JPS60251892A - Ｄ−ｎ−アセチルアミノ酸の製法 - Google Patents
Ｄ−ｎ−アセチルアミノ酸の製法Info
- Publication number
- JPS60251892A JPS60251892A JP10658784A JP10658784A JPS60251892A JP S60251892 A JPS60251892 A JP S60251892A JP 10658784 A JP10658784 A JP 10658784A JP 10658784 A JP10658784 A JP 10658784A JP S60251892 A JPS60251892 A JP S60251892A
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- acid
- acetyl
- acetylamino
- coa
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002253 acid Substances 0.000 title claims abstract description 18
- 150000008574 D-amino acids Chemical class 0.000 claims abstract description 20
- 150000008575 L-amino acids Chemical class 0.000 claims abstract description 11
- LIPOUNRJVLNBCD-UHFFFAOYSA-N acetyl dihydrogen phosphate Chemical compound CC(=O)OP(O)(O)=O LIPOUNRJVLNBCD-UHFFFAOYSA-N 0.000 claims abstract description 9
- 108020002494 acetyltransferase Proteins 0.000 claims abstract description 7
- 102000005421 acetyltransferase Human genes 0.000 claims abstract description 7
- 239000005515 coenzyme Substances 0.000 claims abstract description 7
- 108700023175 Phosphate acetyltransferases Proteins 0.000 claims abstract description 6
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims abstract 2
- 238000000034 method Methods 0.000 claims description 11
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 claims description 2
- 238000006243 chemical reaction Methods 0.000 abstract description 28
- ZSLZBFCDCINBPY-ZSJPKINUSA-N acetyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 ZSLZBFCDCINBPY-ZSJPKINUSA-N 0.000 abstract description 20
- 108090000790 Enzymes Proteins 0.000 abstract description 11
- 102000004190 Enzymes Human genes 0.000 abstract description 11
- 230000003287 optical effect Effects 0.000 abstract description 3
- 229940024606 amino acid Drugs 0.000 description 16
- 235000001014 amino acid Nutrition 0.000 description 10
- 150000001413 amino acids Chemical class 0.000 description 9
- 239000002994 raw material Substances 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 5
- 102000004879 Racemases and epimerases Human genes 0.000 description 4
- 108090001066 Racemases and epimerases Proteins 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 3
- 239000000872 buffer Substances 0.000 description 3
- 229960004452 methionine Drugs 0.000 description 3
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- FFEARJCKVFRZRR-UHFFFAOYSA-N L-Methionine Natural products CSCCC(N)C(O)=O FFEARJCKVFRZRR-UHFFFAOYSA-N 0.000 description 2
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 2
- -1 N-acetylamino acids Chemical class 0.000 description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 2
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 2
- 238000006911 enzymatic reaction Methods 0.000 description 2
- 229930182817 methionine Natural products 0.000 description 2
- 235000006109 methionine Nutrition 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
- YLZOPXRUQYQQID-UHFFFAOYSA-N 3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)-1-[4-[2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidin-5-yl]piperazin-1-yl]propan-1-one Chemical group N1N=NC=2CN(CCC=21)CCC(=O)N1CCN(CC1)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F YLZOPXRUQYQQID-UHFFFAOYSA-N 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- JVWLWSBIRNPNPP-UHFFFAOYSA-N CC(OP(O)(O)=O)=O.Cl Chemical compound CC(OP(O)(O)=O)=O.Cl JVWLWSBIRNPNPP-UHFFFAOYSA-N 0.000 description 1
- 241000193403 Clostridium Species 0.000 description 1
- 239000004470 DL Methionine Substances 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 229930195722 L-methionine Natural products 0.000 description 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
- SNEIUMQYRCDYCH-LURJTMIESA-N N(alpha)-acetyl-L-arginine Chemical compound CC(=O)N[C@H](C(O)=O)CCCNC(N)=N SNEIUMQYRCDYCH-LURJTMIESA-N 0.000 description 1
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 description 1
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 description 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
- QWCKQJZIFLGMSD-UHFFFAOYSA-N alpha-aminobutyric acid Chemical compound CCC(N)C(O)=O QWCKQJZIFLGMSD-UHFFFAOYSA-N 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 229960003121 arginine Drugs 0.000 description 1
- 238000002306 biochemical method Methods 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 229940110377 dl- arginine Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000003456 ion exchange resin Substances 0.000 description 1
- 229920003303 ion-exchange polymer Polymers 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 230000006340 racemization Effects 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 230000002747 voluntary effect Effects 0.000 description 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10658784A JPS60251892A (ja) | 1984-05-28 | 1984-05-28 | Ｄ−ｎ−アセチルアミノ酸の製法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10658784A JPS60251892A (ja) | 1984-05-28 | 1984-05-28 | Ｄ−ｎ−アセチルアミノ酸の製法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS60251892A true JPS60251892A (ja) | 1985-12-12 |
| JPS6235758B2 JPS6235758B2 (enExample) | 1987-08-04 |
Family
ID=14437325
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10658784A Granted JPS60251892A (ja) | 1984-05-28 | 1984-05-28 | Ｄ−ｎ−アセチルアミノ酸の製法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS60251892A (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007222163A (ja) * | 2006-01-27 | 2007-09-06 | Ajinomoto Co Inc | Ｌ−アミノ酸の製造法 |
| EP4516919A4 (en) * | 2022-04-12 | 2025-11-26 | Mint Biotechnologies Co Ltd | PROCESSES FOR PREPARING N-ACETYLD-AMINO ACID, D-AMINO ACID AND D-AMINO ACID DERIVATIVES |
-
1984
- 1984-05-28 JP JP10658784A patent/JPS60251892A/ja active Granted
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007222163A (ja) * | 2006-01-27 | 2007-09-06 | Ajinomoto Co Inc | Ｌ−アミノ酸の製造法 |
| EP4516919A4 (en) * | 2022-04-12 | 2025-11-26 | Mint Biotechnologies Co Ltd | PROCESSES FOR PREPARING N-ACETYLD-AMINO ACID, D-AMINO ACID AND D-AMINO ACID DERIVATIVES |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6235758B2 (enExample) | 1987-08-04 |
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