JPS6227799B2 - - Google Patents
Info
- Publication number
- JPS6227799B2 JPS6227799B2 JP13181383A JP13181383A JPS6227799B2 JP S6227799 B2 JPS6227799 B2 JP S6227799B2 JP 13181383 A JP13181383 A JP 13181383A JP 13181383 A JP13181383 A JP 13181383A JP S6227799 B2 JPS6227799 B2 JP S6227799B2
- Authority
- JP
- Japan
- Prior art keywords
- keto
- acid
- dihydroxy
- producing
- cholic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- BHQCQFFYRZLCQQ-UHFFFAOYSA-N (3alpha,5alpha,7alpha,12alpha)-3,7,12-trihydroxy-cholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 BHQCQFFYRZLCQQ-UHFFFAOYSA-N 0.000 claims description 8
- 239000004380 Cholic acid Substances 0.000 claims description 8
- 241000186216 Corynebacterium Species 0.000 claims description 8
- BHQCQFFYRZLCQQ-OELDTZBJSA-N cholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 BHQCQFFYRZLCQQ-OELDTZBJSA-N 0.000 claims description 8
- 229960002471 cholic acid Drugs 0.000 claims description 8
- 235000019416 cholic acid Nutrition 0.000 claims description 8
- KXGVEGMKQFWNSR-UHFFFAOYSA-N deoxycholic acid Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 KXGVEGMKQFWNSR-UHFFFAOYSA-N 0.000 claims description 8
- 238000004519 manufacturing process Methods 0.000 claims description 7
- 244000005700 microbiome Species 0.000 claims description 4
- CSWRFCISTSMAHQ-FYRHABGPSA-N (5S,8S,9S,10R,13S,14S,17R)-16,16-dihydroxy-13-methyl-17-[(2R)-pentan-2-yl]-1,2,3,4,5,6,7,8,9,11,12,14,15,17-tetradecahydrocyclopenta[a]phenanthrene-10-carboxylic acid Chemical compound C([C@H]1CC2)CCC[C@]1(C(O)=O)[C@@H]1[C@@H]2[C@@H]2CC(O)(O)[C@H]([C@H](C)CCC)[C@@]2(C)CC1 CSWRFCISTSMAHQ-FYRHABGPSA-N 0.000 claims 1
- 235000015097 nutrients Nutrition 0.000 claims 1
- RUDATBOHQWOJDD-UHFFFAOYSA-N (3beta,5beta,7alpha)-3,7-Dihydroxycholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)CC2 RUDATBOHQWOJDD-UHFFFAOYSA-N 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 241000894006 Bacteria Species 0.000 description 5
- RUDATBOHQWOJDD-BSWAIDMHSA-N chenodeoxycholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 RUDATBOHQWOJDD-BSWAIDMHSA-N 0.000 description 4
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 4
- 229960001091 chenodeoxycholic acid Drugs 0.000 description 3
- 239000002689 soil Substances 0.000 description 3
- 229920001817 Agar Polymers 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 229910052697 platinum Inorganic materials 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- RUDATBOHQWOJDD-UZVSRGJWSA-N ursodeoxycholic acid Chemical compound C([C@H]1C[C@@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 RUDATBOHQWOJDD-UZVSRGJWSA-N 0.000 description 2
- 229960001661 ursodiol Drugs 0.000 description 2
- MIHNUBCEFJLAGN-DMMBONCOSA-N 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)C(=O)C1 MIHNUBCEFJLAGN-DMMBONCOSA-N 0.000 description 1
- 229930194542 Keto Natural products 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229940099352 cholate Drugs 0.000 description 1
- 239000000731 choleretic agent Substances 0.000 description 1
- 125000003716 cholic acid group Chemical group 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 208000001130 gallstones Diseases 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 125000000468 ketone group Chemical group 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 238000013048 microbiological method Methods 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- NRHMKIHPTBHXPF-TUJRSCDTSA-M sodium cholate Chemical compound [Na+].C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC([O-])=O)C)[C@@]2(C)[C@@H](O)C1 NRHMKIHPTBHXPF-TUJRSCDTSA-M 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13181383A JPS6024198A (ja) | 1983-07-21 | 1983-07-21 | １２−ケト−３α，７α−ジヒドロキシコラン酸の製造法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13181383A JPS6024198A (ja) | 1983-07-21 | 1983-07-21 | １２−ケト−３α，７α−ジヒドロキシコラン酸の製造法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6024198A JPS6024198A (ja) | 1985-02-06 |
| JPS6227799B2 true JPS6227799B2 (cs) | 1987-06-16 |
Family
ID=15066704
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP13181383A Granted JPS6024198A (ja) | 1983-07-21 | 1983-07-21 | １２−ケト−３α，７α−ジヒドロキシコラン酸の製造法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6024198A (cs) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63164397U (cs) * | 1987-04-10 | 1988-10-26 |
-
1983
- 1983-07-21 JP JP13181383A patent/JPS6024198A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6024198A (ja) | 1985-02-06 |
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