JPS6259207A - 薬物が、非晶化及び／又は結晶化状態で分散する微細球状粒体の簡易な製造法 - Google Patents
薬物が、非晶化及び／又は結晶化状態で分散する微細球状粒体の簡易な製造法Info
- Publication number
- JPS6259207A JPS6259207A JP10003685A JP10003685A JPS6259207A JP S6259207 A JPS6259207 A JP S6259207A JP 10003685 A JP10003685 A JP 10003685A JP 10003685 A JP10003685 A JP 10003685A JP S6259207 A JPS6259207 A JP S6259207A
- Authority
- JP
- Japan
- Prior art keywords
- acrylic acid
- main drug
- suspension
- solid dispersion
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 title claims abstract description 31
- 229940079593 drug Drugs 0.000 title claims abstract description 30
- 239000007962 solid dispersion Substances 0.000 title claims abstract description 24
- 229920001577 copolymer Polymers 0.000 claims abstract description 20
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 13
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000000243 solution Substances 0.000 claims abstract description 11
- 239000007921 spray Substances 0.000 claims abstract description 11
- 239000000725 suspension Substances 0.000 claims abstract description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 5
- 239000007864 aqueous solution Substances 0.000 claims abstract description 4
- 239000000839 emulsion Substances 0.000 claims abstract description 3
- 238000000034 method Methods 0.000 claims description 28
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 15
- 239000007788 liquid Substances 0.000 claims description 14
- 125000004432 carbon atom Chemical group C* 0.000 claims description 13
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 11
- 239000004014 plasticizer Substances 0.000 claims description 8
- 239000003995 emulsifying agent Substances 0.000 claims description 6
- 238000007720 emulsion polymerization reaction Methods 0.000 claims description 6
- 239000007787 solid Substances 0.000 claims description 4
- 239000006072 paste Substances 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims 1
- 125000005907 alkyl ester group Chemical group 0.000 claims 1
- 238000005538 encapsulation Methods 0.000 claims 1
- 238000003756 stirring Methods 0.000 claims 1
- 239000003094 microcapsule Substances 0.000 abstract description 14
- 239000003960 organic solvent Substances 0.000 abstract description 14
- 230000000694 effects Effects 0.000 abstract description 8
- 238000013268 sustained release Methods 0.000 abstract description 6
- 239000012730 sustained-release form Substances 0.000 abstract description 6
- 229920003145 methacrylic acid copolymer Polymers 0.000 abstract description 5
- -1 alkyl methacrylate Chemical compound 0.000 abstract description 3
- 125000005250 alkyl acrylate group Chemical group 0.000 abstract description 2
- 239000008280 blood Substances 0.000 abstract description 2
- 210000004369 blood Anatomy 0.000 abstract description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 abstract 2
- 229920006243 acrylic copolymer Polymers 0.000 abstract 1
- 230000000379 polymerizing effect Effects 0.000 abstract 1
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 description 18
- 239000000203 mixture Substances 0.000 description 9
- 229960000278 theophylline Drugs 0.000 description 9
- 238000010828 elution Methods 0.000 description 8
- 239000000126 substance Substances 0.000 description 8
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 7
- 239000000843 powder Substances 0.000 description 7
- 238000001694 spray drying Methods 0.000 description 7
- JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 6
- 229940093429 polyethylene glycol 6000 Drugs 0.000 description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 5
- 238000002441 X-ray diffraction Methods 0.000 description 5
- 229920002584 Polyethylene Glycol 6000 Polymers 0.000 description 4
- 239000008119 colloidal silica Substances 0.000 description 4
- 239000000969 carrier Substances 0.000 description 3
- 239000010419 fine particle Substances 0.000 description 3
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 2
- 235000011114 ammonium hydroxide Nutrition 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000007907 direct compression Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000002702 enteric coating Substances 0.000 description 2
- 238000009505 enteric coating Methods 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 230000000704 physical effect Effects 0.000 description 2
- 239000002861 polymer material Substances 0.000 description 2
- 239000011550 stock solution Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 229910002012 Aerosil® Inorganic materials 0.000 description 1
- 229910002016 Aerosil® 200 Inorganic materials 0.000 description 1
- 229920003139 Eudragit® L 100 Polymers 0.000 description 1
- 229920003135 Eudragit® L 100-55 Polymers 0.000 description 1
- 229920003136 Eudragit® L polymer Polymers 0.000 description 1
- 229920003141 Eudragit® S 100 Polymers 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 238000005280 amorphization Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- GDCRSXZBSIRSFR-UHFFFAOYSA-N ethyl prop-2-enoate;2-methylprop-2-enoic acid Chemical compound CC(=C)C(O)=O.CCOC(=O)C=C GDCRSXZBSIRSFR-UHFFFAOYSA-N 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 238000004880 explosion Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000007903 gelatin capsule Substances 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 229940068968 polysorbate 80 Drugs 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000012798 spherical particle Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10003685A JPS6259207A (ja) | 1985-05-10 | 1985-05-10 | 薬物が、非晶化及び／又は結晶化状態で分散する微細球状粒体の簡易な製造法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10003685A JPS6259207A (ja) | 1985-05-10 | 1985-05-10 | 薬物が、非晶化及び／又は結晶化状態で分散する微細球状粒体の簡易な製造法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6259207A true JPS6259207A (ja) | 1987-03-14 |
| JPH057366B2 JPH057366B2 (enExample) | 1993-01-28 |
Family
ID=14263298
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10003685A Granted JPS6259207A (ja) | 1985-05-10 | 1985-05-10 | 薬物が、非晶化及び／又は結晶化状態で分散する微細球状粒体の簡易な製造法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6259207A (enExample) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04202124A (ja) * | 1990-11-29 | 1992-07-22 | Fuji Kagaku Kogyo Kk | 噴霧乾燥造粒法による薬物放出の制御された製剤の製造法 |
| JPH04230625A (ja) * | 1990-12-27 | 1992-08-19 | Standard Chem & Pharmaceut Corp Ltd | 噴霧乾燥したジクロフェナクナトリウムを含み腸溶性の被覆を有するマイクロカプセルからなる微分散した錠剤組成物の製造方法 |
| WO1999000112A1 (en) * | 1997-06-30 | 1999-01-07 | Chugai Seiyaku Kabushiki Kaisha | Sucralfate-containing composition and process for the preparation thereof |
| JPH1171285A (ja) * | 1997-06-30 | 1999-03-16 | Chugai Pharmaceut Co Ltd | スクラルファート含有組成物及びその製造方法 |
-
1985
- 1985-05-10 JP JP10003685A patent/JPS6259207A/ja active Granted
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04202124A (ja) * | 1990-11-29 | 1992-07-22 | Fuji Kagaku Kogyo Kk | 噴霧乾燥造粒法による薬物放出の制御された製剤の製造法 |
| JPH04230625A (ja) * | 1990-12-27 | 1992-08-19 | Standard Chem & Pharmaceut Corp Ltd | 噴霧乾燥したジクロフェナクナトリウムを含み腸溶性の被覆を有するマイクロカプセルからなる微分散した錠剤組成物の製造方法 |
| WO1999000112A1 (en) * | 1997-06-30 | 1999-01-07 | Chugai Seiyaku Kabushiki Kaisha | Sucralfate-containing composition and process for the preparation thereof |
| JPH1171285A (ja) * | 1997-06-30 | 1999-03-16 | Chugai Pharmaceut Co Ltd | スクラルファート含有組成物及びその製造方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH057366B2 (enExample) | 1993-01-28 |
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