JPS6241505B2 - - Google Patents

Info

Publication number
JPS6241505B2
JPS6241505B2 JP54138836A JP13883679A JPS6241505B2 JP S6241505 B2 JPS6241505 B2 JP S6241505B2 JP 54138836 A JP54138836 A JP 54138836A JP 13883679 A JP13883679 A JP 13883679A JP S6241505 B2 JPS6241505 B2 JP S6241505B2
Authority
JP
Japan
Prior art keywords
group
formula
carbon atoms
alkyl
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP54138836A
Other languages
English (en)
Japanese (ja)
Other versions
JPS5564571A (en
Inventor
Behingaa Eguberuto
Bozaato Furiidoritsuhi
Fuaataa Burufu
Sutetsuperu Kuruto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of JPS5564571A publication Critical patent/JPS5564571A/ja
Publication of JPS6241505B2 publication Critical patent/JPS6241505B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
JP13883679A 1978-10-31 1979-10-29 Novel 1*44dihydropyridine compound having substituted ester group Granted JPS5564571A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19782847236 DE2847236A1 (de) 1978-10-31 1978-10-31 Neue dihydropyridine mit substituierten estergruppierungen, mehrer verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel

Publications (2)

Publication Number Publication Date
JPS5564571A JPS5564571A (en) 1980-05-15
JPS6241505B2 true JPS6241505B2 (en, 2012) 1987-09-03

Family

ID=6053510

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13883679A Granted JPS5564571A (en) 1978-10-31 1979-10-29 Novel 1*44dihydropyridine compound having substituted ester group

Country Status (6)

Country Link
US (1) US4551467A (en, 2012)
EP (1) EP0012180B1 (en, 2012)
JP (1) JPS5564571A (en, 2012)
AT (1) ATE1238T1 (en, 2012)
DE (2) DE2847236A1 (en, 2012)
ES (1) ES485540A1 (en, 2012)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3022030A1 (de) * 1980-06-12 1981-12-17 Bayer Ag, 5090 Leverkusen 4-thiazol- bzw. 4-imidazol-substituierte, 1,4-dihydropyridine, verfahren zu deren herstellung sowie diese enthaltende arzneimittel
DE3042769A1 (de) * 1980-11-13 1982-06-09 Bayer Ag, 5090 Leverkusen C-3 verknuepfte 1,4-dihydropyridine, ihre verwendung in arzneimitteln und verfahren zu ihrer herstellung
GB2111978B (en) * 1981-10-19 1985-05-01 Maruko Pharmaceutical Co 1 4-dihydropyridine compounds
DE3207982A1 (de) * 1982-03-05 1983-09-08 Bayer Ag, 5090 Leverkusen Neue 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihrer verwendung in arzneimitteln
DE3208628A1 (de) * 1982-03-10 1983-09-22 Bayer Ag, 5090 Leverkusen Neue verbindungen, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
JPS58185562A (ja) * 1982-04-22 1983-10-29 Taisho Pharmaceut Co Ltd １，４−ジヒドロピリジン誘導体
JPS58216158A (ja) * 1982-06-08 1983-12-15 Yoshitomi Pharmaceut Ind Ltd １，４−ジヒドロピリジン誘導体又はその塩類
US4656181A (en) * 1982-11-24 1987-04-07 Cermol S.A. Esters of 1,4-dihydropyridines, processes for the preparation of the new esters, and medicaments containing the same
DE3244178A1 (de) * 1982-11-30 1984-05-30 Bayer Ag, 5090 Leverkusen 1,4-dihydropyridinderivate, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
DE3247118A1 (de) * 1982-12-20 1984-06-20 Cassella Ag, 6000 Frankfurt Neue substituierte 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
JPS6097955A (ja) * 1983-11-01 1985-05-31 Teijin Ltd １，４−ジヒドロピリジン−３，５−ジカルボン酸ジエステル誘導体の製造法
DE4342196A1 (de) * 1993-12-10 1995-06-14 Bayer Ag Neue 4-Phenyl-substituierte 1,4-Dihydropyridine
US4637930A (en) * 1984-02-08 1987-01-20 Yamanouchi Pharmaceutical Co, Ltd. Transdermal formulation of nicardipine hydrochloride
IE57810B1 (en) * 1984-03-27 1993-04-21 Delagrange Lab 1,4-dihydropyridine derivatives,their preparation and their use
GB8413385D0 (en) * 1984-05-24 1984-06-27 Recordati Chem Pharm Carboxylic acid derivatives
JPS6147477A (ja) * 1984-08-14 1986-03-07 Kowa Co 新規１，４−ジヒドロピリジン−３，５−ジカルボン酸エステル誘導体
DE3431152A1 (de) * 1984-08-24 1986-03-06 Cassella Ag, 6000 Frankfurt Verfahren zur herstellung optisch aktiver, substituierter 1,4-dihydropyridine und ihre verwendung als arzneimittel
JPS6157556A (ja) * 1984-08-29 1986-03-24 Teijin Ltd １，４−ジヒドロピリジン誘導体その製造法およびそれを有効成分とする薬剤
DE3514865A1 (de) * 1985-04-25 1986-11-06 Bayer Ag, 5090 Leverkusen 1,4-dihydropyridin-derivate, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
DK8602336A (en, 2012) * 1985-05-21 1986-11-22
US4780538A (en) * 1986-02-12 1988-10-25 Merck & Co., Inc. Process for 1,4-dihydropyridine compounds using a titanamine catalyst
IT1204461B (it) * 1986-02-20 1989-03-01 Glaxo Spa Derivati eterociclici
JPS62292757A (ja) * 1986-06-12 1987-12-19 Taisho Pharmaceut Co Ltd １，４−ジヒドロピリジン誘導体
US5470982A (en) * 1988-01-20 1995-11-28 Bayer Aktiengesellschaft Disubstituted pyridines
US5234821A (en) * 1990-09-01 1993-08-10 Kazuo Achiwa Process for preparing 1,4 dihydropyridine compounds
JPH0641075A (ja) 1990-09-01 1994-02-15 Kazuo Achinami 新規な１，４−ジヒドロピリジン化合物及びその製造方法
US6001857A (en) * 1992-10-30 1999-12-14 Bayer Aktiengesellschaft Heterocyclyl substituted dihydropyridines
DE4236707A1 (de) * 1992-10-30 1994-05-05 Bayer Ag 4-Heterocyclyl substituierte Dihydropyridine
SE9303657D0 (sv) * 1993-11-05 1993-11-05 Astra Ab Short-acting dihydropyridines
DE4342193A1 (de) * 1993-12-10 1995-06-14 Bayer Ag Arylsubstituierte Alkoxycarbonyl-1,4-dihydropyridin-5-carbonsäureester
CN102796502B (zh) * 2012-09-11 2014-02-19 西华师范大学 缓蚀剂溴化-n-烷基吡啶丙烯酸酯及其制备方法
CN103739542B (zh) * 2013-12-06 2018-10-12 威海迪素制药有限公司 3-(2-腈乙基)-5-甲基-2,6-二甲基-4-(3-硝基苯基)-1,4-二氢吡啶-3,5-二羧酸酯的制备方法
CN115850158B (zh) * 2022-11-03 2025-06-06 成都硕德药业有限公司 一种地平类药物中间体m2的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2210672C3 (de) * 1972-03-06 1980-03-20 Bayer Ag, 5090 Leverkusen N-substituierte unsymmetrische 1 ^-Dihydropyridin-S^-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
US3974275A (en) * 1972-04-18 1976-08-10 Bayer Aktiengesellschaft 1,4-Dihydropyridine carboxylic acid esters useful as coronary vessel dilators and anti-hypertensives
DE2228363A1 (de) * 1972-06-10 1974-01-03 Bayer Ag 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US3966946A (en) * 1973-06-12 1976-06-29 Smith Kline & French Laboratories Limited 1,4-Dihydropyridine compounds in treating hypertension
DE2508181A1 (de) * 1975-02-26 1976-09-09 Bayer Ag 1,4-dihydropyridincarbonsaeurearal- kylester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US4284634A (en) * 1975-07-02 1981-08-18 Fujisawa Pharmaceutical Co., Ltd. 1,4-Dihydropyridine derivatives, and pharmaceutical method of the same
US4307103A (en) * 1978-09-08 1981-12-22 Fujisawa Pharmaceutical Co., Ltd. Dihydropyridine derivative, processes for preparation thereof and pharmaceutical composition comprising the same

Also Published As

Publication number Publication date
EP0012180B1 (de) 1982-06-23
US4551467A (en) 1985-11-05
ES485540A1 (es) 1980-05-16
DE2963183D1 (en) 1982-08-12
DE2847236A1 (de) 1980-05-14
JPS5564571A (en) 1980-05-15
ATE1238T1 (de) 1982-07-15
EP0012180A1 (de) 1980-06-25

Similar Documents

Publication Publication Date Title
JPS6241505B2 (en, 2012)
US4248873A (en) Nitro-substituted 1,4-dihydropyridines, processes for _their production and their medicinal use
US4622332A (en) Asymmetric diesters of Hantzsch dihydropyridines with hypotensive activity
EP0071819B2 (de) Dihydropyridine mit positiv inotroper Wirkung, neue Verbindungen, ihre Verwendung in Arzneimitteln und Verfahren zu ihrer Herstellung
JPH0262550B2 (en, 2012)
JPH07600B2 (ja) 新規な光学的活性の１，４−ジヒドロピリジン化合物の製造法
JPS6131100B2 (en, 2012)
JPS6025424B2 (ja) １，４‐ジヒドロピリジンカルボン酸アラルキルエステル
JPH0542431B2 (en, 2012)
JPS6126783B2 (en, 2012)
CA1108615A (en) Dihydropyridine compounds, their production and their medicinal use
EP0296316A1 (de) 1,4-Dihydropyridin-Enantiomere
JPS5943951B2 (ja) アルコキシアルキル−１，４−ジヒドロピリジンエステルまたはその塩の製造法
US4565824A (en) Certain nitratoalkyl ester dihydropyridines having antihypertensive properties
CA1185182A (en) Pharmaceutical compositions containing diethyl-2- methyl-6-propyl-4-(3-nitrophenyl)-1,4- dihydropyridine-3,5-dicarboxylate
DE2658804A1 (de) Kreislaufbeeinflussende mittel
JPS6217595B2 (en, 2012)
DE3130041A1 (de) Dihydropyridine mit positiv inotroper wirkung, neue verbindungen, ihre verwendung in arzneimitteln und verfahren zu ihrer herstellung
US4162321A (en) Sulphur-containing amino-dihydropyridines, and their use as medicants
JPS6326749B2 (en, 2012)
JPH0714931B2 (ja) 新規ジヒドロピリジン誘導体、その製法および用途
US4016277A (en) 4-Quinoline and 4-isoquinoline derivatives of 2,6-diamino-1,4-dihydropyridine
KR800000850B1 (ko) 1,4-디하이드로 피리딘 카복실산 아르알킬 에스테르의 제조방법