JPS63159308A - Hair nourishing cosmetic - Google Patents

Abstract

PURPOSE:To obtain a hair nourishing cosmetic continuously promoting blood circulation of scalp, excellent hair growing effects, preventing effects on fallen hair and on dandruff and weak skin irritation, containing calcium hopantenate. CONSTITUTION:A hair nourishing cosmetic containing 0.05-2.0wt%, preferably 0.1-1.5wt% based on sum of a hair nourishing cosmetic of a well-known calcium popantenate shown by the formula (R1 is HOCH2: R2 is NHCH2 CH2COO) well-known as a drug effective for treating hyperkinesia caused by sequela of encephalitis, cerebral palsy, etc., for reduction in attentiveness or allophasis as an essential component and having the above-mentioned effects. Since the compound has proper percutaneous absorption, it is estimated that effective concentration of the drug in scalp is continued, durable blood circulation promoting action activates hair-matrix cell activates, shows excellent hair nourishing effects and preventing effects on falling hair, normalizes scalp metabolizing ability and raises dandruff inhibitory effects.

Description

DETAILED DESCRIPTION OF THE INVENTION (Technical Field) The present invention relates to a hair nourishing cosmetic containing calcium hopantenate. More specifically, the present invention relates to a hair nourishing cosmetic that continuously promotes blood circulation in the scalp and has excellent hair growth, hair loss prevention, and dandruff prevention effects.

(Prior Art) Hair nourishing cosmetics containing scalp blood circulation promoting substances such as capsicum tincture, Jasmine japonica extract, Korean ginseng extract, nicotinic acid, and methyl nicotinate have been well known.

However, these blood circulation promoting substances are highly irritating to the skin, and there are restrictions on the amount they can be added.The blood circulation promoting effect decreases in a short period of time, or the blood circulation promoting effect is weak. However, the substance was not effective enough to exhibit sufficient effects such as preventing dandruff.

(Disclosure of the Invention) Therefore, as a result of extensive research into blood circulation promoting substances that are effective when incorporated into hair-growth cosmetics, the present inventors found that hair-growth cosmetics containing calcium fobantenate are: Extremely mild skin irritation, continuously promotes blood circulation in the scalp, promotes hair growth,
The present inventors have discovered that the present invention has excellent effects on hair loss prevention, dandruff prevention, etc., and have completed the present invention.

(Objective of the invention) The object of the present invention is to continuously promote blood circulation in the scalp, promote hair growth,
An object of the present invention is to provide a hair-nourishing cosmetic that is excellent in effects such as preventing hair loss and preventing dandruff.

(Structure of the Invention) The present invention is a hair nourishing cosmetic containing calcium hopanthenate.

(Specific explanation of composition) Calcium hopantenate used in the present invention is a known substance, and its pharmacological effect is to promote the uptake of glucose into the brain and its metabolism, and it can cause symptoms such as encephalitis sequelae and cerebral palsy. It is known to be effective in the treatment of hyperactivity, decreased attention, and language disorders associated with children, and is known to have few side effects.

The chemical properties of calcium fobantenate are as follows.

(1) Structure (R3 in the above structural formula is HOCH, R1 is NHC
H2CHz CH! Represents C00 group. ) (2) Chemical name Calcium D-(+)-4-(2,4-dihydroxy-
3,3-dimethyl butyroamide) butyrate hemihydrate Calcium D-(+) -4-(2,
4-dihydroxy-3,3-dimethylb
utyrate hemihydrat (3) P
la name: Calcium hopantenate
(4) Molecular formula: CzoH3hCa NOs ・'/z
Hz 0(5) Molecular weight: 513.60 (6) Melting point: 155-165°C Calcium fobantenate to be added to the hair-growth cosmetic of the present invention is prepared by adding 400n+g of metallic sodium to 40ml of methanol.
was added and heated to form a suspension solution, and 1.2 g of T-aminobutyric acid was added and dissolved therein. Next, Bantolactone 1.
After adding 3 g and stirring for 2 hours, use the apparatus to distill off the solvent, add water to the precipitated white crystals, remove insoluble matter by centrifugation, evaporate the water, and dry the white crystals of hobantenic acid. Obtained calcium.

Calcium hopantenate obtained by the above synthesis method was used in various tests of the present invention.

In addition, the calcium hopantenate used in the present invention has moderate transdermal absorbability, so it maintains an effective concentration of the drug in the scalp, has low skin irritation, and has a sustained blood circulation promoting effect. activates hair matrix cells for excellent hair growth,
It is presumed that it exerts a hair loss preventive effect and further normalizes the scalp metabolic function, thereby increasing the dandruff preventive effect.

The blending amount of calcium hopantenate is 0.05 to 2.0% by weight based on the total weight of the hair nourishing cosmetic composition of the present invention.
(hereinafter abbreviated as wt%), preferably 0.
It is 1 to 1.5 wt%.

If the blending amount is less than 0.05 wt%, it is not sufficient to achieve the desired effect of the present invention, and on the other hand, even if it exceeds 2.0 wL%, an improvement in the effect commensurate with the increase cannot be expected.

The hair nourishing cosmetic composition of the present invention can be made into split molds such as hair tonics, hair lotions, hair creams, etc. according to conventional methods.

The hair nourishing cosmetic composition of the present invention may contain pigments, fragrances, bactericidal agents, preservatives, keratolytic agents, anti-androgens, hair nourishing agents, antioxidants, etc. as appropriate within the scope of achieving the purpose of the present invention. can.

(Examples) Hereinafter, the present invention will be described in detail based on Examples and Comparative Examples.

The skin blood flow test method, the mouse hair growth promoting effect test method, the human hair growth promoting effect test method, and the practical test method described in the Examples are shown below.

(1) Skin blood flow test method The abdomens of three New Sealant White rabbits were separated.
After fasting for 18 hours, the animals are anesthetized by intravenously injecting the sodium salt of pentaparbitol at a rate of 35 mg/kg.

A plate-type transducer was fixed with cellophane tape over the sample application site (test site) on the abdomen, and a cross thermopile type skin blood flow meter (Shinei Co., Ltd. Shincoder, 201) was attached.
Measure the skin blood flow (μ■) using a model (type).

Apply 0.1 g of the sample uniformly to a 3 x 2 cm skin area, and compare the blood flow rate (CB ) before sample application and a certain period of time after sample application (e.g. 0.5, 1, 0, 2.0 hours later). The blood flow rate (Ct) is measured and the blood flow increase rate (Ct) is calculated by the following formula:
%).

The test results were shown as the average value of the blood flow increase rate of the three birds.

Ct-c.

An increase in blood flow of about 5 to 20% was observed even when a cream base was applied as a sample, but when a sample containing ingredients with a remarkable blood circulation promoting effect was applied,
The increase rate is as high as 40-80%.

(2) Mouse hair growth promotion effect test method After cutting the back skin from the tail of AAY white mice (male, 6 weeks old, average weight 35 g) with electric clippers, the hair was completely removed with hair removal cream, and from the next day. Each sample of Examples and Comparative Examples was applied to the skin of the test subject twice daily in the morning and evening, at a dose of O.1 per animal.
I used ml cloth. For each sample, 10 animals were used per group.

The hair growth effect was determined by comparing the visual evaluation score, hair length, and hair weight with the control group according to the criteria shown below.

On the 15th day after the start of the experiment, the animals were visually evaluated according to the stratification criteria, and the evaluation scores were totaled to determine the average evaluation score per animal. Furthermore, after punching out the skin at the test site and drying it,
The weight of the hair was measured, and the lengths of 20 of the hairs were also measured, and the average value of each hair was shown.

Judgment criteria for hair growth effect evaluation score 5 Boundary with surrounding non-hair removal area is unclear 4 Hair growth intensity 3 Moderate hair growth 2 Mild hair growth l Slight hair growth O No hair growth observed ( 2) Human hair growth promotion test The head of 10 test subjects who were male pattern baldness patients was shaved in a circular shape with a diameter of 1 cm at two places on the left and right at a position 5 cm above the ear. Approximately 3 ml of the sample of Example or Comparative Example was applied to the site twice a day, morning and evening, and compared with the untreated right side. To judge the effectiveness, on the 28th day after the start of the test, 20 hairs each on the left and right test sites were shaved, and the average length of the 20 hairs on the left side (where Example or Comparative Example was applied) (B) was divided by the average length (^) of the 20 hairs on the right side (untreated) for evaluation.

The results of the judgment are (B)/(A) for each of the 10 test subjects.
Shown as average value.

(3) Practical test Samples were applied to the heads of 20 test subjects suffering from androgenetic alopecia twice a day in the morning and evening for 6 consecutive months, and then the effects were evaluated. The test results showed that "grown hair became bristly or increased", "hair loss decreased", and "dandruff was reduced" for each of the following categories: hair growth effect, hair loss prevention effect, and dandruff prevention effect. It is shown by the number of people who answered "It has decreased."

Examples 1 to 4, Comparative Examples 1 to 4 [Oily hair tonic] Each hair tonic was prepared by blending various scalp blood circulation promoting substances with the following raw material composition as shown in Table 1. The various tests described above were conducted. In the skin blood flow test, the rate of increase in blood flow was measured at 0.5.1 and 0.2.0 hours after application of the sample.

(1) Composition (2) Preparation method (B) Among the ingredients, nicotinic acid and methyl nicotinate are (A)
In the ingredients, capsicum tincture and calcium hopantenate are dissolved in the (C) ingredient, and after each of the (A) and (B) ingredients are uniformly dissolved, the (A) ingredient and the (B) ingredient are mixed and dispersed, and then and fill it into containers. When using, shake and disperse the contents uniformly.

(3) Characteristics Table 1 shows the results of Artonic tests conducted on each OITSU.

As shown in Table 1, in Comparative Examples 1 to 4, the rate of increase in blood flow was low, or the rate of increase in blood flow decreased over time. In addition, Comparative Examples 2.3.4 caused skin irritation, making it impossible to test on human skin.

The hair nourishing cosmetics of Examples 1 to 4 of the present invention showed clearly good results in all of the various tests.

In Examples 1 to 4, no skin irritation occurred in various tests on human skin.

Examples 5 to 7, Comparative Examples 5 to 7 (Hair Cream) Each hair cream was prepared in the same manner as in Example 1 and various tests were conducted, and the results are listed in Table 1.

(2) Preparation method (B) Among the ingredients, nicotinic acid and methyl nicotinate are (A)
Among the ingredients, capsicum tincture and calcium hopanthenate were dissolved in component (C), and components (^) and (B) each dissolved by heating at a temperature of 80''C were mixed.

Each hair cream was then prepared by cooling to 30''C while stirring.

(3) Characteristics As shown in Table 1, Example 5 is a hair nourishing cosmetic of the present invention.
-7 showed a sustained blood flow increase rate compared to Comparative Examples 5-7 and also showed excellent effects in various tests, and the compounding amount was in the range of 0.05 to 1.5 wt%. The purpose of the invention could be achieved.

(Effects of the Invention) As described above, the present invention provides a hair nourishing cosmetic that continuously promotes blood circulation in the scalp, has excellent effects such as hair growth, hair loss prevention, and dandruff prevention, and is less irritating to the skin. That is clear.

Claims (1)

[Claims] A hair nourishing cosmetic containing calcium hopantenate.