JPS6357588A - ヒダントイン誘導体、その塩並びに該化合物を有効成分とする糖尿病合併症の予防及び治療剤 - Google Patents

ヒダントイン誘導体、その塩並びに該化合物を有効成分とする糖尿病合併症の予防及び治療剤

Info

Publication number
JPS6357588A
JPS6357588A JP19992486A JP19992486A JPS6357588A JP S6357588 A JPS6357588 A JP S6357588A JP 19992486 A JP19992486 A JP 19992486A JP 19992486 A JP19992486 A JP 19992486A JP S6357588 A JPS6357588 A JP S6357588A
Authority
JP
Japan
Prior art keywords
group
imidazolidine
dihydro
spiro
fluoro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP19992486A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0372227B2 (enExample
Inventor
Masatsune Kurono
昌庸 黒野
Yasuaki Kondo
近藤　保昭
Takuji Yamaguchi
山口　卓治
Toshinao Usui
臼井　敏直
Tadashi Terada
寺田　直史
Kyoichi Asano
恭一 浅野
Kuniharu Mizuno
邦治 水野
Akira Matsubara
旭 松原
Noriaki Kato
憲明 加藤
Kiichi Sawai
喜一 澤井
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanwa Kagaku Kenkyusho Co Ltd
Original Assignee
Sanwa Kagaku Kenkyusho Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanwa Kagaku Kenkyusho Co Ltd filed Critical Sanwa Kagaku Kenkyusho Co Ltd
Priority to JP19992486A priority Critical patent/JPS6357588A/ja
Priority to DE8787112497T priority patent/DE3769066D1/de
Priority to EP87112497A priority patent/EP0264586B1/en
Priority to US07/090,729 priority patent/US4861792A/en
Publication of JPS6357588A publication Critical patent/JPS6357588A/ja
Priority to US07/355,623 priority patent/US4985573A/en
Priority to US07/355,624 priority patent/US4978758A/en
Priority to US07/440,135 priority patent/US4985574A/en
Priority to US07/507,608 priority patent/US5001240A/en
Publication of JPH0372227B2 publication Critical patent/JPH0372227B2/ja
Priority to US08/311,005 priority patent/US5447946A/en
Granted legal-status Critical Current

Links

Landscapes

  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP19992486A 1986-08-28 1986-08-28 ヒダントイン誘導体、その塩並びに該化合物を有効成分とする糖尿病合併症の予防及び治療剤 Granted JPS6357588A (ja)

Priority Applications (9)

Application Number Priority Date Filing Date Title
JP19992486A JPS6357588A (ja) 1986-08-28 1986-08-28 ヒダントイン誘導体、その塩並びに該化合物を有効成分とする糖尿病合併症の予防及び治療剤
DE8787112497T DE3769066D1 (de) 1986-08-28 1987-08-27 Hydantoin-derivate zur behandlung von komplikationen bei diabetes.
EP87112497A EP0264586B1 (en) 1986-08-28 1987-08-27 Hydantoin derivatives for treating complications of diabetes
US07/090,729 US4861792A (en) 1986-08-28 1987-08-28 Hydantoin derivatives for treating complications of diabetes
US07/355,624 US4978758A (en) 1986-08-28 1989-05-23 Hydantoin derivatives for treating complications of diabetes
US07/355,623 US4985573A (en) 1986-08-28 1989-05-23 Hydantoin derivatives for treating complications of diabetes
US07/440,135 US4985574A (en) 1986-08-28 1989-11-22 Hydantoin derivatives for treating complications of diabetes
US07/507,608 US5001240A (en) 1986-08-28 1990-04-12 Process for preparing optically active hydantoins
US08/311,005 US5447946A (en) 1986-08-28 1994-09-23 Hydantoin derivatives for treating complications of diabetes

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP19992486A JPS6357588A (ja) 1986-08-28 1986-08-28 ヒダントイン誘導体、その塩並びに該化合物を有効成分とする糖尿病合併症の予防及び治療剤

Publications (2)

Publication Number Publication Date
JPS6357588A true JPS6357588A (ja) 1988-03-12
JPH0372227B2 JPH0372227B2 (enExample) 1991-11-18

Family

ID=16415860

Family Applications (1)

Application Number Title Priority Date Filing Date
JP19992486A Granted JPS6357588A (ja) 1986-08-28 1986-08-28 ヒダントイン誘導体、その塩並びに該化合物を有効成分とする糖尿病合併症の予防及び治療剤

Country Status (1)

Country Link
JP (1) JPS6357588A (enExample)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63250373A (ja) * 1987-04-08 1988-10-18 Sanwa Kagaku Kenkyusho Co Ltd （＋）―３，４―ジヒドロ―４―オキソ―２ｈ―１―ベンゾピラン―２―カルボン酸誘導体及びその製法
JPH037225A (ja) * 1989-02-22 1991-01-14 Sanwa Kagaku Kenkyusho Co Ltd アルドース還元酵素阻害作用を有し且つ吸収性の良好な薬剤組成物
US5036080A (en) * 1988-04-07 1991-07-30 Sanwa Kagaku Kenyusho Co., Ltd. (D)-6-fluoro-2,3-dihydro-2',5-dioxo-spiro[4H-1-benzopyran-4,4'-imidazolide]-2-carboxamide compounds
JPH049384A (ja) * 1990-04-27 1992-01-14 Sanwa Kagaku Kenkyusho Co Ltd ヒダントイン誘導体を有効成分とする循環器系疾患の予防及び治療剤並びに循環器系疾患と糖尿病合併症の同時的予防及び治療剤
WO2005079792A1 (ja) * 2004-02-20 2005-09-01 Sanwa Kagaku Kenkyusho Co., Ltd. 重症糖尿病網膜症の予防又は治療剤
WO2006090699A1 (ja) * 2005-02-22 2006-08-31 Sanwa Kagaku Kenkyusho Co., Ltd. 虚血又は虚血再灌流によって起こる心機能障害若しくは心筋障害の予防又は治療剤
WO2011136161A1 (ja) 2010-04-28 2011-11-03 株式会社 三和化学研究所 内耳障害の予防又は治療薬

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5353653A (en) * 1976-10-18 1978-05-16 Pfizer Hydantoin derivatives medicines
JPS53144575A (en) * 1977-05-23 1978-12-15 Pfizer Spiroohydantoin
JPS5745185A (en) * 1980-07-21 1982-03-13 Eisai Co Ltd Hydantoin derivative and its preparation
JPS58213717A (ja) * 1982-01-20 1983-12-12 Eisai Co Ltd ヒダントイン誘導体を含有する治療用薬剤
JPS61200991A (ja) * 1985-03-04 1986-09-05 Sanwa Kagaku Kenkyusho:Kk スピロ―３―ヘテロアゾリジン化合物、その製法及びそれを有効成分とする糖尿病合併症の予防及び治療剤

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5353653A (en) * 1976-10-18 1978-05-16 Pfizer Hydantoin derivatives medicines
JPS53144575A (en) * 1977-05-23 1978-12-15 Pfizer Spiroohydantoin
JPS5745185A (en) * 1980-07-21 1982-03-13 Eisai Co Ltd Hydantoin derivative and its preparation
JPS58213717A (ja) * 1982-01-20 1983-12-12 Eisai Co Ltd ヒダントイン誘導体を含有する治療用薬剤
JPS61200991A (ja) * 1985-03-04 1986-09-05 Sanwa Kagaku Kenkyusho:Kk スピロ―３―ヘテロアゾリジン化合物、その製法及びそれを有効成分とする糖尿病合併症の予防及び治療剤

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63250373A (ja) * 1987-04-08 1988-10-18 Sanwa Kagaku Kenkyusho Co Ltd （＋）―３，４―ジヒドロ―４―オキソ―２ｈ―１―ベンゾピラン―２―カルボン酸誘導体及びその製法
US5036080A (en) * 1988-04-07 1991-07-30 Sanwa Kagaku Kenyusho Co., Ltd. (D)-6-fluoro-2,3-dihydro-2',5-dioxo-spiro[4H-1-benzopyran-4,4'-imidazolide]-2-carboxamide compounds
JPH037225A (ja) * 1989-02-22 1991-01-14 Sanwa Kagaku Kenkyusho Co Ltd アルドース還元酵素阻害作用を有し且つ吸収性の良好な薬剤組成物
JPH049384A (ja) * 1990-04-27 1992-01-14 Sanwa Kagaku Kenkyusho Co Ltd ヒダントイン誘導体を有効成分とする循環器系疾患の予防及び治療剤並びに循環器系疾患と糖尿病合併症の同時的予防及び治療剤
WO2005079792A1 (ja) * 2004-02-20 2005-09-01 Sanwa Kagaku Kenkyusho Co., Ltd. 重症糖尿病網膜症の予防又は治療剤
WO2006090699A1 (ja) * 2005-02-22 2006-08-31 Sanwa Kagaku Kenkyusho Co., Ltd. 虚血又は虚血再灌流によって起こる心機能障害若しくは心筋障害の予防又は治療剤
JP5022214B2 (ja) * 2005-02-22 2012-09-12 株式会社三和化学研究所 虚血又は虚血再灌流によって起こる心機能障害若しくは心筋障害の予防又は治療剤
WO2011136161A1 (ja) 2010-04-28 2011-11-03 株式会社 三和化学研究所 内耳障害の予防又は治療薬

Also Published As

Publication number Publication date
JPH0372227B2 (enExample) 1991-11-18

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