JPS643115A - Liposome preparation - Google Patents

Liposome preparation

Info

Publication number
JPS643115A
JPS643115A JP15909087A JP15909087A JPS643115A JP S643115 A JPS643115 A JP S643115A JP 15909087 A JP15909087 A JP 15909087A JP 15909087 A JP15909087 A JP 15909087A JP S643115 A JPS643115 A JP S643115A
Authority
JP
Japan
Prior art keywords
liposome
water dispersion
give
saccharide
freeze
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP15909087A
Other languages
Japanese (ja)
Other versions
JP2550352B2 (en
JPH013115A (en
Inventor
Hiroshi Kikuchi
Sadao Hirota
Hitoshi Yamauchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Pharmaceutical Co Ltd
Original Assignee
Daiichi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Pharmaceutical Co Ltd filed Critical Daiichi Pharmaceutical Co Ltd
Priority to JP62159090A priority Critical patent/JP2550352B2/en
Publication of JPS643115A publication Critical patent/JPS643115A/en
Publication of JPH013115A publication Critical patent/JPH013115A/en
Application granted granted Critical
Publication of JP2550352B2 publication Critical patent/JP2550352B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)

Abstract

PURPOSE: To obtain a liposome water dispersion showing liposome stability for a long period, by freeze-drying or spray-drying a liposome water dispersion containing a saccharide and having a specific ionic concentration.
CONSTITUTION: 1pt.wt. lipid is blended with 0W1pt.wt. sterol as a membrane stabilizer and 0W0.2pt.wt. charged substance to give a liposome membrane component substance, which is dissolved in a proper solvent such as chloroform, the solvent is distilled away under reduced pressure to form a lipid film, which is suspended in water. 1pt.wt. water dispersion is incorporated with 0.001W0.3pt.wt., preferably 0.01W0.15pt.wt. saccharide (e.g. lactose or mannitol), adjusted to pH 6.0W8.0 by using a monovalent base or acid in an amount to give ≤20mM ionic concentration of finally obtained water dispersion. The water dispersion is freeze-dried or spray-dried to give a stable liposome preparation.
COPYRIGHT: (C)1989,JPO&Japio
JP62159090A 1987-06-26 1987-06-26 Liposomal formulation Expired - Lifetime JP2550352B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP62159090A JP2550352B2 (en) 1987-06-26 1987-06-26 Liposomal formulation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62159090A JP2550352B2 (en) 1987-06-26 1987-06-26 Liposomal formulation

Publications (3)

Publication Number Publication Date
JPS643115A true JPS643115A (en) 1989-01-06
JPH013115A JPH013115A (en) 1989-01-06
JP2550352B2 JP2550352B2 (en) 1996-11-06

Family

ID=15686019

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62159090A Expired - Lifetime JP2550352B2 (en) 1987-06-26 1987-06-26 Liposomal formulation

Country Status (1)

Country Link
JP (1) JP2550352B2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005524635A (en) * 2002-02-08 2005-08-18 アボット ゲーエムベーハー ウント カンパニー カーゲー Process for producing water-dispersible dry powder from poorly soluble compounds
JP2006510717A (en) * 2002-12-17 2006-03-30 メディミューン・ヴァクシンズ・インコーポレーテッド High pressure spray drying of bioactive materials

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6058915A (en) * 1983-09-12 1985-04-05 Fujisawa Pharmaceut Co Ltd Lipid microcapsule preparation containing medicament
JPS61100518A (en) * 1984-10-22 1986-05-19 Ono Pharmaceut Co Ltd Lyophilized ribosome pharmaceutical preparation comprising dimyristoylphosphatidylcholine as main component

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6058915A (en) * 1983-09-12 1985-04-05 Fujisawa Pharmaceut Co Ltd Lipid microcapsule preparation containing medicament
JPS61100518A (en) * 1984-10-22 1986-05-19 Ono Pharmaceut Co Ltd Lyophilized ribosome pharmaceutical preparation comprising dimyristoylphosphatidylcholine as main component

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005524635A (en) * 2002-02-08 2005-08-18 アボット ゲーエムベーハー ウント カンパニー カーゲー Process for producing water-dispersible dry powder from poorly soluble compounds
JP2006510717A (en) * 2002-12-17 2006-03-30 メディミューン・ヴァクシンズ・インコーポレーテッド High pressure spray drying of bioactive materials
JP4680601B2 (en) * 2002-12-17 2011-05-11 メディミューン・エルエルシー High pressure spray drying of bioactive materials

Also Published As

Publication number Publication date
JP2550352B2 (en) 1996-11-06

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