JPS6324991B2 - - Google Patents

Info

Publication number
JPS6324991B2
JPS6324991B2 JP54129120A JP12912079A JPS6324991B2 JP S6324991 B2 JPS6324991 B2 JP S6324991B2 JP 54129120 A JP54129120 A JP 54129120A JP 12912079 A JP12912079 A JP 12912079A JP S6324991 B2 JPS6324991 B2 JP S6324991B2
Authority
JP
Japan
Prior art keywords
reaction
difluoro
compound
crystals
dihydroquinoline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP54129120A
Other languages
English (en)
Japanese (ja)
Other versions
JPS5653656A (en
Inventor
Yoshitaka Mushishika
Junichi Tani
Totaro Yamaguchi
Satoshi Ooshima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Tanabe Pharma Corp
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Priority to JP12912079A priority Critical patent/JPS5653656A/ja
Priority to US06/188,713 priority patent/US4327101A/en
Priority to EP80105711A priority patent/EP0028698B1/en
Priority to DE8080105711T priority patent/DE3061438D1/de
Publication of JPS5653656A publication Critical patent/JPS5653656A/ja
Publication of JPS6324991B2 publication Critical patent/JPS6324991B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/07—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
    • C07C205/11—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings
    • C07C205/12—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings the six-membered aromatic ring or a condensed ring system containing that ring being substituted by halogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
JP12912079A 1979-10-05 1979-10-05 Quinoline derivative and its preparation Granted JPS5653656A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP12912079A JPS5653656A (en) 1979-10-05 1979-10-05 Quinoline derivative and its preparation
US06/188,713 US4327101A (en) 1979-10-05 1980-09-19 Quinoline compound useful as antibacterial agents in warm-blooded animals
EP80105711A EP0028698B1 (en) 1979-10-05 1980-09-23 Quinoline compounds, process for their preparation, and pharmaceutical compositions
DE8080105711T DE3061438D1 (en) 1979-10-05 1980-09-23 Quinoline compounds, process for their preparation, and pharmaceutical compositions

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12912079A JPS5653656A (en) 1979-10-05 1979-10-05 Quinoline derivative and its preparation

Publications (2)

Publication Number Publication Date
JPS5653656A JPS5653656A (en) 1981-05-13
JPS6324991B2 true JPS6324991B2 (en, 2012) 1988-05-23

Family

ID=15001560

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12912079A Granted JPS5653656A (en) 1979-10-05 1979-10-05 Quinoline derivative and its preparation

Country Status (4)

Country Link
US (1) US4327101A (en, 2012)
EP (1) EP0028698B1 (en, 2012)
JP (1) JPS5653656A (en, 2012)
DE (1) DE3061438D1 (en, 2012)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57145862A (en) 1981-03-06 1982-09-09 Kyorin Pharmaceut Co Ltd Quinolinecarboxylic acid derivative
EP0090424B1 (en) * 1982-03-31 1986-05-28 Sterling Drug Inc. New quinolone compounds and preparation thereof
DE3318145A1 (de) * 1983-05-18 1984-11-22 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-6,8-difluor-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
US4914110A (en) * 1984-05-11 1990-04-03 Societe De Conseils De Recherches Et D'applications Scientifiques Quinoline derivatives, their preparation and therapeutic compositions containing the same
GB8412094D0 (en) * 1984-05-11 1984-06-20 Scras Quinoline derivatives
DE3441788A1 (de) * 1984-11-15 1986-05-15 Bayer Ag, 5090 Leverkusen Alkyl-1-cyclopropyl-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
US5103040A (en) * 1988-06-21 1992-04-07 Pfizer Inc. 6-fluoro-1,4-dihydroquinol-4-one-3-carboxylic acid derivatives and intermediates therefor
US5039682A (en) * 1988-06-21 1991-08-13 Pfizer Inc. 6-fluoro-1,4-dihydroquinol-4-one-3-carboxylic acid derivatives and intermediates therefor
US5104868A (en) * 1988-06-21 1992-04-14 Pfizer Inc. Tricyclic derivatives of 7-substituted-6-fluoro-1,4-dihydroquinol-4-one-3-carboxylic acids and esters
US5233091A (en) * 1988-06-21 1993-08-03 Pfizer Inc. 6-fluoro-1,4-dihydroquinol-4-one-3-carboxylic acid derivatives and intermediates therefor
US20080139574A1 (en) 2006-11-30 2008-06-12 Cadila Healthcare Limited Novel quinoline derivatives

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB830832A (en) 1957-02-15 1960-03-23 Ici Ltd New quinolones and therapeutic compositions containing them
CA947301A (en) * 1970-01-28 1974-05-14 Sumitomo Chemical Company Process for the preparation of compound having antibacterial action
DE2246503A1 (de) * 1972-09-22 1974-04-04 Boehringer Mannheim Gmbh 7,8-dimethylchinolon-3-carbonsaeurederivate
US4146625A (en) * 1976-07-16 1979-03-27 E. I. Du Pont De Nemours And Company Quinolonecarboxylic acids for control of bacterial diseases in plants
US4264604A (en) * 1977-07-01 1981-04-28 Ciba-Geigy Corporation Quinolonecarboxylic acid derivatives as bactericides
JPS54112877A (en) * 1978-02-20 1979-09-04 Sumitomo Chem Co Ltd Preparation of 1-substituted-1,4-dihydro-4-oxo-3-pyridine carboxylic acid derivatives

Also Published As

Publication number Publication date
JPS5653656A (en) 1981-05-13
DE3061438D1 (en) 1983-01-27
EP0028698B1 (en) 1982-12-22
US4327101A (en) 1982-04-27
EP0028698A1 (en) 1981-05-20

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