JPS59108786A - ブリオスタチン類 - Google Patents

ブリオスタチン類

Info

Publication number
JPS59108786A
JPS59108786A JP58215148A JP21514883A JPS59108786A JP S59108786 A JPS59108786 A JP S59108786A JP 58215148 A JP58215148 A JP 58215148A JP 21514883 A JP21514883 A JP 21514883A JP S59108786 A JPS59108786 A JP S59108786A
Authority
JP
Japan
Prior art keywords
bryostatin
acid
methanol
spectrum
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP58215148A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0556357B2 (enExample
Inventor
ジヨ−ジ・ロバ−ト・ペテイツト
チヤ−リ−・エル・ヘラルド
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Arizona State University
Original Assignee
Arizona State University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arizona State University filed Critical Arizona State University
Publication of JPS59108786A publication Critical patent/JPS59108786A/ja
Publication of JPH0556357B2 publication Critical patent/JPH0556357B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP58215148A 1982-11-17 1983-11-17 ブリオスタチン類 Granted JPS59108786A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US44248782A 1982-11-17 1982-11-17
US06/513,148 US4560774A (en) 1982-11-17 1983-07-12 Macrocyclic lactones
US513148 1983-07-12
US442487 1995-05-14

Publications (2)

Publication Number Publication Date
JPS59108786A true JPS59108786A (ja) 1984-06-23
JPH0556357B2 JPH0556357B2 (enExample) 1993-08-19

Family

ID=27033183

Family Applications (1)

Application Number Title Priority Date Filing Date
JP58215148A Granted JPS59108786A (ja) 1982-11-17 1983-11-17 ブリオスタチン類

Country Status (4)

Country Link
US (1) US4560774A (enExample)
EP (1) EP0109811B1 (enExample)
JP (1) JPS59108786A (enExample)
DE (1) DE3363960D1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63183585A (ja) * 1986-07-28 1988-07-28 アリゾナ　ボ−ド　オブ　リ−ゼンツ ブリオスタチン類
JPH01308228A (ja) * 1988-01-13 1989-12-12 Univ Arizona Found 免疫調整剤

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4611066A (en) * 1984-08-10 1986-09-09 Arizona State University Bryostatins 4 to 8
CA1291036C (en) * 1986-04-23 1991-10-22 Edwin I. Stoltz Nasal administration of drugs
US5955501A (en) * 1986-06-11 1999-09-21 Procyon Pharmaceuticals, Inc. Protein kinase C modulators O
IL82811A0 (en) * 1986-06-11 1987-12-20 Alder Res Center Corp Anti-inflammatory compositions containing methanol derivatives and novel compounds contained therein
US5891906A (en) * 1986-06-11 1999-04-06 Procyon Pharmaceuticals, Inc. Polyacetate-derived phorboids having anti-inflammatory and other uses
US5891870A (en) * 1986-06-11 1999-04-06 Procyon Pharmaceuticals, Inc. Protein kinase C modulators Q
US5716968A (en) * 1986-06-11 1998-02-10 Procyon Pharmaceuticals, Inc. Protein kinase C modulators. H.
US6043270A (en) * 1986-06-11 2000-03-28 Procyon Pharmaceuticals, Inc. Protein kinase C modulators V
US5358711A (en) * 1987-11-23 1994-10-25 Johns Hopkins University Stimulation of stem cell growth by the bryostatins
IT1229569B (it) * 1989-04-17 1991-09-04 Giuliani Spa Derivati di acidi biliari, loro preparazione e composizioni farmaceutiche che li contengono.
US5072004A (en) * 1990-12-31 1991-12-10 Arizona Board Of Regents Acting On Behalf Of Arizona State University Synthetic conversion of bryostatin 2 into bryostatin 1
US5196447A (en) * 1991-08-08 1993-03-23 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting On Behalf Of Arizona State University Neristatin 1
US5393897A (en) * 1993-07-02 1995-02-28 Arizona Board Of Regents Acting On Behalf Of Arizona State University Isolation and structure of spongistatins 5,7,8 and 9
US5684036A (en) * 1994-02-18 1997-11-04 Harbor Branch Oceanographic Institution, Inc. Cytotoxic macrolides and methods of use
US5478861A (en) * 1994-02-18 1995-12-26 Harbor Branch Oceanographic Institution, Inc. Cytotoxic macrolides and methods of use
WO1997034598A1 (en) * 1996-03-20 1997-09-25 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Method of treating cancer using c-26 modified bryostatin
NZ336381A (en) * 1996-12-30 2000-11-24 Battelle Memorial Institute Formulation and method for treating neoplasms by inhalation
AUPO864097A0 (en) * 1997-08-19 1997-09-11 Peplin Pty Ltd Anti-cancer compounds
US6221153B1 (en) * 1998-06-09 2001-04-24 Trevor Percival Castor Method for producing large crystals of complex molecules
CA2393026A1 (en) * 1999-11-30 2001-06-07 Paul A. Wender Bryostatin analogues, synthetic methods and uses
US7256286B2 (en) * 1999-11-30 2007-08-14 The Board Of Trustees Of The Leland Stanford Junior University Bryostatin analogues, synthetic methods and uses
AUPQ801700A0 (en) * 2000-06-07 2000-06-29 Peplin Research Pty Ltd Enzyme and viral activation
AUPQ923100A0 (en) 2000-08-07 2000-08-31 Peplin Research Pty Ltd Treatment of prostate cancer
WO2002087423A2 (en) * 2001-05-02 2002-11-07 Blanchette Rockefeller Neurosciences Institute Carbonic anhydrase activators for enhancing learning and memory
US20080004332A1 (en) * 2002-03-07 2008-01-03 Alkon Daniel L Methods for alzheimer's disease treatment and cognitive enhancement
US6825229B2 (en) 2002-03-07 2004-11-30 Blanchette Rockefeller Neurosciences Institute Methods for Alzheimer's Disease treatment and cognitive enhancement
US20050065205A1 (en) * 2002-03-07 2005-03-24 Daniel Alkon Methods for Alzheimer's disease treatment and cognitive enhance
TW201207390A (en) * 2004-05-18 2012-02-16 Brni Neurosciences Inst Method for screening agent for antidepressant activity
WO2006063382A1 (en) * 2004-12-13 2006-06-22 Peplin Research Pty Ltd Treatment of solid cancers
US20070054890A1 (en) * 2005-07-29 2007-03-08 Alkon Daniel L Protein synthesis required for long-term memory is induced by PKC activation on days preceding associative learning
CN101360506A (zh) * 2005-11-25 2009-02-04 派普林研究股份有限公司 创伤愈合的方法
EP2762136A1 (en) 2006-07-28 2014-08-06 Blanchette Rockefeller Neurosciences, Institute Methods of stimulating cellular growth, synaptic remodeling and consolidation of long-term memory
CN101848726A (zh) 2007-02-09 2010-09-29 布朗歇特洛克菲勒神经科学研究所 苔藓抑素、苔藓抑素类似物和其它相关物质对头部创伤引起的记忆缺陷和脑损伤的疗效
ES2528033T3 (es) 2007-02-09 2015-02-03 Blanchette Rockefeller Neurosciences Institute Efectos terapéuticos de las briostatinas sobre la alteración de la memoria inducida por isquemia/accidente vascular cerebral y lesiones cerebrales
US9994585B2 (en) 2007-12-31 2018-06-12 Aphios Corporation Transplantation therapies
EP2590642B1 (en) 2010-07-08 2018-03-14 Daniel L. Alkon Pkc activators and anticoagulant in regimen for treating stroke
JP6062362B2 (ja) 2010-08-19 2017-01-18 ブランシェット・ロックフェラー・ニューロサイエンスィズ・インスティテュート Ｐｋｃ活性化剤を使用した、異常な樹状突起棘に関連した認知障害の治療
WO2013071282A1 (en) 2011-11-13 2013-05-16 Blanchette Rockefeller Neurosciences Institute Pkc activators and combinations thereof
US9034347B2 (en) 2011-12-19 2015-05-19 Arphios Corporation Drug delivery system and method for the treatment of neuro-degenerative disease
JP6579956B2 (ja) 2012-11-28 2019-09-25 アフィオス コーポレーション 神経変性疾患および他の疾患の治療のための併用治療薬および方法
US20180030095A1 (en) 2015-02-13 2018-02-01 George Robert Pettit Silstatin compounds
US20180217163A1 (en) 2015-05-11 2018-08-02 Daniel L. Alkon Treatment of neurodegenerative conditions using pkc activators after determining the presence of the apoe4 allele
CN109982695A (zh) 2016-08-18 2019-07-05 国立大学法人奈良先端科学技术大学院大学 免疫调节剂
WO2018187647A1 (en) 2017-04-06 2018-10-11 Neurotrope Bioscience, Inc. Methods and compositions for treatment of neurological diseases, disorders, or conditions
WO2019094709A1 (en) 2017-11-09 2019-05-16 Pettit George R Betulastatin compounds
US20190350898A1 (en) 2018-05-18 2019-11-21 Neurotrope Bioscience, Inc. Methods and compositions for treatment of alzheimer's disease

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63183585A (ja) * 1986-07-28 1988-07-28 アリゾナ　ボ−ド　オブ　リ−ゼンツ ブリオスタチン類
JPH01308228A (ja) * 1988-01-13 1989-12-12 Univ Arizona Found 免疫調整剤

Also Published As

Publication number Publication date
DE3363960D1 (en) 1986-07-10
US4560774A (en) 1985-12-24
JPH0556357B2 (enExample) 1993-08-19
EP0109811B1 (en) 1986-06-04
EP0109811A3 (en) 1984-07-11
EP0109811A2 (en) 1984-05-30

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