JPS5938240B2 - １６α↓−置換プレグネン類 - Google Patents

１６α↓−置換プレグネン類

Info

Publication number
JPS5938240B2
JPS5938240B2 JP51059529A JP5952976A JPS5938240B2 JP S5938240 B2 JPS5938240 B2 JP S5938240B2 JP 51059529 A JP51059529 A JP 51059529A JP 5952976 A JP5952976 A JP 5952976A JP S5938240 B2 JPS5938240 B2 JP S5938240B2
Authority
JP
Japan
Prior art keywords
fluoro
dione
hydroxypregn
ene
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP51059529A
Other languages
English (en)
Japanese (ja)
Other versions
JPS5253849A (en
Inventor
クリストフア・ミツチエル・シマラステイ
ラビ・ケイ・パーマ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of JPS5253849A publication Critical patent/JPS5253849A/ja
Publication of JPS5938240B2 publication Critical patent/JPS5938240B2/ja
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
    • C07J7/0025—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa substituted in position 16
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Cosmetics (AREA)
JP51059529A 1975-10-29 1976-05-22 １６α↓−置換プレグネン類 Expired JPS5938240B2 (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/626,947 US3976638A (en) 1975-10-29 1975-10-29 16α-ARYLCARBONYLPREGNENES

Publications (2)

Publication Number Publication Date
JPS5253849A JPS5253849A (en) 1977-04-30
JPS5938240B2 true JPS5938240B2 (ja) 1984-09-14

Family

ID=24512527

Family Applications (2)

Application Number Title Priority Date Filing Date
JP51059529A Expired JPS5938240B2 (ja) 1975-10-29 1976-05-22 １６α↓−置換プレグネン類
JP59005498A Pending JPS59161400A (ja) 1975-10-29 1984-01-14 １６α−置換プレグネン類の中間体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP59005498A Pending JPS59161400A (ja) 1975-10-29 1984-01-14 １６α−置換プレグネン類の中間体

Country Status (6)

Country Link
US (1) US3976638A (enExample)
JP (2) JPS5938240B2 (enExample)
CA (1) CA1064908A (enExample)
DE (1) DE2621620A1 (enExample)
FR (1) FR2329288A1 (enExample)
GB (1) GB1531079A (enExample)

Also Published As

Publication number Publication date
JPS59161400A (ja) 1984-09-12
DE2621620A1 (de) 1977-05-12
JPS5253849A (en) 1977-04-30
GB1531079A (en) 1978-11-01
CA1064908A (en) 1979-10-23
US3976638A (en) 1976-08-24
FR2329288A1 (fr) 1977-05-27
FR2329288B1 (enExample) 1979-08-24

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