JPS61100518A - ジミリストイルホスフアチジルコリンを主成分とする凍結乾燥されたリポゾ−ム製剤 - Google Patents
ジミリストイルホスフアチジルコリンを主成分とする凍結乾燥されたリポゾ−ム製剤Info
- Publication number
- JPS61100518A JPS61100518A JP59220565A JP22056584A JPS61100518A JP S61100518 A JPS61100518 A JP S61100518A JP 59220565 A JP59220565 A JP 59220565A JP 22056584 A JP22056584 A JP 22056584A JP S61100518 A JPS61100518 A JP S61100518A
- Authority
- JP
- Japan
- Prior art keywords
- liposome
- drug
- dimyristoylphosphatidylcholine
- arachidonic acid
- main component
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- CITHEXJVPOWHKC-UUWRZZSWSA-N 1,2-di-O-myristoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCC CITHEXJVPOWHKC-UUWRZZSWSA-N 0.000 title claims 2
- 229960003724 dimyristoylphosphatidylcholine Drugs 0.000 title claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 239000002502 liposome Substances 0.000 claims 8
- 238000002360 preparation method Methods 0.000 claims 6
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical class CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 claims 3
- 150000002632 lipids Chemical class 0.000 claims 3
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N lactose group Chemical group OC1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@H](O2)CO)[C@H](O1)CO GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 2
- 239000000463 material Substances 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- 230000007935 neutral effect Effects 0.000 claims 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
- 239000002532 enzyme inhibitor Substances 0.000 claims 1
- KAQKFAOMNZTLHT-VVUHWYTRSA-N epoprostenol Chemical compound O1C(=CCCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@@H]21 KAQKFAOMNZTLHT-VVUHWYTRSA-N 0.000 claims 1
- 229960001123 epoprostenol Drugs 0.000 claims 1
- 239000008101 lactose Substances 0.000 claims 1
- 150000002617 leukotrienes Chemical class 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 150000003180 prostaglandins Chemical group 0.000 claims 1
- 235000000346 sugar Nutrition 0.000 claims 1
- 150000008163 sugars Chemical class 0.000 claims 1
- RZWIIPASKMUIAC-VQTJNVASSA-N thromboxane Chemical compound CCCCCCCC[C@H]1OCCC[C@@H]1CCCCCCC RZWIIPASKMUIAC-VQTJNVASSA-N 0.000 claims 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP59220565A JPS61100518A (ja) | 1984-10-22 | 1984-10-22 | ジミリストイルホスフアチジルコリンを主成分とする凍結乾燥されたリポゾ−ム製剤 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP59220565A JPS61100518A (ja) | 1984-10-22 | 1984-10-22 | ジミリストイルホスフアチジルコリンを主成分とする凍結乾燥されたリポゾ−ム製剤 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS61100518A true JPS61100518A (ja) | 1986-05-19 |
JPH0362696B2 JPH0362696B2 (en, 2012) | 1991-09-26 |
Family
ID=16752979
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP59220565A Granted JPS61100518A (ja) | 1984-10-22 | 1984-10-22 | ジミリストイルホスフアチジルコリンを主成分とする凍結乾燥されたリポゾ−ム製剤 |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS61100518A (en, 2012) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS643115A (en) * | 1987-06-26 | 1989-01-06 | Dai Ichi Seiyaku Co Ltd | Liposome preparation |
JPS643114A (en) * | 1987-06-25 | 1989-01-06 | Dai Ichi Seiyaku Co Ltd | Stable liposome water dispersion |
JPH02504027A (ja) * | 1987-05-22 | 1990-11-22 | ザ リポソーム カンパニー,インコーポレイテッド | プロスタグランジン‐脂質製剤 |
US5082664A (en) * | 1987-05-22 | 1992-01-21 | The Liposome Company, Inc. | Prostaglandin-lipid formulations |
JPH04356421A (ja) * | 1991-03-06 | 1992-12-10 | Green Cross Corp:The | プロスタグランジン類含有脂肪小体組成物 |
US5262168A (en) * | 1987-05-22 | 1993-11-16 | The Liposome Company, Inc. | Prostaglandin-lipid formulations |
DE4309579A1 (de) * | 1993-03-24 | 1994-09-29 | Sanol Arznei Schwarz Gmbh | Pharmazeutische Zusammensetzung in Form eines Kits |
US5925375A (en) * | 1987-05-22 | 1999-07-20 | The Liposome Company, Inc. | Therapeutic use of multilamellar liposomal prostaglandin formulations |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS53142514A (en) * | 1977-05-10 | 1978-12-12 | Ici Ltd | Freeze dried latent liposome mixture * aqueous liposome preparation and production thereof |
JPS55153713A (en) * | 1979-05-02 | 1980-11-29 | Kureha Chem Ind Co Ltd | Pharmaceutical preparation of ribosome containing active substance |
JPS567714A (en) * | 1979-06-22 | 1981-01-27 | Hoffmann La Roche | Pharmaceutical medicine |
-
1984
- 1984-10-22 JP JP59220565A patent/JPS61100518A/ja active Granted
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS53142514A (en) * | 1977-05-10 | 1978-12-12 | Ici Ltd | Freeze dried latent liposome mixture * aqueous liposome preparation and production thereof |
JPS55153713A (en) * | 1979-05-02 | 1980-11-29 | Kureha Chem Ind Co Ltd | Pharmaceutical preparation of ribosome containing active substance |
JPS567714A (en) * | 1979-06-22 | 1981-01-27 | Hoffmann La Roche | Pharmaceutical medicine |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH02504027A (ja) * | 1987-05-22 | 1990-11-22 | ザ リポソーム カンパニー,インコーポレイテッド | プロスタグランジン‐脂質製剤 |
US5082664A (en) * | 1987-05-22 | 1992-01-21 | The Liposome Company, Inc. | Prostaglandin-lipid formulations |
US5262168A (en) * | 1987-05-22 | 1993-11-16 | The Liposome Company, Inc. | Prostaglandin-lipid formulations |
US5925375A (en) * | 1987-05-22 | 1999-07-20 | The Liposome Company, Inc. | Therapeutic use of multilamellar liposomal prostaglandin formulations |
JPS643114A (en) * | 1987-06-25 | 1989-01-06 | Dai Ichi Seiyaku Co Ltd | Stable liposome water dispersion |
JPS643115A (en) * | 1987-06-26 | 1989-01-06 | Dai Ichi Seiyaku Co Ltd | Liposome preparation |
JPH04356421A (ja) * | 1991-03-06 | 1992-12-10 | Green Cross Corp:The | プロスタグランジン類含有脂肪小体組成物 |
DE4309579A1 (de) * | 1993-03-24 | 1994-09-29 | Sanol Arznei Schwarz Gmbh | Pharmazeutische Zusammensetzung in Form eines Kits |
US5681855A (en) * | 1993-03-24 | 1997-10-28 | Schwarz Pharma Ag | PGE1 emulsion composition kit |
DE4309579C3 (de) * | 1993-03-24 | 2000-01-27 | Sanol Arznei Schwarz Gmbh | Pharmazeutische Zusammensetzung in Form einer Packung |
Also Published As
Publication number | Publication date |
---|---|
JPH0362696B2 (en, 2012) | 1991-09-26 |
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