JPS6078913A - Cosmetic - Google Patents

Abstract

PURPOSE:To provide a cosmetic obtained by compounding L-ascorbic acid-2- sulfate or its salt with vitamin E, and having improved transcutaneous permeability, synergistically increased beautifying effect, and improved effect to prevent the aging, without lowering the stability of the former component. CONSTITUTION:A cosmetic having remarkably improved beautifying and aging- preventive effect can be produced by compounding L-ascorbic acid-2-sulfate or its salt (e.g. salt of Na, K, Mg, Ca, etc.) and a vitamin E compound (e.g. alpha-, beta-, gamma-tocopherol, tocopherol acetate, etc.). The use of 10wt% L-ascorbic acid-2- sulfate and 2wt% vitamin E is sufficient to attain the above effects. The combined use of the above components enables the increase in the transcutaneous permeability and the remarkable improvement in the spots and freckles without lowering the stability of L-ascorbic acid-2-sulfate. The content of soluble collagen in the living tissue can be increased to prevent the aging of the body.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a novel cosmetic material with significantly improved whitening and anti-aging effects.

Traditionally - Whitening cosmetics are mainly used to whiten sunburned skin that causes age spots and freckles, and consumers have very high expectations among cosmetics. Ascorbic acid is tyrosine. It inhibits the action of tyrosinase that produces melanin, and also has the effect of returning the dark oxidized melanin to the light reduced melanin, resulting in skin whitening, age spots, freckles, and melasma. Although it is well known that it is an effective compound for the treatment of melasma and other skin conditions, it is extremely unstable and easily oxidized by heat and light, and is particularly useful in cosmetics containing water. Easy to decompose and cause discoloration. Therefore, in order to stabilize ascorbic acid, it has been proposed to blend ascorbic acid as an ester of higher 1ffi 1IJj acid or phosphoric acid, or to add an antioxidant or reducing agent. The more you use it, the more the whitening effect will fade, and if you increase the amount, it will cause irritation to your skin.

Recently, L-ascorbic acid-2-sulfuric acid, which is obtained by converting the hydroxyl group at the 2-position of L-ascorbic acid into a sulfuric acid ester, has been developed, and has been greatly improved in terms of stabilization. However, the current situation is that there is still room for investigation in terms of transdermal permeability.

Recently, there have been reports that α-tocopherol has a whitening effect, but according to the inventors' follow-up tests, the effect was negligible.As for the anti-aging effect, vitamin E has no effect. Although it is said that there is, it is still insufficient.

In view of these circumstances, the present inventors have conducted extensive research to obtain cosmetics with truly excellent whitening and anti-aging effects. By incorporating Mitamin E into cosmetics, transdermal permeability increases without impairing the stability of L-ascorbic acid-2-sulfuric acid, and stains, freckles, dark skin, etc. are significantly improved. The whitening effect increases synergistically.
Furthermore, it was discovered that aging can be significantly prevented, leading to the completion of the present invention.In other words, the present invention provides L-ascorbic acid-2-sulfuric acid,
and one or more selected from the group consisting of salts thereof.

(Margin below) Next, the configuration of the present invention will be described.

The L-ascorbic acid-2-sulfuric acid used in the present invention is L-
It is obtained by converting the hydroxyl group at the 2-position of ascorbic acid into a sulfuric acid ester. L-ascorbic acid-2- used in Honjomei
Examples of sulfuric acid salts include Na, K, Mg, and Oa salts.

L-ascorbic acid-2-sulfuric acid or its salt is effective when incorporated in the amount of cosmetics in an amount of 0,001% by weight or more, and approximately 1% by weight is sufficient to exhibit the effects of the present invention.

Examples of vitamin E used in the present invention include C, α-
Examples include tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, tocopherol acetate, and tocopherol honeynicotinate, which contain 0% in cosmetics.
001% by weight or more exhibits a synergistic effect,
About % by weight is sufficient.

In addition to the above-mentioned essential ingredients, the cosmetics of the present invention contain ingredients that are usually added to cosmetics, such as ultraviolet absorbers, humectants, preservatives, surfactants, fragrances, pigments, etc., without impairing the effects of the present invention. They can be used in appropriate combinations within the range.

Next, the present invention will be explained in more detail with reference to Examples. The present invention is not limited thereby. The blending amount is by weight (%).

Prior to examples, test methods and judgment methods will be explained.

(Test method) Hartley male guinea pigs (300
~3509) was used. After applying 50~ of the sample lotion to 5 cm2 of dorsal skin that had been depilated before Experiment 41, it was immediately closed with a plastic film.

a $i 24 hours [1 Jg] After wiping the surface of the skin with absorbent cotton moistened with ethanol and water, the stratum corneum was peeled off by tilting with cellophane tape. Next, the branch was cut out, immediately frozen, and after removing the subcutaneous tissue, 25 thin sections were made from the dermis side parallel to the 119th surface of the skin using a microtome. %-1500μm window as dermal layer, L-ascorbine ff1-2- in each section
The amount of sulfuric acid was measured and used as the transdermal permeation amount.

The transdermal permeation amount was the average value of three guinea pigs.

(Judgment) ◎: The amount of L-ascorbic acid-2-sulfuric acid that permeated through the skin into the epidermal cell layer and dermal layer after the sample application period was 1 of the applied amount.
If it is 0% or more.

○: 5 to 10% of the coating amount.

×: 5% or less of the coating amount.

(Hereinafter referred to as general) <Test on whitening effect by cumulative application> (Test method) One sample lotion was applied to the face morning and evening every day for 3 months as a test subject suffering from dark skin, age spots, freckles, etc. for 3 months. We investigated its whitening effect on a monthly basis.

(Judgment criteria) Significant results: Pigmentation is almost invisible.

Valid: Very tingling.

Slightly effective: Slightly tingling.

Invalid: No change.

(Judgment) ◎: The percentage of subjects showing significant or effective response (A) efficiency is 80% or more.

Q: 50% to 80%.

×: 50% or less.

Collagen Synthesis Test Collagen is a fibrous protein that constitutes the dermal tissue of mammals, and there are two types: soluble collagen and insoluble collagen. Generally, an increase in insoluble collagen is cited as a cause of aging. In other words, by increasing soluble collagen and decreasing insoluble collagen, it is believed that aging can be prevented and skin can be maintained with a fresh appearance.

(Test method) Wistar male rats were used as experimental animals. 05 ml of the sample was applied once a day for 7 days to 5×5 cJ of the back skin that had been subjected to depilation treatment. On the 8th day, the animal was sacrificed and the skin 1e
After removing the subcutaneous tissue, only the epidermis and dermis layers were homogenized. Soluble collagen and insoluble collagen were extracted from the homogenate and quantified as the amount of hydroxyproline.

(Judgment) ◎: The sum of the increase ratio of soluble collagen when applied to DJ soluble collagen when not applied and the decrease ratio of insoluble collagen when applied to DJ soluble collagen when not applied is 50% or more. .

△: ~50%.

X: //21: 4% or less.

-〇1 A lotion having the composition shown in Table 1 described in Examples 1 to 3 and Comparative Examples 1 to 2 was prepared, and its transdermal permeability and whitening effect upon cumulative application were investigated.

The manufacturing method was adjusted as follows. That is, 95% ethyl alcohol 109 and topherol acetate are required! :,F
Mix 0.59% of OR (Incorporated) lauryl ether and fragrance, then add 2 s of glycerin, 1 q of propylene glycol, 29 citric acid, 29 L-ascorbic acid, and sulfuric acid. water, total weight 100
g, mixed, and prepared in 1f.

(Margin below) Table 1 As is clear from Table 1, the cosmetic of the present invention is a novel cosmetic with excellent whitening and anti-aging effects.

(Margin below) Example 4 Milk liquid A milky lotion was produced by a conventional method according to the following recipe.

Stearic acid 2.0 Setanol LO Vaseline 3゜ Lanolin alcohol 2+.

Liquid paraffin a.

Squalane 3.0 S-Riki Roll 507 2+0 α-tocopherol 0.06 L-ascorbic acid-2-sulfur 1! i! 2Na O,00
1P OIn(10) mo/oleate z5 Triethanolamine 1.0 Propylene glyconyl 5°Fragrance Appropriate amount Preservative Appropriate amount Distilled water 70.439 (Left below) Example 5 Nutritional cream Cream was made in a conventional manner according to the following recipe. Manufactured.

Stearic acid zO Stearyl alcohol 7.0 Reduced lanolin zO Squalane 5.0 Octyldodecanol 60 Polyoxyethylene cetyl ether (25EQ) 3.
0 Lipophilic glyceryl monostearate 2.0 Tocopherol nicotinate 0.01 L-ascorbic acid-2-sulfuric acid 005 Propylene glycol 50 Flavor Appropriate amount Preservative Appropriate amount Distilled water 67.94 (Example 6 in the margin below) A pack was manufactured by a conventional method according to the following recipe.

Kaolin 691 Tart 190 Propylene glycol 50 Calcium acetate α01 Uric acid 0.5 L-ascorbic acid-2-sulfuric acid 5.0 α-tocopherol 1.0 Fragrance 0.39 (1. Extra) Example 7 Batha 15. Pasta was produced according to the following recipe by a conventional method.
0 Polyoxyethylene sorbitan monooleate 2-O Via ≠ Cell 1.0 Glycerin 100 Hydroxyethyl heptalulose 4.0 L-Ascorbic acid-2-sulfuric acid 10 L-Ascorbic acid-2-sulfuric acid M 30 α-Tocopherol 05 Tocopherol acetate 05 Fragrance Appropriate amount Preservative Appropriate amount Purified water 630 The cosmetics obtained in Examples 4 to 7 were excellent in Eihaku effect 1 anti-aging effect.

Patent applicant Shiseido Co., Ltd.

Claims (2)

[Claims] (1) Cosmetics characterized by containing one or more types selected from the group consisting of L-ascorbic acid-2-sulfuric acid and its salts and one or more types of vitamin E. fee. (2) Salts of L-ascorbic acid-2-sulfuric acid are Ha. The cosmetic according to claim 1, which is a salt of an alkali metal such as K and an alkaline earth metal such as Mg and Ca. The cosmetic according to any one of claims 1 to 2, which is ferol or tocopherol nicotinate.