JPS6185331A - 直打用賦形薬の製造法 - Google Patents
直打用賦形薬の製造法Info
- Publication number
- JPS6185331A JPS6185331A JP20863784A JP20863784A JPS6185331A JP S6185331 A JPS6185331 A JP S6185331A JP 20863784 A JP20863784 A JP 20863784A JP 20863784 A JP20863784 A JP 20863784A JP S6185331 A JPS6185331 A JP S6185331A
- Authority
- JP
- Japan
- Prior art keywords
- mannitol
- excipient
- starch hydrolyzate
- value
- moldability
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000546 pharmaceutical excipient Substances 0.000 title claims abstract description 26
- 238000004519 manufacturing process Methods 0.000 title claims description 18
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims abstract description 83
- 235000010355 mannitol Nutrition 0.000 claims abstract description 45
- 229920002472 Starch Polymers 0.000 claims abstract description 43
- 239000008107 starch Substances 0.000 claims abstract description 43
- 235000019698 starch Nutrition 0.000 claims abstract description 43
- 239000007864 aqueous solution Substances 0.000 claims abstract description 18
- 238000001694 spray drying Methods 0.000 claims abstract description 16
- 235000000346 sugar Nutrition 0.000 claims abstract description 10
- 239000002002 slurry Substances 0.000 claims abstract description 9
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims abstract description 5
- 239000008103 glucose Substances 0.000 claims abstract description 4
- 239000007787 solid Substances 0.000 claims abstract description 3
- 238000000034 method Methods 0.000 claims description 17
- 238000002347 injection Methods 0.000 claims description 16
- 239000007924 injection Substances 0.000 claims description 16
- 238000007907 direct compression Methods 0.000 claims description 5
- 239000000843 powder Substances 0.000 description 25
- 239000003826 tablet Substances 0.000 description 18
- 239000000203 mixture Substances 0.000 description 17
- 239000003814 drug Substances 0.000 description 14
- 238000002360 preparation method Methods 0.000 description 12
- 229940079593 drug Drugs 0.000 description 11
- 238000009472 formulation Methods 0.000 description 11
- 239000007788 liquid Substances 0.000 description 10
- 238000012360 testing method Methods 0.000 description 9
- 238000001035 drying Methods 0.000 description 8
- 238000002441 X-ray diffraction Methods 0.000 description 6
- 239000002131 composite material Substances 0.000 description 6
- 239000002245 particle Substances 0.000 description 6
- 229930195725 Mannitol Natural products 0.000 description 5
- 239000011230 binding agent Substances 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 239000010419 fine particle Substances 0.000 description 5
- 239000000594 mannitol Substances 0.000 description 5
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
- 238000003677 abuse test Methods 0.000 description 4
- 230000002349 favourable effect Effects 0.000 description 4
- 241000411851 herbal medicine Species 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 230000008859 change Effects 0.000 description 3
- 238000007906 compression Methods 0.000 description 3
- 230000006835 compression Effects 0.000 description 3
- 239000013078 crystal Substances 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 229940069428 antacid Drugs 0.000 description 2
- 239000003159 antacid agent Substances 0.000 description 2
- 229960005070 ascorbic acid Drugs 0.000 description 2
- 235000010323 ascorbic acid Nutrition 0.000 description 2
- 239000011668 ascorbic acid Substances 0.000 description 2
- 238000005336 cracking Methods 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- 239000002075 main ingredient Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 238000001878 scanning electron micrograph Methods 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 1
- BSYNRYMUTXBXSQ-FOQJRBATSA-N 59096-14-9 Chemical compound CC(=O)OC1=CC=CC=C1[14C](O)=O BSYNRYMUTXBXSQ-FOQJRBATSA-N 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
- 241001474374 Blennius Species 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- DCXXMTOCNZCJGO-UHFFFAOYSA-N Glycerol trioctadecanoate Natural products CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- 241000254158 Lampyridae Species 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 241000978776 Senegalia senegal Species 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 102000011759 adducin Human genes 0.000 description 1
- 108010076723 adducin Proteins 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 229940035676 analgesics Drugs 0.000 description 1
- 150000008064 anhydrides Chemical class 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000007910 chewable tablet Substances 0.000 description 1
- 239000007891 compressed tablet Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 238000012948 formulation analysis Methods 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 239000011812 mixed powder Substances 0.000 description 1
- 150000002772 monosaccharides Chemical class 0.000 description 1
- 239000004570 mortar (masonry) Substances 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 235000011837 pasties Nutrition 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 229910052573 porcelain Inorganic materials 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 239000002918 waste heat Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000003232 water-soluble binding agent Substances 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
- 238000002424 x-ray crystallography Methods 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP20863784A JPS6185331A (ja) | 1984-10-04 | 1984-10-04 | 直打用賦形薬の製造法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP20863784A JPS6185331A (ja) | 1984-10-04 | 1984-10-04 | 直打用賦形薬の製造法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6185331A true JPS6185331A (ja) | 1986-04-30 |
| JPH0586373B2 JPH0586373B2 (enrdf_load_stackoverflow) | 1993-12-10 |
Family
ID=16559532
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP20863784A Granted JPS6185331A (ja) | 1984-10-04 | 1984-10-04 | 直打用賦形薬の製造法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6185331A (enrdf_load_stackoverflow) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5573777A (en) * | 1993-09-28 | 1996-11-12 | Roquette Freres | Pulverulent mannitol of moderate friability and process for its preparation |
| JP2001346600A (ja) * | 2000-03-29 | 2001-12-18 | Roquette Freres | 粉末マンニトール、及びそれを調製するための方法 |
| WO2010125313A1 (fr) * | 2009-04-30 | 2010-11-04 | Roquette Freres | Coagglomerats de mannitol et d'amidon granulaire comprimables et a ecoulement libre |
| JP2011103818A (ja) * | 2009-11-18 | 2011-06-02 | Pokka Corp | 液状食品の噴霧乾燥方法及び乾燥された液状食品 |
| JP2011526612A (ja) * | 2008-07-04 | 2011-10-13 | ロケット・フルーレ | 口腔内崩壊性マンニトール |
-
1984
- 1984-10-04 JP JP20863784A patent/JPS6185331A/ja active Granted
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5573777A (en) * | 1993-09-28 | 1996-11-12 | Roquette Freres | Pulverulent mannitol of moderate friability and process for its preparation |
| JP2001346600A (ja) * | 2000-03-29 | 2001-12-18 | Roquette Freres | 粉末マンニトール、及びそれを調製するための方法 |
| JP2011526612A (ja) * | 2008-07-04 | 2011-10-13 | ロケット・フルーレ | 口腔内崩壊性マンニトール |
| WO2010125313A1 (fr) * | 2009-04-30 | 2010-11-04 | Roquette Freres | Coagglomerats de mannitol et d'amidon granulaire comprimables et a ecoulement libre |
| FR2944971A1 (fr) * | 2009-04-30 | 2010-11-05 | Roquette Freres | Coagglomerats de mannitol et d'amidon granulaire comprimables et a ecoulement libre |
| CN102413819A (zh) * | 2009-04-30 | 2012-04-11 | 罗盖特公司 | 甘露醇和颗粒淀粉的可压制的并且自由流动的共凝聚体 |
| US9937131B2 (en) | 2009-04-30 | 2018-04-10 | Roquette Freres | Compressible and free-flow co-agglomerates of mannitol and granular starch |
| US11364204B2 (en) | 2009-04-30 | 2022-06-21 | Roquette Freeres | Compressible and free-flow co-agglomerates of mannitol and granual starch |
| JP2011103818A (ja) * | 2009-11-18 | 2011-06-02 | Pokka Corp | 液状食品の噴霧乾燥方法及び乾燥された液状食品 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0586373B2 (enrdf_load_stackoverflow) | 1993-12-10 |
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