JPS6169725A - 抗腫瘍性物質ｓｐｆ−１４０及びその製法 - Google Patents
抗腫瘍性物質ｓｐｆ−１４０及びその製法Info
- Publication number
- JPS6169725A JPS6169725A JP59190560A JP19056084A JPS6169725A JP S6169725 A JPS6169725 A JP S6169725A JP 59190560 A JP59190560 A JP 59190560A JP 19056084 A JP19056084 A JP 19056084A JP S6169725 A JPS6169725 A JP S6169725A
- Authority
- JP
- Japan
- Prior art keywords
- substance
- reaction
- spf
- antitumor
- antitumor substance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000126 substance Substances 0.000 title claims abstract description 66
- 230000000259 anti-tumor effect Effects 0.000 title claims abstract description 43
- 238000002360 preparation method Methods 0.000 title abstract description 4
- 238000006243 chemical reaction Methods 0.000 claims abstract description 20
- 241000194017 Streptococcus Species 0.000 claims abstract description 11
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims abstract description 9
- 238000000034 method Methods 0.000 claims abstract description 9
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 claims abstract description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 6
- 239000007864 aqueous solution Substances 0.000 claims abstract description 6
- 238000000354 decomposition reaction Methods 0.000 claims abstract description 4
- 239000000843 powder Substances 0.000 claims abstract description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 4
- 229930182555 Penicillin Natural products 0.000 claims abstract description 3
- 229940049954 penicillin Drugs 0.000 claims abstract description 3
- 230000006641 stabilisation Effects 0.000 claims abstract description 3
- 238000011105 stabilization Methods 0.000 claims abstract description 3
- 239000003381 stabilizer Substances 0.000 claims abstract description 3
- FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 claims abstract 2
- 241000894006 Bacteria Species 0.000 claims description 9
- 238000000862 absorption spectrum Methods 0.000 claims description 8
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 6
- 238000002523 gelfiltration Methods 0.000 claims description 6
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 4
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 4
- 230000002378 acidificating effect Effects 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims description 4
- 238000010521 absorption reaction Methods 0.000 claims description 3
- 238000012258 culturing Methods 0.000 claims description 3
- 238000000921 elemental analysis Methods 0.000 claims description 3
- 239000002904 solvent Substances 0.000 claims description 3
- NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 claims description 2
- UIHCLUNTQKBZGK-UHFFFAOYSA-N Methyl isobutyl ketone Natural products CCC(C)C(C)=O UIHCLUNTQKBZGK-UHFFFAOYSA-N 0.000 claims description 2
- 229910052739 hydrogen Inorganic materials 0.000 claims description 2
- 230000007935 neutral effect Effects 0.000 claims description 2
- 229910052757 nitrogen Inorganic materials 0.000 claims description 2
- ZXEKIIBDNHEJCQ-UHFFFAOYSA-N isobutanol Chemical compound CC(C)CO ZXEKIIBDNHEJCQ-UHFFFAOYSA-N 0.000 claims 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims 2
- WHBHBVVOGNECLV-OBQKJFGGSA-N 11-deoxycortisol Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 WHBHBVVOGNECLV-OBQKJFGGSA-N 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 abstract description 4
- 238000013019 agitation Methods 0.000 abstract 1
- 238000004458 analytical method Methods 0.000 abstract 1
- 238000004040 coloring Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000002609 medium Substances 0.000 description 24
- 239000000243 solution Substances 0.000 description 21
- 210000004027 cell Anatomy 0.000 description 14
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 10
- 229940079593 drug Drugs 0.000 description 7
- 239000003814 drug Substances 0.000 description 7
- 230000000844 anti-bacterial effect Effects 0.000 description 6
- 229940041514 candida albicans extract Drugs 0.000 description 6
- 239000001963 growth medium Substances 0.000 description 6
- 239000002244 precipitate Substances 0.000 description 6
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 6
- 239000012138 yeast extract Substances 0.000 description 6
- 239000004480 active ingredient Substances 0.000 description 5
- 239000000284 extract Substances 0.000 description 5
- 150000002500 ions Chemical class 0.000 description 5
- 239000011780 sodium chloride Substances 0.000 description 5
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 4
- 241000193996 Streptococcus pyogenes Species 0.000 description 4
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 4
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 4
- 235000011130 ammonium sulphate Nutrition 0.000 description 4
- 230000001580 bacterial effect Effects 0.000 description 4
- 230000012010 growth Effects 0.000 description 4
- 230000005764 inhibitory process Effects 0.000 description 4
- 235000013372 meat Nutrition 0.000 description 4
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 description 4
- 230000004083 survival effect Effects 0.000 description 4
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 3
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 3
- 241000699670 Mus sp. Species 0.000 description 3
- 229920005654 Sephadex Polymers 0.000 description 3
- 239000012507 Sephadex™ Substances 0.000 description 3
- 239000013543 active substance Substances 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 239000008363 phosphate buffer Substances 0.000 description 3
- 229910000160 potassium phosphate Inorganic materials 0.000 description 3
- 235000011009 potassium phosphates Nutrition 0.000 description 3
- 229920001817 Agar Polymers 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 239000007853 buffer solution Substances 0.000 description 2
- 210000003850 cellular structure Anatomy 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000010828 elution Methods 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 238000005342 ion exchange Methods 0.000 description 2
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 2
- 235000019341 magnesium sulphate Nutrition 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 229940056360 penicillin g Drugs 0.000 description 2
- 235000010333 potassium nitrate Nutrition 0.000 description 2
- 239000004323 potassium nitrate Substances 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 210000004881 tumor cell Anatomy 0.000 description 2
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
- 206010003445 Ascites Diseases 0.000 description 1
- 101100283604 Caenorhabditis elegans pigk-1 gene Proteins 0.000 description 1
- 235000011511 Diospyros Nutrition 0.000 description 1
- 244000236655 Diospyros kaki Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 101000801195 Homo sapiens TLE family member 5 Proteins 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 239000006146 Roswell Park Memorial Institute medium Substances 0.000 description 1
- 208000006268 Sarcoma 180 Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000003698 anagen phase Effects 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 229940041181 antineoplastic drug Drugs 0.000 description 1
- 238000003287 bathing Methods 0.000 description 1
- 239000007621 bhi medium Substances 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 229960003067 cystine Drugs 0.000 description 1
- CGMRCMMOCQYHAD-UHFFFAOYSA-J dicalcium hydroxide phosphate Chemical compound [OH-].[Ca++].[Ca++].[O-]P([O-])([O-])=O CGMRCMMOCQYHAD-UHFFFAOYSA-J 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000009422 growth inhibiting effect Effects 0.000 description 1
- 230000002949 hemolytic effect Effects 0.000 description 1
- 208000014617 hemorrhoid Diseases 0.000 description 1
- 102000056245 human TLE5 Human genes 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- -1 inobutanol Chemical compound 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 239000003456 ion exchange resin Substances 0.000 description 1
- 229920003303 ion-exchange polymer Polymers 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 229960000318 kanamycin Drugs 0.000 description 1
- 229930027917 kanamycin Natural products 0.000 description 1
- SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 description 1
- 229930182823 kanamycin A Natural products 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 230000001293 nucleolytic effect Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000012629 purifying agent Substances 0.000 description 1
- 238000011218 seed culture Methods 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- 229920003176 water-insoluble polymer Polymers 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
- C12P1/04—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/46—Streptococcus ; Enterococcus; Lactococcus
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Mycology (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59190560A JPS6169725A (ja) | 1984-09-13 | 1984-09-13 | 抗腫瘍性物質ｓｐｆ−１４０及びその製法 |
| GB08522309A GB2164338B (en) | 1984-09-13 | 1985-09-09 | Tumoricidal substance spf-140 and process for the preparation thereof |
| NL8502483A NL8502483A (nl) | 1984-09-13 | 1985-09-11 | Geneesmiddel spf-140 met een werking tegen tumoren, en werkwijze voor de bereiding hiervan. |
| DE3532321A DE3532321C2 (de) | 1984-09-13 | 1985-09-11 | Tumorizide Substanz SPF-140 und Verfahren zu deren Herstellung |
| SE8504228A SE461222B (sv) | 1984-09-13 | 1985-09-12 | Tumoerdoedande aemne spf-140 och foerfarande foer framstaellning daerav |
| FR8513603A FR2569983B1 (fr) | 1984-09-13 | 1985-09-13 | Substance tumoricide spf-140 et procede pour sa preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59190560A JPS6169725A (ja) | 1984-09-13 | 1984-09-13 | 抗腫瘍性物質ｓｐｆ−１４０及びその製法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6169725A true JPS6169725A (ja) | 1986-04-10 |
| JPH0156073B2 JPH0156073B2 (enrdf_load_stackoverflow) | 1989-11-28 |
Family
ID=16260095
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP59190560A Granted JPS6169725A (ja) | 1984-09-13 | 1984-09-13 | 抗腫瘍性物質ｓｐｆ−１４０及びその製法 |
Country Status (6)
| Country | Link |
|---|---|
| JP (1) | JPS6169725A (enrdf_load_stackoverflow) |
| DE (1) | DE3532321C2 (enrdf_load_stackoverflow) |
| FR (1) | FR2569983B1 (enrdf_load_stackoverflow) |
| GB (1) | GB2164338B (enrdf_load_stackoverflow) |
| NL (1) | NL8502483A (enrdf_load_stackoverflow) |
| SE (1) | SE461222B (enrdf_load_stackoverflow) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS557014A (en) * | 1978-06-29 | 1980-01-18 | Chugai Pharmaceut Co Ltd | Antitumor agent and its preparation |
| JPS5632492A (en) * | 1979-08-28 | 1981-04-01 | Mitsui Toatsu Chem Inc | Antitumor active substance, its preparation and pharmaceutical |
| JPS58222026A (ja) * | 1982-06-18 | 1983-12-23 | Masahiro Yoshimura | 抗ガン性物質 |
| JPS6092218A (ja) * | 1983-10-26 | 1985-05-23 | Juzo Udaka | 抗腫瘍性物質の製造法 |
| CA1262442A (en) * | 1984-03-09 | 1989-10-24 | Yasuo Kawai | Anticariogenic or antiperiodontitic agent |
-
1984
- 1984-09-13 JP JP59190560A patent/JPS6169725A/ja active Granted
-
1985
- 1985-09-09 GB GB08522309A patent/GB2164338B/en not_active Expired
- 1985-09-11 DE DE3532321A patent/DE3532321C2/de not_active Expired - Fee Related
- 1985-09-11 NL NL8502483A patent/NL8502483A/nl not_active Application Discontinuation
- 1985-09-12 SE SE8504228A patent/SE461222B/sv not_active IP Right Cessation
- 1985-09-13 FR FR8513603A patent/FR2569983B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| SE461222B (sv) | 1990-01-22 |
| DE3532321C2 (de) | 1994-04-07 |
| DE3532321A1 (de) | 1986-03-27 |
| GB8522309D0 (en) | 1985-10-16 |
| FR2569983A1 (fr) | 1986-03-14 |
| SE8504228D0 (sv) | 1985-09-12 |
| FR2569983B1 (fr) | 1988-08-19 |
| GB2164338B (en) | 1988-05-05 |
| SE8504228L (sv) | 1986-03-14 |
| NL8502483A (nl) | 1986-04-01 |
| GB2164338A (en) | 1986-03-19 |
| JPH0156073B2 (enrdf_load_stackoverflow) | 1989-11-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107137628B (zh) | 来源于共生发酵生成物的透明质酸酶抑制剂及其应用 | |
| DE69116601T2 (de) | Verfahren zur Herstellung von Antitumordextran | |
| DE2919132A1 (de) | Substanz ks-2-b, verfahren zu deren herstellung und diese substanz enthaltende mittel | |
| US4209507A (en) | Novel anti-tumor substance and preparation thereof | |
| JPS6169725A (ja) | 抗腫瘍性物質ｓｐｆ−１４０及びその製法 | |
| US4656037A (en) | SPF-100 and process for the preparation thereof | |
| JPS60246396A (ja) | 酵素阻害物質ジヒドロデスオキシグリゼオ−ル酸及びその塩類 | |
| DE2326916C2 (de) | Anhydro-4-carbamoyl-5-hydroxy-1-ribofuranosylimidazoliumhydroxyd | |
| JPH0699314B2 (ja) | マクロフア−ジ活性化剤 | |
| JPS5946597B2 (ja) | 新抗生物質ｓｆ−１１３０−ｘ１物質，その製造法及び免疫賦活剤 | |
| KR20230155271A (ko) | 홍삼 다당체를 이용하여 제조된 히알루론산을 포함하는 피부 보습용 화장료 조성물 | |
| JPH08333214A (ja) | 抗ウイルス・菌剤 | |
| JPH06183981A (ja) | クロレラ菌体外粘質多糖体を含有する抗腫瘍剤 | |
| CH583296A5 (en) | Bredinine - antiviral agent and immunosuppressant | |
| JPS6216426A (ja) | 抗腫瘍性成分ｓｐｆ−１０及びその製法 | |
| JPH0155276B2 (enrdf_load_stackoverflow) | ||
| JPH0156076B2 (enrdf_load_stackoverflow) | ||
| JPS60104017A (ja) | 抗腫瘍剤 | |
| JPS63156707A (ja) | ヒアルロン酸含有化粧料 | |
| JPS60218323A (ja) | 抗腫瘍性物質ｓｐｆ―１０００及びその製法 | |
| JPH03184995A (ja) | 抗腫瘍剤 | |
| JPS62164629A (ja) | 抗腫瘍性成分ｓｐｆ１０−１２及びその製法 | |
| JPH0156075B2 (enrdf_load_stackoverflow) | ||
| DE1203913B (de) | Verfahren zur Herstellung von hochmolekularen arzneilichen Wirkstoffen aus apathogenen Anaerobierkulturen | |
| JPS6379585A (ja) | 新規物質オバリシン |