JPS63500799A - 持続性オピオイド拮抗作用を得るための方法および組成物 - Google Patents

持続性オピオイド拮抗作用を得るための方法および組成物

Info

Publication number
JPS63500799A
JPS63500799A JP61505302A JP50530286A JPS63500799A JP S63500799 A JPS63500799 A JP S63500799A JP 61505302 A JP61505302 A JP 61505302A JP 50530286 A JP50530286 A JP 50530286A JP S63500799 A JPS63500799 A JP S63500799A
Authority
JP
Japan
Prior art keywords
methylene
anesthetic
opioid
cyclopropylmethyl
subject
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP61505302A
Other languages
English (en)
Japanese (ja)
Inventor
タットル，ロナルド・アール
ハウズ，ジョン
Original Assignee
ベーカー・カミンス・ファーマシューティカルス・インコーポレーテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ベーカー・カミンス・ファーマシューティカルス・インコーポレーテッド filed Critical ベーカー・カミンス・ファーマシューティカルス・インコーポレーテッド
Publication of JPS63500799A publication Critical patent/JPS63500799A/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine

Landscapes

  • Health & Medical Sciences (AREA)
  • Emergency Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP61505302A 1985-09-06 1986-09-08 持続性オピオイド拮抗作用を得るための方法および組成物 Pending JPS63500799A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77321385A 1985-09-06 1985-09-06
US773213 2001-01-31

Publications (1)

Publication Number Publication Date
JPS63500799A true JPS63500799A (ja) 1988-03-24

Family

ID=25097554

Family Applications (1)

Application Number Title Priority Date Filing Date
JP61505302A Pending JPS63500799A (ja) 1985-09-06 1986-09-08 持続性オピオイド拮抗作用を得るための方法および組成物

Country Status (5)

Country Link
EP (1) EP0236477B1 (https=)
JP (1) JPS63500799A (https=)
AT (1) ATE84717T1 (https=)
DE (2) DE3690457T1 (https=)
WO (1) WO1987001282A2 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1041987B1 (en) 1997-12-22 2006-04-19 Euro-Celtique S.A. Pharmaceutical oral dosage form comprising a combination of an opioid agonist and naltrexone
EP2092936B1 (en) 2000-02-08 2013-03-20 Euro-Celtique S.A. Tamper-resistant oral opioid agonist formulations
EP1387673B1 (en) 2001-05-11 2010-12-29 Endo Pharmaceuticals Inc. Abuse-resistant controlled-release opioid dosage form
IL160222A0 (en) 2001-08-06 2004-07-25 Euro Celtique Sa Opioid agonist formulations with releasable and sequestered antagonist
HUE032656T2 (en) 2002-04-05 2017-10-30 Euro Celtique Sa Pharmaceutical composition containing oxicodone and naloxone
CN1703200B (zh) 2002-09-20 2012-02-29 奥尔制药公司 隔离亚单元和相关组合物及方法
MY135852A (en) 2003-04-21 2008-07-31 Euro Celtique Sa Pharmaceutical products
EP1702558A1 (en) 2005-02-28 2006-09-20 Euro-Celtique S.A. Method and device for the assessment of bowel function
SI2719378T1 (sl) 2006-06-19 2016-11-30 Alpharma Pharmaceuticals Llc Farmacevtski sestavki
US8623418B2 (en) 2007-12-17 2014-01-07 Alpharma Pharmaceuticals Llc Pharmaceutical composition
SG174286A1 (en) 2009-03-10 2011-10-28 Euro Celtique Sa Immediate release pharmaceutical compositions comprising oxycodone and naloxone
JP2016525138A (ja) 2013-07-23 2016-08-22 ユーロ−セルティーク エス．エイ． 疼痛および腸内ディスバイオシスをもたらす疾患および／または腸内細菌移行に対するリスクを高める疾患に罹患している患者における痛みの治療への使用のためのオキシコドンおよびナロキソンの組み合わせ

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4858000A (https=) * 1971-11-26 1973-08-14
JPS56167687A (en) * 1980-04-28 1981-12-23 Du Pont 17-substituted-6-desoxy-7,8-dihydro-6 alpha- methyl-noroxymorphone anesthetic antagonist substance

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB769517A (en) * 1953-10-20 1957-03-06 Merck & Co Inc Analgesic compositions
US3493657A (en) * 1961-03-14 1970-02-03 Mozes Juda Lewenstein Therapeutic compositions of n-allyl-14-hydroxy - dihydronormorphinane and morphine
EP0103636B1 (en) * 1982-03-16 1990-09-12 Rockefeller University Use of opium antagonists for the manufacture of medicaments for controlling gastrointestinal dysmotility
US4567185A (en) * 1983-05-13 1986-01-28 Key Pharmaceuticals, Inc. Endorphin blockage
US4535157A (en) * 1983-11-01 1985-08-13 Key Pharmaceuticals, Inc. Process for making 6-desoxy-6-methylenenaloxone and 6-desoxy-6-methylenenaltrexone
GB8332556D0 (en) * 1983-12-06 1984-01-11 Reckitt & Colmann Prod Ltd Analgesic compositions

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4858000A (https=) * 1971-11-26 1973-08-14
JPS56167687A (en) * 1980-04-28 1981-12-23 Du Pont 17-substituted-6-desoxy-7,8-dihydro-6 alpha- methyl-noroxymorphone anesthetic antagonist substance

Also Published As

Publication number Publication date
DE3687575T2 (de) 1993-07-01
DE3690457T1 (https=) 1987-08-06
EP0236477B1 (en) 1993-01-20
WO1987001282A3 (en) 1987-08-13
EP0236477A1 (en) 1987-09-16
ATE84717T1 (de) 1993-02-15
WO1987001282A2 (en) 1987-03-12
DE3687575D1 (de) 1993-03-04

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