JPS61207322A - アスコルビン酸含有発泡性固形組成物 - Google Patents
アスコルビン酸含有発泡性固形組成物Info
- Publication number
- JPS61207322A JPS61207322A JP60048959A JP4895985A JPS61207322A JP S61207322 A JPS61207322 A JP S61207322A JP 60048959 A JP60048959 A JP 60048959A JP 4895985 A JP4895985 A JP 4895985A JP S61207322 A JPS61207322 A JP S61207322A
- Authority
- JP
- Japan
- Prior art keywords
- ascorbic acid
- polymeric substance
- carbonate
- component
- coated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 title claims abstract description 136
- 235000010323 ascorbic acid Nutrition 0.000 title claims abstract description 65
- 229960005070 ascorbic acid Drugs 0.000 title claims abstract description 65
- 239000011668 ascorbic acid Substances 0.000 title claims abstract description 65
- 239000008247 solid mixture Substances 0.000 title claims abstract description 15
- 239000000126 substance Substances 0.000 claims abstract description 43
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims abstract description 31
- 239000000203 mixture Substances 0.000 claims abstract description 28
- 239000011248 coating agent Substances 0.000 claims abstract description 20
- 238000000576 coating method Methods 0.000 claims abstract description 19
- 230000002378 acidificating effect Effects 0.000 claims abstract description 17
- 230000007935 neutral effect Effects 0.000 claims abstract description 10
- JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 claims abstract description 7
- 229910001431 copper ion Inorganic materials 0.000 claims abstract description 7
- 229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 claims abstract description 4
- 229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 claims abstract description 3
- 238000005187 foaming Methods 0.000 claims description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 18
- 238000013329 compounding Methods 0.000 claims description 8
- 229920003145 methacrylic acid copolymer Polymers 0.000 claims description 8
- 229940117841 methacrylic acid copolymer Drugs 0.000 claims description 8
- 229920000642 polymer Polymers 0.000 claims description 8
- IWVKTOUOPHGZRX-UHFFFAOYSA-N methyl 2-methylprop-2-enoate;2-methylprop-2-enoic acid Chemical compound CC(=C)C(O)=O.COC(=O)C(C)=C IWVKTOUOPHGZRX-UHFFFAOYSA-N 0.000 claims description 6
- GDCRSXZBSIRSFR-UHFFFAOYSA-N ethyl prop-2-enoate;2-methylprop-2-enoic acid Chemical compound CC(=C)C(O)=O.CCOC(=O)C=C GDCRSXZBSIRSFR-UHFFFAOYSA-N 0.000 claims description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 4
- 229920002678 cellulose Polymers 0.000 claims description 4
- 239000001913 cellulose Substances 0.000 claims description 4
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 3
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 3
- 125000004185 ester group Chemical group 0.000 claims description 3
- 239000003814 drug Substances 0.000 abstract description 5
- 230000000845 anti-microbial effect Effects 0.000 abstract description 4
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 abstract description 4
- ORTQZVOHEJQUHG-UHFFFAOYSA-L copper(II) chloride Chemical compound Cl[Cu]Cl ORTQZVOHEJQUHG-UHFFFAOYSA-L 0.000 abstract description 3
- 239000000463 material Substances 0.000 abstract description 3
- 229910000027 potassium carbonate Inorganic materials 0.000 abstract description 2
- 229910021592 Copper(II) chloride Inorganic materials 0.000 abstract 1
- 235000015320 potassium carbonate Nutrition 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 22
- 239000004615 ingredient Substances 0.000 description 17
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 12
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 12
- 239000000243 solution Substances 0.000 description 11
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 10
- 238000000034 method Methods 0.000 description 10
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 8
- 230000000844 anti-bacterial effect Effects 0.000 description 8
- 239000008101 lactose Substances 0.000 description 8
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 7
- 238000007796 conventional method Methods 0.000 description 7
- 238000002845 discoloration Methods 0.000 description 7
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 7
- 150000007524 organic acids Chemical class 0.000 description 7
- -1 sodium carbonate Chemical compound 0.000 description 7
- 239000001569 carbon dioxide Substances 0.000 description 6
- 229910002092 carbon dioxide Inorganic materials 0.000 description 6
- 235000013305 food Nutrition 0.000 description 6
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 6
- 239000002537 cosmetic Substances 0.000 description 5
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 5
- 235000017557 sodium bicarbonate Nutrition 0.000 description 5
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 4
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 4
- 229910052782 aluminium Inorganic materials 0.000 description 4
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 4
- 229920001577 copolymer Polymers 0.000 description 4
- 239000000645 desinfectant Substances 0.000 description 4
- 239000011888 foil Substances 0.000 description 4
- 239000008187 granular material Substances 0.000 description 4
- 229940093915 gynecological organic acid Drugs 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 235000005985 organic acids Nutrition 0.000 description 4
- 230000000087 stabilizing effect Effects 0.000 description 4
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 3
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 3
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 3
- 229930003268 Vitamin C Natural products 0.000 description 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 229910000365 copper sulfate Inorganic materials 0.000 description 3
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 description 3
- 238000004090 dissolution Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000006260 foam Substances 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 239000003205 fragrance Substances 0.000 description 3
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 3
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 239000011975 tartaric acid Substances 0.000 description 3
- 235000002906 tartaric acid Nutrition 0.000 description 3
- 235000019154 vitamin C Nutrition 0.000 description 3
- 239000011718 vitamin C Substances 0.000 description 3
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 2
- 102100028675 DNA polymerase subunit gamma-2, mitochondrial Human genes 0.000 description 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 2
- 229920003134 Eudragit® polymer Polymers 0.000 description 2
- 101000837415 Homo sapiens DNA polymerase subunit gamma-2, mitochondrial Proteins 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 239000013040 bath agent Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 2
- 239000012459 cleaning agent Substances 0.000 description 2
- JZCCFEFSEZPSOG-UHFFFAOYSA-L copper(II) sulfate pentahydrate Chemical compound O.O.O.O.O.[Cu+2].[O-]S([O-])(=O)=O JZCCFEFSEZPSOG-UHFFFAOYSA-L 0.000 description 2
- 230000003111 delayed effect Effects 0.000 description 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 239000000049 pigment Substances 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 229910000029 sodium carbonate Inorganic materials 0.000 description 2
- 235000017550 sodium carbonate Nutrition 0.000 description 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 229920003169 water-soluble polymer Polymers 0.000 description 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- MUZDXNQOSGWMJJ-UHFFFAOYSA-N 2-methylprop-2-enoic acid;prop-2-enoic acid Chemical compound OC(=O)C=C.CC(=C)C(O)=O MUZDXNQOSGWMJJ-UHFFFAOYSA-N 0.000 description 1
- ATRRKUHOCOJYRX-UHFFFAOYSA-N Ammonium bicarbonate Chemical compound [NH4+].OC([O-])=O ATRRKUHOCOJYRX-UHFFFAOYSA-N 0.000 description 1
- 229920000623 Cellulose acetate phthalate Polymers 0.000 description 1
- CIWBSHSKHKDKBQ-DUZGATOHSA-N D-araboascorbic acid Natural products OC[C@@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-DUZGATOHSA-N 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- 229920003149 Eudragit® E 100 Polymers 0.000 description 1
- 229920003136 Eudragit® L polymer Polymers 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 102220570135 Histone PARylation factor 1_L30D_mutation Human genes 0.000 description 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- MKRNVBXERAPZOP-UHFFFAOYSA-N Starch acetate Chemical compound O1C(CO)C(OC)C(O)C(O)C1OCC1C(OC2C(C(O)C(OC)C(CO)O2)OC(C)=O)C(O)C(O)C(OC2C(OC(C)C(O)C2O)CO)O1 MKRNVBXERAPZOP-UHFFFAOYSA-N 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 239000001099 ammonium carbonate Substances 0.000 description 1
- 235000012501 ammonium carbonate Nutrition 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 239000003637 basic solution Substances 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- NEDGUIRITORSKL-UHFFFAOYSA-N butyl 2-methylprop-2-enoate;2-(dimethylamino)ethyl 2-methylprop-2-enoate;methyl 2-methylprop-2-enoate Chemical compound COC(=O)C(C)=C.CCCCOC(=O)C(C)=C.CN(C)CCOC(=O)C(C)=C NEDGUIRITORSKL-UHFFFAOYSA-N 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- KHKKBAJAVLCDOE-UHFFFAOYSA-N carbonic acid;phthalic acid Chemical compound OC(O)=O.OC(=O)C1=CC=CC=C1C(O)=O KHKKBAJAVLCDOE-UHFFFAOYSA-N 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 229940081734 cellulose acetate phthalate Drugs 0.000 description 1
- 239000007931 coated granule Substances 0.000 description 1
- 230000005757 colony formation Effects 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- SVOAENZIOKPANY-CVBJKYQLSA-L copper;(z)-octadec-9-enoate Chemical compound [Cu+2].CCCCCCCC\C=C/CCCCCCCC([O-])=O.CCCCCCCC\C=C/CCCCCCCC([O-])=O SVOAENZIOKPANY-CVBJKYQLSA-L 0.000 description 1
- 229960003280 cupric chloride Drugs 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000000249 desinfective effect Effects 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 239000004205 dimethyl polysiloxane Substances 0.000 description 1
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 1
- 238000007907 direct compression Methods 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 235000010350 erythorbic acid Nutrition 0.000 description 1
- 239000004318 erythorbic acid Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 239000003337 fertilizer Substances 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 230000000855 fungicidal effect Effects 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 150000004677 hydrates Chemical class 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- RSAZYXZUJROYKR-UHFFFAOYSA-N indophenol Chemical compound C1=CC(O)=CC=C1N=C1C=CC(=O)C=C1 RSAZYXZUJROYKR-UHFFFAOYSA-N 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 229940026239 isoascorbic acid Drugs 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000011736 potassium bicarbonate Substances 0.000 description 1
- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 1
- 235000015497 potassium bicarbonate Nutrition 0.000 description 1
- 235000011181 potassium carbonates Nutrition 0.000 description 1
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000001603 reducing effect Effects 0.000 description 1
- 235000015424 sodium Nutrition 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 1
- 229910000031 sodium sesquicarbonate Inorganic materials 0.000 description 1
- 235000018341 sodium sesquicarbonate Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- WCTAGTRAWPDFQO-UHFFFAOYSA-K trisodium;hydrogen carbonate;carbonate Chemical compound [Na+].[Na+].[Na+].OC([O-])=O.[O-]C([O-])=O WCTAGTRAWPDFQO-UHFFFAOYSA-K 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/046—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/22—Gas releasing
- A61K2800/222—Effervescent
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dispersion Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Confectionery (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60048959A JPS61207322A (ja) | 1985-03-11 | 1985-03-11 | アスコルビン酸含有発泡性固形組成物 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60048959A JPS61207322A (ja) | 1985-03-11 | 1985-03-11 | アスコルビン酸含有発泡性固形組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS61207322A true JPS61207322A (ja) | 1986-09-13 |
| JPH025726B2 JPH025726B2 (enrdf_load_stackoverflow) | 1990-02-05 |
Family
ID=12817815
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP60048959A Granted JPS61207322A (ja) | 1985-03-11 | 1985-03-11 | アスコルビン酸含有発泡性固形組成物 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS61207322A (enrdf_load_stackoverflow) |
Cited By (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63275520A (ja) * | 1987-05-08 | 1988-11-14 | Takenori Tsuchiya | 発泡薬剤組成物 |
| JPH0390030A (ja) * | 1989-08-31 | 1991-04-16 | Ss Pharmaceut Co Ltd | カルシウム製剤 |
| JPH07258053A (ja) * | 1994-02-03 | 1995-10-09 | Kao Corp | 口腔用組成物 |
| US5885949A (en) * | 1996-06-05 | 1999-03-23 | Amway Corporation | Tableted household cleaner comprising carboxylic acid, BI carbonate and polyvinyl alcohol |
| EP0945075A1 (en) * | 1998-03-25 | 1999-09-29 | Eliseo Garuti | Nutritional supplement |
| JP2001031567A (ja) * | 1999-05-20 | 2001-02-06 | Takeda Chem Ind Ltd | アスコルビン酸塩含有組成物 |
| WO2000067704A3 (en) * | 1999-05-10 | 2001-09-13 | Lush Ltd | Containers for cosmetic products and the like |
| WO2002055054A1 (fr) * | 2001-01-16 | 2002-07-18 | Tsumura & Co. | Composition additive pour le bain |
| WO2002080941A1 (fr) * | 2001-04-06 | 2002-10-17 | Masaya Tanaka | Compositions destinees a preparer des agents exterieurs du dioxyde de carbone |
| US6689339B1 (en) | 1997-11-07 | 2004-02-10 | Medion Research Laboratories Inc. | Viscous compositions containing carbon dioxide |
| JP2005537233A (ja) * | 2002-06-04 | 2005-12-08 | エルテーエス ローマン テラピー−ジステーメ アーゲー | 活性物質放出のためのフィルム成形された溶解可能な製剤およびこれらの製造方法 |
| JP2006508060A (ja) * | 2002-09-19 | 2006-03-09 | アーダナ バイオサイエンス リミテッド | アポモルヒネを含む発泡性製剤 |
| JP2007077242A (ja) * | 2005-09-13 | 2007-03-29 | Sanei Gen Ffi Inc | コーティング組成物 |
| JP2007524575A (ja) * | 2003-01-30 | 2007-08-30 | エティファーム | 味マスキング被覆粒子、その調製方法および前記被覆粒子を含有する口腔内崩壊錠剤 |
| JP2011148781A (ja) * | 2010-01-22 | 2011-08-04 | Hwakwang Trading Co Ltd | 水溶性に優れた皮膚洗浄剤 |
| JP2013536697A (ja) * | 2010-09-07 | 2013-09-26 | アール・ジエイ・レイノルズ・タバコ・カンパニー | 発泡性組成物を含む無煙タバコ製品 |
| JP2014193934A (ja) * | 2013-01-22 | 2014-10-09 | Toyo Shinyaku Co Ltd | 発泡性皮膚外用剤 |
| JP2015017346A (ja) * | 2013-07-12 | 2015-01-29 | 花王株式会社 | ナノファイバシート及びその製造方法 |
| JP2016098227A (ja) * | 2014-11-26 | 2016-05-30 | 花王株式会社 | 発泡性固形状組成物の製造方法 |
| JPWO2014042120A1 (ja) * | 2012-09-13 | 2016-08-18 | ライオン株式会社 | 発泡性口腔用組成物、発泡性口腔用固形製剤及び発泡性口腔用製品 |
| JP2017036220A (ja) * | 2015-08-06 | 2017-02-16 | 忠洋 嶋田 | 発泡性の化粧料 |
| JP2018123107A (ja) * | 2017-02-03 | 2018-08-09 | 株式会社東洋炭酸研究所 | 口腔ケア用固形組成物 |
| US10252041B2 (en) | 2012-10-29 | 2019-04-09 | C&Tech Corporation | Pack for supplying carbon dioxide to skin and manufacturing method thereof |
| JP2020103185A (ja) * | 2018-12-27 | 2020-07-09 | 花王株式会社 | 密封容器入り発泡性経口錠剤 |
-
1985
- 1985-03-11 JP JP60048959A patent/JPS61207322A/ja active Granted
Cited By (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63275520A (ja) * | 1987-05-08 | 1988-11-14 | Takenori Tsuchiya | 発泡薬剤組成物 |
| JPH0390030A (ja) * | 1989-08-31 | 1991-04-16 | Ss Pharmaceut Co Ltd | カルシウム製剤 |
| JPH07258053A (ja) * | 1994-02-03 | 1995-10-09 | Kao Corp | 口腔用組成物 |
| US5885949A (en) * | 1996-06-05 | 1999-03-23 | Amway Corporation | Tableted household cleaner comprising carboxylic acid, BI carbonate and polyvinyl alcohol |
| US6057281A (en) * | 1996-06-05 | 2000-05-02 | Amway Corporation | Tableted household cleaner comprising carboxylic acid, (Bi)carbonate and polyvinyl alcohol |
| US6689339B1 (en) | 1997-11-07 | 2004-02-10 | Medion Research Laboratories Inc. | Viscous compositions containing carbon dioxide |
| CN1278733B (zh) | 1997-11-07 | 2012-04-25 | 中央医科学研究室株式会社 | 含有二氧化碳的粘性组合物 |
| EP0945075A1 (en) * | 1998-03-25 | 1999-09-29 | Eliseo Garuti | Nutritional supplement |
| WO2000067704A3 (en) * | 1999-05-10 | 2001-09-13 | Lush Ltd | Containers for cosmetic products and the like |
| JP2001031567A (ja) * | 1999-05-20 | 2001-02-06 | Takeda Chem Ind Ltd | アスコルビン酸塩含有組成物 |
| WO2002055054A1 (fr) * | 2001-01-16 | 2002-07-18 | Tsumura & Co. | Composition additive pour le bain |
| WO2002080941A1 (fr) * | 2001-04-06 | 2002-10-17 | Masaya Tanaka | Compositions destinees a preparer des agents exterieurs du dioxyde de carbone |
| US7879359B2 (en) | 2001-04-06 | 2011-02-01 | Neochemir Inc. | Compositions for preparing external carbon dioxide agents |
| CN100415246C (zh) * | 2001-04-06 | 2008-09-03 | 新化学人股份有限公司 | 二氧化碳外用剂调制用组合物 |
| JP2005537233A (ja) * | 2002-06-04 | 2005-12-08 | エルテーエス ローマン テラピー−ジステーメ アーゲー | 活性物質放出のためのフィルム成形された溶解可能な製剤およびこれらの製造方法 |
| JP2006508060A (ja) * | 2002-09-19 | 2006-03-09 | アーダナ バイオサイエンス リミテッド | アポモルヒネを含む発泡性製剤 |
| JP2007524575A (ja) * | 2003-01-30 | 2007-08-30 | エティファーム | 味マスキング被覆粒子、その調製方法および前記被覆粒子を含有する口腔内崩壊錠剤 |
| JP4699350B2 (ja) * | 2003-01-30 | 2011-06-08 | エティファーム | 味マスキング被覆粒子、その調製方法および前記被覆粒子を含有する口腔内崩壊錠剤 |
| JP2007077242A (ja) * | 2005-09-13 | 2007-03-29 | Sanei Gen Ffi Inc | コーティング組成物 |
| JP2011148781A (ja) * | 2010-01-22 | 2011-08-04 | Hwakwang Trading Co Ltd | 水溶性に優れた皮膚洗浄剤 |
| JP2013536697A (ja) * | 2010-09-07 | 2013-09-26 | アール・ジエイ・レイノルズ・タバコ・カンパニー | 発泡性組成物を含む無煙タバコ製品 |
| JPWO2014042120A1 (ja) * | 2012-09-13 | 2016-08-18 | ライオン株式会社 | 発泡性口腔用組成物、発泡性口腔用固形製剤及び発泡性口腔用製品 |
| US10252041B2 (en) | 2012-10-29 | 2019-04-09 | C&Tech Corporation | Pack for supplying carbon dioxide to skin and manufacturing method thereof |
| JP2017105864A (ja) * | 2013-01-22 | 2017-06-15 | 株式会社東洋新薬 | 発泡性皮膚外用剤 |
| JP2014193934A (ja) * | 2013-01-22 | 2014-10-09 | Toyo Shinyaku Co Ltd | 発泡性皮膚外用剤 |
| JP2014193842A (ja) * | 2013-01-22 | 2014-10-09 | Toyo Shinyaku Co Ltd | 発泡性皮膚外用剤 |
| JP2015017346A (ja) * | 2013-07-12 | 2015-01-29 | 花王株式会社 | ナノファイバシート及びその製造方法 |
| JP2016098227A (ja) * | 2014-11-26 | 2016-05-30 | 花王株式会社 | 発泡性固形状組成物の製造方法 |
| JP2017036220A (ja) * | 2015-08-06 | 2017-02-16 | 忠洋 嶋田 | 発泡性の化粧料 |
| JP2018123107A (ja) * | 2017-02-03 | 2018-08-09 | 株式会社東洋炭酸研究所 | 口腔ケア用固形組成物 |
| JP2020103185A (ja) * | 2018-12-27 | 2020-07-09 | 花王株式会社 | 密封容器入り発泡性経口錠剤 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH025726B2 (enrdf_load_stackoverflow) | 1990-02-05 |
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