JPS6348310B2 - - Google Patents
Info
- Publication number
- JPS6348310B2 JPS6348310B2 JP3463681A JP3463681A JPS6348310B2 JP S6348310 B2 JPS6348310 B2 JP S6348310B2 JP 3463681 A JP3463681 A JP 3463681A JP 3463681 A JP3463681 A JP 3463681A JP S6348310 B2 JPS6348310 B2 JP S6348310B2
- Authority
- JP
- Japan
- Prior art keywords
- serum separation
- separation tube
- blood
- serum
- tube according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 210000002966 serum Anatomy 0.000 claims description 82
- 239000003795 chemical substances by application Substances 0.000 claims description 74
- 238000000926 separation method Methods 0.000 claims description 74
- 210000004369 blood Anatomy 0.000 claims description 63
- 239000008280 blood Substances 0.000 claims description 63
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 43
- 230000005484 gravity Effects 0.000 claims description 40
- 229920001577 copolymer Polymers 0.000 claims description 36
- 239000004711 α-olefin Substances 0.000 claims description 35
- 230000023555 blood coagulation Effects 0.000 claims description 26
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 20
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims description 18
- 239000011976 maleic acid Substances 0.000 claims description 18
- 210000000601 blood cell Anatomy 0.000 claims description 17
- 125000004432 carbon atom Chemical group C* 0.000 claims description 14
- 239000000377 silicon dioxide Substances 0.000 claims description 14
- -1 2-ethylhexyl group Chemical group 0.000 claims description 13
- 229910021647 smectite Inorganic materials 0.000 claims description 13
- 230000009974 thixotropic effect Effects 0.000 claims description 12
- 239000004927 clay Substances 0.000 claims description 11
- 239000004745 nonwoven fabric Substances 0.000 claims description 10
- 239000000843 powder Substances 0.000 claims description 9
- 230000001737 promoting effect Effects 0.000 claims description 9
- 239000013256 coordination polymer Substances 0.000 claims description 7
- 239000005909 Kieselgur Substances 0.000 claims description 5
- 125000000217 alkyl group Chemical group 0.000 claims description 5
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 claims description 5
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 claims description 4
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical class OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 claims description 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 4
- 239000002245 particle Substances 0.000 claims description 4
- 239000004576 sand Substances 0.000 claims description 4
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 3
- 229910002026 crystalline silica Inorganic materials 0.000 claims description 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 3
- 239000011521 glass Substances 0.000 claims description 3
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims description 3
- 235000012239 silicon dioxide Nutrition 0.000 claims description 3
- 239000005995 Aluminium silicate Substances 0.000 claims description 2
- 235000012211 aluminium silicate Nutrition 0.000 claims description 2
- 239000000440 bentonite Substances 0.000 claims description 2
- 229910000278 bentonite Inorganic materials 0.000 claims description 2
- 239000004744 fabric Substances 0.000 claims description 2
- 229920000742 Cotton Polymers 0.000 claims 1
- 239000000126 substance Substances 0.000 description 26
- 239000000499 gel Substances 0.000 description 23
- 239000000306 component Substances 0.000 description 16
- 239000000463 material Substances 0.000 description 15
- 239000000203 mixture Substances 0.000 description 14
- 238000005119 centrifugation Methods 0.000 description 12
- 239000007788 liquid Substances 0.000 description 12
- 208000007536 Thrombosis Diseases 0.000 description 10
- 206010018910 Haemolysis Diseases 0.000 description 9
- 230000008588 hemolysis Effects 0.000 description 9
- 239000011230 binding agent Substances 0.000 description 7
- 238000004519 manufacturing process Methods 0.000 description 7
- 238000005191 phase separation Methods 0.000 description 7
- 239000005871 repellent Substances 0.000 description 7
- 230000000694 effects Effects 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 230000015271 coagulation Effects 0.000 description 5
- 238000005345 coagulation Methods 0.000 description 5
- 239000003607 modifier Substances 0.000 description 5
- 229920001296 polysiloxane Polymers 0.000 description 5
- 150000001412 amines Chemical class 0.000 description 4
- 229920001971 elastomer Polymers 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 239000005060 rubber Substances 0.000 description 4
- 102000009123 Fibrin Human genes 0.000 description 3
- 108010073385 Fibrin Proteins 0.000 description 3
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 3
- 230000003111 delayed effect Effects 0.000 description 3
- 229950003499 fibrin Drugs 0.000 description 3
- 239000000945 filler Substances 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 229910052739 hydrogen Inorganic materials 0.000 description 3
- 239000001257 hydrogen Substances 0.000 description 3
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 3
- 230000002940 repellent Effects 0.000 description 3
- 238000010008 shearing Methods 0.000 description 3
- 229920002307 Dextran Polymers 0.000 description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
- 239000005062 Polybutadiene Substances 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 125000001931 aliphatic group Chemical class 0.000 description 2
- 238000010876 biochemical test Methods 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 239000004359 castor oil Substances 0.000 description 2
- 235000019438 castor oil Nutrition 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 238000010908 decantation Methods 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 238000004388 gamma ray sterilization Methods 0.000 description 2
- 238000001879 gelation Methods 0.000 description 2
- 239000003349 gelling agent Substances 0.000 description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 2
- 239000002736 nonionic surfactant Substances 0.000 description 2
- 230000000704 physical effect Effects 0.000 description 2
- 229920002857 polybutadiene Polymers 0.000 description 2
- 229920000728 polyester Polymers 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 229910002016 Aerosil® 200 Inorganic materials 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- IEPRKVQEAMIZSS-UHFFFAOYSA-N Di-Et ester-Fumaric acid Natural products CCOC(=O)C=CC(=O)OCC IEPRKVQEAMIZSS-UHFFFAOYSA-N 0.000 description 1
- 235000009161 Espostoa lanata Nutrition 0.000 description 1
- 240000001624 Espostoa lanata Species 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- 235000010724 Wisteria floribunda Nutrition 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 238000005054 agglomeration Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 150000001336 alkenes Chemical class 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 239000012503 blood component Substances 0.000 description 1
- 238000004820 blood count Methods 0.000 description 1
- 229920005549 butyl rubber Polymers 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 229910010293 ceramic material Inorganic materials 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- 239000000701 coagulant Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 239000004205 dimethyl polysiloxane Substances 0.000 description 1
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 238000005243 fluidization Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000004508 fractional distillation Methods 0.000 description 1
- 230000005251 gamma ray Effects 0.000 description 1
- 230000002949 hemolytic effect Effects 0.000 description 1
- 239000012052 hydrophilic carrier Substances 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 239000002563 ionic surfactant Substances 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- 230000000379 polymerizing effect Effects 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000012414 sterilization procedure Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 239000004034 viscosity adjusting agent Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D43/00—Separating particles from liquids, or liquids from solids, otherwise than by sedimentation or filtration
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Centrifugal Separators (AREA)
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3463681A JPS57149964A (en) | 1981-03-12 | 1981-03-12 | Serum separating tube |
| ES501923A ES8300261A1 (es) | 1980-05-08 | 1981-05-06 | Aparato para separacion de la sangre |
| DE8181103440T DE3165646D1 (en) | 1980-05-08 | 1981-05-06 | Apparatus for separating blood |
| EP81103440A EP0039898B1 (en) | 1980-05-08 | 1981-05-06 | Apparatus for separating blood |
| CA000376994A CA1178257A (en) | 1980-05-08 | 1981-05-06 | Apparatus for separating blood |
| FR8109106A FR2484648B1 (fr) | 1980-05-08 | 1981-05-07 | Appareil pour la separation du sang |
| GB8114159A GB2075377B (en) | 1980-05-08 | 1981-05-08 | Blood separation |
| IT8121577A IT1211037B (it) | 1980-05-08 | 1981-05-08 | Dispositivo per la separazione di sangue. |
| US06/473,975 US4426290A (en) | 1980-05-08 | 1983-03-11 | Apparatus for separating blood |
| CA000444175A CA1187057A (en) | 1980-05-08 | 1983-12-22 | Apparatus for separating blood |
| US07/070,673 US4770779A (en) | 1980-05-08 | 1987-07-01 | Apparatus for separating blood |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3463681A JPS57149964A (en) | 1981-03-12 | 1981-03-12 | Serum separating tube |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS57149964A JPS57149964A (en) | 1982-09-16 |
| JPS6348310B2 true JPS6348310B2 (enrdf_load_stackoverflow) | 1988-09-28 |
Family
ID=12419888
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP3463681A Granted JPS57149964A (en) | 1980-05-08 | 1981-03-12 | Serum separating tube |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS57149964A (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010053180A1 (ja) | 2008-11-07 | 2010-05-14 | 日立化成工業株式会社 | 血清又は血漿分離材及びそれを用いた採血管 |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58105064A (ja) * | 1981-12-17 | 1983-06-22 | Sekisui Chem Co Ltd | 血液凝固促進剤 |
| JPS58206964A (ja) * | 1982-05-28 | 1983-12-02 | Terumo Corp | 血液分離管 |
| JPS6053845A (ja) * | 1983-09-05 | 1985-03-27 | Terumo Corp | 血液分離管 |
| JPH0677014B2 (ja) * | 1987-08-14 | 1994-09-28 | テルモ株式会社 | 血液分離管 |
| CA2004535A1 (en) * | 1988-12-08 | 1990-06-08 | Toru Tagawa | Liquid separating agent |
| US4994393A (en) * | 1989-02-22 | 1991-02-19 | Becton, Dickinson And Company | Blood partitioning composition |
| US20040059255A1 (en) * | 2002-09-23 | 2004-03-25 | Dimitrios Manoussakis | High bias gel tube and process for making tube |
-
1981
- 1981-03-12 JP JP3463681A patent/JPS57149964A/ja active Granted
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010053180A1 (ja) | 2008-11-07 | 2010-05-14 | 日立化成工業株式会社 | 血清又は血漿分離材及びそれを用いた採血管 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS57149964A (en) | 1982-09-16 |
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