JPS635024B2 - - Google Patents

Info

Publication number
JPS635024B2
JPS635024B2 JP57067759A JP6775982A JPS635024B2 JP S635024 B2 JPS635024 B2 JP S635024B2 JP 57067759 A JP57067759 A JP 57067759A JP 6775982 A JP6775982 A JP 6775982A JP S635024 B2 JPS635024 B2 JP S635024B2
Authority
JP
Japan
Prior art keywords
ester
nitratoethyl
acid
group
dihydropyridine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP57067759A
Other languages
English (en)
Japanese (ja)
Other versions
JPS58185562A (ja
Inventor
Katsuo Hatayama
Atsuo Nakazato
Toshihisa Ogawa
Shoichi Ito
Jiro Sawada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taisho Pharmaceutical Co Ltd
Original Assignee
Taisho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taisho Pharmaceutical Co Ltd filed Critical Taisho Pharmaceutical Co Ltd
Priority to JP57067759A priority Critical patent/JPS58185562A/ja
Priority to EP83302075A priority patent/EP0092936B1/en
Priority to DE8383302075T priority patent/DE3370620D1/de
Priority to US06/486,508 priority patent/US4472411A/en
Priority to SE8305467A priority patent/SE440648B/sv
Priority to AU19941/83A priority patent/AU565424B2/en
Priority to BE0/211728A priority patent/BE898024A/fr
Priority to NL8303616A priority patent/NL8303616A/nl
Publication of JPS58185562A publication Critical patent/JPS58185562A/ja
Publication of JPS635024B2 publication Critical patent/JPS635024B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP57067759A 1982-04-22 1982-04-22 １，４−ジヒドロピリジン誘導体 Granted JPS58185562A (ja)

Priority Applications (8)

Application Number Priority Date Filing Date Title
JP57067759A JPS58185562A (ja) 1982-04-22 1982-04-22 １，４−ジヒドロピリジン誘導体
EP83302075A EP0092936B1 (en) 1982-04-22 1983-04-13 1,4-dihydropyridine derivatives
DE8383302075T DE3370620D1 (en) 1982-04-22 1983-04-13 1,4-dihydropyridine derivatives
US06/486,508 US4472411A (en) 1982-04-22 1983-04-19 1,4-Dihydropyridine derivatives and use as vasodilators
SE8305467A SE440648B (sv) 1982-04-22 1983-10-05 1,4-dihydropyridin-dikarboxylsyra-nitratoalkylestrar
AU19941/83A AU565424B2 (en) 1982-04-22 1983-10-06 2,6-dimethyl-4 (nitrophenyl) -1,4-dihydropyridine-3,5 -dicarboxylic acid esters
BE0/211728A BE898024A (fr) 1982-04-22 1983-10-19 Derives de 1,4-dihydropyridine et compositions pharmaceutiques a action vasodilatatrice les contenant.
NL8303616A NL8303616A (nl) 1982-04-22 1983-10-20 1,4-dihydropyridinederivaten.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP57067759A JPS58185562A (ja) 1982-04-22 1982-04-22 １，４−ジヒドロピリジン誘導体

Publications (2)

Publication Number Publication Date
JPS58185562A JPS58185562A (ja) 1983-10-29
JPS635024B2 true JPS635024B2 (enExample) 1988-02-01

Family

ID=13354183

Family Applications (1)

Application Number Title Priority Date Filing Date
JP57067759A Granted JPS58185562A (ja) 1982-04-22 1982-04-22 １，４−ジヒドロピリジン誘導体

Country Status (8)

Country Link
US (1) US4472411A (enExample)
EP (1) EP0092936B1 (enExample)
JP (1) JPS58185562A (enExample)
AU (1) AU565424B2 (enExample)
BE (1) BE898024A (enExample)
DE (1) DE3370620D1 (enExample)
NL (1) NL8303616A (enExample)
SE (1) SE440648B (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3244178A1 (de) * 1982-11-30 1984-05-30 Bayer Ag, 5090 Leverkusen 1,4-dihydropyridinderivate, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
EP0127150A3 (en) * 1983-05-27 1987-07-22 Fujisawa Pharmaceutical Co., Ltd. 2,6-disubstituted-1,4-dihydropyridine derivative, process for the preparation of the same and pharmaceutical composition comprising the same
GB8314744D0 (en) * 1983-05-27 1983-07-06 Fujisawa Pharmaceutical Co 2 6-disubstituted-1 4-dihydropyridine derivative
JPS60156671A (ja) * 1984-01-25 1985-08-16 Yamanouchi Pharmaceut Co Ltd ジヒドロピリジン誘導体およびその製造法
US4730052A (en) * 1984-07-13 1988-03-08 Taisho Pharmaceutical Co., Ltd. Method for preparing unsymmetrical 1,4-dihydropyridine-3,5-dicarboxylic acid diesters
ES8708211A1 (es) 1985-06-14 1987-10-01 Sankyo Co Un procedimiento para la preparacion de nuevos derivados de 4-(fenil sustituido)-1,4-dihidropiridina.
JPS62174050A (ja) * 1985-10-21 1987-07-30 Nippon Shoji Kk ３−アミノカルボニル−１，４−ジヒドロピリジン−５−カルボン酸誘導体、その製法および医薬組成物
US4780538A (en) * 1986-02-12 1988-10-25 Merck & Co., Inc. Process for 1,4-dihydropyridine compounds using a titanamine catalyst
JPS62292757A (ja) * 1986-06-12 1987-12-19 Taisho Pharmaceut Co Ltd １，４−ジヒドロピリジン誘導体
JPS6396126A (ja) * 1986-10-13 1988-04-27 Taisho Pharmaceut Co Ltd 安定化組成物
US5047543A (en) * 1988-11-24 1991-09-10 Taisho Pharmaceutical Co., Ltd. 1,4-dihydropyridine derivatives
NL9001752A (nl) * 1990-08-02 1992-03-02 Cedona Pharm Bv Nieuwe 1,4-dihydropyridinederivaten.
WO2003009815A2 (en) 2001-07-25 2003-02-06 Biomarin Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
US8847766B2 (en) 2005-04-28 2014-09-30 Proteus Digital Health, Inc. Pharma-informatics system
JP2010503710A (ja) 2006-09-18 2010-02-04 ラプトール ファーマシューティカル インコーポレイテッド 受容体関連タンパク質（ｒａｐ）結合体の投与による肝障害の処置
EP2398500B1 (en) 2009-02-20 2019-03-13 2-BBB Medicines B.V. Glutathione-based drug delivery system
BRPI1011188B1 (pt) 2009-05-06 2019-10-15 Laboratory Skin Care, Inc. Composições de liberação dérmica compreendendo complexos de partículas de agente ativo-fosfato de cálcio e métodos para usar as mesmas
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670827C3 (de) * 1967-03-20 1974-10-24 Bayer Ag, 5090 Leverkusen 4-(2'-Nitrophenyl)-2,6-dimethyl-3,5-dicarbmethoxy-1,4-dihydropyridin
DE2117573C3 (de) * 1971-04-10 1978-07-27 Bayer Ag, 5090 Leverkusen Verfahren zur Herstellung von unsymmetrischen l,4-Dihydropyridin-3,5dicarbonsäureestern, sowie ihre Verwendung als Arzneimittel
DE2847236A1 (de) * 1978-10-31 1980-05-14 Bayer Ag Neue dihydropyridine mit substituierten estergruppierungen, mehrer verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel

Also Published As

Publication number Publication date
SE440648B (sv) 1985-08-12
JPS58185562A (ja) 1983-10-29
US4472411A (en) 1984-09-18
AU565424B2 (en) 1987-09-17
EP0092936B1 (en) 1987-04-01
BE898024A (fr) 1984-04-19
EP0092936A1 (en) 1983-11-02
DE3370620D1 (en) 1987-05-07
SE8305467D0 (sv) 1983-10-05
SE8305467L (sv) 1985-04-06
NL8303616A (nl) 1985-05-17
AU1994183A (en) 1985-04-18

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