JPS61197506A - Prevention of color-blackening of living bodies with gamma-pyrone derivative - Google Patents

Abstract

PURPOSE:A gamma-pyronic acid derivative is used to inhibit, e.g., living bodies from browning with sun beams, e.g., sunburn or freckles, lotus roots from blackening and construction material from causing problems by tannin. CONSTITUTION:A derivative of a gamma-pyronic acid such as Kojic acid, comenic acid, pyrocomenic acid, their esters, maltol, ethylmaltol, 3-hydroxy-2-hydroxy- methyl-4(H)-pyran-4-one is used to inhibit living bodies of men, fishes from browning, such as sunburn, freckles or blackening of shrimps, gold fishes, etc., browning of lotus roots, etc.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a method for preventing changes in the body color of living organisms by applying a γ--ron conductor. More specifically, kojicacid
ic acid Xpyrocomenic acid
and its esters, maltol,
ethylmaltol, hydroxymalt,
ol (3-hydroxy-2-hydroxy
-methyl-4(H) -pyran-4-o
ne).

As for the blackening of the body color of animals and plants due to ultraviolet rays, 5u for humans is
nburn
This applies to the stubborn wood.

In recent years, knowledge has been increasing regarding the significance of carotenoids and melanins as biological pigments in the plant and animal kingdoms, especially those that control body color.

In humans, the color of both skin and hair is determined by the pigment melanin (eu
It is dominated by melanin (Xphaeomelanin), and is not only emphasized as one of the biological factors of racial problems, but also its relationship with the occurrence of melasma, freckles, sunburn, etc. has also attracted attention.

caro in crustaceans, fish, birds, and other animals
Many tenoids have important significance as pigments for body color, and it is gradually becoming clear that tenoids are delicately interrelated with melanin pigments.

This poses an important economic problem when it comes to cultivating and preserving colored foods such as shrimp and sea bream due to changes in body color.

On the other hand, even in the case of plant foods, there are many examples in which changes in color are deeply linked to the value of the food, as seen in the browning and blackening of lotus roots, for example. In the case of lotus root, the production of a black substance similar to melanin is a major problem.

As for the blackening of plants, the occurrence of stains on building materials is also a serious problem from an aesthetic point of view.

At first glance, the above-mentioned problems may seem to be nothing more than issues of customs and customs, but they all involve major political and economic issues and cannot be ignored.

The inventor has long studied the melanin pigment and carotenoi.
Although he has been involved in AS research, he searched for solutions to the above-mentioned problems based on his own academic achievements, and after a long period of trial and error, he completed the present invention.

Example 1 Air was dramatically blown into a 0.05% L-Dopa aqueous solution (pH 7.0 phosphate buffer), and the blackening of the liquid was reduced to 470%.
It is measured by absorption at a wavelength of nm. This reaction indicates the production of bald melanin, and the reaction is completed in about 3 days at room temperature.

Now, when this reaction is carried out under ultraviolet irradiation, it is significantly accelerated. A UM-452 (Ushio Inc.) high-pressure mercury lamp (having a strong line spectrum between 665 and 579.1 nm) was used as the light source, and the distance between the light source and the specimen was 95111. When the above-mentioned reaction is carried out at a liquid temperature of 20 to 25°C, it is completed in 3 hours.

If the γ-pyrone derivative is added to the reaction liquid phase at a IIk degree of o,o 1 %, this effect of UV irradiation is significantly suppressed.

Example 2 Black paper with numerous windows of about 1 am'' was attached to the skin on the side of the flexor progenitor muscle of a human, and ultraviolet rays were irradiated. The influence of derivatives was investigated.The light source was 297 nm, 30 nm.
Two types, a hybrid of 5 nm and 352 nm, were used. The subjects were 2 boys and 1 girl.

Example 6 Effect of γ-pyrone derivative on black goldfish When rearing black goldfish with 0.25-1% pyrone derivative,
The black color fades and turns yellow. Since the effects of Kojic acid have already been reported (1), the effects of other derivatives were compared.

Table 3 BLE of γ-Pyrones against black goldfish
When a black goldfish that had turned yellow was returned to pure water and irradiated with ultraviolet rays due to the eching action r-pyrone derivative, the black color quickly recovered. was significantly suppressed.

This suppressive effect was most pronounced in maltol.

The blackening of the body color of red sea bream due to ultraviolet rays significantly reduces its commercial value, but the blackening of the body color (carotenoids) of sea bream in an aquarium due to ultraviolet ray irradiation can also be prevented with γ-pyrone, just like goldfish. It was done.

Example 4 Effect of γ-pyrone on the body color of tiger prawns When prawns are reared in shallow artificial seawater and irradiated with ultraviolet rays, their body color significantly turns black. This seems to be due to increased melanin formation. At this time, when 0.1% of a γ-pyrone derivative was added to the artificial seawater, blackening was significantly suppressed.

Example 5 Effect of γ-ron on blackening of lotus root slices When lotus root slices are placed in pure water and irradiated with ultraviolet rays, blackening is significantly accelerated. At this time, if 0.1% of an r-pyrone derivative is added, blackening is significantly suppressed.

Reference 1) Hideo Nakayama et al. Treatment of Melasma by Topical Kojic Acid 1 Skin 36 (7) Nia 15-722.1982

Claims (1)

[Claims] A method for preventing the body color of an organism from turning black due to the influence of ultraviolet rays, the method comprising applying a γ-pyrone derivative.