JPS6169756A - スレオ−ｄ−２−ヒドロキシ−３−（２′−アミノフエニルチオ）−３−（４″−メトキシフエニル）−プロピオン酸の製造法 - Google Patents
スレオ−ｄ−２−ヒドロキシ−３−（２′−アミノフエニルチオ）−３−（４″−メトキシフエニル）−プロピオン酸の製造法Info
- Publication number
- JPS6169756A JPS6169756A JP19196084A JP19196084A JPS6169756A JP S6169756 A JPS6169756 A JP S6169756A JP 19196084 A JP19196084 A JP 19196084A JP 19196084 A JP19196084 A JP 19196084A JP S6169756 A JPS6169756 A JP S6169756A
- Authority
- JP
- Japan
- Prior art keywords
- threo
- hydroxy
- aminophenylthio
- methoxyphenyl
- propionic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Substances CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 title claims abstract 6
- 238000004519 manufacturing process Methods 0.000 title claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 8
- 235000019260 propionic acid Nutrition 0.000 claims 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 abstract description 11
- 230000003287 optical effect Effects 0.000 abstract description 4
- 230000037007 arousal Effects 0.000 abstract 1
- 210000004556 brain Anatomy 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
- 230000000304 vasodilatating effect Effects 0.000 abstract 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 18
- 239000002253 acid Substances 0.000 description 10
- 150000003839 salts Chemical class 0.000 description 10
- 239000013078 crystal Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000012452 mother liquor Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 229940085242 benzothiazepine derivative selective calcium channel blockers with direct cardiac effects Drugs 0.000 description 1
- 150000007657 benzothiazepines Chemical class 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 230000010339 dilation Effects 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 125000000286 phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP19196084A JPS6169756A (ja) | 1984-09-13 | 1984-09-13 | スレオ−ｄ−２−ヒドロキシ−３−（２′−アミノフエニルチオ）−３−（４″−メトキシフエニル）−プロピオン酸の製造法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP19196084A JPS6169756A (ja) | 1984-09-13 | 1984-09-13 | スレオ−ｄ−２−ヒドロキシ−３−（２′−アミノフエニルチオ）−３−（４″−メトキシフエニル）−プロピオン酸の製造法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6169756A true JPS6169756A (ja) | 1986-04-10 |
| JPH0430949B2 JPH0430949B2 (enrdf_load_stackoverflow) | 1992-05-25 |
Family
ID=16283306
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP19196084A Granted JPS6169756A (ja) | 1984-09-13 | 1984-09-13 | スレオ−ｄ−２−ヒドロキシ−３−（２′−アミノフエニルチオ）−３−（４″−メトキシフエニル）−プロピオン酸の製造法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6169756A (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5225557A (en) * | 1988-05-10 | 1993-07-06 | Hoffmann-La Roche Inc. | Process for making optically active naphtho[1,2-b]thiazepin-4(5H)-ones |
-
1984
- 1984-09-13 JP JP19196084A patent/JPS6169756A/ja active Granted
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5225557A (en) * | 1988-05-10 | 1993-07-06 | Hoffmann-La Roche Inc. | Process for making optically active naphtho[1,2-b]thiazepin-4(5H)-ones |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0430949B2 (enrdf_load_stackoverflow) | 1992-05-25 |
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