JPS60217897A - 乳酸の分離精製方法 - Google Patents
乳酸の分離精製方法Info
- Publication number
- JPS60217897A JPS60217897A JP7544584A JP7544584A JPS60217897A JP S60217897 A JPS60217897 A JP S60217897A JP 7544584 A JP7544584 A JP 7544584A JP 7544584 A JP7544584 A JP 7544584A JP S60217897 A JPS60217897 A JP S60217897A
- Authority
- JP
- Japan
- Prior art keywords
- lactic acid
- crystals
- solution
- magnesium lactate
- magnesium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 title claims abstract description 96
- 239000004310 lactic acid Substances 0.000 title claims abstract description 48
- 235000014655 lactic acid Nutrition 0.000 title claims abstract description 48
- 238000000034 method Methods 0.000 title claims abstract description 37
- 239000013078 crystal Substances 0.000 claims abstract description 58
- 239000000243 solution Substances 0.000 claims abstract description 32
- OVGXLJDWSLQDRT-UHFFFAOYSA-L magnesium lactate Chemical compound [Mg+2].CC(O)C([O-])=O.CC(O)C([O-])=O OVGXLJDWSLQDRT-UHFFFAOYSA-L 0.000 claims abstract description 28
- 239000000626 magnesium lactate Substances 0.000 claims abstract description 24
- 235000015229 magnesium lactate Nutrition 0.000 claims abstract description 24
- 229960004658 magnesium lactate Drugs 0.000 claims abstract description 24
- 238000000855 fermentation Methods 0.000 claims abstract description 17
- 230000004151 fermentation Effects 0.000 claims abstract description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 16
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 claims abstract description 12
- 239000003456 ion exchange resin Substances 0.000 claims abstract description 9
- 229920003303 ion-exchange polymer Polymers 0.000 claims abstract description 9
- 238000000926 separation method Methods 0.000 claims abstract description 8
- 239000012266 salt solution Substances 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 abstract description 9
- 150000002681 magnesium compounds Chemical class 0.000 abstract description 8
- 239000007864 aqueous solution Substances 0.000 abstract description 5
- 239000007788 liquid Substances 0.000 description 22
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 description 13
- 239000001527 calcium lactate Substances 0.000 description 13
- 235000011086 calcium lactate Nutrition 0.000 description 13
- 229960002401 calcium lactate Drugs 0.000 description 13
- 239000012535 impurity Substances 0.000 description 10
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 7
- 239000012153 distilled water Substances 0.000 description 7
- 238000000746 purification Methods 0.000 description 7
- 241000894006 Bacteria Species 0.000 description 6
- 238000001816 cooling Methods 0.000 description 6
- 230000001580 bacterial effect Effects 0.000 description 5
- 238000002425 crystallisation Methods 0.000 description 5
- 230000008025 crystallization Effects 0.000 description 5
- 150000003839 salts Chemical class 0.000 description 5
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
- JVTAAEKCZFNVCJ-REOHCLBHSA-N L-lactic acid Chemical compound C[C@H](O)C(O)=O JVTAAEKCZFNVCJ-REOHCLBHSA-N 0.000 description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 4
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 4
- 238000001035 drying Methods 0.000 description 4
- 229940001447 lactate Drugs 0.000 description 4
- 238000001556 precipitation Methods 0.000 description 4
- 238000001953 recrystallisation Methods 0.000 description 4
- 241000235527 Rhizopus Species 0.000 description 3
- 239000003729 cation exchange resin Substances 0.000 description 3
- 239000012141 concentrate Substances 0.000 description 3
- 238000007796 conventional method Methods 0.000 description 3
- 238000004042 decolorization Methods 0.000 description 3
- 238000004821 distillation Methods 0.000 description 3
- 238000002955 isolation Methods 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 239000011347 resin Substances 0.000 description 3
- 229920005989 resin Polymers 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 description 2
- 230000003544 deproteinization Effects 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 230000003472 neutralizing effect Effects 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 description 1
- 239000001888 Peptone Substances 0.000 description 1
- 108010080698 Peptones Proteins 0.000 description 1
- 240000005384 Rhizopus oryzae Species 0.000 description 1
- 235000013752 Rhizopus oryzae Nutrition 0.000 description 1
- 241000033695 Sige Species 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
- 235000011130 ammonium sulphate Nutrition 0.000 description 1
- 239000003957 anion exchange resin Substances 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 229940041514 candida albicans extract Drugs 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 230000032050 esterification Effects 0.000 description 1
- 238000005886 esterification reaction Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000005194 fractionation Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 description 1
- 239000000347 magnesium hydroxide Substances 0.000 description 1
- 229910001862 magnesium hydroxide Inorganic materials 0.000 description 1
- 229910001425 magnesium ion Inorganic materials 0.000 description 1
- 239000000395 magnesium oxide Substances 0.000 description 1
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 1
- 159000000003 magnesium salts Chemical class 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 235000019319 peptone Nutrition 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000001172 regenerating effect Effects 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
- 229940005581 sodium lactate Drugs 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 238000003828 vacuum filtration Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7544584A JPS60217897A (ja) | 1984-04-13 | 1984-04-13 | 乳酸の分離精製方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7544584A JPS60217897A (ja) | 1984-04-13 | 1984-04-13 | 乳酸の分離精製方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS60217897A true JPS60217897A (ja) | 1985-10-31 |
| JPS6338B2 JPS6338B2 (en, 2012) | 1988-01-05 |
Family
ID=13576456
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP7544584A Granted JPS60217897A (ja) | 1984-04-13 | 1984-04-13 | 乳酸の分離精製方法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS60217897A (en, 2012) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0191788A (ja) * | 1987-09-30 | 1989-04-11 | Shimadzu Corp | 乳酸の精製法 |
| WO2012081533A1 (ja) | 2010-12-13 | 2012-06-21 | 東レ株式会社 | 乳酸塩の製造方法 |
| JP2014530636A (ja) * | 2011-10-25 | 2014-11-20 | ピュラック バイオケム ビー． ブイ． | リグノセルロース物質を有機酸に転化する方法 |
| JP2015523968A (ja) * | 2012-05-24 | 2015-08-20 | ピュラック バイオケム ビー． ブイ． | マグネシウムカルボキシレート混合物からのカルボン酸回収 |
| JP2019513379A (ja) * | 2016-04-12 | 2019-05-30 | ピュラック バイオケム ビー． ブイ． | 乳酸マグネシウム発酵方法 |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0231498A (ja) * | 1988-07-21 | 1990-02-01 | Nippon Sanmou Senshoku Kk | 静電気除電マット |
| US7705180B2 (en) | 2004-06-17 | 2010-04-27 | Purac Biochem B.V. | Process for the preparation of lactic acid or lactate from a magnesium lactate comprising medium |
-
1984
- 1984-04-13 JP JP7544584A patent/JPS60217897A/ja active Granted
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0191788A (ja) * | 1987-09-30 | 1989-04-11 | Shimadzu Corp | 乳酸の精製法 |
| WO2012081533A1 (ja) | 2010-12-13 | 2012-06-21 | 東レ株式会社 | 乳酸塩の製造方法 |
| JP2014530636A (ja) * | 2011-10-25 | 2014-11-20 | ピュラック バイオケム ビー． ブイ． | リグノセルロース物質を有機酸に転化する方法 |
| JP2015523968A (ja) * | 2012-05-24 | 2015-08-20 | ピュラック バイオケム ビー． ブイ． | マグネシウムカルボキシレート混合物からのカルボン酸回収 |
| US9422217B2 (en) | 2012-05-24 | 2016-08-23 | Purac Biochem Bv | Carboxylic acid recovery from magnesium carboxylate mixture |
| JP2017071621A (ja) * | 2012-05-24 | 2017-04-13 | ピュラック バイオケム ビー． ブイ． | マグネシウムカルボキシレート混合物からのカルボン酸回収 |
| US10040746B2 (en) | 2012-05-24 | 2018-08-07 | Purac Biochem B.V. | Carboxylic acid recovery from magnesium carboxylate mixture |
| JP2019513379A (ja) * | 2016-04-12 | 2019-05-30 | ピュラック バイオケム ビー． ブイ． | 乳酸マグネシウム発酵方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6338B2 (en, 2012) | 1988-01-05 |
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