JPS61259675A - 骨欠損部及び空隙部充てん材 - Google Patents
骨欠損部及び空隙部充てん材Info
- Publication number
- JPS61259675A JPS61259675A JP60101193A JP10119385A JPS61259675A JP S61259675 A JPS61259675 A JP S61259675A JP 60101193 A JP60101193 A JP 60101193A JP 10119385 A JP10119385 A JP 10119385A JP S61259675 A JPS61259675 A JP S61259675A
- Authority
- JP
- Japan
- Prior art keywords
- bone
- calcium phosphate
- phosphate compound
- filling material
- crystal structure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000000988 bone and bone Anatomy 0.000 title claims description 40
- 238000011049 filling Methods 0.000 title claims description 22
- 239000000463 material Substances 0.000 title claims description 12
- 239000001506 calcium phosphate Substances 0.000 claims description 22
- -1 calcium phosphate compound Chemical class 0.000 claims description 21
- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 20
- 235000011010 calcium phosphates Nutrition 0.000 claims description 20
- 230000007547 defect Effects 0.000 claims description 15
- 239000013078 crystal Substances 0.000 claims description 14
- 239000011148 porous material Substances 0.000 claims description 12
- 229910052586 apatite Inorganic materials 0.000 claims description 10
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 108010007726 Bone Morphogenetic Proteins Proteins 0.000 claims description 6
- 102000007350 Bone Morphogenetic Proteins Human genes 0.000 claims description 6
- 239000012153 distilled water Substances 0.000 claims description 6
- 239000011800 void material Substances 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 3
- 239000000945 filler Substances 0.000 claims 1
- 239000011575 calcium Substances 0.000 description 16
- 239000000843 powder Substances 0.000 description 11
- 230000002188 osteogenic effect Effects 0.000 description 10
- 238000010304 firing Methods 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 230000011164 ossification Effects 0.000 description 6
- 239000008187 granular material Substances 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 3
- 241000283973 Oryctolagus cuniculus Species 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 229910052799 carbon Inorganic materials 0.000 description 3
- 239000002131 composite material Substances 0.000 description 3
- 238000000502 dialysis Methods 0.000 description 3
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 208000005422 Foreign-Body reaction Diseases 0.000 description 2
- 241000283977 Oryctolagus Species 0.000 description 2
- 238000001354 calcination Methods 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 229910010293 ceramic material Inorganic materials 0.000 description 2
- WORJEOGGNQDSOE-UHFFFAOYSA-N chloroform;methanol Chemical compound OC.ClC(Cl)Cl WORJEOGGNQDSOE-UHFFFAOYSA-N 0.000 description 2
- 238000004108 freeze drying Methods 0.000 description 2
- 229960000789 guanidine hydrochloride Drugs 0.000 description 2
- PJJJBBJSCAKJQF-UHFFFAOYSA-N guanidinium chloride Chemical compound [Cl-].NC(N)=[NH2+] PJJJBBJSCAKJQF-UHFFFAOYSA-N 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000005065 mining Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000002002 slurry Substances 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 208000006386 Bone Resorption Diseases 0.000 description 1
- 102100022544 Bone morphogenetic protein 7 Human genes 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 235000019739 Dicalciumphosphate Nutrition 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 101000899361 Homo sapiens Bone morphogenetic protein 7 Proteins 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 230000024279 bone resorption Effects 0.000 description 1
- 210000001217 buttock Anatomy 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000002301 combined effect Effects 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 229910000390 dicalcium phosphate Inorganic materials 0.000 description 1
- 229940038472 dicalcium phosphate Drugs 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 238000002523 gelfiltration Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000001027 hydrothermal synthesis Methods 0.000 description 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229910001092 metal group alloy Inorganic materials 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000012264 purified product Substances 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Vascular Medicine (AREA)
- Inorganic Chemistry (AREA)
- Composite Materials (AREA)
- Materials Engineering (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Materials For Medical Uses (AREA)
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60101193A JPS61259675A (ja) | 1985-05-15 | 1985-05-15 | 骨欠損部及び空隙部充てん材 |
| GB8611603A GB2176192B (en) | 1985-05-15 | 1986-05-13 | Bone fillers |
| DE19863616365 DE3616365A1 (de) | 1985-05-15 | 1986-05-15 | Fuellmaterial zum fuellen von defekten und hohlraeumen in knochen |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60101193A JPS61259675A (ja) | 1985-05-15 | 1985-05-15 | 骨欠損部及び空隙部充てん材 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS61259675A true JPS61259675A (ja) | 1986-11-17 |
| JPH0533062B2 JPH0533062B2 (enrdf_load_stackoverflow) | 1993-05-18 |
Family
ID=14294111
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP60101193A Granted JPS61259675A (ja) | 1985-05-15 | 1985-05-15 | 骨欠損部及び空隙部充てん材 |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JPS61259675A (enrdf_load_stackoverflow) |
| DE (1) | DE3616365A1 (enrdf_load_stackoverflow) |
| GB (1) | GB2176192B (enrdf_load_stackoverflow) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01151461A (ja) * | 1987-12-08 | 1989-06-14 | Koransha Co Ltd | 生体用補綴材料 |
| JPH01158965A (ja) * | 1987-12-16 | 1989-06-22 | Tokuyama Soda Co Ltd | 硬化性組成物 |
| JPH0345267A (ja) * | 1989-07-12 | 1991-02-26 | Mitsubishi Materials Corp | 骨欠損部及び骨空隙部充てん材 |
| WO2008050905A1 (fr) * | 2006-10-27 | 2008-05-02 | Mmt Co., Ltd. | Élément biologique |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0271668B1 (de) * | 1986-10-22 | 1991-12-18 | Gesellschaft für Biotechnologische Forschung mbH (GBF) | Wachstumstimulierendes Material, Herstellungsverfahren und therapeutische Zusammensetzung |
| JPH0231749A (ja) * | 1988-07-20 | 1990-02-01 | Mitsubishi Mining & Cement Co Ltd | 骨欠損部及び骨粗鬆部充てん材 |
| DE68918043T2 (de) * | 1988-10-25 | 1995-03-02 | Takao Yamamuro | Knochenersatzmaterial und Knochenzement. |
| DE4121043A1 (de) * | 1991-06-26 | 1993-01-07 | Merck Patent Gmbh | Knochenersatzmaterial mit fgf |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5654841A (en) * | 1979-10-08 | 1981-05-15 | Mitsubishi Mining & Cement Co | Bone broken portion and filler for void portion and method of treating bone of animal using said filler |
| JPS59131347A (ja) * | 1983-01-18 | 1984-07-28 | 科学技術庁無機材質研究所長 | 人工骨または人工歯用インプラント材の製造法 |
| JPS6014860A (ja) * | 1983-07-06 | 1985-01-25 | 三菱鉱業セメント株式会社 | 無機質インプラント材 |
| JPS6018174A (ja) * | 1983-07-09 | 1985-01-30 | 住友セメント株式会社 | 新生骨の誘起方法及びセラミツク材料 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3203957A1 (de) * | 1982-02-05 | 1983-08-18 | Chemokol Gesellschaft zur Entwicklung von Kollagenprodukten, 5190 Stolberg | Verfahren zur herstellung von feinporigen kollagenschwaemmen |
| DE3414924A1 (de) * | 1984-04-19 | 1985-10-31 | Klaus Dr.med. Dr.med.habil. 8000 München Draenert | Beschichtetes verankerungsteil fuer implantate |
| JPS60253455A (ja) * | 1984-05-28 | 1985-12-14 | 京セラ株式会社 | 骨形成因子を含有する生体材料とその製造方法 |
-
1985
- 1985-05-15 JP JP60101193A patent/JPS61259675A/ja active Granted
-
1986
- 1986-05-13 GB GB8611603A patent/GB2176192B/en not_active Expired
- 1986-05-15 DE DE19863616365 patent/DE3616365A1/de active Granted
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5654841A (en) * | 1979-10-08 | 1981-05-15 | Mitsubishi Mining & Cement Co | Bone broken portion and filler for void portion and method of treating bone of animal using said filler |
| JPS59131347A (ja) * | 1983-01-18 | 1984-07-28 | 科学技術庁無機材質研究所長 | 人工骨または人工歯用インプラント材の製造法 |
| JPS6014860A (ja) * | 1983-07-06 | 1985-01-25 | 三菱鉱業セメント株式会社 | 無機質インプラント材 |
| JPS6018174A (ja) * | 1983-07-09 | 1985-01-30 | 住友セメント株式会社 | 新生骨の誘起方法及びセラミツク材料 |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01151461A (ja) * | 1987-12-08 | 1989-06-14 | Koransha Co Ltd | 生体用補綴材料 |
| JPH01158965A (ja) * | 1987-12-16 | 1989-06-22 | Tokuyama Soda Co Ltd | 硬化性組成物 |
| JPH0345267A (ja) * | 1989-07-12 | 1991-02-26 | Mitsubishi Materials Corp | 骨欠損部及び骨空隙部充てん材 |
| WO2008050905A1 (fr) * | 2006-10-27 | 2008-05-02 | Mmt Co., Ltd. | Élément biologique |
Also Published As
| Publication number | Publication date |
|---|---|
| GB2176192B (en) | 1989-07-05 |
| GB2176192A (en) | 1986-12-17 |
| DE3616365A1 (de) | 1986-11-20 |
| DE3616365C2 (enrdf_load_stackoverflow) | 1989-09-14 |
| JPH0533062B2 (enrdf_load_stackoverflow) | 1993-05-18 |
| GB8611603D0 (en) | 1986-06-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP4815102B2 (ja) | 機械加工によって予備形成されたリン酸カルシウム骨代用材料インプラント | |
| Brown et al. | Hydroxyapatite and related materials | |
| EP0224545B1 (en) | Pharmaceutical depot preparation | |
| JPS6343106B2 (enrdf_load_stackoverflow) | ||
| JP2004033772A (ja) | ゼラチン処理によって多孔質リン酸カルシウム小片および小粒を調製する方法 | |
| Park et al. | Synthesis and characterization of nanocrystalline calcium sulfate for use in osseous regeneration | |
| JPH01236058A (ja) | 骨修復組成物及び方法 | |
| CN102631702A (zh) | 矿化胶原蛋白与生物陶瓷的复合物及其制造方法 | |
| WO2007002239A2 (en) | Porous beta-tricalcium phosphate and methods for producing the same | |
| JPH0359703B2 (enrdf_load_stackoverflow) | ||
| Kumar et al. | Eggshell waste: a gold mine for sustainable bioceramics | |
| WO2015020192A1 (ja) | 骨再生材料キット、ペースト状骨再生材料、骨再生材料及び骨接合材 | |
| JP5234536B2 (ja) | セメント用材料及びセメント | |
| IL153699A (en) | The composition for transplantation basically | |
| JP4158945B2 (ja) | セメント用材料及びセメント | |
| JPS61259675A (ja) | 骨欠損部及び空隙部充てん材 | |
| JPH04164456A (ja) | 水酸化アパタイト多孔質生体充填剤並びにその製造方法 | |
| JP2002501785A5 (enrdf_load_stackoverflow) | ||
| KR101885896B1 (ko) | 인체뼈 유래 무기질을 포함하는 천연 골재생재 | |
| KR101747697B1 (ko) | 골이식재의 제조 방법 및 그 제조 방법에 의해 제조되는 골이식재 | |
| CN101193834A (zh) | 成形物品 | |
| JPS6040298B2 (ja) | 骨欠損部及び空隙部充てん材 | |
| US20100233269A1 (en) | Mineralized polymer particles and the method for their production | |
| JP4683590B2 (ja) | 新規なリン酸カルシウム多孔体およびその製造方法 | |
| JPS63125258A (ja) | 骨欠損部、空隙部及び吸収部充てん材 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313113 |
|
| R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
| EXPY | Cancellation because of completion of term |