JPS6125688B2 - - Google Patents

Info

Publication number

JPS6125688B2

JPS6125688B2 JP53125417A JP12541778A JPS6125688B2 JP S6125688 B2 JPS6125688 B2 JP S6125688B2 JP 53125417 A JP53125417 A JP 53125417A JP 12541778 A JP12541778 A JP 12541778A JP S6125688 B2 JPS6125688 B2 JP S6125688B2

Authority

JP

Japan

Prior art keywords

biotin

water

lactose

ammonia

aqueous solution

Prior art date

1978-10-11

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Links

• Espacenet
• Global Dossier
• Discuss

• YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 94
• 229960002685 biotin Drugs 0.000 claims description 47
• 235000020958 biotin Nutrition 0.000 claims description 47
• 239000011616 biotin Substances 0.000 claims description 47
• QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 24
• GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 21
• 239000008101 lactose Substances 0.000 claims description 21
• 239000007864 aqueous solution Substances 0.000 claims description 13
• GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 11
• 229910021529 ammonia Inorganic materials 0.000 claims description 11
• 238000002360 preparation method Methods 0.000 claims description 9
• 238000001694 spray drying Methods 0.000 claims description 5
• 238000004519 manufacturing process Methods 0.000 claims description 4
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 19
• 238000000034 method Methods 0.000 description 13
• VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 8
• 239000000203 mixture Substances 0.000 description 6
• 239000002245 particle Substances 0.000 description 6
• 239000007921 spray Substances 0.000 description 5
• 239000007788 liquid Substances 0.000 description 4
• 239000012798 spherical particle Substances 0.000 description 4
• 238000009472 formulation Methods 0.000 description 3
• 238000010438 heat treatment Methods 0.000 description 3
• 239000000243 solution Substances 0.000 description 3
• NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonium chloride Substances [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 2
• 238000010521 absorption reaction Methods 0.000 description 2
• 235000011114 ammonium hydroxide Nutrition 0.000 description 2
• 239000003651 drinking water Substances 0.000 description 2
• 235000020188 drinking water Nutrition 0.000 description 2
• 244000144972 livestock Species 0.000 description 2
• 238000002156 mixing Methods 0.000 description 2
• 239000000725 suspension Substances 0.000 description 2
• 241000251468 Actinopterygii Species 0.000 description 1
• VCUFZILGIRCDQQ-KRWDZBQOSA-N N-[[(5S)-2-oxo-3-(2-oxo-3H-1,3-benzoxazol-6-yl)-1,3-oxazolidin-5-yl]methyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C1O[C@H](CN1C1=CC2=C(NC(O2)=O)C=C1)CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F VCUFZILGIRCDQQ-KRWDZBQOSA-N 0.000 description 1
• 239000003674 animal food additive Substances 0.000 description 1
• 238000000889 atomisation Methods 0.000 description 1
• 230000000694 effects Effects 0.000 description 1
• 239000008187 granular material Substances 0.000 description 1
• 238000004128 high performance liquid chromatography Methods 0.000 description 1
• 208000017520 skin disease Diseases 0.000 description 1
• 238000005507 spraying Methods 0.000 description 1
• 238000003756 stirring Methods 0.000 description 1

Cited By (5)