JPS6028933A - 新規な多糖体、その製造法、及び該多糖体を有効成分とする癌症状改善剤 - Google Patents
新規な多糖体、その製造法、及び該多糖体を有効成分とする癌症状改善剤Info
- Publication number
- JPS6028933A JPS6028933A JP58135089A JP13508983A JPS6028933A JP S6028933 A JPS6028933 A JP S6028933A JP 58135089 A JP58135089 A JP 58135089A JP 13508983 A JP13508983 A JP 13508983A JP S6028933 A JPS6028933 A JP S6028933A
- Authority
- JP
- Japan
- Prior art keywords
- iia
- sugar
- polysaccharide
- observed
- gel filtration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000004676 glycans Chemical class 0.000 title claims abstract description 21
- 229920001282 polysaccharide Polymers 0.000 title claims abstract description 21
- 239000005017 polysaccharide Substances 0.000 title claims abstract description 21
- 208000024891 symptom Diseases 0.000 title claims abstract description 6
- 239000004480 active ingredient Substances 0.000 title claims description 4
- 238000002360 preparation method Methods 0.000 title abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 24
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims abstract description 15
- 239000007864 aqueous solution Substances 0.000 claims abstract description 14
- 238000001641 gel filtration chromatography Methods 0.000 claims abstract description 13
- 235000001287 Guettarda speciosa Nutrition 0.000 claims abstract description 12
- 239000000843 powder Substances 0.000 claims abstract description 11
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000002244 precipitate Substances 0.000 claims abstract description 10
- 241000196324 Embryophyta Species 0.000 claims abstract description 9
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000003960 organic solvent Substances 0.000 claims abstract description 8
- 241000208173 Apiaceae Species 0.000 claims abstract description 7
- 239000000243 solution Substances 0.000 claims abstract description 7
- 238000000921 elemental analysis Methods 0.000 claims abstract description 5
- 229910017053 inorganic salt Inorganic materials 0.000 claims abstract description 5
- 230000002209 hydrophobic effect Effects 0.000 claims abstract description 4
- 238000000108 ultra-filtration Methods 0.000 claims abstract description 3
- 229930182830 galactose Natural products 0.000 claims abstract 4
- 235000000346 sugar Nutrition 0.000 claims description 20
- 241000125175 Angelica Species 0.000 claims description 11
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 8
- 239000000470 constituent Substances 0.000 claims description 8
- 238000005199 ultracentrifugation Methods 0.000 claims description 8
- 238000000862 absorption spectrum Methods 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 6
- 239000000126 substance Substances 0.000 claims description 6
- 150000008163 sugars Chemical class 0.000 claims description 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 4
- 238000010521 absorption reaction Methods 0.000 claims description 4
- 229910052799 carbon Inorganic materials 0.000 claims description 4
- 238000001962 electrophoresis Methods 0.000 claims description 4
- 238000000655 nuclear magnetic resonance spectrum Methods 0.000 claims description 4
- 230000003287 optical effect Effects 0.000 claims description 4
- 238000000746 purification Methods 0.000 claims description 4
- 238000005160 1H NMR spectroscopy Methods 0.000 claims description 3
- 238000011033 desalting Methods 0.000 claims description 3
- 239000000385 dialysis solution Substances 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 238000005481 NMR spectroscopy Methods 0.000 claims 3
- BPPVUXSMLBXYGG-UHFFFAOYSA-N 4-[3-(4,5-dihydro-1,2-oxazol-3-yl)-2-methyl-4-methylsulfonylbenzoyl]-2-methyl-1h-pyrazol-3-one Chemical compound CC1=C(C(=O)C=2C(N(C)NC=2)=O)C=CC(S(C)(=O)=O)=C1C1=NOCC1 BPPVUXSMLBXYGG-UHFFFAOYSA-N 0.000 claims 1
- 241001091551 Clio Species 0.000 claims 1
- 101100027998 Schizosaccharomyces pombe (strain 972 / ATCC 24843) omh2 gene Proteins 0.000 claims 1
- 239000006286 aqueous extract Substances 0.000 claims 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 abstract description 5
- 235000011130 ammonium sulphate Nutrition 0.000 abstract description 5
- 239000003125 aqueous solvent Substances 0.000 abstract description 5
- 230000001737 promoting effect Effects 0.000 abstract description 5
- 229920006395 saturated elastomer Polymers 0.000 abstract description 4
- 238000000354 decomposition reaction Methods 0.000 abstract description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract description 2
- 235000019789 appetite Nutrition 0.000 abstract description 2
- 230000036528 appetite Effects 0.000 abstract description 2
- 230000002401 inhibitory effect Effects 0.000 abstract description 2
- 239000003053 toxin Substances 0.000 abstract description 2
- 231100000765 toxin Toxicity 0.000 abstract description 2
- 150000001720 carbohydrates Chemical class 0.000 abstract 2
- 239000003925 fat Substances 0.000 abstract 2
- 239000003921 oil Substances 0.000 abstract 2
- 244000061520 Angelica archangelica Species 0.000 abstract 1
- 239000000706 filtrate Substances 0.000 abstract 1
- 238000002523 gelfiltration Methods 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 9
- 239000007924 injection Substances 0.000 description 7
- 238000002347 injection Methods 0.000 description 7
- 206010003445 Ascites Diseases 0.000 description 6
- 206010028980 Neoplasm Diseases 0.000 description 6
- 201000011510 cancer Diseases 0.000 description 6
- 239000003814 drug Substances 0.000 description 5
- 230000004130 lipolysis Effects 0.000 description 5
- 201000007270 liver cancer Diseases 0.000 description 5
- 208000014018 liver neoplasm Diseases 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 239000002904 solvent Substances 0.000 description 5
- 241000700159 Rattus Species 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- 238000000502 dialysis Methods 0.000 description 4
- 239000012153 distilled water Substances 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 239000000275 Adrenocorticotropic Hormone Substances 0.000 description 3
- 101800000414 Corticotropin Proteins 0.000 description 3
- 102100027467 Pro-opiomelanocortin Human genes 0.000 description 3
- 210000000577 adipose tissue Anatomy 0.000 description 3
- 238000005119 centrifugation Methods 0.000 description 3
- IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 description 3
- 229960000258 corticotropin Drugs 0.000 description 3
- 238000001990 intravenous administration Methods 0.000 description 3
- 238000004255 ion exchange chromatography Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 238000005377 adsorption chromatography Methods 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 206010061428 decreased appetite Diseases 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 235000021050 feed intake Nutrition 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 238000004128 high performance liquid chromatography Methods 0.000 description 2
- 230000002366 lipolytic effect Effects 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 238000001644 13C nuclear magnetic resonance spectroscopy Methods 0.000 description 1
- 101800000263 Acidic protein Proteins 0.000 description 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 240000005893 Pteridium aquilinum Species 0.000 description 1
- 235000009936 Pteridium aquilinum Nutrition 0.000 description 1
- 206010070863 Toxicity to various agents Diseases 0.000 description 1
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 1
- 238000011047 acute toxicity test Methods 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 150000001336 alkenes Chemical class 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Natural products N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 1
- 239000003708 ampul Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 208000022531 anorexia Diseases 0.000 description 1
- 230000004596 appetite loss Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 229940098773 bovine serum albumin Drugs 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 235000011148 calcium chloride Nutrition 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 231100000517 death Toxicity 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000012847 fine chemical Substances 0.000 description 1
- 238000005227 gel permeation chromatography Methods 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000003978 infusion fluid Substances 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 230000037356 lipid metabolism Effects 0.000 description 1
- 208000019017 loss of appetite Diseases 0.000 description 1
- 235000021266 loss of appetite Nutrition 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 231100000989 no adverse effect Toxicity 0.000 description 1
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 description 1
- 229940124595 oriental medicine Drugs 0.000 description 1
- 230000010287 polarization Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
- 238000003809 water extraction Methods 0.000 description 1
Landscapes
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58135089A JPS6028933A (ja) | 1983-07-26 | 1983-07-26 | 新規な多糖体、その製造法、及び該多糖体を有効成分とする癌症状改善剤 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58135089A JPS6028933A (ja) | 1983-07-26 | 1983-07-26 | 新規な多糖体、その製造法、及び該多糖体を有効成分とする癌症状改善剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6028933A true JPS6028933A (ja) | 1985-02-14 |
| JPH038361B2 JPH038361B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1991-02-05 |
Family
ID=15143571
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP58135089A Granted JPS6028933A (ja) | 1983-07-26 | 1983-07-26 | 新規な多糖体、その製造法、及び該多糖体を有効成分とする癌症状改善剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6028933A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999019365A1 (en) * | 1997-10-10 | 1999-04-22 | Korea Institute Of Science And Technology | Novel pectic polysaccharides purified from angelica gigas nakai and purification method and use as immuno-stimulating agent thereof |
| KR20030003669A (ko) * | 2001-03-24 | 2003-01-10 | 주식회사 메덱스바이오 | 강활 추출물을 유효성분으로 하는 다이옥신 유사물질에대한 길항성 조성물 |
| KR100413051B1 (ko) * | 2000-10-06 | 2003-12-31 | 주식회사 에이티엔씨 | 강활 추출물 또는 이로부터 분리한 화합물을 포함하는전립선 질환 치료 및 예방을 위한 조성물 및 그의 분리 방법 |
| KR100413964B1 (ko) * | 2000-10-06 | 2004-01-13 | 주식회사 에이티엔씨 | 강활추출물 또는 이로부터 분리한 화합물을 포함하는 암치료 및 예방을 위한 조성물 및 그의 분리 방법 |
| CN103864947A (zh) * | 2014-03-17 | 2014-06-18 | 重庆医科大学 | 当归多糖的分离提取工艺及其应用 |
-
1983
- 1983-07-26 JP JP58135089A patent/JPS6028933A/ja active Granted
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999019365A1 (en) * | 1997-10-10 | 1999-04-22 | Korea Institute Of Science And Technology | Novel pectic polysaccharides purified from angelica gigas nakai and purification method and use as immuno-stimulating agent thereof |
| KR100413051B1 (ko) * | 2000-10-06 | 2003-12-31 | 주식회사 에이티엔씨 | 강활 추출물 또는 이로부터 분리한 화합물을 포함하는전립선 질환 치료 및 예방을 위한 조성물 및 그의 분리 방법 |
| KR100413964B1 (ko) * | 2000-10-06 | 2004-01-13 | 주식회사 에이티엔씨 | 강활추출물 또는 이로부터 분리한 화합물을 포함하는 암치료 및 예방을 위한 조성물 및 그의 분리 방법 |
| KR20030003669A (ko) * | 2001-03-24 | 2003-01-10 | 주식회사 메덱스바이오 | 강활 추출물을 유효성분으로 하는 다이옥신 유사물질에대한 길항성 조성물 |
| CN103864947A (zh) * | 2014-03-17 | 2014-06-18 | 重庆医科大学 | 当归多糖的分离提取工艺及其应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH038361B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1991-02-05 |
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