JPS59159827A - 細胞毒性物質を結合した反応性重合体の製造法 - Google Patents

細胞毒性物質を結合した反応性重合体の製造法

Info

Publication number
JPS59159827A
JPS59159827A JP58032955A JP3295583A JPS59159827A JP S59159827 A JPS59159827 A JP S59159827A JP 58032955 A JP58032955 A JP 58032955A JP 3295583 A JP3295583 A JP 3295583A JP S59159827 A JPS59159827 A JP S59159827A
Authority
JP
Japan
Prior art keywords
group
polymer
reactive
cytotoxic substance
bonded
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP58032955A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0149298B2 (https=
Inventor
Yoshinori Kato
加藤　喜規
Takeshi Hara
健 原
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Ltd
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Priority to JP58032955A priority Critical patent/JPS59159827A/ja
Publication of JPS59159827A publication Critical patent/JPS59159827A/ja
Publication of JPH0149298B2 publication Critical patent/JPH0149298B2/ja
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polyamides (AREA)
  • Medicinal Preparation (AREA)
JP58032955A 1983-03-02 1983-03-02 細胞毒性物質を結合した反応性重合体の製造法 Granted JPS59159827A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP58032955A JPS59159827A (ja) 1983-03-02 1983-03-02 細胞毒性物質を結合した反応性重合体の製造法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP58032955A JPS59159827A (ja) 1983-03-02 1983-03-02 細胞毒性物質を結合した反応性重合体の製造法

Publications (2)

Publication Number Publication Date
JPS59159827A true JPS59159827A (ja) 1984-09-10
JPH0149298B2 JPH0149298B2 (https=) 1989-10-24

Family

ID=12373351

Family Applications (1)

Application Number Title Priority Date Filing Date
JP58032955A Granted JPS59159827A (ja) 1983-03-02 1983-03-02 細胞毒性物質を結合した反応性重合体の製造法

Country Status (1)

Country Link
JP (1) JPS59159827A (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60172935A (ja) * 1984-02-16 1985-09-06 Green Cross Corp:The 制癌作用物質複合体の製造方法
JPH0344399A (ja) * 1989-07-07 1991-02-26 Abbott Lab イオン捕捉試薬およびそれを用いた結合イムノアッセイ法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5731930A (en) * 1980-08-04 1982-02-20 Teijin Ltd Production of cytotoxic substance-bound reactive polymer

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5731930A (en) * 1980-08-04 1982-02-20 Teijin Ltd Production of cytotoxic substance-bound reactive polymer

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60172935A (ja) * 1984-02-16 1985-09-06 Green Cross Corp:The 制癌作用物質複合体の製造方法
JPH0344399A (ja) * 1989-07-07 1991-02-26 Abbott Lab イオン捕捉試薬およびそれを用いた結合イムノアッセイ法

Also Published As

Publication number Publication date
JPH0149298B2 (https=) 1989-10-24

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