JPS5910814B2 - 傷口封緘用組成物 - Google Patents
傷口封緘用組成物Info
- Publication number
- JPS5910814B2 JPS5910814B2 JP56020800A JP2080081A JPS5910814B2 JP S5910814 B2 JPS5910814 B2 JP S5910814B2 JP 56020800 A JP56020800 A JP 56020800A JP 2080081 A JP2080081 A JP 2080081A JP S5910814 B2 JPS5910814 B2 JP S5910814B2
- Authority
- JP
- Japan
- Prior art keywords
- composition
- weight
- ketone
- polyethylene glycol
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000203 mixture Substances 0.000 title claims description 66
- 238000007789 sealing Methods 0.000 title claims description 24
- 206010052428 Wound Diseases 0.000 claims description 23
- 208000027418 Wounds and injury Diseases 0.000 claims description 23
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 claims description 15
- 150000002148 esters Chemical class 0.000 claims description 13
- 150000001346 alkyl aryl ethers Chemical class 0.000 claims description 12
- 229920001223 polyethylene glycol Polymers 0.000 claims description 12
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 claims description 11
- IJVRPNIWWODHHA-UHFFFAOYSA-N 2-cyanoprop-2-enoic acid Chemical compound OC(=O)C(=C)C#N IJVRPNIWWODHHA-UHFFFAOYSA-N 0.000 claims description 11
- 239000002202 Polyethylene glycol Substances 0.000 claims description 11
- -1 butyl α-cyanacrylate Chemical compound 0.000 claims description 10
- FGBJXOREULPLGL-UHFFFAOYSA-N ethyl cyanoacrylate Chemical compound CCOC(=O)C(=C)C#N FGBJXOREULPLGL-UHFFFAOYSA-N 0.000 claims description 8
- 150000002576 ketones Chemical class 0.000 claims description 8
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 6
- IQDPHMACOQAPBQ-UHFFFAOYSA-N 2-ethoxyethyl 2-cyanoprop-2-enoate Chemical compound CCOCCOC(=O)C(=C)C#N IQDPHMACOQAPBQ-UHFFFAOYSA-N 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 3
- 239000004615 ingredient Substances 0.000 description 12
- 208000032843 Hemorrhage Diseases 0.000 description 10
- 230000000740 bleeding effect Effects 0.000 description 10
- 208000007107 Stomach Ulcer Diseases 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 230000035515 penetration Effects 0.000 description 5
- 230000002265 prevention Effects 0.000 description 5
- 238000001356 surgical procedure Methods 0.000 description 4
- 208000008469 Peptic Ulcer Diseases 0.000 description 3
- 239000004698 Polyethylene Substances 0.000 description 3
- 208000025865 Ulcer Diseases 0.000 description 3
- 239000000853 adhesive Substances 0.000 description 3
- 230000001070 adhesive effect Effects 0.000 description 3
- 230000001684 chronic effect Effects 0.000 description 3
- 230000002183 duodenal effect Effects 0.000 description 3
- JJJFUHOGVZWXNQ-UHFFFAOYSA-N enbucrilate Chemical compound CCCCOC(=O)C(=C)C#N JJJFUHOGVZWXNQ-UHFFFAOYSA-N 0.000 description 3
- 229950010048 enbucrilate Drugs 0.000 description 3
- 210000004185 liver Anatomy 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 210000004738 parenchymal cell Anatomy 0.000 description 3
- 229920000573 polyethylene Polymers 0.000 description 3
- 210000004872 soft tissue Anatomy 0.000 description 3
- 208000011580 syndromic disease Diseases 0.000 description 3
- 231100000397 ulcer Toxicity 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 206010053768 Gastroduodenal haemorrhage Diseases 0.000 description 2
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 239000012300 argon atmosphere Substances 0.000 description 2
- 210000000941 bile Anatomy 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- MWKFXSUHUHTGQN-UHFFFAOYSA-N decan-1-ol Chemical compound CCCCCCCCCCO MWKFXSUHUHTGQN-UHFFFAOYSA-N 0.000 description 2
- 238000001839 endoscopy Methods 0.000 description 2
- 230000005713 exacerbation Effects 0.000 description 2
- 229960002897 heparin Drugs 0.000 description 2
- 229920000669 heparin Polymers 0.000 description 2
- 238000010348 incorporation Methods 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 210000005228 liver tissue Anatomy 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 238000009736 wetting Methods 0.000 description 2
- MBDOYVRWFFCFHM-SNAWJCMRSA-N (2E)-hexenal Chemical compound CCC\C=C\C=O MBDOYVRWFFCFHM-SNAWJCMRSA-N 0.000 description 1
- DURPTKYDGMDSBL-UHFFFAOYSA-N 1-butoxybutane Chemical compound CCCCOCCCC DURPTKYDGMDSBL-UHFFFAOYSA-N 0.000 description 1
- LWOXLCQLVLCHOC-UHFFFAOYSA-N 1-ethoxyethyl 2-cyanoprop-2-enoate Chemical compound CCOC(C)OC(=O)C(=C)C#N LWOXLCQLVLCHOC-UHFFFAOYSA-N 0.000 description 1
- 229920001651 Cyanoacrylate Polymers 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 206010017788 Gastric haemorrhage Diseases 0.000 description 1
- 206010061968 Gastric neoplasm Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 206010052535 Small intestinal haemorrhage Diseases 0.000 description 1
- 208000005298 acute pain Diseases 0.000 description 1
- 125000002947 alkylene group Chemical group 0.000 description 1
- 238000002266 amputation Methods 0.000 description 1
- 230000001588 bifunctional effect Effects 0.000 description 1
- 238000006065 biodegradation reaction Methods 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 208000000718 duodenal ulcer Diseases 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 210000001156 gastric mucosa Anatomy 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000001046 green dye Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 125000001183 hydrocarbyl group Chemical group 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000000622 irritating effect Effects 0.000 description 1
- 238000002350 laparotomy Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 239000006199 nebulizer Substances 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000012299 nitrogen atmosphere Substances 0.000 description 1
- 210000004197 pelvis Anatomy 0.000 description 1
- 208000011906 peptic ulcer disease Diseases 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 229920001289 polyvinyl ether Polymers 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 210000000574 retroperitoneal space Anatomy 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/06—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/043—Mixtures of macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J4/00—Adhesives based on organic non-macromolecular compounds having at least one polymerisable carbon-to-carbon unsaturated bond ; adhesives, based on monomers of macromolecular compounds of groups C09J183/00 - C09J183/16
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Surgery (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU2912942 | 1980-02-14 | ||
| SU2912942 | 1980-02-14 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS56128159A JPS56128159A (en) | 1981-10-07 |
| JPS5910814B2 true JPS5910814B2 (ja) | 1984-03-12 |
Family
ID=20890919
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP56020800A Expired JPS5910814B2 (ja) | 1980-02-14 | 1981-02-14 | 傷口封緘用組成物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US4479933A (enExample) |
| JP (1) | JPS5910814B2 (enExample) |
| DE (1) | DE3105132C2 (enExample) |
| FR (1) | FR2475896A1 (enExample) |
| GB (1) | GB2071678B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04118116U (ja) * | 1991-04-01 | 1992-10-22 | 三菱農機株式会社 | トラクタにおけるフイルター |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2610828B1 (fr) * | 1987-02-17 | 1990-09-14 | Mo Med Inst Pirogova | Compose pour l'occlusion des conduits et des cavites dans l'organisme |
| EP0374252A4 (en) * | 1988-05-26 | 1991-05-08 | Vsesojuzny Nauchno-Issledovatelsky I Ispytatelny Institut Meditsinskoi Tekhniki | Injection-type hemostatic composition |
| CA2053642C (en) * | 1990-12-13 | 2003-12-30 | George R. Proto | Method and apparatus for tipping sutures |
| CA2193968A1 (en) * | 1994-06-28 | 1996-01-11 | Jeffrey G. Clark | Ph-modified biocompatible monomer and polymer compositions |
| US6102205A (en) * | 1997-10-08 | 2000-08-15 | Medlogic Global Corporation | Prepolymer compositions comprising an antimicrobial agent |
| US6512023B1 (en) | 1998-06-18 | 2003-01-28 | Closure Medical Corporation | Stabilized monomer adhesive compositions |
| DE19843254C2 (de) * | 1998-09-10 | 2000-07-06 | Schering Ag | Verwendung von Polymermischungen, die Cyanacrylat oder Methylenmalonester enthalten, zur Beschichtung medizinischer Geräte und Implantate, medizinische Implantate und Verfahren zu ihrer Herstellung |
| US6494896B1 (en) | 1999-11-30 | 2002-12-17 | Closure Medical Corporation | Applicator for laparoscopic or endoscopic surgery |
| US6767552B2 (en) | 2001-07-05 | 2004-07-27 | Closure Medical Corporation | Adhesive treatment for oral fungal infection |
| US6746667B2 (en) | 2001-07-05 | 2004-06-08 | Closure Medical Corporation | Adhesive treatment for tinea pedis |
| US6942875B2 (en) * | 2001-07-05 | 2005-09-13 | Closure Medical Corporation | Adhesive treatment for skin yeast infections |
| US6585967B2 (en) | 2001-07-05 | 2003-07-01 | Closure Medical Corporation | Adhesive treatment for tinea cruris |
| US6602496B2 (en) | 2001-07-05 | 2003-08-05 | Closure Medical Corporation | Adhesive treatment for tinea corporis |
| AU2002343739A1 (en) * | 2001-11-14 | 2003-05-26 | Medlogic Global Limited | Improved therapy for topical diseases |
| US20040101507A1 (en) * | 2002-11-27 | 2004-05-27 | Janco Predovan | Skin cream |
| CN2662872Y (zh) * | 2003-08-16 | 2004-12-15 | 王厦定 | 卫生护理床 |
| CN111699228A (zh) * | 2018-02-09 | 2020-09-22 | 东亚合成株式会社 | 水易分解性粘接剂组合物 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3759264A (en) * | 1966-04-07 | 1973-09-18 | Eastman Kodak Co | Surgical method |
| US3559652A (en) * | 1968-08-05 | 1971-02-02 | Minnesota Mining & Mfg | Method of adhesively repairing body tissue with alkoxyalkyl 2-cyanoacrylate |
| FR2047874A6 (enExample) * | 1969-06-10 | 1971-03-19 | Nouvel Lucien | |
| US3699876A (en) * | 1971-08-09 | 1972-10-24 | Clarence E Ellis | Combined charcoal grill and pit barbecue cooker |
| GB1413132A (en) * | 1972-10-20 | 1975-11-05 | Vni I Ispygatelny I Med Tekhn | Surgical adhesive |
| JPS6037836B2 (ja) * | 1977-08-05 | 1985-08-28 | 東亞合成株式会社 | 接着剤組成物 |
| US4199564A (en) * | 1978-09-22 | 1980-04-22 | Masti-Kure Products Company, Inc. | Film-forming alcoholic microbicidal teat dip and method of use thereof |
-
1981
- 1981-02-11 GB GB8104192A patent/GB2071678B/en not_active Expired
- 1981-02-12 DE DE3105132A patent/DE3105132C2/de not_active Expired
- 1981-02-13 FR FR8102904A patent/FR2475896A1/fr active Granted
- 1981-02-14 JP JP56020800A patent/JPS5910814B2/ja not_active Expired
-
1982
- 1982-09-16 US US06/419,039 patent/US4479933A/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04118116U (ja) * | 1991-04-01 | 1992-10-22 | 三菱農機株式会社 | トラクタにおけるフイルター |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2475896A1 (fr) | 1981-08-21 |
| GB2071678B (en) | 1983-06-22 |
| DE3105132C2 (de) | 1983-07-14 |
| US4479933A (en) | 1984-10-30 |
| FR2475896B1 (enExample) | 1984-09-07 |
| DE3105132A1 (de) | 1982-01-07 |
| GB2071678A (en) | 1981-09-23 |
| JPS56128159A (en) | 1981-10-07 |
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