JPS60258110A - 静脈注射可能なプロゲステロン乳化注射液 - Google Patents
静脈注射可能なプロゲステロン乳化注射液Info
- Publication number
- JPS60258110A JPS60258110A JP11525084A JP11525084A JPS60258110A JP S60258110 A JPS60258110 A JP S60258110A JP 11525084 A JP11525084 A JP 11525084A JP 11525084 A JP11525084 A JP 11525084A JP S60258110 A JPS60258110 A JP S60258110A
- Authority
- JP
- Japan
- Prior art keywords
- progesterone
- injection
- emulsified
- lecithin
- oil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 title claims abstract description 105
- 239000000186 progesterone Substances 0.000 title claims abstract description 51
- 229960003387 progesterone Drugs 0.000 title claims abstract description 51
- 239000003182 parenteral nutrition solution Substances 0.000 title abstract 2
- 238000002347 injection Methods 0.000 claims abstract description 29
- 239000007924 injection Substances 0.000 claims abstract description 29
- SESFRYSPDFLNCH-UHFFFAOYSA-N benzyl benzoate Chemical compound C=1C=CC=CC=1C(=O)OCC1=CC=CC=C1 SESFRYSPDFLNCH-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000000243 solution Substances 0.000 claims abstract description 19
- 235000015112 vegetable and seed oil Nutrition 0.000 claims abstract description 14
- 239000008158 vegetable oil Substances 0.000 claims abstract description 14
- 229960002903 benzyl benzoate Drugs 0.000 claims abstract description 12
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims abstract description 11
- 239000000787 lecithin Substances 0.000 claims abstract description 11
- 235000010445 lecithin Nutrition 0.000 claims abstract description 11
- 229940067606 lecithin Drugs 0.000 claims abstract description 11
- 239000002245 particle Substances 0.000 abstract description 20
- 235000012424 soybean oil Nutrition 0.000 abstract description 13
- 239000003549 soybean oil Substances 0.000 abstract description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 12
- JQWAHKMIYCERGA-UHFFFAOYSA-N (2-nonanoyloxy-3-octadeca-9,12-dienoyloxypropoxy)-[2-(trimethylazaniumyl)ethyl]phosphinate Chemical compound CCCCCCCCC(=O)OC(COP([O-])(=O)CC[N+](C)(C)C)COC(=O)CCCCCCCC=CCC=CCCCCC JQWAHKMIYCERGA-UHFFFAOYSA-N 0.000 abstract description 9
- 239000003921 oil Substances 0.000 abstract description 9
- 235000019198 oils Nutrition 0.000 abstract description 9
- 230000001954 sterilising effect Effects 0.000 abstract description 7
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 7
- 239000013078 crystal Substances 0.000 abstract description 6
- 239000011259 mixed solution Substances 0.000 abstract description 6
- 230000015572 biosynthetic process Effects 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 3
- 238000010438 heat treatment Methods 0.000 abstract description 3
- 239000002904 solvent Substances 0.000 abstract description 3
- -1 egg yolk lecithin Chemical compound 0.000 abstract description 2
- 230000007774 longterm Effects 0.000 abstract description 2
- 239000002244 precipitate Substances 0.000 abstract description 2
- 239000000431 corpus luteum hormone Substances 0.000 abstract 1
- 238000010253 intravenous injection Methods 0.000 abstract 1
- 239000000839 emulsion Substances 0.000 description 12
- 239000000203 mixture Substances 0.000 description 9
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 7
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 238000004945 emulsification Methods 0.000 description 6
- 238000001556 precipitation Methods 0.000 description 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- 229910052757 nitrogen Inorganic materials 0.000 description 4
- 239000003708 ampul Substances 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 239000012153 distilled water Substances 0.000 description 3
- 239000005457 ice water Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- BCKXLBQYZLBQEK-KVVVOXFISA-M Sodium oleate Chemical compound [Na+].CCCCCCCC\C=C/CCCCCCCC([O-])=O BCKXLBQYZLBQEK-KVVVOXFISA-M 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 230000001804 emulsifying effect Effects 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 238000010255 intramuscular injection Methods 0.000 description 2
- 239000007927 intramuscular injection Substances 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- 235000010356 sorbitol Nutrition 0.000 description 2
- 229940083466 soybean lecithin Drugs 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- WHUFYYNKCXXKSU-UHFFFAOYSA-M 3-benzylbenzoate Chemical compound [O-]C(=O)C1=CC=CC(CC=2C=CC=CC=2)=C1 WHUFYYNKCXXKSU-UHFFFAOYSA-M 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 239000007900 aqueous suspension Substances 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 235000012343 cottonseed oil Nutrition 0.000 description 1
- 239000002385 cottonseed oil Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 239000003978 infusion fluid Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000000583 progesterone congener Substances 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 229940045870 sodium palmitate Drugs 0.000 description 1
- GGXKEBACDBNFAF-UHFFFAOYSA-M sodium;hexadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCC([O-])=O GGXKEBACDBNFAF-UHFFFAOYSA-M 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11525084A JPS60258110A (ja) | 1984-06-05 | 1984-06-05 | 静脈注射可能なプロゲステロン乳化注射液 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11525084A JPS60258110A (ja) | 1984-06-05 | 1984-06-05 | 静脈注射可能なプロゲステロン乳化注射液 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS60258110A true JPS60258110A (ja) | 1985-12-20 |
| JPH047724B2 JPH047724B2 (cg-RX-API-DMAC10.html) | 1992-02-12 |
Family
ID=14658044
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP11525084A Granted JPS60258110A (ja) | 1984-06-05 | 1984-06-05 | 静脈注射可能なプロゲステロン乳化注射液 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS60258110A (cg-RX-API-DMAC10.html) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62192322A (ja) * | 1986-02-13 | 1987-08-22 | カビ・フアーマシア・アクチエボラーグ | 静脈内投与用組成物およびその製法 |
| US4927816A (en) * | 1987-08-20 | 1990-05-22 | Ester George C | Formulae and methods for sublingual ingestion of natural progesterone |
| DE4440337A1 (de) * | 1994-11-11 | 1996-05-15 | Dds Drug Delivery Services Ges | Pharmazeutische Nanosuspensionen zur Arzneistoffapplikation als Systeme mit erhöhter Sättigungslöslichkeit und Lösungsgeschwindigkeit |
| FR2832065A1 (fr) * | 2001-11-13 | 2003-05-16 | Besins Int Belgique | Composition pharmaceutique a base de progesterone micronisee son procede de preparation et ses utilisations |
| JP2006527736A (ja) * | 2003-06-18 | 2006-12-07 | ベー・ブラウン・メルズンゲン・アクチエンゲゼルシャフト | 出生後ホルモン置換のためのオイルエマルジョン |
| JP2009534425A (ja) * | 2006-04-20 | 2009-09-24 | アムゲン インコーポレイティッド | 安定乳化製剤 |
| WO2011134944A2 (en) | 2010-04-26 | 2011-11-03 | Besins Healthcare Luxembourg Sarl | Low-oil pharmaceutical emulsion compositions comprising progestogen |
| WO2013127728A1 (en) | 2012-02-29 | 2013-09-06 | B. Braun Melsungen Ag | Hormone containing emulsion |
| EP3178479A1 (en) * | 2015-12-08 | 2017-06-14 | Verano Ilac Sanayi Ve Ticaret A.S. | An injectable composition of ricobendazole |
| CN111346054A (zh) * | 2020-03-10 | 2020-06-30 | 上海图珐医药科技有限公司 | 一种黄体酮乳剂型注射剂及其制备方法 |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102233126B1 (ko) * | 2020-08-11 | 2021-03-26 | 주식회사 신세계아이앤씨 | 바코드 스캔 여부 검증 방법 및 시스템 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2715886A1 (de) * | 1976-04-14 | 1977-11-03 | Exxon Research Engineering Co | Injizierbare arzneimittelmischung |
| JPS56135416A (en) * | 1980-03-27 | 1981-10-22 | Mitsubishi Chem Ind Ltd | Pharmaceutical preparation for skin |
| JPS56167616A (en) * | 1980-05-15 | 1981-12-23 | Green Cross Corp:The | Steroid preparation |
-
1984
- 1984-06-05 JP JP11525084A patent/JPS60258110A/ja active Granted
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2715886A1 (de) * | 1976-04-14 | 1977-11-03 | Exxon Research Engineering Co | Injizierbare arzneimittelmischung |
| JPS56135416A (en) * | 1980-03-27 | 1981-10-22 | Mitsubishi Chem Ind Ltd | Pharmaceutical preparation for skin |
| JPS56167616A (en) * | 1980-05-15 | 1981-12-23 | Green Cross Corp:The | Steroid preparation |
Cited By (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62192322A (ja) * | 1986-02-13 | 1987-08-22 | カビ・フアーマシア・アクチエボラーグ | 静脈内投与用組成物およびその製法 |
| US4927816A (en) * | 1987-08-20 | 1990-05-22 | Ester George C | Formulae and methods for sublingual ingestion of natural progesterone |
| DE4440337A1 (de) * | 1994-11-11 | 1996-05-15 | Dds Drug Delivery Services Ges | Pharmazeutische Nanosuspensionen zur Arzneistoffapplikation als Systeme mit erhöhter Sättigungslöslichkeit und Lösungsgeschwindigkeit |
| US5858410A (en) * | 1994-11-11 | 1999-01-12 | Medac Gesellschaft Fur Klinische Spezialpraparate | Pharmaceutical nanosuspensions for medicament administration as systems with increased saturation solubility and rate of solution |
| FR2832065A1 (fr) * | 2001-11-13 | 2003-05-16 | Besins Int Belgique | Composition pharmaceutique a base de progesterone micronisee son procede de preparation et ses utilisations |
| WO2003041720A1 (fr) * | 2001-11-13 | 2003-05-22 | Besins International Belgique | Composition pharmaceutique a base de progesterone micronisee, son procede de preparation et ses utilisations |
| JP2006527736A (ja) * | 2003-06-18 | 2006-12-07 | ベー・ブラウン・メルズンゲン・アクチエンゲゼルシャフト | 出生後ホルモン置換のためのオイルエマルジョン |
| JP2009534425A (ja) * | 2006-04-20 | 2009-09-24 | アムゲン インコーポレイティッド | 安定乳化製剤 |
| WO2011134944A2 (en) | 2010-04-26 | 2011-11-03 | Besins Healthcare Luxembourg Sarl | Low-oil pharmaceutical emulsion compositions comprising progestogen |
| WO2011134937A2 (en) | 2010-04-26 | 2011-11-03 | Besins Healthcare Luxembourg Sarl | Pharmaceutical emulsion compositions comprising progestogen |
| WO2011134937A3 (en) * | 2010-04-26 | 2012-02-02 | Besins Healthcare Luxembourg Sarl | Pharmaceutical emulsion compositions comprising progestogen |
| WO2011134944A3 (en) * | 2010-04-26 | 2012-02-09 | Besins Healthcare Luxembourg Sarl | Low-oil pharmaceutical emulsion compositions comprising progestogen |
| EP2801353A1 (en) | 2010-04-26 | 2014-11-12 | Besins Healthcare Luxembourg | Pharmaceutical Emulsion Compositions Comprising Progestogen |
| EP2857042A1 (en) | 2010-04-26 | 2015-04-08 | Besins Healthcare Luxembourg | Low-oil pharmaceutical emulsion compositions comprising progestogen |
| WO2013127728A1 (en) | 2012-02-29 | 2013-09-06 | B. Braun Melsungen Ag | Hormone containing emulsion |
| WO2013127727A1 (en) | 2012-02-29 | 2013-09-06 | B. Braun Melsungen Ag | Hormone containing emulsion comprising krill phospholipids |
| EP3178479A1 (en) * | 2015-12-08 | 2017-06-14 | Verano Ilac Sanayi Ve Ticaret A.S. | An injectable composition of ricobendazole |
| WO2017097855A1 (en) * | 2015-12-08 | 2017-06-15 | Verano Ilac Sanayi Ticaret Anonim Sirketi | An injectable composition of ricobendazole |
| CN111346054A (zh) * | 2020-03-10 | 2020-06-30 | 上海图珐医药科技有限公司 | 一种黄体酮乳剂型注射剂及其制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH047724B2 (cg-RX-API-DMAC10.html) | 1992-02-12 |
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