JPS6040436B2 - ４，５，６，７‐テトラヒドロ‐チエノ〔２，３‐ｃ〕‐及び〔３，２‐ｃ〕ピリジン誘導体、その製造方法及び治療用組成物 - Google Patents
４，５，６，７‐テトラヒドロ‐チエノ〔２，３‐ｃ〕‐及び〔３，２‐ｃ〕ピリジン誘導体、その製造方法及び治療用組成物Info
- Publication number
- JPS6040436B2 JPS6040436B2 JP53000787A JP78778A JPS6040436B2 JP S6040436 B2 JPS6040436 B2 JP S6040436B2 JP 53000787 A JP53000787 A JP 53000787A JP 78778 A JP78778 A JP 78778A JP S6040436 B2 JPS6040436 B2 JP S6040436B2
- Authority
- JP
- Japan
- Prior art keywords
- formula
- tables
- formulas
- chemical formulas
- carbon atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
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- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000012299 nitrogen atmosphere Substances 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 125000006504 o-cyanobenzyl group Chemical group [H]C1=C([H])C(C#N)=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- SOQBVABWOPYFQZ-UHFFFAOYSA-N oxygen(2-);titanium(4+) Chemical class [O-2].[O-2].[Ti+4] SOQBVABWOPYFQZ-UHFFFAOYSA-N 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 229960001412 pentobarbital Drugs 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 239000002893 slag Substances 0.000 description 1
- 239000008107 starch Chemical class 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 238000002627 tracheal intubation Methods 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- KHPCPRHQVVSZAH-UHFFFAOYSA-N trans-cinnamyl beta-D-glucopyranoside Chemical class OC1C(O)C(O)C(CO)OC1OCC=CC1=CC=CC=C1 KHPCPRHQVVSZAH-UHFFFAOYSA-N 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7700408 | 1977-01-07 | ||
| FR7700408A FR2376860A1 (fr) | 1977-01-07 | 1977-01-07 | Tetrahydro-4,5,6,7 thieno (2,3-c) et (3,2-c) pyridines, leur procede de preparation et leur application therapeutique |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5387394A JPS5387394A (en) | 1978-08-01 |
| JPS6040436B2 true JPS6040436B2 (ja) | 1985-09-11 |
Family
ID=9185247
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP53000787A Expired JPS6040436B2 (ja) | 1977-01-07 | 1978-01-07 | ４，５，６，７‐テトラヒドロ‐チエノ〔２，３‐ｃ〕‐及び〔３，２‐ｃ〕ピリジン誘導体、その製造方法及び治療用組成物 |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US4147787A (en, 2012) |
| JP (1) | JPS6040436B2 (en, 2012) |
| AR (1) | AR217668A1 (en, 2012) |
| AT (1) | AT357532B (en, 2012) |
| AU (1) | AU508277B2 (en, 2012) |
| BE (1) | BE862695A (en, 2012) |
| CA (1) | CA1087187A (en, 2012) |
| CH (1) | CH631179A5 (en, 2012) |
| DD (1) | DD133673A5 (en, 2012) |
| DE (1) | DE2800596C2 (en, 2012) |
| DK (1) | DK147826C (en, 2012) |
| ES (1) | ES465683A1 (en, 2012) |
| FI (1) | FI62308C (en, 2012) |
| FR (1) | FR2376860A1 (en, 2012) |
| GB (1) | GB1574394A (en, 2012) |
| GR (1) | GR66061B (en, 2012) |
| HU (1) | HU175645B (en, 2012) |
| IE (1) | IE46288B1 (en, 2012) |
| IL (1) | IL53708A (en, 2012) |
| LU (1) | LU78816A1 (en, 2012) |
| MX (1) | MX5274E (en, 2012) |
| NL (1) | NL184220C (en, 2012) |
| NO (1) | NO780050L (en, 2012) |
| NZ (1) | NZ186168A (en, 2012) |
| PH (1) | PH12856A (en, 2012) |
| PL (1) | PL118048B1 (en, 2012) |
| PT (1) | PT67501B (en, 2012) |
| SE (1) | SE421922B (en, 2012) |
| SU (1) | SU683625A3 (en, 2012) |
| YU (1) | YU40023B (en, 2012) |
| ZA (1) | ZA7833B (en, 2012) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA743814B (en) * | 1973-06-15 | 1976-01-28 | Merck & Co Inc | Mercaptoalkylpyridines and derivatives |
| US4400384A (en) * | 1980-10-06 | 1983-08-23 | Sanofi, S.A. | 5-o-Cyanobenzyl-4,5,6,7-tetrahydrothieno [3,2-c] pyridine methanesulfonate and other novel salts thereof |
| US4448779A (en) * | 1981-07-16 | 1984-05-15 | Sanofi | Use of MS salt in geriatric medicine |
| US4775757A (en) * | 1986-09-22 | 1988-10-04 | Ortho Pharmaceutical Corporation | Thienopyridines useful as cardiovascular agents |
| US4906756A (en) * | 1988-05-10 | 1990-03-06 | Syntex (U.S.A.) Inc. | 2-(2-nitrovinyl)thiophene reduction and synthesis of thieno[3,2-c]pyridine derivatives |
| US5342953A (en) * | 1991-01-31 | 1994-08-30 | Syntex (U.S.A.) Inc. | N-2-chlorobenzyl-2-oxo and N-2-chlorobenzyl-2,2-dioxo-1,2,3-oxathiazolidine derivatives, their preparation and synthesis of thieno[3,2-c]pyridine derivatives therefrom |
| ATE177094T1 (de) * | 1992-07-31 | 1999-03-15 | Hoechst Ag | Verfahren zur biotechnischen herstellung von l- thienylalaninen in enantiomerenreiner form aus 2- hydroxy-3-thienyl-acrylsäuren und ihre verwendung |
| FR2710495B1 (fr) * | 1993-09-28 | 1995-10-27 | Celaflor Gmbh | Dispositif pour effectuer des traitements insecticides, et leur utilisation dans les habitations. |
| IL113196A0 (en) | 1994-03-31 | 1995-06-29 | Bristol Myers Squibb Co | Imidazole derivatives and pharmaceutical compositions containing the same |
| AU4288599A (en) * | 1998-07-01 | 2000-01-24 | Sun Pharmaceutical Industries Ltd. | Stable pharmaceutical compositions of thieno (3,2-c) pyridine derivatives |
| US6323215B1 (en) | 1999-07-09 | 2001-11-27 | Ortho-Mcneil Pharmaceutical, Inc. | Neurotrophic tetrahydroisoquinolines and tetrahydrothienopyridines, and related compositions and methods |
| ES2311498T3 (es) * | 2000-12-25 | 2009-02-16 | Daiichi Sankyo Company, Limited | Composiciones medicinales que contienen aspirina. |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3823151A (en) * | 1968-08-02 | 1974-07-09 | Ciba Geigy Corp | 4,5,6,7-tetrahydrothieno(2,3-d)pyridines |
| FR2215948B1 (en, 2012) * | 1973-02-01 | 1976-05-14 | Centre Etd Ind Pharma | |
| US3997545A (en) * | 1973-07-23 | 1976-12-14 | Takeda Chemical Industries, Ltd. | Thienopyridine-carboxylic acid derivatives |
| FR2312246A1 (fr) * | 1975-05-28 | 1976-12-24 | Parcor | Derives de la tetrahydro-4,5,6,7 thieno (3,2-c) pyridine, leur procede de preparation et leurs applications |
| FR2312247A1 (fr) * | 1975-05-30 | 1976-12-24 | Parcor | Derives de la thieno-pyridine, leur procede de preparation et leurs applications |
-
1977
- 1977-01-07 FR FR7700408A patent/FR2376860A1/fr active Granted
- 1977-12-22 YU YU3040/77A patent/YU40023B/xx unknown
- 1977-12-27 US US05/864,939 patent/US4147787A/en not_active Expired - Lifetime
- 1977-12-28 IL IL53708A patent/IL53708A/xx unknown
- 1977-12-30 SE SE7714940A patent/SE421922B/sv not_active IP Right Cessation
- 1977-12-30 IE IE2655/77A patent/IE46288B1/en unknown
-
1978
- 1978-01-02 NL NLAANVRAGE7800034,A patent/NL184220C/xx not_active IP Right Cessation
- 1978-01-03 GB GB68/78A patent/GB1574394A/en not_active Expired
- 1978-01-03 HU HU78PA1299A patent/HU175645B/hu unknown
- 1978-01-04 CA CA294,348A patent/CA1087187A/en not_active Expired
- 1978-01-04 ZA ZA00780033A patent/ZA7833B/xx unknown
- 1978-01-04 CH CH7178A patent/CH631179A5/fr not_active IP Right Cessation
- 1978-01-04 GR GR55094A patent/GR66061B/el unknown
- 1978-01-04 AT AT6178A patent/AT357532B/de not_active IP Right Cessation
- 1978-01-05 LU LU78816A patent/LU78816A1/xx unknown
- 1978-01-05 ES ES465683A patent/ES465683A1/es not_active Expired
- 1978-01-05 AR AR270641A patent/AR217668A1/es active
- 1978-01-05 DD DD7800203109A patent/DD133673A5/xx not_active IP Right Cessation
- 1978-01-06 SU SU782562904A patent/SU683625A3/ru active
- 1978-01-06 NZ NZ186168A patent/NZ186168A/xx unknown
- 1978-01-06 BE BE184146A patent/BE862695A/xx not_active IP Right Cessation
- 1978-01-06 NO NO780050A patent/NO780050L/no unknown
- 1978-01-06 DK DK7578A patent/DK147826C/da not_active IP Right Cessation
- 1978-01-06 AU AU32238/78A patent/AU508277B2/en not_active Expired
- 1978-01-06 MX MX786754U patent/MX5274E/es unknown
- 1978-01-06 PL PL1978203863A patent/PL118048B1/pl unknown
- 1978-01-06 PT PT67501A patent/PT67501B/pt unknown
- 1978-01-06 FI FI780048A patent/FI62308C/fi not_active IP Right Cessation
- 1978-01-07 DE DE2800596A patent/DE2800596C2/de not_active Expired
- 1978-01-07 JP JP53000787A patent/JPS6040436B2/ja not_active Expired
- 1978-01-09 PH PH20633A patent/PH12856A/en unknown
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