JPS58500064A - １α，２５−ジヒドロキシ−２β−フルオロビタミンＤ↓３ - Google Patents

１α，２５−ジヒドロキシ−２β−フルオロビタミンＤ↓３

Info

Publication number
JPS58500064A
JPS58500064A JP57500786A JP50078682A JPS58500064A JP S58500064 A JPS58500064 A JP S58500064A JP 57500786 A JP57500786 A JP 57500786A JP 50078682 A JP50078682 A JP 50078682A JP S58500064 A JPS58500064 A JP S58500064A
Authority
JP
Japan
Prior art keywords
vitamin
fluorovitamin
dihydroxy
prepared
calcium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP57500786A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0314303B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html
Inventor
デル−カ・ヘクタ−・エフ
シユノ−ズ・ハインリツヒ・ケ−
池川　信夫
洋子 田中
森崎　益雄
押田　淳一
Original Assignee
ウイスコンシン　アラムナイ　リサ−チ　フオンデ−シヨン
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ウイスコンシン　アラムナイ　リサ−チ　フオンデ−シヨン filed Critical ウイスコンシン　アラムナイ　リサ−チ　フオンデ−シヨン
Publication of JPS58500064A publication Critical patent/JPS58500064A/ja
Publication of JPH0314303B2 publication Critical patent/JPH0314303B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Nutrition Science (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Secondary Cells (AREA)
  • Battery Electrode And Active Subsutance (AREA)
JP57500786A 1981-02-17 1982-01-28 １α，２５−ジヒドロキシ−２β−フルオロビタミンＤ↓３ Granted JPS58500064A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US235262 1981-02-17
US06/235,262 US4307025A (en) 1981-02-17 1981-02-17 1α, 25-dihydroxy-2β-fluorovitamin D3

Publications (2)

Publication Number Publication Date
JPS58500064A true JPS58500064A (ja) 1983-01-13
JPH0314303B2 JPH0314303B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1991-02-26

Family

ID=22884774

Family Applications (1)

Application Number Title Priority Date Filing Date
JP57500786A Granted JPS58500064A (ja) 1981-02-17 1982-01-28 １α，２５−ジヒドロキシ−２β−フルオロビタミンＤ↓３

Country Status (8)

Country Link
US (1) US4307025A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS58500064A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU8148782A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3233717A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (1) FR2499985A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (1) GB2093033B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL64933A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
WO (1) WO1982002893A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4307025A (en) * 1981-02-17 1981-12-22 Wisconsin Alumni Research Foundation 1α, 25-dihydroxy-2β-fluorovitamin D3
US4666634A (en) * 1984-12-05 1987-05-19 Chugai Seiyaku Kabushiki Kaisha vitamin D3 derivatives having a substituent at 2-position
US4594192A (en) * 1985-03-20 1986-06-10 Wisconsin Alumni Research Foundation 2α-fluorovitamin D3
JP3201411B2 (ja) * 1990-06-15 2001-08-20 メルシャン株式会社 ビタミンｄ類の生物学的製造方法
IL107748A (en) * 1992-11-27 1998-08-16 Chugai Pharmaceutical Co Ltd A method for producing a history of vitamin D.
DE4334154C2 (de) * 1993-10-01 1997-05-22 Schering Ag 2-Halogeno-1,25-dihydroxy-cholecalciferole und pharmazeutische Zusammensetzungen
US5877168A (en) * 1995-02-10 1999-03-02 Chugai Seiyaku Kabushiki Kaisha Vitamin D derivative with substituent at the 2β-position
US5716946A (en) * 1996-02-13 1998-02-10 Wisconsin Alumni Research Foundation Multiple sclerosis treatment
TW584627B (en) * 1996-07-01 2004-04-21 Chugai Pharmaceutical Co Ltd The method for purifying vitamin D derivatives and its crystalline products
US6479474B2 (en) * 1999-07-08 2002-11-12 Wisconsin Alumni Research Foundation Dietary calcium as a supplement to vitamin D compound treatment of multiple sclerosis
CA2750659C (en) 2009-01-27 2017-11-21 Berg Biosystems, Llc Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy
JP5978130B2 (ja) 2009-08-14 2016-08-24 バーグ エルエルシー 脱毛症を治療するためのビタミンｄ３およびその類似体
KR20160013201A (ko) 2013-05-29 2016-02-03 버그 엘엘씨 비타민 d를 이용한 화학요법 유발 탈모증의 예방 또는 완화

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4226787A (en) * 1978-07-26 1980-10-07 Wisconsin Alumni Research Foundation Fluorovitamin D compounds and processes for their preparation
US4224230A (en) * 1978-07-26 1980-09-23 Wisconsin Alumni Research Foundation Fluorovitamin D compounds and processes for their preparation
US4263214A (en) * 1978-07-26 1981-04-21 Wisconsin Alumni Research Foundation Fluorovitamin D compounds and processes for their preparation
US4196133A (en) * 1979-03-05 1980-04-01 Wisconsin Alumni Research Foundation 24,24-Difluoro-25-hydroxycholecalciferol
US4254045A (en) * 1980-04-21 1981-03-03 Wisconsin Alumni Research Foundation 1α-Hydroxy-2β-fluorocholecalciferol
US4307025A (en) * 1981-02-17 1981-12-22 Wisconsin Alumni Research Foundation 1α, 25-dihydroxy-2β-fluorovitamin D3

Also Published As

Publication number Publication date
DE3233717A1 (de) 1983-02-10
GB2093033B (en) 1985-01-03
FR2499985B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1984-12-07
FR2499985A1 (fr) 1982-08-20
IL64933A0 (en) 1982-04-30
JPH0314303B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1991-02-26
AU8148782A (en) 1982-09-14
WO1982002893A1 (en) 1982-09-02
US4307025A (en) 1981-12-22
IL64933A (en) 1984-10-31
GB2093033A (en) 1982-08-25

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