JPH11286425A - Composition for suppressing aged person smell - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a means capable of controlling 'aged person smell' being a body odor characteristic of middle and old aged persons. SOLUTION: This composition for suppressing a body odor controls even the occurrence of aged person smell by repressing the occurrence of an unsaturated aldehyde being octenal and/or nonenal as the main genesis primary factor of aged person smell by the use of an antimicrobial agent.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to the technical field of the composition for suppressing body odor. More specifically, the invention relates to a composition for suppressing an aging odor that can suppress the "aging odor" observed with aging.

[0002]

2. Description of the Related Art Body odor can be roughly classified into "odors of various parts of the body" such as bad breath, foot odor, axillary odor, and scalp odor, and "smell combining odors emitted from the trunk". from now on,
Many studies have already been made on the former "odor of each part of the body", the main components of the odor have been elucidated, and many excellent countermeasures have been proposed. For example,
It is already known that sweat odor, axillary odor, foot odor, and the like are produced by "sweat" that causes odor and "skin resident bacteria" that produces odor. Sweat is secreted from sweat glands and is mainly categorized into eccrine and apocrine glands. The sweat secreted from the eccrine glands distributed throughout the human body is called eccrine sweat, most of which is composed of water, and also contains some sodium chloride, lactic acid, urea and the like. On the other hand, apocrine glands are sweat glands associated with hair and exist only in specific sites such as the axilla, areola, and genital area. The apocrine gland secreted from this is milk-like sweat containing proteins, lipids, fatty acids, cholesterol, glucose, ammonia, iron and the like.

[0003] These secreted sweats do not themselves emit strong odors, but are known to be converted to odorous substances by bacteria indigenous to the skin existing on the skin surface.
As a result of analysis of axillary odor and foot odor, lower fatty acids such as pelargonic acid and capric acid were specifically detected from the axillary odor, and isovaleric acid was specifically detected from the foot odor. Have been. At present, as a means of preventing these body odors, antiperspirants that suppress perspiration that is the basis of these odors, antibacterial agents that suppress the growth of bacteria resident on the skin, and the above-mentioned lower fatty acids that are the basis of the generated body odors, etc. A deodorant for suppressing substances, a masking agent for masking body odor with another scent (for example, a masking fragrance composition described in JP-A-6-179610, etc.) and the like are used.

[0004]

As described above, while the former "odor of each part of the body" has a great deal of knowledge, the latter "smell that combines the odor emitted from the trunk"
Almost nothing has been elucidated. In other words, many people feel that the smell of a person changes with age, such as "the smell of a baby", "the smell of youth", "the smell of grandpa", but the smell is It is often unknown what kind of substance it is and why it is emitted, and no studies have been seen.

[0005] On the other hand, recently, "being odorless" is preferred, and the tendency to dislike "smelling" is very strong. For example, the so-called "aging odor" observed after middle-aged and older is one of the odors that is particularly disliked at present (the most prominent one is "uncle's odor"). However, although it is clear that this “aging odor” exists, the cause of the odor has not yet been elucidated.
In addition, it is clear that in order to remove the odor, it is not possible to completely protect the odor by the conventional method of dealing with the "odor of each part of the body".

Accordingly, an object of the present invention is to provide a means for removing the above-mentioned "age odor". In other words, what kind of odor is "aging odor"?
It is an object of the present invention to find out the essence thereof and to provide an aging odor suppressant capable of removing this “aging odor”.

[0007]

Means for Solving the Problems The present inventor has made intensive studies to solve this problem. As a result, this age-related odor is not a odor caused by the lower fatty acid, which is conventionally recognized as a typical cause of the "odor of each part of the body", but is surprisingly a cause of the conventional odor. It was found that it was a completely new property of body odor, which was not recognized as a substance at all, and is strongly related to unsaturated aldehydes such as octenal and nonenal.

That is, the present inventors have healthy men or women in their twenties to seventies wear a shirt that has been washed in advance after taking a bath, and the body odor attached to the shirt is measured by a “headspace collection method”. Was absorbed and desorbed to TENAX TA resin, and the obtained body odor component was analyzed using GC / MS (G1800A GCD system, INNOWAX 60m × 0.25mm column, manufactured by Hewlett-Packard). In addition, sensory evaluation by a specialized panel was also performed on body odor of each panel.

The results are shown in Table 1.

[Table 1]

<GS / MS analysis> +++: detected as a peak three times or more of +. ++: Detected as a peak 1.5 to 3 times of +. +: Detected as a peak. -: Not detected.

<Sensory evaluation> +++: The odor is felt very strongly. ++: The smell is strongly felt. +: Feel the smell. ±: The odor is slightly weakened. -: The odor is not felt.

According to the sensory evaluation, the age-related odor was clearly different from the sweat odor and the armpit odor, and was characteristically recognized in the panels after middle and old age. Moreover, among the aldehydes detected by GS / MS analysis, unsaturated aldehydes such as octenal and nonenal were recognized as components increasing with age.

Based on these results, the present inventors have found that the odor-causing substance is an unsaturated aldehyde represented by octenal and nonenal (specifically, 2-octenal and 2-octenal).
Nonenal, etc., and especially these trans forms). The present inventors have presumed that these unsaturated aldehydes are produced by aging as follows.

As a premise, it is already known that the lipid peroxide in the living body is formed by the action of ultraviolet rays or enzymes such as lipoxygenase [for example, squalene (C ₃₀ H ₅₀ ) present in sebum is exposed to ultraviolet rays. Squalene hydroperoxide (hereinafter SQ)
It is known that HPO is formed (for example, Ohsawa K. et al., J. Toxicol. Sci. 9, 151 (1984)). It is known that, although degraded by defense mechanisms, the functions of these biological defense mechanisms tend to decline with age. On the other hand, the ratio of fatty acids in sebum changes with aging, and the ratio of cis6-hexadecenoic acid in sebum, which was abundant at a young age, relatively decreases, and the ratio of palmitoleic acid (9-hexadecenoic acid) decreases. It is also known to increase (The journal of investigative dermat
ology 73: 112-117,1979). Then, it is considered that the fatty acids in the sebum are generated by the skin-resident bacteria present on the skin.

That is, the present inventors have developed a lipid peroxide (eg, the above-mentioned SQHPO or the like) which is formed from palmitoleic acid, which is considered to be involved in the generation of the indigenous skin bacteria, and which is not decomposed by a biological defense mechanism. It is presumed that palmitoleic acid hydroperoxide (also referred to as palmitoleic acid HPO) is generated by the oxidative propagation according to (1), and then the palmitoleic acid HPO is β-cleaved to generate octenal and nonenal, which cause aging odor.

Based on this hypothesis, the present inventor has found that it is possible to suppress the generation of the unsaturated aldehyde by using an antibacterial agent to suppress the generation of an aging odor. Thus, the present invention has been completed.

That is, the present invention is an invention which provides a composition for suppressing an aging odor containing an antibacterial agent. The composition for suppressing an aging odor according to the present invention is a composition that can also take an aspect as a composition for suppressing the generation of unsaturated aldehydes such as nonenal and / or octenal. Furthermore, it is one of particularly preferred embodiments to use the composition for suppressing an aging odor according to the present invention as an external preparation for skin.

[0018]

Embodiments of the present invention will be described below. The composition for suppressing aging odor according to the present invention (hereinafter also referred to as the composition for suppressing aging odor of the present invention) is a composition for suppressing aging odor containing an antibacterial agent as described above.

[0019] In the present invention odor inhibiting composition, type of antimicrobial agent may be compounded, higher unsaturated fatty acids in sebum, particularly skin flora to produce palmitoleic acid, for example Staphylococcus Epyidamidisu (Staphylococ
cus epidermidis , Corynebacterium minutissimum , Malassezia furfur, etc., as long as they are antibacterial agents capable of suppressing Staphylococcus epiidamidis, in particular.

Specific examples include trichlorocarbanilide, benzalkonium chloride, benzethonium chloride, halocarban, chlorhexidine hydrochloride and the like. In addition, the composition for suppressing aging odor according to the present invention is obtained by combining dihydrofarnesol (Japanese Unexamined Patent Publication No. 8-245979), which is an "antibacterial fragrance" having both effects as an antibacterial agent and a fragrance, in combination with the above antioxidant as an antibacterial agent. It can also be compounded inside.

The amount of these antibacterial agents in the composition for suppressing aging odor of the present invention should be appropriately selected depending on the kind of antibacterial agent to be selected, the relationship with other compounding components, and the like. Although not required, the composition generally has a.
0001% by weight or more and 10.0% by weight or less, preferably 0.005% by weight or more and 5.0% by weight or less.

This amount is 0.0001% by weight of the composition
If it is less than 0.01, it is difficult to sufficiently exert the desired effect of removing the age-related odor.
Even if it is added in excess of weight%, there is a strong tendency that the suppression effect on the aging odor commensurate with the increase in the amount is not recognized,
Further, depending on the kind of the selected antibacterial agent, there may be a problem in the preparation, which is not preferable. In addition, one of these antibacterial agents can be blended in the composition for suppressing an aging odor of the present invention, but two or more can be blended in combination.

In this manner, the generation of higher unsaturated fatty acids such as palmitoleic acid in sebum, which causes the generation of aging odor, due to indigenous bacteria of the skin is suppressed, and the generation of the above unsaturated aldehyde is suppressed. The composition for suppressing aging of the present invention, which can suppress odor, is provided. This use of “age odor control” is a new use that should be clearly distinguished from mere “body odor control”.

That is, the “aging odor” is a body odor derived from a causative substance which is clearly different from the known causative substances of body odor such as sweat odor and armpit odor (as described above). Can be generated independently of axillary odor and foot odor, and the age group where aging odors occur is literally middle-aged and older, and aging odors should be eliminated by the conventionally used body odor control measures Taking into account the difficulties (described later) and the like, this is clearly an application independent of normal “body odor control”.

Therefore, the use of “age odor control” is a use that is clearly distinguished from ordinary body odor control means in terms of both technical and social wisdom. The composition for suppressing an aging odor of the present invention can be used, for example, as an external preparation for skin such as cosmetics, pharmaceuticals, and quasi-drugs.

Further, the composition for suppressing an aging odor of the present invention prevents, for example, sebum adhering to clothes from being naturally oxidized by air to be converted into unsaturated aldehydes, so that aging odor is not generated in the clothes. For this reason, it can be used as a means for preventing generation of an odor in the clothes, or as means for preventing the odor generated in the body from attaching to the clothes.

Further, the composition for suppressing an aging odor according to the present invention may also take a form as a composition for suppressing the generation of unsaturated aldehydes such as nonenal and / or octenal, which are main causative substances of the aging odor.

In the composition for suppressing aging odor of the present invention,
In addition to the above-mentioned antibacterial agent, a component capable of cutting off the generation of the unsaturated aldehyde, which is a substance causing the aging odor, through a route different from that of the antibacterial agent may be added.

First, an antioxidant capable of blocking an oxidation process such as the above-described oxidative propagation that produces an unsaturated aldehyde is combined with the antibacterial agent of the present invention in combination with the antibacterial agent. Further, generation of an aging odor can be further suppressed.

Specifically, carotenoids such as α-carotene, β-carotene, γ-carotene, lycopene, cryptoxanthin, zeaxanthin, isoseaxanthin, rhodoxanthin, capsanthin, crocetin;
2,5-dimethylfuran, 2-methylfuran, 2,5-
Furans such as diphenylfuran and 1,3-diphenylisobenzofuran; vitamins E such as α-tocopherol, β-tocopherol, γ-tocopherol and δ-tocopherol; histidine, tryptophan, methionine, alanine, alkyl esters of alanine, etc. Amino acids: 1,4-diadicyclooctane, dibutylhydroxytoluene (BHT), gallic esters, ascorbic acid, tannins, flavonoids, and the like, but are not limited thereto.

An extract of a crude drug having an antioxidant effect can be used as the antioxidant. In particular,
For example, Japanese gourd extract, Japanese sage extract, Acacia extract, sage extract, tea extract, rosemary extract, fennel extract, thyme extract, nutmeg extract, pepper extract, turmeric extract, vanilla extract, Crude drug extracts such as paprika extract, yokuinin extract, psycho extract, cucumber extract, suhou extract, curen extract and John Lab extract can be mentioned.
It is not limited to these.

When this antioxidant is incorporated into the composition for suppressing an aging odor of the present invention, it is generally 0.001% by weight or more and 10.0% by weight or less, preferably 0.01% by weight of the composition.
As described above, it can be blended in the range of 1.0% by weight or less.

In addition, it inhibits the action of lipoxygenase, an in vivo enzyme that produces lipid peroxides (eg, linoleic acid hydroperoxide) that induces oxidative propagation to induce palmitoleic acid HPO from palmitoleic acid.
When a lipoxygenase inhibitor is combined with the above antibacterial agent in the composition for suppressing aging odor of the present invention, generation of aging odor can be further suppressed.

Examples of the lipoxygenase inhibitor include tranexamic acid and β-carotene (when this β-carotene is selected as a lipoxygenase inhibitor, the above-mentioned antioxidants include antioxidants other than β-carotene. It is preferable to select).

When this lipoxygenase inhibitor is added to the composition for suppressing the aging odor of the present invention, the lipoxygenase inhibitor is used in an amount of about 0.1%.
0001% by weight or more and 10.0% by weight or less, preferably 0.005% by weight or more and 5.0% by weight or less.

Further, a fragrance other than the above-mentioned "antibacterial fragrance" other than dihydrofarnesol may be added to the composition for suppressing an aging odor of the present invention in order to mask or harmonize the aging odor that leaks out. Can be.

In addition to these components directly related to the suppression of the aging odor, the composition according to the present invention can be usually added to the composition according to the aging odor depending on the specific embodiment which can be employed. General components can be added as long as the effects of the present invention are not impaired.

For example, when the composition for suppressing aging odor of the present invention is used as an external preparation for skin, paraaminobenzoic acid-based ultraviolet absorbers such as paraaminobenzoic acid; anthranilic acid-based ultraviolet absorbers such as methyl anthranilate; salicylic acid Salicylic acid UV absorbers such as octyl, phenyl salicylate and homomenthyl salicylate; isopropyl paramethoxycinnamate, octyl paramethoxycinnamate, 2-ethylhexyl paramethoxycinnamate, mono-2-ethyl diparamethoxycinnamate Glyceryl hexanoate, [4
-Bis (trimethylsiloxy) methylsilyl-3-methylbutyl] -3,4,5-trimethoxycinnamic acid esters and the like; 2,4-dihydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone Benzophenone ultraviolet absorbers, such as sodium 2-hydroxy-4-methoxybenzophenone-5-sulfonate, sodium 2-hydroxy-4-methoxybenzophenone-5-sulfonate; urocanic acid, ethyl urocanate, 2-phenyl-5- Methyl benzoxazole,
2- (2 ^'- hydroxy-5'-methylphenyl) benzotriazole, 4-tert - butyl-4'-methoxy dibenzoyl present invention odor inhibiting composition for an ultraviolet absorber, such as methane, as a skin external preparation It can be compounded inside.

Further, polyethylene glycol, propylene glycol, dipropylene glycol, 1,3-butylene glycol, hexylene glycol, glycerin,
Diglycerin, xylitol, maltitol, maltose, D-mannitol, water candy, glucose, fructose, lactose,
A moisturizing agent such as chondroitin sulfate sodium, sodium hyaluronate, sodium adenosine phosphate, sodium lactate, bile salt, pyrrolidone carboxylic acid, glucosamine, cyclodextrin, etc., is contained in the composition for suppressing aging of the present invention as a skin external preparation. Can be blended.

Further, as a drug component, a drug having a medicinal effect other than the above-mentioned antioxidant, for example, vitamins such as inosit, pyridoxine hydrochloride, benzyl nicotinate, nicotinamide, vitamin D ₂ (ergocalciferol), biotin; estradiol; Hormones such as ethinyl estradiol; anti-inflammatory agents such as allantoin, azulene and glycyrrhetinic acid; whitening agents such as arbutin; astringents such as zinc oxide and tannic acid; cooling agents such as L-menthol and camphor; sulfur; lysozyme chloride; Can be added to the composition for suppressing aging of the present invention as an external preparation for skin. In addition, an extract other than the crude drug extract that can be used as the above-mentioned antioxidant can be incorporated into the composition for suppressing aging of the present invention as an external preparation for skin.

The other components listed above are not limited to other components that can be added to the composition for suppressing an aging odor of the present invention. In addition to the above-mentioned medicinal ingredients, besides being solely incorporated into the composition for suppressing aging of the present invention as an external preparation for the skin, two or more kinds of the above-mentioned ingredients are appropriately combined and combined according to the purpose. It is also possible.

The composition for suppressing an aging odor according to the present invention may be used as an external preparation for skin, such as pharmaceuticals, quasi-drugs (ointments, dentifrices, etc.) and cosmetics (facial cleansers, emulsions, creams, gels, essences (cosmetics), Basic cosmetics such as packs and masks; makeup cosmetics such as foundations and lipsticks;
Aromatic cosmetics, hair cosmetics, body cosmetics, etc.]. These forms are not limited to possible forms of the composition for suppressing aging of the present invention as an external preparation for skin.

The dosage forms are aqueous, solubilizing, emulsifying, powder, oil-liquid, gel, ointment, aerosol,
A wide range of dosage forms such as a water-oil two-layer system and a water-oil-powder three-layer system can be adopted. In using the composition for suppressing an aging odor of the present invention as an external preparation for the skin, a known base component or the like depending on the desired form or dosage form may impair the intended effect of the present invention by its combination. It can be blended and used widely within a range that does not exist.

That is, oils such as liquid fats and oils, liquid or solid fats and oils, solid fats and oils, waxes and the like can be incorporated into the composition for suppressing aging odor of the present invention as a skin external preparation. Further, an ester oil, a hydrocarbon oil, or silicone can be blended in the composition for suppressing aging of the present invention as a skin external preparation.

Also, the present invention is applicable to a skin external preparation using surfactants such as anionic surfactants, cationic surfactants and amphoteric surfactants; lipophilic nonionic surfactants and hydrophilic nonionic surfactants. It can be blended into the composition for suppressing aging odor. And lower alcohols, sterols,
Plant-based, microbial, starch-based, animal-based, cellulose-based, alginic-acid-based, vinyl-based, acrylic-based, and water-soluble polymers as skin external preparations It can be blended in the composition for suppressing aging odor of the present invention.

Further, sequestering agents, neutralizing agents, pH
A regulator and the like can be incorporated into the composition for suppressing aging of the present invention as an external preparation for skin. Here, the above-mentioned base components and the like are merely examples, and the base components that can be incorporated into the composition for suppressing aging odor of the present invention as a skin external preparation are not limited to these base components and the like.

These base components can be combined with the composition for suppressing aging of the present invention as an external preparation for skin according to the formulation according to the desired form. The specific formulation of the composition for suppressing an aging odor of the present invention as a skin external preparation is described in Examples below.

Further, as described above, the composition for suppressing an aging odor according to the present invention includes means for preventing aging odor, which tends to adhere to clothes and the like, from being generated in the clothes and the like, It can also be used as a means to prevent odor from attaching to clothing. Specifically, it can be used, for example, in the form of a laundry finishing agent for clothes or a coating agent for clothes.

When used in such an embodiment, for example, a fixing agent or the like for fixing the composition for suppressing an aging odor of the present invention to an object such as clothing may be incorporated into the composition according to the purpose. it can. The composition for suppressing an aging odor of the present invention used in this aspect is preferably used, for example, in the form of a liquid or a spray.

[0050]

EXAMPLES Hereinafter, the present invention will be described more specifically with reference to Examples, but the scope of the present invention is not limited by these Examples. Unless otherwise specified, the compounding amount is represented by% by weight based on the entire system in which the component is compounded.

[Test Example 1] Generation test of age-related odor by microorganisms Skin bacterial flora is involved in generation of characteristic odors in various parts of the body, such as sweat odor, foot odor, armpit odor, and scalp odor. That is, for example foot odor, body odor and scalp odor respectively Staphylococcus Epidamidisu the occurrence of (dandruff smell) (Staphylococc
us epidermidis ), Corynebacterium minutissimum and Malassezia furfur are said to be involved, and sebum and sweat are decomposed by enzymes such as lipase and esterase to cause foot odor and armpit odor It is known to produce lower fatty acids such as isovaleric acid and 3-methyl-2-hexenoic acid, which are odor components characteristic of scalp odor. However, no association with body odor, particularly with generation of aging odor, has been reported.

Therefore, in order to prove the above-mentioned hypothesis, an experiment was conducted in vitro on the generation of an aging odor, focusing on the relationship between the generation of the aging odor and the skin bacterial flora.

[0053] Test Method Staphylococcus Epitamidisu (Staphylococcus
epidermidis : SE), Corynebacterium minutissimum (CM) and Malassezia furfur ( MF)
Then, one platinum loop was inoculated into 5 mL of a sensitive bouillon medium from a slant medium, and cultured with shaking at 37 ° C. for 24 hours. After this culture, the cells were collected by centrifugation, and each cell was washed with 0.1 M phosphate buffer (pH 7.4), and resuspended in 10 mL of the same buffer to obtain a test bacterial solution.

In a 200 mL Erlenmeyer flask, 0.1 M
30 mL of a phosphate buffer (pH 7.4), 1 mL of cis-9-hexadecenoic acid (Tokyo Kasei) and 10 mL of each test bacterial solution were added, followed by shaking culture at 37 ° C for 5 days. After completion of the culture, the mixture was extracted with diethyl ether under sulfuric acidity, dehydrated with anhydrous sodium sulfate, concentrated, and subjected to sensory evaluation and GC-MS analysis.

The results of this test are shown in Table 2. Table 2 ─────────────────────────────────── Aging odor Detected aldehyde ───── ＳＥ SE / hexadecenoic acid available Heptanal, heptenal, octenal, nonenal CM / hexadecenoic acid available (weak ) Heptanal, octenal, nonenal MF / hexadecenoic acid Yes (trace) Octenal, nonenal (all traces) ─────────────────────────── ────────

According to Table 2, it was found that hexadecenoic acid was decomposed by microorganisms present on the skin to produce an aging odor. It was also confirmed that aldehydes such as octenal and nonenal, which are components characteristic of the aging odor, were generated. These results clearly and experimentally support the hypothesis about the generation of aging odor.

[Test Example 2] Inhibition test of age-related odor by antibacterial agent According to the above-mentioned Test Example 1, sebum is decomposed by microorganisms present in the skin to produce aldehyde which is a characteristic component of the age-related odor. Therefore, we examined the effect of antibacterial agents to prevent the generation of aging odor.

Test Methods As examples of antibacterial agents, trichlorocarbanilide, benzalkonium chloride and dihydrofarnesol were examined for their effect of preventing the generation of aging odor. That is, Staphylococcus epidermidis:
One loopful of SE) was inoculated from a slant medium into 5 mL of a sensitive bouillon medium and cultured with shaking at 37 ° C. for 24 hours.

After this culture, the cells were collected by centrifugation, and the cells were washed with 0.1 M phosphate buffer (pH 7.4), and resuspended in 10 mL of the same buffer to obtain a test bacterial solution. In a 200 mL Erlenmeyer flask, 0.1 M phosphate buffer (pH 7.
4) 30 mL, cis-9-hexadecenoic acid (Tokyo Kasei) 1
Any of trichlorocarbanilide, benzalkonium chloride, and dihydrofarnesol was added to the mL and 10 mL of the test bacterial solution to a concentration of 0.05%, followed by shaking culture at 37 ° C for 5 days.

Dihydrofarnesol is all-
Dihydrofarnesol (3,7,11-trimethyl-6,10-dodecadien-1-ol) synthesized from trans-nerolidol was used. After completion of the culture, the mixture was extracted with diethyl ether under sulfuric acidity, dehydrated with anhydrous sodium sulfate, concentrated, and subjected to sensory evaluation and GC-MS analysis.

The results are shown in Table 3. Table 3 抗菌 Antibacterial agent Aging odor aldehyde detected ─── ──────────────────────────────── Not added Yes Heptanal, heptenal, octenal, nonenal + trichlorocarbanilide No No + Benzalkonium chloride None None + Dihydrofarnesol None None ───────────────────────────────────

Table 3 shows that the addition of an antibacterial agent can suppress the decomposition of fatty acids by microorganisms and prevent the generation of an aging odor.

Next, the case where the composition for suppressing aging odor of the present invention takes the form of a skin external preparation which is a typical embodiment thereof will be examined. That is, the formulation of the composition for suppressing aging of the present invention as an external preparation for skin is described below along with Comparative Examples as Examples, and the sensory evaluation of these external preparations for skin is described below.
The procedure was as follows.

Method for sensory evaluation of external preparation for skin Select a person who is healthy middle-aged and elderly (50-70s) and who has judged by sensory evaluation that the body odor (aging odor) peculiar to middle-aged and elderly is strong. Were divided into a group using the body odor preventive agent of the prescription of the example and a group using the one shown in the comparative example. Then, in each group, the body odor preventive agent shown in the prescription example was used every day after or at the time of bathing (sprayed over the entire body as a spray). After this use was continued for 3 days, a sensory evaluation was performed by a specialized panel.

Judgment ◎: No odor at all ：: Almost no odor △: Slight odor ×: Strong odor

[0066] Example 1 Lotion Ingredients Amount (wt%) (1) Glycerin 4.0 (2) 1,3-butylene glycol 4.0 (3) Ethanol 7.0 (4) Polyoxyethylene (18) Oleyl alcohol ether 0.5 (5) Citric acid 0.05 (6) Sodium citrate 0.1 (7) Trisodium ethylenediaminetetraacetate 0.02 (8) Dihydrofarnesol 0.5 (9) Purified water Remaining

<Production method> Citric acid, sodium citrate, glycerin, 1,3-butylene glycol and trisodium ethylenediaminetetraacetate were dissolved in purified water to prepare an aqueous phase. Then, dihydrofarnesol and polyoxyethylene (18) oleyl alcohol ether were separately dissolved in ethanol. This was then added to the aqueous phase to solubilize it, and further filtered to obtain the desired lotion.

The lotion prepared in the same manner as in Example 1 except that component (8) was removed from the lotion having the formulation of Comparative Example 1 was prepared.
And

<Test Results> The sensory evaluation was conducted using the lotion of Example 1 and Comparative Example 1. The group sprayed with the lotion of Example 1 was replaced with the group sprayed with the lotion of the Comparative Example. In comparison, it was found that body odor was significantly reduced. The results are shown in Table 4.

Table 4 Panel No. Composition used Body odor after 3 days １ 1 Example 1 ○ 2 Example 1 ○ 3 Example 1 ◎ 4 Example 1 ◎ 5 Example 1 ○ 6 Comparative Example 1 × 7 Comparative Example 1 △ 8 Comparative Example 1 △ 9 Comparative Example 1 × 10 Comparative Example 1 △ ───────────── ────────────────

Example 2 Emulsion Component Amount (% by Weight) (1) Stearic Acid 1.5 (2) Cetyl Alcohol 0.5 (3) Beeswax 2.0 (4) Polyoxyethylene (10) Mono Oleic acid ester 1.0 (5) Octyl methoxycinnamate 2.0 (6) Benzalkonium chloride 0.2 (7) Sodium hyaluronate 0.01 (8) Triethanolamine 0.75 (9) Glycerin 7 0.0 (10) Inosit 0.5 (11) Sodium ethylenediaminehydroxytriacetate 0.01 (12) Purified water residue

<Production method> Benzalkonium chloride, sodium hyaluronate, glycerin, inosit and sodium ethylenediaminehydroxytriacetate were added, and
An aqueous phase was prepared while maintaining the temperature. On the other hand, other components were mixed, dissolved by heating, and kept at 70 ° C. to prepare an oil phase.
Next, this oil phase was added to the aqueous phase to carry out preliminary emulsification, and after uniform emulsification with a homomixer, the mixture was rapidly cooled with stirring to obtain a desired emulsion.

From the emulsion of the formulation of Example 2, the blending component (6) was removed, and an emulsion similarly prepared was used as Comparative Example 2.

When the emulsions of Example 2 and Comparative Example 2 were carefully applied to the upper body, the body odor of the subject was clearly alleviated.

Example 3 Lotion Type Spray Compounding Components (Weight%) (Stock solution formulation) (1) Zinc paraphenolsulfonate 2.0 (2) Ethanol 92.8 (3) 1,3-butylene Glycol 3.0 (4) Isopropyl myristate 2.0 (5) Trichlorocarbanide 0.2 (filling formulation) (6) Stock solution 50 (7) LPG 50

<Production method> The stock solution was dissolved in ethanol, filtered, and the obtained stock solution was poured into an aerosol container, fitted with a valve, and filled with LPG to prepare a desired cosmetic spray. .

The formulation (5) was removed from the undiluted component of the lotion spray having the formulation of Example 3 and a lotion spray prepared similarly was designated as Comparative Example 3.

<Test Results> The above-mentioned sensory evaluation was carried out using the lotion type sprays of Example 3 and Comparative Example 3. The group using the lotion type spray of Example 3 was the group using the lotion type spray of Comparative Example 3. It was found that the body odor was significantly reduced as compared with the group using the type spray.

[Example 4] Amount of the lotion component (% by weight) (1) Glycerin 4.0 (2) 1,3-butylene glycol 4.0 (3) Ethanol 7.0 (4) Polyoxyethylene (18) Oleyl alcohol ether 0.5 (5) Citric acid 0.05 (6) Sodium citrate 0.1 (7) Trisodium ethylenediaminetetraacetate 0.02 (8) Vitamin E 0.5 (9) Dihydrofarnesol 0.1 (10) Purified water residue

<Production Method> Citric acid, sodium citrate, glycerin, 1,3-butylene glycol and trisodium ethylenediaminetetraacetate were dissolved in purified water to prepare an aqueous phase. Separately, polyoxyethylene (18) oleyl alcohol ether, vitamin E and dihydrofarnesol were dissolved in ethanol, added to the aqueous phase, solubilized, and filtered to obtain a desired lotion.

From the lotion formulation of the formulation of Example 4,
The components (8) and (9) were removed, and a lotion similarly prepared was used as Comparative Example 4 (same as Comparative Example 1).

<Test Results> When the above-mentioned sensory evaluation was performed using the lotion of Example 4 and Comparative Example 4, the group sprayed with the lotion of Example 4 was replaced with the group sprayed with the lotion of the Comparative Example. In comparison, it was found that body odor was significantly reduced. The results are shown in Table 5.

Table 5 Panel No. Composition used Body odor after 3 days １ 1 Example 4 ○ 2 Example 4 ○ 3 Example 4 ◎ 4 Example 4 ◎ 5 Example 4 ◎ 6 Comparative Example 4 × 7 Comparative Example 4 △ 8 Comparative Example 4 △ 9 Comparative Example 4 × 10 Comparative Example 4 △ ───────────── ────────────────

[Example 5] Emulsion compounding ingredients (% by weight) (1) Stearic acid 1.5 (2) Cetyl alcohol 0.5 (3) Beeswax 2.0 (4) Polyoxyethylene (10) mono Oleic acid ester 1.0 (5) Octyl methoxycinnamate 2.0 (6) Benzalkonium chloride 0.2 (7) Tranexamic acid 0.5 (8) Sodium hyaluronate 0.01 (9) Triethanolamine 0.75 (10) Glycerin 7.0 (11) Inosit 0.5 (12) Sodium ethylenediaminehydroxytriacetate 0.01 (13) Purified water residue

<Production method> Benzalkonium chloride, tranexamic acid, sodium hyaluronate, glycerin, inosit and sodium ethylenediaminehydroxytriacetate were added to purified water, and the mixture was maintained at 70 ° C to prepare an aqueous phase. On the other hand, other components were mixed, dissolved by heating, and kept at 70 ° C. to prepare an oil phase. Next, this oil phase was added to the aqueous phase to carry out preliminary emulsification, and after uniform emulsification with a homomixer, the mixture was rapidly cooled with stirring to obtain a desired emulsion.

The ingredients (6) and (7) were removed from the emulsion of the formulation of Example 5, and an emulsion prepared similarly was designated as Comparative Example 5 (same as Comparative Example 2).

When the emulsions of Example 5 and Comparative Example 5 were applied carefully to the upper body, the body odor of the subject was clearly alleviated.

Example 6 A lotion-type spray compounding component (% by weight) (stock solution formulation) (1) zinc paraphenolsulfonate 2.0 (2) ethanol 92.6 (3) 1,3-butylene Glycol 3.0 (4) Isopropyl myristate 2.0 (5) Trichlorocarbanide 0.2 (6) Tranexamic acid 0.2 (filling formulation) (7) Stock solution 50 (8) LPG 50

<Production Method> First, the stock solution was dissolved in ethanol, filtered, and the obtained stock solution was poured into an aerosol container. After attaching a valve, LPG was filled and a desired lotion type spray was prepared. Prepared.

The ingredients (5) and (6) were removed from the stock solution of the lotion spray having the formulation of Example 6, and
Comparative Example 6 (Comparative Example 3)
And the same).

<Test Results> The sensory evaluation was carried out using the lotion type sprays of Example 6 and Comparative Example 6. The group using the lotion type spray of Example 6 was the group using the lotion type spray of Comparative Example 6. It was found that the body odor was significantly reduced as compared with the group using the type spray.

[Example 7] Amount (wt%) of lotion component (1) Glycerin 4.0 (2) 1,3-butylene glycol 4.0 (3) Ethanol 7.0 (4) Polyoxyethylene (18) Oleyl alcohol ether 0.5 (5) Citric acid 0.05 (6) Sodium citrate 0.1 (7) Trisodium ethylenediaminetetraacetate 0.02 (8) Curen extract 0.5 (9) β -Carotene 0.5 (10) Dihydrofarnesol 0.1 (11) Purified water residue

<Manufacturing method> Curen extract was prepared by adding 500 mL of water to 500 g of cullen and extracting at 50 ° C. for 60 minutes. After cooling, natural filtration was performed with filter paper, and purified water was further added to the filtrate. To prepare a total volume of 500 mL. Then, in purified water, citric acid, sodium citrate, glycerin, 1,3-butylene glycol, curen extract,
An aqueous phase was prepared by dissolving trisodium ethylenediaminetetraacetate. Separately, polyoxyethylene (18) oleyl alcohol ether, β-carotene and dihydrofarnesol are dissolved in ethanol, added to the above aqueous phase, solubilized, and filtered to obtain a desired lotion. Was.

From the formulation of the lotion of the formulation of Example 6,
The components (8), (9) and (10) were removed, and a lotion similarly prepared was used as Comparative Example 7 (same as Comparative Example 1).

<Test Results> The above-mentioned sensory evaluation was carried out using the lotion of Example 7 and Comparative Example 7. The group sprayed with the lotion of Example 7 was the same as the group sprayed with the lotion of the Comparative Example. In comparison, it was found that body odor was significantly reduced. The results are shown in Table 6.

Table 6 Panel No. Composition used Body odor after 3 days １ 1 Example 7 ◎ 2 Example 7 ◎ 3 Example 7 ◎ 4 Example 7 ◎ 5 Example 7 ○ 6 Comparative Example 7 × 7 Comparative Example 7 × 8 Comparative Example 7 △ 9 Comparative Example 7 × 10 Comparative Example 7 △ ───────────── ────────────────

Example 8 Emulsion Component Amount (% by Weight) (1) Stearic Acid 1.5 (2) Cetyl Alcohol 0.5 (3) Beeswax 2.0 (4) Polyoxyethylene (10) Mono Oleic acid ester 1.0 (5) Octyl methoxycinnamate 2.0 (6) Ogon extract 0.2 (7) Tranexamic acid 0.5 (8) Dihydrofarnesol 0.2 (9) Sodium hyaluronate 01 (10) Triethanolamine 0.75 (11) Glycerin 7.0 (12) Inosit 0.5 (13) Sodium ethylenediaminehydroxytriacetate 0.01 (14) Purified water residue

<Manufacturing method> The extract of Orgonum cruzi was obtained by adding purified water (500 mL) to 500 g of the root shreds excluding the pericarp of Oryzias laevis, extracting at 50 ° C for 60 minutes, cooling, and filtering naturally with filter paper to purify. Water was added to adjust the total volume to 500 mL. Then, a goug extract, tranexamic acid, sodium hyaluronate, glycerin, inosit and sodium ethylenediaminehydroxytriacetate were added to the purified water, and the mixture was maintained at 70 ° C. to prepare an aqueous phase. On the other hand,
Other components were mixed, dissolved by heating, and maintained at 70 ° C. to prepare an oil phase. Next, this oil phase was added to the aqueous phase to carry out preliminary emulsification, and after uniform emulsification with a homomixer, the mixture was rapidly cooled with stirring to obtain a desired emulsion.

The ingredients (6), (7) and (8) were removed from the emulsion of the formulation of Example 8, and an emulsion prepared similarly was designated as Comparative Example 8 (same as Comparative Example 2).

When the emulsions of Example 8 and Comparative Example 8 were applied carefully to the upper body, the body odor of the subject was clearly alleviated.

Example 9 Lotion type spray compounding ingredients (% by weight) (stock solution formulation) (1) Zinc paraphenol sulfonate 2.0 (2) Ethanol 92.4 (3) 1,3-butylene Glycol 3.0 (4) Isopropyl myristate 2.0 (5) Psycho extract 0.2 (6) Tranexamic acid 0.2 (7) Dihydrofarnesol 0.2 (filling formulation) (8) Stock solution 50 (9) LPG 50

<Production method> Psycho extract was prepared by adding 500 mL of purified water to 500 g of chopped root of Mishima saiko,
After extraction at 60 ° C. for 60 minutes, the mixture was cooled, filtered naturally with filter paper, and purified water was added to make a total volume of 500 mL. First, the stock solution was dissolved in ethanol, filtered, and the obtained stock solution was poured into an aerosol container, fitted with a valve, and then filled with LPG to prepare a desired cosmetic spray.

[0103] Comparative Example 9 was prepared by removing the ingredients (5), (6) and (7) from the stock solution of the lotion type spray having the formulation of Example 9 and preparing the same.
(Same as Comparative Example 3).

<Test Results> The sensory evaluation was conducted using the lotion type sprays of Example 9 and Comparative Example 9. The group using the lotion type spray of Example 9 was the group using the lotion type spray of Comparative Example 9. It was found that the body odor was significantly reduced as compared with the group using the type spray.

From these results, it was clarified that the composition for suppressing an aging odor of the present invention containing an antibacterial agent effectively removes the aging odor as an external preparation for the skin. In addition, it has been found that by combining, for example, an antioxidant and a lipoxygenase inhibitor together with an antibacterial agent, a more excellent aging odor removing effect can be exhibited.

[0106]

According to the present invention, there is provided a composition for suppressing an aging odor which can effectively remove the aging odor.

 ──────────────────────────────────────────────────続 き Continuing on the front page (72) Inventor Shoji Nakamura 1050 Nippa-cho, Kohoku-ku, Yokohama-shi, Kanagawa Prefecture Inside Shiseido First Research Center Co., Ltd. (72) Inventor Riki Saito 1050 Nippa-cho, Kohoku-ku, Yokohama-shi, Kanagawa (72) Inventor Kiyohito Sawano 1-4-11 Nishi-Hachiman, Hiratsuka-shi, Kanagawa Prefecture (72) Inventor Kazuo Yamazaki 1-4-11 Nishi-Hachiman, Hiratsuka-shi, Kanagawa Prefecture (72) Inventor Masataka Miyasaka 1-4-11 Nishihachiman, Hiratsuka-shi, Kanagawa

Claims (4)

[Claims] 1. A composition for suppressing aging odor, comprising an antibacterial agent. 2. The composition for suppressing an aging odor according to claim 1, wherein the composition for suppressing an aging odor is a composition for suppressing the generation of unsaturated aldehyde. 3. The composition for suppressing aging odor according to claim 2, wherein the unsaturated aldehyde is octenal and / or nonenal. 4. The composition for suppressing an aging odor is an external preparation for skin.
The composition for suppressing aging according to any one of claims 1 to 3.