JPS59500418A - 胃腸能動作用障害を回復する方法 - Google Patents

胃腸能動作用障害を回復する方法

Info

Publication number
JPS59500418A
JPS59500418A JP58501579A JP50157983A JPS59500418A JP S59500418 A JPS59500418 A JP S59500418A JP 58501579 A JP58501579 A JP 58501579A JP 50157983 A JP50157983 A JP 50157983A JP S59500418 A JPS59500418 A JP S59500418A
Authority
JP
Japan
Prior art keywords
opium
total weight
administration
result
functional
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP58501579A
Other languages
English (en)
Japanese (ja)
Other versions
JPH045647B2 (OSRAM
Inventor
クリ−ク・メアリ−・ジ−ン
フイツシユマン・ジヤツク
Original Assignee
ザ　ロツクフエラ−　ユニバ−シテイ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ザ　ロツクフエラ−　ユニバ−シテイ filed Critical ザ　ロツクフエラ−　ユニバ−シテイ
Publication of JPS59500418A publication Critical patent/JPS59500418A/ja
Publication of JPH045647B2 publication Critical patent/JPH045647B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pinball Game Machines (AREA)
  • Medicinal Preparation (AREA)
JP58501579A 1982-03-16 1983-03-14 胃腸能動作用障害を回復する方法 Granted JPS59500418A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US35882082A 1982-03-16 1982-03-16
US46411083A 1983-02-04 1983-02-04
US464110FREGB 1983-02-04
US358820FREGB 1983-02-04

Publications (2)

Publication Number Publication Date
JPS59500418A true JPS59500418A (ja) 1984-03-15
JPH045647B2 JPH045647B2 (OSRAM) 1992-02-03

Family

ID=27000205

Family Applications (1)

Application Number Title Priority Date Filing Date
JP58501579A Granted JPS59500418A (ja) 1982-03-16 1983-03-14 胃腸能動作用障害を回復する方法

Country Status (6)

Country Link
EP (1) EP0103636B1 (OSRAM)
JP (1) JPS59500418A (OSRAM)
CA (1) CA1212323A (OSRAM)
DE (1) DE3381877D1 (OSRAM)
IT (1) IT1212714B (OSRAM)
WO (1) WO1983003197A1 (OSRAM)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009539837A (ja) * 2006-06-05 2009-11-19 オレキシジェン・セラピューティクス・インコーポレーテッド ナルトレキソンの徐放型配合物
JP2014129397A (ja) * 2002-04-05 2014-07-10 Euro-Celtique Sa オキシコドン及びナロキソンを含有する医薬製剤

Families Citing this family (46)

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US4477457A (en) * 1982-10-28 1984-10-16 E. I. Du Pont De Nemours And Company Method for inducing anorexia using nalmetrene
EP0236477B1 (en) * 1985-09-06 1993-01-20 Baker Norton Pharmaceuticals, Inc. Use of 6-methylene-6-desoxy-n-cyclopropylmethyl-14-hydroxydihydronormorphine
EP0306575B1 (en) * 1987-09-10 1992-07-29 The University Of Chicago Quaternary derivatives of noroxymorphone which relieve nausea and emesis
DE19605590A1 (de) * 1996-02-15 1997-08-21 Inresa Arzneimittel Gmbh Verwendung eines transdermalen therapeutischen Naloxon-Systems (Naloxon TTS)
AU2059297A (en) * 1996-03-12 1997-10-01 Alza Corporation Composition and dosage form comprising opioid antagonist
DE19651551C2 (de) 1996-12-11 2000-02-03 Klinge Co Chem Pharm Fab Opioidantagonisthaltige galenische Formulierung
US6274591B1 (en) 1997-11-03 2001-08-14 Joseph F. Foss Use of methylnaltrexone and related compounds
US6375957B1 (en) 1997-12-22 2002-04-23 Euro-Celtique, S.A. Opioid agonist/opioid antagonist/acetaminophen combinations
NZ505192A (en) 1997-12-22 2003-05-30 Euro Celtique S A method of preventing abuse of opioid dosage forms , whereby opioid agonist and opioid antagonist are only extractable together
US6277384B1 (en) 1997-12-22 2001-08-21 Euro-Celtique S.A. Opioid agonist/antagonist combinations
DK1225897T3 (da) * 1999-11-01 2005-01-10 John Rhodes Sammensætning til behandling af obstipation og colon irritabile
MXPA02005336A (es) * 1999-11-29 2003-01-28 Adolor Corp Metodos novedosos para el tratamiento y prevencion del ileo.
US6469030B2 (en) 1999-11-29 2002-10-22 Adolor Corporation Methods for the treatment and prevention of ileus
ES2540103T3 (es) 2000-02-08 2015-07-08 Euro-Celtique S.A. Formulaciones orales de agonistas opioides resistentes a manipulaciones indebidas
US6716449B2 (en) 2000-02-08 2004-04-06 Euro-Celtique S.A. Controlled-release compositions containing opioid agonist and antagonist
CA2446550C (en) 2001-05-11 2012-03-06 Endo Pharmaceuticals, Inc. Abuse-resistant controlled-release opioid dosage form
PL367427A1 (en) 2001-08-06 2005-02-21 Euro-Celtique S.A. Opioid agonist formulations with releasable and sequestered antagonist
HRP20150037T4 (hr) 2003-04-08 2022-09-02 Progenics Pharmaceuticals, Inc. Farmaceutske formulacije koje sadrže metilnaltrekson
MY135852A (en) 2003-04-21 2008-07-31 Euro Celtique Sa Pharmaceutical products
DK2316456T3 (en) 2003-04-29 2017-09-11 Orexigen Therapeutics Inc Compositions for affecting weight loss comprising an opioid antagonist and bupropion
EP1702558A1 (en) 2005-02-28 2006-09-20 Euro-Celtique S.A. Method and device for the assessment of bowel function
US9662325B2 (en) 2005-03-07 2017-05-30 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
US8518962B2 (en) 2005-03-07 2013-08-27 The University Of Chicago Use of opioid antagonists
ES2714198T3 (es) 2005-03-07 2019-05-27 Univ Chicago Uso de antagonistas opioideos para atenuar la proliferación y la migración de células endoteliales
US8524731B2 (en) 2005-03-07 2013-09-03 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
US8858765B2 (en) 2005-05-20 2014-10-14 Ecolab Usa Inc. Acidic electrolyzed water production system and generation control method
AR057325A1 (es) 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
AR057035A1 (es) 2005-05-25 2007-11-14 Progenics Pharm Inc SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
WO2007055184A1 (ja) 2005-11-09 2007-05-18 Toray Industries, Inc. 機能性腸障害の治療または予防剤
JP5180092B2 (ja) 2005-11-22 2013-04-10 オレキシジェン・セラピューティクス・インコーポレーテッド インスリン感受性を増すための組成物および方法
US8916195B2 (en) 2006-06-05 2014-12-23 Orexigen Therapeutics, Inc. Sustained release formulation of naltrexone
ES2600141T3 (es) 2006-06-19 2017-02-07 Alpharma Pharmaceuticals Llc Composiciones farmacéuticas
TWI489984B (zh) 2006-08-04 2015-07-01 Wyeth Corp 用於非經腸道傳輸化合物之配方及其用途
AU2007319472B2 (en) 2006-11-09 2013-01-17 Nalpropion Pharmaceuticals Llc Methods Of Administering Weight Loss Medications
SI2139890T1 (sl) 2007-03-29 2014-12-31 Wyeth Llc Antagonisti perifernih opioidnih receptorjev in njih uporaba
CA2865389A1 (en) 2007-03-29 2008-10-09 Progenics Pharmaceuticals, Inc. Crystal forms and uses thereof
CL2008000905A1 (es) 2007-03-29 2008-08-22 Progenics Pharm Inc Compuestos derivados de morfina, antagonistas del receptor opioide periferico; metodo de preparacion; composicion farmaceutica; y uso para reducir los efectos de la actividad opioide endogena.
WO2009099411A1 (en) 2008-02-06 2009-08-13 Progenics Pharmaceuticals, Inc. Preparation and use of (r),(r)-2,2'-bis-methylnaltrexone
AU2009225434B2 (en) 2008-03-21 2014-05-22 The University Of Chicago Treatment with opioid antagonists and mTOR inhibitors
CA2725930A1 (en) 2008-05-30 2009-12-30 Orexigen Therapeutics, Inc. Methods for treating visceral fat conditions
CA2676881C (en) 2008-09-30 2017-04-25 Wyeth Peripheral opioid receptor antagonists and uses thereof
SMT201900023T1 (it) 2009-03-10 2019-02-28 Euro Celtique Sa Composizioni farmaceutiche a rilascio immediato comprendenti ossicodone e naloxone
ES2762113T3 (es) 2010-01-11 2020-05-22 Nalpropion Pharmaceuticals Inc Métodos de proporcionar terapia de pérdida de peso en pacientes con depresión mayor
KR20210012056A (ko) 2012-06-06 2021-02-02 오렉시젠 세러퓨틱스 인크. 과체중 및 비만의 치료 방법
WO2015011189A1 (en) 2013-07-23 2015-01-29 Euro-Celtique S.A. A combination of oxycodone and naloxone for use in treating pain in patients suffering from pain and a disease resulting in intestinal dysbiosis and/or increasing the risk for intestinal bacterial translocation
US8969371B1 (en) 2013-12-06 2015-03-03 Orexigen Therapeutics, Inc. Compositions and methods for weight loss in at risk patient populations

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3214341A (en) * 1962-01-15 1965-10-26 Feinstone Wolffe Harry Prolonged action medicament
JPS4961324A (OSRAM) * 1972-10-11 1974-06-14
JPS53119899A (en) * 1977-03-23 1978-10-19 Reckitt & Colmann Prod Ltd Morphine derivative
JPS53121798A (en) * 1977-03-23 1978-10-24 Reckitt & Colmann Prod Ltd Morphine derivative
JPS54117499A (en) * 1978-02-10 1979-09-12 Miles Lab 4*5 alphaaepoxymorphinanee66one compound* its manufacture and its pharmacological use
US4277605A (en) * 1980-03-07 1981-07-07 Bristol-Myers Company Chemical compounds

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3060086A (en) * 1958-07-21 1962-10-23 Abbott Lab Anti-diarrhea composition
US3254088A (en) 1961-03-14 1966-05-31 Lewenstein Morphine derivative
US3332950A (en) 1963-03-23 1967-07-25 Endo Lab 14-hydroxydihydronormorphinone derivatives
NL297631A (OSRAM) * 1963-06-03
US3320262A (en) 1964-09-22 1967-05-16 Lewenstein 14 hydroxy morphine and codeine carboxymethyloximes
US3896226A (en) 1971-11-26 1975-07-22 Lewinstein Evalina 6-methylene-6-desoxy dihydro morphine and codeine derivatives and pharmaceutically acceptable salts thereof, and use of the same as a narcotic antagonist
GB1522480A (en) * 1975-10-31 1978-08-23 British Ind Sand Rendering
GB1579818A (en) * 1977-06-07 1980-11-26 Yamanouchi Pharma Co Ltd Nifedipine-containing solid preparation composition
US4272541A (en) * 1978-06-02 1981-06-09 Miles Laboratories, Inc. 7,8 and 7-8 Substituted 4,5α-epoxymorphinan-6-one compounds, and methods of treating pain and drug dependence with them
US4176186A (en) 1978-07-28 1979-11-27 Boehringer Ingelheim Gmbh Quaternary derivatives of noroxymorphone which relieve intestinal immobility

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3214341A (en) * 1962-01-15 1965-10-26 Feinstone Wolffe Harry Prolonged action medicament
JPS4961324A (OSRAM) * 1972-10-11 1974-06-14
JPS53119899A (en) * 1977-03-23 1978-10-19 Reckitt & Colmann Prod Ltd Morphine derivative
JPS53121798A (en) * 1977-03-23 1978-10-24 Reckitt & Colmann Prod Ltd Morphine derivative
JPS54117499A (en) * 1978-02-10 1979-09-12 Miles Lab 4*5 alphaaepoxymorphinanee66one compound* its manufacture and its pharmacological use
US4277605A (en) * 1980-03-07 1981-07-07 Bristol-Myers Company Chemical compounds

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014129397A (ja) * 2002-04-05 2014-07-10 Euro-Celtique Sa オキシコドン及びナロキソンを含有する医薬製剤
JP2009539837A (ja) * 2006-06-05 2009-11-19 オレキシジェン・セラピューティクス・インコーポレーテッド ナルトレキソンの徐放型配合物
JP2016029111A (ja) * 2006-06-05 2016-03-03 オレキシジェン・セラピューティクス・インコーポレーテッド ナルトレキソンの徐放型配合物

Also Published As

Publication number Publication date
CA1212323A (en) 1986-10-07
WO1983003197A1 (en) 1983-09-29
EP0103636A1 (en) 1984-03-28
EP0103636A4 (en) 1986-03-04
JPH045647B2 (OSRAM) 1992-02-03
IT1212714B (it) 1989-11-30
EP0103636B1 (en) 1990-09-12
IT8320106A0 (it) 1983-03-16
DE3381877D1 (de) 1990-10-18

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