JPS6217595B2 - - Google Patents

Info

Publication number
JPS6217595B2
JPS6217595B2 JP54108996A JP10899679A JPS6217595B2 JP S6217595 B2 JPS6217595 B2 JP S6217595B2 JP 54108996 A JP54108996 A JP 54108996A JP 10899679 A JP10899679 A JP 10899679A JP S6217595 B2 JPS6217595 B2 JP S6217595B2
Authority
JP
Japan
Prior art keywords
group
methyl
general formula
formula
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP54108996A
Other languages
English (en)
Japanese (ja)
Other versions
JPS5533497A (en
Inventor
Tatsuke Rainhoruto
Bentoraage Anke
Tobaruto Roberutoson
Fuataa Burufu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of JPS5533497A publication Critical patent/JPS5533497A/ja
Publication of JPS6217595B2 publication Critical patent/JPS6217595B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP10899679A 1978-08-28 1979-08-27 Silaasubstituted 1*44dihydropyridine derivative Granted JPS5533497A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19782837477 DE2837477A1 (de) 1978-08-28 1978-08-28 Sila-substituierte 1,4-dihydropyridin- derivate

Publications (2)

Publication Number Publication Date
JPS5533497A JPS5533497A (en) 1980-03-08
JPS6217595B2 true JPS6217595B2 (en, 2012) 1987-04-18

Family

ID=6048072

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10899679A Granted JPS5533497A (en) 1978-08-28 1979-08-27 Silaasubstituted 1*44dihydropyridine derivative

Country Status (8)

Country Link
US (1) US4237137A (en, 2012)
EP (1) EP0010130B1 (en, 2012)
JP (1) JPS5533497A (en, 2012)
AT (1) ATE489T1 (en, 2012)
CA (1) CA1135699A (en, 2012)
DE (2) DE2837477A1 (en, 2012)
ES (1) ES483661A1 (en, 2012)
IL (1) IL58103A (en, 2012)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2915355A1 (de) * 1979-04-14 1980-10-23 Nattermann A & Cie Neue 1,4-dihydropyridin-bderivate mit antihypertensiver wirkung
US4325389A (en) * 1980-09-22 1982-04-20 Cordis Corporation Tip assembly for a carbon fiber implantable lead
DE3339236A1 (de) * 1983-10-28 1985-05-09 Bayer Ag Arzneimittelzubereitung
DE3433239A1 (de) * 1984-09-11 1986-03-20 Bayer Ag, 5090 Leverkusen Feste arzneizubereitung enthaltend nitrendipin und verfahren zu ihrer herstellung
US4593033A (en) * 1985-04-24 1986-06-03 Merck & Co., Inc. Substituted indeno[2,1-c] pyridines useful as calcium channel blockers
US4605660A (en) * 1985-06-03 1986-08-12 Merck & Co., Inc. Indeno[2,1-c]pyridine compounds, and their use as calcium channel blockers
US4670443A (en) * 1985-07-02 1987-06-02 Merck & Co., Inc. Benzo(f)isoquinoline compounds useful as calcium entry blockers
US4735956A (en) * 1985-09-13 1988-04-05 Merck & Co., Inc. Certain 1,4-dihydro-2,6-di-lower hydrocarbyl-4-heterocyclic-3,5-pyridine dicarboxylates which are useful as calcium channel blockers
DE3677319D1 (de) * 1985-10-22 1991-03-07 Sanwa Kagaku Kenkyusho Co Pharmazeutische 1,4-dihydropyridinderivate, ihre salze und herstellung.
US4788203A (en) * 1985-11-26 1988-11-29 Merck & Co., Inc. Cyclized N-substituted-tetrahydropyridine compounds, useful in the treatment of cardiovascular disorders
US4721708A (en) * 1985-11-26 1988-01-26 Merck & Co., Inc. Cyclized N-substituted-tetrahydropyridine compounds and cardiovascular use
EP0287659A4 (de) * 1986-10-21 1990-02-05 Inst Organicheskogo Sinteza Ak 2,6-dimethyl-3,5-dimethoxykarbonyl-4-(5'-trimethylsilyl-2'-furyl)-1,4-dihydropyridine.
DE102005056050A1 (de) * 2005-11-24 2007-05-31 Wacker Chemie Ag Alpha-(beta-Ketocarbonyl)-funktionelle Organosiliciumverbindungen und deren Herstellung

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3355455A (en) * 1964-08-06 1967-11-28 Dow Corning Certain pyridyl silane derivatives
US3816439A (en) * 1970-06-19 1974-06-11 Monsanto Co Substituted 1,2-dihydropyridines and process for preparing same
DE2117571C3 (de) * 1971-04-10 1979-10-11 Bayer Ag, 5090 Leverkusen Unsymmetrische 1,4-Dihydropyridin-33-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
US3781291A (en) * 1971-05-26 1973-12-25 R Sulzbach Silylated 1,4-dihydropyridines
US4031104A (en) * 1972-04-18 1977-06-21 Bayer Aktiengesellschaft 1,4-Dihydropyridine carboxylic acid esters
DE2248150A1 (de) * 1972-09-30 1974-04-04 Bayer Ag Dihydropyridinpolyester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE2508181A1 (de) * 1975-02-26 1976-09-09 Bayer Ag 1,4-dihydropyridincarbonsaeurearal- kylester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel

Also Published As

Publication number Publication date
EP0010130A1 (de) 1980-04-30
EP0010130B1 (de) 1981-12-23
US4237137A (en) 1980-12-02
ES483661A1 (es) 1980-04-16
CA1135699A (en) 1982-11-16
DE2961609D1 (en) 1982-02-11
ATE489T1 (de) 1982-01-15
DE2837477A1 (de) 1980-03-13
IL58103A0 (en) 1979-12-30
IL58103A (en) 1983-06-15
JPS5533497A (en) 1980-03-08

Similar Documents

Publication Publication Date Title
US4248873A (en) Nitro-substituted 1,4-dihydropyridines, processes for _their production and their medicinal use
US3905970A (en) 1,4-Dihydropyridine carboxylic acid esters
US4551467A (en) Vasodilating cyanoalkyl esters of 1,4-dihydropyridines
US4044141A (en) 1,4-Dihydropyridines
US4849433A (en) The compound, (⃡)1,4-dihydro-2,6-dimethyl-4-(2'-nitrophenyl)-pyridine-3,5-dicarboxylic acid, methyl isobutyl ester, compositions containing same and a method for effecting coronary dilation
JPH0262550B2 (en, 2012)
IL41668A (en) N-Transformed History of Dihydropyridine, Their Manufacture, and Pharmaceutical Preparations Containing Them
JPH0613484B2 (ja) 新規なジヒドロピリミジン類
US3708489A (en) Azido-aryl 1,4-dihydropyridines and their production
JPS6217595B2 (en, 2012)
JPH05271078A (ja) ジヒドロピリジン類
EP0097821B1 (en) Dihydropyridines with an antagonistic activity to calcium, process for their preparation, and pharmaceutical compositions containing them
CA1108615A (en) Dihydropyridine compounds, their production and their medicinal use
KR910007973B1 (ko) 크로몬-및 티오크로몬-치환된 1,4-디하이드로피리딘 유도체의 제조방법
CA1185182A (en) Pharmaceutical compositions containing diethyl-2- methyl-6-propyl-4-(3-nitrophenyl)-1,4- dihydropyridine-3,5-dicarboxylate
JPS61291567A (ja) 新規な１，４−ジヒドロピリジン類
JPS5965047A (ja) ２―ニトロ―１、１―エテンジアミン類およびそれらの製造法
EP0194685A1 (en) 1,4-Dihydropyridines
US4162321A (en) Sulphur-containing amino-dihydropyridines, and their use as medicants
US3887558A (en) Process for producing 2,6-diamino -1,4- dihydro-3,5-pyridine-dicarboxylates and derivatives thereof
US4166855A (en) 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ester, and its use as a peripheral vasodilator
JPS6326749B2 (en, 2012)
IE43984B1 (en) A 1,4-dihydropyridine-3 5-dicarboxylic acid di-ester derivative, several processes for its preparation,and its use as a coronary therapeutic agent
JPH0134971B2 (en, 2012)
JP2640245B2 (ja) １，４−ジヒドロピリジン誘導体