JPS60172343A - 多重マイクロカプセルの製造法およびその装置 - Google Patents
多重マイクロカプセルの製造法およびその装置Info
- Publication number
- JPS60172343A JPS60172343A JP2746084A JP2746084A JPS60172343A JP S60172343 A JPS60172343 A JP S60172343A JP 2746084 A JP2746084 A JP 2746084A JP 2746084 A JP2746084 A JP 2746084A JP S60172343 A JPS60172343 A JP S60172343A
- Authority
- JP
- Japan
- Prior art keywords
- nozzle
- component
- core component
- item
- multiplex
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003094 microcapsule Substances 0.000 title claims abstract description 24
- 239000008358 core component Substances 0.000 claims abstract description 40
- 239000000306 component Substances 0.000 claims abstract description 36
- 238000001816 cooling Methods 0.000 claims abstract description 5
- 239000010419 fine particle Substances 0.000 claims abstract description 5
- 239000011248 coating agent Substances 0.000 claims description 22
- 238000000576 coating method Methods 0.000 claims description 22
- 239000000463 material Substances 0.000 claims description 20
- 230000001681 protective effect Effects 0.000 claims description 18
- 239000007788 liquid Substances 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 16
- 239000010410 layer Substances 0.000 claims description 10
- 239000011241 protective layer Substances 0.000 claims description 10
- 239000002245 particle Substances 0.000 claims description 9
- 238000004519 manufacturing process Methods 0.000 claims description 8
- 239000003507 refrigerant Substances 0.000 claims description 5
- 238000005507 spraying Methods 0.000 claims description 5
- 239000000126 substance Substances 0.000 claims description 5
- 239000007921 spray Substances 0.000 claims description 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 3
- 239000012530 fluid Substances 0.000 claims description 3
- 108010010803 Gelatin Proteins 0.000 claims description 2
- 229920000159 gelatin Polymers 0.000 claims description 2
- 239000008273 gelatin Substances 0.000 claims description 2
- 235000019322 gelatine Nutrition 0.000 claims description 2
- 235000011852 gelatine desserts Nutrition 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 239000011882 ultra-fine particle Substances 0.000 claims description 2
- 229910001873 dinitrogen Inorganic materials 0.000 claims 1
- 238000007599 discharging Methods 0.000 claims 1
- 239000004552 water soluble powder Substances 0.000 claims 1
- 239000002775 capsule Substances 0.000 abstract description 13
- 238000007664 blowing Methods 0.000 abstract 1
- 239000002826 coolant Substances 0.000 abstract 1
- 239000000843 powder Substances 0.000 description 13
- 239000012085 test solution Substances 0.000 description 6
- 239000003814 drug Substances 0.000 description 4
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- 235000011293 Brassica napus Nutrition 0.000 description 2
- 240000008100 Brassica rapa Species 0.000 description 2
- 235000000540 Brassica rapa subsp rapa Nutrition 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 238000007711 solidification Methods 0.000 description 2
- 230000008023 solidification Effects 0.000 description 2
- 150000005846 sugar alcohols Polymers 0.000 description 2
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical class OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- DCXXMTOCNZCJGO-UHFFFAOYSA-N Glycerol trioctadecanoate Natural products CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 229960001138 acetylsalicylic acid Drugs 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000004203 carnauba wax Substances 0.000 description 1
- 235000013869 carnauba wax Nutrition 0.000 description 1
- 238000005354 coacervation Methods 0.000 description 1
- 230000001112 coagulating effect Effects 0.000 description 1
- 238000004581 coalescence Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 229940075507 glyceryl monostearate Drugs 0.000 description 1
- -1 glyhirides Chemical class 0.000 description 1
- 239000005457 ice water Substances 0.000 description 1
- 239000003317 industrial substance Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 235000011837 pasties Nutrition 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2746084A JPS60172343A (ja) | 1984-02-15 | 1984-02-15 | 多重マイクロカプセルの製造法およびその装置 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2746084A JPS60172343A (ja) | 1984-02-15 | 1984-02-15 | 多重マイクロカプセルの製造法およびその装置 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS60172343A true JPS60172343A (ja) | 1985-09-05 |
| JPH0526535B2 JPH0526535B2 (enExample) | 1993-04-16 |
Family
ID=12221724
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2746084A Granted JPS60172343A (ja) | 1984-02-15 | 1984-02-15 | 多重マイクロカプセルの製造法およびその装置 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS60172343A (enExample) |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06233369A (ja) * | 1992-12-10 | 1994-08-19 | Ki-Un Lee | 自動伴奏器が内装されたマイク |
| KR20020075745A (ko) * | 2002-08-01 | 2002-10-05 | 이상희 | 별난환(鼈卵丸)의 새로운 제환법(새로운 韓方的 방법에의한 자라알 모양의 환 제조방법) |
| WO2005025609A1 (ja) * | 2003-09-10 | 2005-03-24 | Nrl Pharma, Inc. | ラクトフェリン素材組成物 |
| JP2009519354A (ja) * | 2005-11-11 | 2009-05-14 | フイルメニツヒ ソシエテ アノニム | フレーバーおよび／またはフレグランスカプセル |
| WO2009128476A1 (ja) * | 2008-04-16 | 2009-10-22 | 森下仁丹株式会社 | 蓄熱シームレスカプセルおよびその製造方法 |
| JP2010184913A (ja) * | 2009-02-13 | 2010-08-26 | Freunt Ind Co Ltd | 微生物または生物由来物質含有微細粒子およびその製造方法 |
| WO2013145379A1 (ja) | 2012-03-30 | 2013-10-03 | 森下仁丹株式会社 | 大腸特異崩壊性カプセル |
| CN107486111A (zh) * | 2017-09-27 | 2017-12-19 | 广州立白企业集团有限公司 | 一种多层包埋微胶囊的制备方法 |
| WO2019111711A1 (ja) | 2017-12-08 | 2019-06-13 | 森下仁丹株式会社 | 非水素添加油脂で構成された三層構造カプセルおよびその製造方法 |
| WO2019142799A1 (ja) | 2018-01-18 | 2019-07-25 | 学校法人慶應義塾 | 潰瘍性大腸炎治療カプセル剤 |
| WO2020251039A1 (ja) | 2019-06-14 | 2020-12-17 | 森下仁丹株式会社 | 遅延崩壊型カプセルおよびその製造方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4992242A (enExample) * | 1972-12-28 | 1974-09-03 | ||
| JPS59173132A (ja) * | 1983-03-22 | 1984-10-01 | Matsumoto Yushi Seiyaku Kk | 耐溶剤性熱膨張性マイクロカプセル |
-
1984
- 1984-02-15 JP JP2746084A patent/JPS60172343A/ja active Granted
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4992242A (enExample) * | 1972-12-28 | 1974-09-03 | ||
| JPS59173132A (ja) * | 1983-03-22 | 1984-10-01 | Matsumoto Yushi Seiyaku Kk | 耐溶剤性熱膨張性マイクロカプセル |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06233369A (ja) * | 1992-12-10 | 1994-08-19 | Ki-Un Lee | 自動伴奏器が内装されたマイク |
| KR20020075745A (ko) * | 2002-08-01 | 2002-10-05 | 이상희 | 별난환(鼈卵丸)의 새로운 제환법(새로운 韓方的 방법에의한 자라알 모양의 환 제조방법) |
| WO2005025609A1 (ja) * | 2003-09-10 | 2005-03-24 | Nrl Pharma, Inc. | ラクトフェリン素材組成物 |
| JP2009519354A (ja) * | 2005-11-11 | 2009-05-14 | フイルメニツヒ ソシエテ アノニム | フレーバーおよび／またはフレグランスカプセル |
| JP5579597B2 (ja) * | 2008-04-16 | 2014-08-27 | 森下仁丹株式会社 | 蓄熱シームレスカプセルおよびその製造方法 |
| WO2009128476A1 (ja) * | 2008-04-16 | 2009-10-22 | 森下仁丹株式会社 | 蓄熱シームレスカプセルおよびその製造方法 |
| JP2010184913A (ja) * | 2009-02-13 | 2010-08-26 | Freunt Ind Co Ltd | 微生物または生物由来物質含有微細粒子およびその製造方法 |
| WO2013145379A1 (ja) | 2012-03-30 | 2013-10-03 | 森下仁丹株式会社 | 大腸特異崩壊性カプセル |
| CN107486111A (zh) * | 2017-09-27 | 2017-12-19 | 广州立白企业集团有限公司 | 一种多层包埋微胶囊的制备方法 |
| CN107486111B (zh) * | 2017-09-27 | 2019-08-06 | 广州立白企业集团有限公司 | 一种多层包埋微胶囊的制备方法 |
| WO2019111711A1 (ja) | 2017-12-08 | 2019-06-13 | 森下仁丹株式会社 | 非水素添加油脂で構成された三層構造カプセルおよびその製造方法 |
| WO2019142799A1 (ja) | 2018-01-18 | 2019-07-25 | 学校法人慶應義塾 | 潰瘍性大腸炎治療カプセル剤 |
| WO2020251039A1 (ja) | 2019-06-14 | 2020-12-17 | 森下仁丹株式会社 | 遅延崩壊型カプセルおよびその製造方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0526535B2 (enExample) | 1993-04-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EXPY | Cancellation because of completion of term |