JPS6316120B2 - - Google Patents

Info

Publication number
JPS6316120B2
JPS6316120B2 JP54173819A JP17381979A JPS6316120B2 JP S6316120 B2 JPS6316120 B2 JP S6316120B2 JP 54173819 A JP54173819 A JP 54173819A JP 17381979 A JP17381979 A JP 17381979A JP S6316120 B2 JPS6316120 B2 JP S6316120B2
Authority
JP
Japan
Prior art keywords
culture
medium
antibiotic
ethyl acetate
added
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP54173819A
Other languages
English (en)
Japanese (ja)
Other versions
JPS56102793A (en
Inventor
Kazunori Hatano
Masanari Nakamichi
Shunichi Akyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Priority to JP17381979A priority Critical patent/JPS56102793A/ja
Priority to DE8080107008T priority patent/DE3066026D1/de
Priority to AT80107008T priority patent/ATE5726T1/de
Priority to EP80107008A priority patent/EP0031430B1/en
Priority to ES497033A priority patent/ES8107306A1/es
Priority to US06/209,983 priority patent/US4356265A/en
Priority to HU803107A priority patent/HU182267B/hu
Publication of JPS56102793A publication Critical patent/JPS56102793A/ja
Publication of JPS6316120B2 publication Critical patent/JPS6316120B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/365—Nocardia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/872—Nocardia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP17381979A 1979-12-28 1979-12-28 Preparation of antibiotic c-15003 p-3 Granted JPS56102793A (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP17381979A JPS56102793A (en) 1979-12-28 1979-12-28 Preparation of antibiotic c-15003 p-3
DE8080107008T DE3066026D1 (en) 1979-12-28 1980-11-13 A method for the production of antibiotic c-15003 p-3
AT80107008T ATE5726T1 (de) 1979-12-28 1980-11-13 Verfahren zur herstellung von antibiotikum c15003 p3.
EP80107008A EP0031430B1 (en) 1979-12-28 1980-11-13 A method for the production of antibiotic c-15003 p-3
ES497033A ES8107306A1 (es) 1979-12-28 1980-11-21 Un metodo mejorado para producir y acumular el antibiotico c-15003 p-3
US06/209,983 US4356265A (en) 1979-12-28 1980-11-24 Method for the production of antibiotic C-15003 P-3
HU803107A HU182267B (en) 1979-12-28 1980-12-23 Process for preparing the antibiotic c-15003 p-3

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP17381979A JPS56102793A (en) 1979-12-28 1979-12-28 Preparation of antibiotic c-15003 p-3

Publications (2)

Publication Number Publication Date
JPS56102793A JPS56102793A (en) 1981-08-17
JPS6316120B2 true JPS6316120B2 (enExample) 1988-04-07

Family

ID=15967733

Family Applications (1)

Application Number Title Priority Date Filing Date
JP17381979A Granted JPS56102793A (en) 1979-12-28 1979-12-28 Preparation of antibiotic c-15003 p-3

Country Status (7)

Country Link
US (1) US4356265A (enExample)
EP (1) EP0031430B1 (enExample)
JP (1) JPS56102793A (enExample)
AT (1) ATE5726T1 (enExample)
DE (1) DE3066026D1 (enExample)
ES (1) ES8107306A1 (enExample)
HU (1) HU182267B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0839708A (ja) * 1994-08-01 1996-02-13 Teikoku Ink Seizo Kk 非粘着性表面を有する物品およびその製造方法

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0293133A3 (en) * 1987-05-26 1990-01-31 Merck & Co. Inc. Microorganisms and processes for the manufacture of antifungal tri-yne carbonates
US4977083A (en) * 1988-04-11 1990-12-11 Eli Lilly And Company Processes for preparing A54145 compounds
US6573074B2 (en) * 2000-04-12 2003-06-03 Smithkline Beecham Plc Methods for ansamitocin production
US6790954B2 (en) * 2002-01-29 2004-09-14 Immunogen, Inc. Mutant Actinosynnema pretiosum strain with increased maytansinoid production
EP1627069A4 (en) * 2002-08-08 2010-06-02 Glaxosmithkline Llc PROCESS FOR THE ISOLATION AND PURIFICATION OF ANSAMITOCINES
DE10248111A1 (de) * 2002-10-15 2004-04-29 Goldschmidt Ag Verwendung von Photoinitiatoren vom Typ Hydroxyalkylphenon in strahlenhärtbaren Organopolysiloxanen für die Herstellung von abhäsiven Beschichtungen
US7432088B2 (en) * 2003-05-08 2008-10-07 Immunogen Inc. Methods for the production of ansamitocins
US20070135629A1 (en) * 2005-12-08 2007-06-14 Millennium Pharmaceuticals, Inc. Isolation of ansamitocins
EP1806365A1 (en) 2006-01-05 2007-07-11 Boehringer Ingelheim International GmbH Antibody molecules specific for fibroblast activation protein and immunoconjugates containing them
AU2010278738A1 (en) * 2009-07-31 2012-02-16 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Antiangiogenic small molecules and methods of use
CN101921817A (zh) * 2010-09-07 2010-12-22 上海交通大学 安莎霉素发酵产量提高方法
CN102732581B (zh) * 2012-07-18 2014-07-16 上海交联药物研发有限公司 一种高表达安丝菌素p-3的方法
PT3956332T (pt) 2019-04-18 2023-04-24 Indena Spa Processo diasterosselectivo para a preparação de ésteres de maitansinoides contendo tiol ou dissulfeto e seus intermediários

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3795585A (en) * 1972-08-31 1974-03-05 Agency Ind Science Techn Method for manufacture of alpha-galactosidase
US4162940A (en) * 1977-03-31 1979-07-31 Takeda Chemical Industries, Ltd. Method for producing Antibiotic C-15003 by culturing nocardia
US4151042A (en) * 1977-03-31 1979-04-24 Takeda Chemical Industries, Ltd. Method for producing maytansinol and its derivatives
JPS6016236B2 (ja) * 1977-11-18 1985-04-24 武田薬品工業株式会社 抗生物質ｃ―１５００３ ｐ―３の製造法
JPS6010720B2 (ja) * 1977-11-18 1985-03-19 武田薬品工業株式会社 抗生物質ｃ―１５００３ ｐ―４の製造法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0839708A (ja) * 1994-08-01 1996-02-13 Teikoku Ink Seizo Kk 非粘着性表面を有する物品およびその製造方法

Also Published As

Publication number Publication date
US4356265A (en) 1982-10-26
EP0031430A3 (en) 1981-10-07
EP0031430A2 (en) 1981-07-08
ES497033A0 (es) 1981-10-01
HU182267B (en) 1983-12-28
ES8107306A1 (es) 1981-10-01
EP0031430B1 (en) 1983-12-28
DE3066026D1 (en) 1984-02-02
ATE5726T1 (de) 1984-01-15
JPS56102793A (en) 1981-08-17

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