JPS6155893B2 - - Google Patents
Info
- Publication number
- JPS6155893B2 JPS6155893B2 JP56137824A JP13782481A JPS6155893B2 JP S6155893 B2 JPS6155893 B2 JP S6155893B2 JP 56137824 A JP56137824 A JP 56137824A JP 13782481 A JP13782481 A JP 13782481A JP S6155893 B2 JPS6155893 B2 JP S6155893B2
- Authority
- JP
- Japan
- Prior art keywords
- lysine
- muscle
- aspartic acid
- complex
- relaxation agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000003795 chemical substances by application Substances 0.000 claims description 8
- 230000004118 muscle contraction Effects 0.000 claims description 8
- 210000003205 muscle Anatomy 0.000 claims description 5
- 239000007864 aqueous solution Substances 0.000 claims description 4
- 239000004480 active ingredient Substances 0.000 claims description 3
- 239000000839 emulsion Substances 0.000 claims description 3
- 125000004432 carbon atom Chemical group C* 0.000 claims description 2
- 239000006071 cream Substances 0.000 claims description 2
- 239000007787 solid Substances 0.000 claims description 2
- 239000004472 Lysine Substances 0.000 description 12
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 11
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 10
- CPYVQXAASIFAMD-KNIFDHDWSA-N (2s)-2-aminobutanedioic acid;(2s)-2,6-diaminohexanoic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O.NCCCC[C@H](N)C(O)=O CPYVQXAASIFAMD-KNIFDHDWSA-N 0.000 description 9
- 241001465754 Metazoa Species 0.000 description 8
- 235000003704 aspartic acid Nutrition 0.000 description 8
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 8
- 241000283973 Oryctolagus cuniculus Species 0.000 description 7
- 239000002253 acid Substances 0.000 description 7
- 239000000126 substance Substances 0.000 description 7
- 125000002252 acyl group Chemical group 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 206010049565 Muscle fatigue Diseases 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 230000002265 prevention Effects 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 229940024606 amino acid Drugs 0.000 description 4
- 235000001014 amino acid Nutrition 0.000 description 4
- 150000001413 amino acids Chemical class 0.000 description 4
- KJFMBFZCATUALV-UHFFFAOYSA-N phenolphthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2C(=O)O1 KJFMBFZCATUALV-UHFFFAOYSA-N 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 206010015946 Eye irritation Diseases 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 206010040880 Skin irritation Diseases 0.000 description 3
- 230000005856 abnormality Effects 0.000 description 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 239000003974 emollient agent Substances 0.000 description 3
- 231100000013 eye irritation Toxicity 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 238000011084 recovery Methods 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 210000003491 skin Anatomy 0.000 description 3
- 231100000475 skin irritation Toxicity 0.000 description 3
- 230000036556 skin irritation Effects 0.000 description 3
- MKNQNPYGAQGARI-UHFFFAOYSA-N 4-(bromomethyl)phenol Chemical compound OC1=CC=C(CBr)C=C1 MKNQNPYGAQGARI-UHFFFAOYSA-N 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 206010015150 Erythema Diseases 0.000 description 2
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 description 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- 125000003277 amino group Chemical group 0.000 description 2
- 229940009098 aspartate Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 210000002615 epidermis Anatomy 0.000 description 2
- 231100000321 erythema Toxicity 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- CEQFOVLGLXCDCX-WUKNDPDISA-N methyl red Chemical compound C1=CC(N(C)C)=CC=C1\N=N\C1=CC=CC=C1C(O)=O CEQFOVLGLXCDCX-WUKNDPDISA-N 0.000 description 2
- 230000001766 physiological effect Effects 0.000 description 2
- 230000002040 relaxant effect Effects 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 241000282412 Homo Species 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 description 1
- 206010039509 Scab Diseases 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000010562 histological examination Methods 0.000 description 1
- 230000000544 hyperemic effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 125000005645 linoleyl group Chemical group 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 230000037311 normal skin Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000006461 physiological response Effects 0.000 description 1
- 230000012191 relaxation of muscle Effects 0.000 description 1
- 230000000246 remedial effect Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 210000002460 smooth muscle Anatomy 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 230000036269 ulceration Effects 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
- A01N37/46—N-acyl derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Plant Pathology (AREA)
- Wood Science & Technology (AREA)
- Chemical & Material Sciences (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Dentistry (AREA)
- Pest Control & Pesticides (AREA)
- Pharmacology & Pharmacy (AREA)
- Agronomy & Crop Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8025732A FR2495608A1 (fr) | 1980-12-04 | 1980-12-04 | Nouveaux derives de l'acide aspartique et leurs usages |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS57145808A JPS57145808A (en) | 1982-09-09 |
| JPS6155893B2 true JPS6155893B2 (US06521211-20030218-C00004.png) | 1986-11-29 |
Family
ID=9248648
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP56137824A Granted JPS57145808A (en) | 1980-12-04 | 1981-09-03 | Complex of aspartic acid or acylaspartic acid with lysine and compounded agent containing either one or both of complexes as active constituent |
Country Status (5)
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6448940A (en) * | 1987-08-13 | 1989-02-23 | Ibiden Co Ltd | Washstand having shower equipment |
| JPH03118367U (US06521211-20030218-C00004.png) * | 1990-03-19 | 1991-12-06 |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2587173B1 (fr) * | 1985-09-17 | 1991-05-03 | Mil Edmond De | Procede permettant l'augmentation de la fertilite florale des vegetaux |
| US5661103A (en) * | 1992-11-05 | 1997-08-26 | Donlar Corporation | Seed treatment composition and method |
| FR2753096B1 (fr) * | 1996-09-09 | 1998-12-04 | Seppic Sa | Utilisation cosmetique de composes a structure lipoaminoacide et compositions cosmetiques a activite apaisante incorporant certains de ces composes |
| WO1998009611A1 (fr) * | 1996-09-09 | 1998-03-12 | Societe D'exploitation De Produits Pour Les Industries Chimiques - Seppic | Utilisation cosmetique de composes a structure lipoaminoacide et compositions cosmetiques a activite apaisante incorporant certains de ces composes |
| US20050252013A1 (en) * | 2004-05-12 | 2005-11-17 | Stocco Leo J | Device for extracting particles from liquid |
| US8337869B2 (en) | 2007-08-07 | 2012-12-25 | Gross Robert L | Analgesic cream |
| IT202000019576A1 (it) * | 2020-08-07 | 2022-02-07 | Beauty & Business Spa | Composizioni coloranti per capelli |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA513125A (en) * | 1955-05-24 | D. Emmick Robert | Resolution of amino acid | |
| GB773653A (en) * | 1955-08-22 | 1957-05-01 | Int Minerals & Chem Corp | Improvements in or relating to process for resolution of dl-alpha-amino dicarboxylicacids |
| FR86M (US06521211-20030218-C00004.png) * | 1960-07-29 | 1961-01-09 | ||
| GB965637A (en) * | 1962-04-23 | 1964-08-06 | Tanabe Seiyaku Co | L-ornithine l-aspartate |
| NL302572A (US06521211-20030218-C00004.png) * | 1962-12-27 | |||
| GB1034358A (en) * | 1963-05-01 | 1966-06-29 | Chugai Pharmaceutical Co Ltd | Body-protein-biosynthesis promoting composition |
| GB1067742A (en) * | 1963-09-16 | 1967-05-03 | Kyowa Hakko Kogyo Kk | Process for the preparation of l-ornithine l-aspartate |
| FR1435005A (fr) * | 1965-02-04 | 1966-04-15 | Sobio Lab | Procédé de préparation de sels de l'acide nu-acétylaspartique avec des acides aminés et produits ainsi obtenus |
| GB1091089A (en) * | 1965-08-20 | 1967-11-15 | Pierre Wirth | Organic base salts of n-carbamyl-aspartic acids |
| NL132126C (US06521211-20030218-C00004.png) * | 1966-10-13 | |||
| FR2074632B1 (US06521211-20030218-C00004.png) * | 1970-01-13 | 1973-01-12 | Roussel Uclaf | |
| FR2320759A1 (fr) * | 1975-08-11 | 1977-03-11 | Union Pharma Scient Appl | Solution d'acide acetylsalicylique extemporanee injectable |
-
1980
- 1980-12-04 FR FR8025732A patent/FR2495608A1/fr active Granted
-
1981
- 1981-09-03 JP JP56137824A patent/JPS57145808A/ja active Granted
- 1981-11-23 US US06/324,004 patent/US4447366A/en not_active Expired - Fee Related
- 1981-12-02 GB GB8136355A patent/GB2088867A/en active Pending
- 1981-12-04 DE DE3148082A patent/DE3148082C2/de not_active Expired
-
1983
- 1983-10-29 US US06/543,217 patent/US4464397A/en not_active Expired - Fee Related
Non-Patent Citations (1)
| Title |
|---|
| CHEM. ABSTR. * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6448940A (en) * | 1987-08-13 | 1989-02-23 | Ibiden Co Ltd | Washstand having shower equipment |
| JPH03118367U (US06521211-20030218-C00004.png) * | 1990-03-19 | 1991-12-06 |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2495608B1 (US06521211-20030218-C00004.png) | 1984-08-10 |
| FR2495608A1 (fr) | 1982-06-11 |
| DE3148082A1 (de) | 1982-06-16 |
| GB2088867A (en) | 1982-06-16 |
| DE3148082C2 (de) | 1987-04-30 |
| US4464397A (en) | 1984-08-07 |
| US4447366A (en) | 1984-05-08 |
| JPS57145808A (en) | 1982-09-09 |
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