360931A JP 61204269 A JP61204269 A JP 61204269A JP 20426986 A JP20426986 A JP 20426986A JP S6360931 A JPS6360931 A JP S6360931A
- Authority
- JP
- Japan
- Prior art keywords
- blood
- glycerin
- preservation
- mannitol
- storage
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004369 blood Anatomy 0.000 title claims description 72
- 239000008280 blood Substances 0.000 title claims description 70
- 238000000034 method Methods 0.000 title claims description 30
- 239000003761 preservation solution Substances 0.000 title claims description 27
- 239000010836 blood and blood product Substances 0.000 title claims description 24
- 229940125691 blood product Drugs 0.000 title claims description 24
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 98
- 235000011187 glycerol Nutrition 0.000 claims description 49
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 31
- 229930195725 Mannitol Natural products 0.000 claims description 31
- 239000000594 mannitol Substances 0.000 claims description 31
- 235000010355 mannitol Nutrition 0.000 claims description 31
- 239000000243 solution Substances 0.000 claims description 29
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 27
- 210000003743 erythrocyte Anatomy 0.000 claims description 25
- 238000004555 blood preservation Methods 0.000 claims description 19
- 210000000601 blood cell Anatomy 0.000 claims description 18
- 238000004321 preservation Methods 0.000 claims description 17
- 230000006870 function Effects 0.000 claims description 13
- 239000000126 substance Substances 0.000 claims description 13
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 11
- 239000003146 anticoagulant agent Substances 0.000 claims description 11
- 229940127219 anticoagulant drug Drugs 0.000 claims description 11
- 239000008103 glucose Substances 0.000 claims description 11
- 239000001509 sodium citrate Substances 0.000 claims description 10
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 10
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 8
- 238000007710 freezing Methods 0.000 claims description 8
- 230000008014 freezing Effects 0.000 claims description 8
- 230000002503 metabolic effect Effects 0.000 claims description 7
- 206010018910 Haemolysis Diseases 0.000 description 19
- 230000008588 hemolysis Effects 0.000 description 19
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 14
- 229910052700 potassium Inorganic materials 0.000 description 14
- 239000011591 potassium Substances 0.000 description 14
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 13
- 230000000694 effects Effects 0.000 description 13
- 239000003792 electrolyte Substances 0.000 description 13
- 229910052708 sodium Inorganic materials 0.000 description 13
- 239000011734 sodium Substances 0.000 description 13
- 230000007423 decrease Effects 0.000 description 11
- 102000001554 Hemoglobins Human genes 0.000 description 9
- 108010054147 Hemoglobins Proteins 0.000 description 9
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 6
- 230000006866 deterioration Effects 0.000 description 6
- 230000003915 cell function Effects 0.000 description 5
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 description 4
- 229930024421 Adenine Natural products 0.000 description 3
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 3
- ZKHQWZAMYRWXGA-UHFFFAOYSA-N Adenosine triphosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C1O ZKHQWZAMYRWXGA-UHFFFAOYSA-N 0.000 description 3
- 229930091371 Fructose Natural products 0.000 description 3
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 3
- 239000005715 Fructose Substances 0.000 description 3
- 229910019142 PO4 Inorganic materials 0.000 description 3
- 229960000643 adenine Drugs 0.000 description 3
- 239000001569 carbon dioxide Substances 0.000 description 3
- 229910002092 carbon dioxide Inorganic materials 0.000 description 3
- 230000006837 decompression Effects 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 230000004060 metabolic process Effects 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 230000003204 osmotic effect Effects 0.000 description 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 3
- 239000010452 phosphate Substances 0.000 description 3
- 239000002504 physiological saline solution Substances 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 206010048962 Brain oedema Diseases 0.000 description 2
- 239000002126 C01EB10 - Adenosine Substances 0.000 description 2
- 229930010555 Inosine Natural products 0.000 description 2
- UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 description 2
- BZHJMEDXRYGGRV-UHFFFAOYSA-N Vinyl chloride Chemical compound ClC=C BZHJMEDXRYGGRV-UHFFFAOYSA-N 0.000 description 2
- 229960005305 adenosine Drugs 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 208000006752 brain edema Diseases 0.000 description 2
- 230000003139 buffering effect Effects 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 210000000170 cell membrane Anatomy 0.000 description 2
- 238000005138 cryopreservation Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 229960003786 inosine Drugs 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 239000002207 metabolite Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- XOHUEYCVLUUEJJ-UHFFFAOYSA-N 2,3-Bisphosphoglyceric acid Chemical compound OP(=O)(O)OC(C(=O)O)COP(O)(O)=O XOHUEYCVLUUEJJ-UHFFFAOYSA-N 0.000 description 1
- XOHUEYCVLUUEJJ-UHFFFAOYSA-I 2,3-Diphosphoglycerate Chemical compound [O-]P(=O)([O-])OC(C(=O)[O-])COP([O-])([O-])=O XOHUEYCVLUUEJJ-UHFFFAOYSA-I 0.000 description 1
- ZKHQWZAMYRWXGA-KQYNXXCUSA-J ATP(4-) Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]1O ZKHQWZAMYRWXGA-KQYNXXCUSA-J 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 102000005393 Sodium-Potassium-Exchanging ATPase Human genes 0.000 description 1
- 108010006431 Sodium-Potassium-Exchanging ATPase Proteins 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000019522 cellular metabolic process Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000005515 coenzyme Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000002414 glycolytic effect Effects 0.000 description 1
- 230000002949 hemolytic effect Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007102 metabolic function Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 1
- 235000019799 monosodium phosphate Nutrition 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000011814 protection agent Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 235000011008 sodium phosphates Nutrition 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
- 239000000057 synthetic resin Substances 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
- A01N1/122—Preservation or perfusion media
- A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Biotechnology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Cell Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Environmental Sciences (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61204269A JPS6360931A (ja) | 1986-08-29 | 1986-08-29 | 血液または血液製剤保存液およびこれを用いた血液または血液製剤の保存方法 |
| US07/088,450 US4812310A (en) | 1986-08-29 | 1987-08-24 | Preserving solution for blood or packed blood cells and method for preserving blood or packed blood cells by using the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61204269A JPS6360931A (ja) | 1986-08-29 | 1986-08-29 | 血液または血液製剤保存液およびこれを用いた血液または血液製剤の保存方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6360931A true JPS6360931A (ja) | 1988-03-17 |
| JPH0262534B2 JPH0262534B2 (https=) | 1990-12-26 |
Family
ID=16487675
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP61204269A Granted JPS6360931A (ja) | 1986-08-29 | 1986-08-29 | 血液または血液製剤保存液およびこれを用いた血液または血液製剤の保存方法 |
Country Status (2)
| Country | Link |
|---|---|
| US (1) | US4812310A (https=) |
| JP (1) | JPS6360931A (https=) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63132841A (ja) * | 1986-11-21 | 1988-06-04 | Nitsushiyoo:Kk | 血液バツグ |
| US5530930A (en) * | 1993-06-09 | 1996-06-25 | Hyundai Electronics Industries, Co., Ltd. | Step counter usable as pocket paging receiver and method for controlling the same |
| JP2012117910A (ja) * | 2010-11-30 | 2012-06-21 | Waseda Univ | 血液適合性等の評価用の実験システム及び実験方法、並びに、これらに用いるサンプル容器 |
| CN114617903A (zh) * | 2022-03-15 | 2022-06-14 | 中国人民解放军总医院第一医学中心 | 一种用于血浆冻干的组合物及其应用 |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5192553A (en) | 1987-11-12 | 1993-03-09 | Biocyte Corporation | Isolation and preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood and methods of therapeutic use |
| US5147776A (en) * | 1990-02-26 | 1992-09-15 | University Of Iowa Research Foundation | Use of 2,5-anhydromannitol for control of pH during blood storage |
| JP3185108B2 (ja) * | 1990-11-07 | 2001-07-09 | バクスター、インターナショナル、インコーポレイテッド | 赤血球貯蔵溶液 |
| US5328821A (en) * | 1991-12-12 | 1994-07-12 | Robyn Fisher | Cold and cryo-preservation methods for human tissue slices |
| US6300322B1 (en) | 1993-06-04 | 2001-10-09 | Biotime, Inc. | Plasma-like solution |
| US6680305B1 (en) * | 1993-06-04 | 2004-01-20 | Biotime, Inc. | Physiologically acceptable aqueous solutions and methods for their use |
| US5702880A (en) * | 1993-06-04 | 1997-12-30 | Biotime, Inc. | Blood substitute comprising 0-5 mM K+ |
| US6218099B1 (en) | 1994-06-03 | 2001-04-17 | Biotime, Inc. | Methods and compositions for use in perfusion applications |
| US5605934A (en) * | 1995-03-23 | 1997-02-25 | Baxter International Inc. | Method of manufacturing and storing solutions |
| US7569342B2 (en) * | 1997-12-10 | 2009-08-04 | Sierra Molecular Corp. | Removal of molecular assay interferences |
| US20080064108A1 (en) * | 1997-12-10 | 2008-03-13 | Tony Baker | Urine Preservation System |
| JP2002516254A (ja) | 1998-05-26 | 2002-06-04 | ライフセル コーポレイション | ヒト赤血球の低温保存 |
| DE19836559A1 (de) | 1998-08-12 | 2000-03-23 | Antigen Gmbh | Gefäß zur Entnahme von Blut |
| US6267925B1 (en) | 1998-12-07 | 2001-07-31 | Haemonetics Corporation | Method for cryopreservation and recovery of red blood cells |
| US6589223B1 (en) | 1999-02-03 | 2003-07-08 | Biotime, Inc. | Method and compositions for use in perfusion applications |
| ATE384954T1 (de) * | 2000-11-08 | 2008-02-15 | Becton Dickinson Co | Verfahren und vorrichtung zum sammeln und zum stabilisieren einer biologischen probe |
| US6602718B1 (en) * | 2000-11-08 | 2003-08-05 | Becton, Dickinson And Company | Method and device for collecting and stabilizing a biological sample |
| EP1471140A4 (en) * | 2002-01-31 | 2005-02-16 | Asahi Techno Glass Cosporation | LIQUID FOR FROZEN STORAGE OF PRIMATE EMBRYONIC STEM CELLS AND FREEZING STORAGE METHOD |
| WO2004068109A2 (en) * | 2003-01-27 | 2004-08-12 | Harvest Technologies Inc | Autologous or homologous coagulant produced from anticoagulated whole blood |
| ES2668551T3 (es) | 2005-09-26 | 2018-05-18 | Lifecell Corporation | Composición seca de plaquetas |
| WO2008089337A1 (en) * | 2007-01-19 | 2008-07-24 | The Regents Of The University Of Michigan | Compositions and methods for preserving red blood cells |
| US20110229871A1 (en) * | 2010-02-16 | 2011-09-22 | Ericson Daniel G | Nucleoside-containing compositions and methods for treating red blood cells |
| JP5823985B2 (ja) | 2010-02-16 | 2015-11-25 | ビアセル，リミティド ライアビリティ カンパニー | 赤血球を治療するためのアルギニン含有組成物および方法 |
| CN104717970A (zh) | 2012-07-23 | 2015-06-17 | 万德-生物技术及制药有限公司 | 提高谷胱甘肽的组合物及其用途 |
| US10117428B2 (en) | 2013-07-17 | 2018-11-06 | Rythrx Therapeutics, Llc | Compositions and methods for preserving donated blood |
| CN105284787A (zh) * | 2015-10-23 | 2016-02-03 | 深圳爱生再生医学科技有限公司 | 骨髓间充质干细胞的保存试剂及其应用 |
| WO2018112780A1 (en) * | 2016-12-21 | 2018-06-28 | Chung Chin Sun | Novel method for blood plasma protein activity preservation |
| CN106577637A (zh) * | 2017-01-20 | 2017-04-26 | 北京天晟宇生物科技有限公司 | 人羊膜间充质干细胞的保存方法 |
| CN112293409B (zh) * | 2020-11-02 | 2022-09-30 | 国康生物科技有限公司 | 一种细胞冻存液 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3874384A (en) * | 1971-11-01 | 1975-04-01 | American Hospital Supply Corp | Improved blood storage unit and method of storing blood |
| US4473552A (en) * | 1981-03-16 | 1984-09-25 | Jost Leonora I | Anaerobic method for preserving whole blood, tissue and components containing living mammalian cells |
| JPS59137064A (ja) * | 1983-01-28 | 1984-08-06 | 新技術開発事業団 | 血液保存方法及びその保存用容器 |
| JPS60168464A (ja) * | 1983-11-18 | 1985-08-31 | 新技術事業団 | 血液保存方法及びその保存用容器 |
| US4585735A (en) * | 1984-07-19 | 1986-04-29 | American National Red Cross | Prolonged storage of red blood cells |
| US4704352A (en) * | 1985-06-25 | 1987-11-03 | Baxter Travenol Laboratories, Inc. | L-ascorbate-2-phosphate salts in blood cell storage |
| JPH06125558A (ja) * | 1992-08-25 | 1994-05-06 | Sony Corp | 衛星通信システム |
-
1986
- 1986-08-29 JP JP61204269A patent/JPS6360931A/ja active Granted
-
1987
- 1987-08-24 US US07/088,450 patent/US4812310A/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63132841A (ja) * | 1986-11-21 | 1988-06-04 | Nitsushiyoo:Kk | 血液バツグ |
| US5530930A (en) * | 1993-06-09 | 1996-06-25 | Hyundai Electronics Industries, Co., Ltd. | Step counter usable as pocket paging receiver and method for controlling the same |
| JP2012117910A (ja) * | 2010-11-30 | 2012-06-21 | Waseda Univ | 血液適合性等の評価用の実験システム及び実験方法、並びに、これらに用いるサンプル容器 |
| CN114617903A (zh) * | 2022-03-15 | 2022-06-14 | 中国人民解放军总医院第一医学中心 | 一种用于血浆冻干的组合物及其应用 |
| CN114617903B (zh) * | 2022-03-15 | 2024-05-24 | 中国人民解放军总医院第一医学中心 | 一种用于血浆冻干的组合物及其应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0262534B2 (https=) | 1990-12-26 |
| US4812310A (en) | 1989-03-14 |
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