JPS6232749B2 - - Google Patents

Info

Publication number
JPS6232749B2
JPS6232749B2 JP11159082A JP11159082A JPS6232749B2 JP S6232749 B2 JPS6232749 B2 JP S6232749B2 JP 11159082 A JP11159082 A JP 11159082A JP 11159082 A JP11159082 A JP 11159082A JP S6232749 B2 JPS6232749 B2 JP S6232749B2
Authority
JP
Japan
Prior art keywords
hydroxycamptothecin
tetrahydrocamptothecin
camptothecin
mmol
room temperature
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP11159082A
Other languages
English (en)
Japanese (ja)
Other versions
JPS595188A (ja
Inventor
Sada Myasaka
Seigo Sawada
Kenichiro Nogata
Masahiko Mutai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yakult Honsha Co Ltd
Original Assignee
Yakult Honsha Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yakult Honsha Co Ltd filed Critical Yakult Honsha Co Ltd
Priority to JP11159082A priority Critical patent/JPS595188A/ja
Publication of JPS595188A publication Critical patent/JPS595188A/ja
Publication of JPS6232749B2 publication Critical patent/JPS6232749B2/ja
Priority to BR1100882-2A priority patent/BR1100882A/pt
Granted legal-status Critical Current

Links

Landscapes

  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP11159082A 1982-06-30 1982-06-30 １０−ヒドロキシカンプトテシンの製造法 Granted JPS595188A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP11159082A JPS595188A (ja) 1982-06-30 1982-06-30 １０−ヒドロキシカンプトテシンの製造法
BR1100882-2A BR1100882A (pt) 1982-06-30 1997-05-14 Processo para a preparação de 10-hidroxicamptotecina

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11159082A JPS595188A (ja) 1982-06-30 1982-06-30 １０−ヒドロキシカンプトテシンの製造法

Publications (2)

Publication Number Publication Date
JPS595188A JPS595188A (ja) 1984-01-12
JPS6232749B2 true JPS6232749B2 (enrdf_load_html_response) 1987-07-16

Family

ID=14565217

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11159082A Granted JPS595188A (ja) 1982-06-30 1982-06-30 １０−ヒドロキシカンプトテシンの製造法

Country Status (1)

Country Link
JP (1) JPS595188A (enrdf_load_html_response)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0615546B2 (ja) * 1986-02-24 1994-03-02 株式会社ヤクルト本社 新規なカンプトテシン誘導体
US4981968A (en) * 1987-03-31 1991-01-01 Research Triangle Institute Synthesis of camptothecin and analogs thereof
US5364858A (en) * 1987-03-31 1994-11-15 Research Triangle Institute Camptothecin analogs as potent inhibitors of topoisomerase I
US5122526A (en) * 1987-03-31 1992-06-16 Research Triangle Institute Camptothecin and analogs thereof and pharmaceutical compositions and method using them
US5227380A (en) * 1987-03-31 1993-07-13 Research Triangle Institute Pharmaceutical compositions and methods employing camptothecins
US5106742A (en) * 1987-03-31 1992-04-21 Wall Monroe E Camptothecin analogs as potent inhibitors of topoisomerase I
US5053512A (en) * 1987-04-14 1991-10-01 Research Triangle Institute Total synthesis of 20(S) and 20(R)-camptothecin and compthothecin derivatives
US5340817A (en) * 1987-04-14 1994-08-23 Research Triangle Institute Method of treating tumors with anti-tumor effective camptothecin compounds
US5180722A (en) * 1987-04-14 1993-01-19 Research Triangle Institute 10,11-methylenedioxy-20(RS)-camptothecin and 10,11-methylenedioxy-20(S)-camptothecin analogs
US5049668A (en) * 1989-09-15 1991-09-17 Research Triangle Institute 10,11-methylenedioxy-20(RS)-camptothecin analogs
US5122606A (en) * 1987-04-14 1992-06-16 Research Triangle Institute 10,11-methylenedioxy camptothecins
US5552154A (en) * 1989-11-06 1996-09-03 The Stehlin Foundation For Cancer Research Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
US5225404A (en) * 1989-11-06 1993-07-06 New York University Methods of treating colon tumors with tumor-inhibiting camptothecin compounds
WO1992005785A1 (en) * 1990-09-28 1992-04-16 Smithkline Beecham Corporation Water soluble camptothecin analogues, processes and methods
US5883255A (en) * 1990-10-31 1999-03-16 Smithkline Beecham Corporation Substituted indolizino 1,2-b!quinolinones
US6080751A (en) * 1992-01-14 2000-06-27 The Stehlin Foundation For Cancer Research Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
US5447936A (en) * 1993-12-22 1995-09-05 Bionumerik Pharmaceuticals, Inc. Lactone stable formulation of 10-hydroxy 7-ethyl camptothecin and methods for uses thereof
US5468754A (en) * 1994-04-19 1995-11-21 Bionumerik Pharmaceuticals, Inc. 11,7 substituted camptothecin derivatives and formulations of 11,7 substituted camptothecin derivatives and methods for uses thereof
US5646159A (en) * 1994-07-20 1997-07-08 Research Triangle Institute Water-soluble esters of camptothecin compounds
US5614529A (en) * 1994-09-22 1997-03-25 Research Triangle Institute Inhibition of plasmodia parasites by camptothecin compounds
AU7732996A (en) * 1995-11-22 1997-06-11 Research Triangle Institute Camptothecin compounds with combined topoisomerase i inhibition and dna alkylation properties
KR100717916B1 (ko) 2000-02-28 2007-05-11 아방티 파르마 소시에테 아노님 캄프토테신 및 피리미딘 유도체를 포함하는 암 치료용 조성물
US6545010B2 (en) 2000-03-17 2003-04-08 Aventis Pharma S.A. Composition comprising camptothecin or a camptothecin derivative and a platin derivative for the treatment of cancer
US6486320B2 (en) 2000-09-15 2002-11-26 Aventis Pharma S.A. Preparation of camptothecin and of its derivatives
AU1602902A (en) 2000-10-27 2002-05-06 Aventis Pharma Sa A combination comprising camptothecin and a stilbene derivative for the treatment of cancer
WO2004055020A1 (en) * 2002-12-16 2004-07-01 Council Of Scientific And Industrial Research Process for the direct preparation of 5-alkoxy and 5-acyloxy analogues of campthothecins or mappicene ketones
CN100344633C (zh) 2003-05-12 2007-10-24 台湾神隆股份有限公司 用于制备7－烷基－10－羟基－20(s)－喜树碱的方法
CZ298934B6 (cs) * 2003-08-26 2008-03-12 Pliva- Lachema A.S. Zpusob výroby 7-ethyl-10-hydroxykamptothecinu
CZ299593B6 (cs) * 2003-12-16 2008-09-10 Pliva-Lachema A. S. Zpusob výroby 7-ethyl-10-hydroxykamptothecinu
US20050272757A1 (en) * 2004-06-04 2005-12-08 Phytogen Life Sciences Inc. Process to prepare camptothecin derivatives and novel intermediate and compounds thereof
US8299251B2 (en) 2008-05-29 2012-10-30 Sichuan Xieli Pharmaceutical Co., Ltd. Method for producing camptothecin derivatives

Also Published As

Publication number Publication date
JPS595188A (ja) 1984-01-12

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