JPS5849352A - アルギニンバソプレシンの抗利尿及び／又は血圧上昇作用の新規な「きつ」抗剤 - Google Patents

アルギニンバソプレシンの抗利尿及び／又は血圧上昇作用の新規な「きつ」抗剤

Info

Publication number
JPS5849352A
JPS5849352A JP57044789A JP4478982A JPS5849352A JP S5849352 A JPS5849352 A JP S5849352A JP 57044789 A JP57044789 A JP 57044789A JP 4478982 A JP4478982 A JP 4478982A JP S5849352 A JPS5849352 A JP S5849352A
Authority
JP
Japan
Prior art keywords
antidiuretic
compound
arginine
acid
valine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP57044789A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0325439B2 (enExample
Inventor
モウリス・マンニング
ウイルバ−・ヘンダノン・ソウヤ−
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Columbia University in the City of New York
Original Assignee
Columbia University in the City of New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Columbia University in the City of New York filed Critical Columbia University in the City of New York
Publication of JPS5849352A publication Critical patent/JPS5849352A/ja
Publication of JPH0325439B2 publication Critical patent/JPH0325439B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/16—Oxytocins; Vasopressins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/15—Oxytocin or vasopressin; related peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP57044789A 1981-03-24 1982-03-23 アルギニンバソプレシンの抗利尿及び／又は血圧上昇作用の新規な「きつ」抗剤 Granted JPS5849352A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US06/247,008 US4367225A (en) 1981-03-24 1981-03-24 Novel antagonists of the antidiuretic and/or vasopressor action of arginine vasopressin
US247008 1981-03-24
US322071 1981-11-16

Publications (2)

Publication Number Publication Date
JPS5849352A true JPS5849352A (ja) 1983-03-23
JPH0325439B2 JPH0325439B2 (enExample) 1991-04-05

Family

ID=22933152

Family Applications (2)

Application Number Title Priority Date Filing Date
JP57044789A Granted JPS5849352A (ja) 1981-03-24 1982-03-23 アルギニンバソプレシンの抗利尿及び／又は血圧上昇作用の新規な「きつ」抗剤
JP62283225A Pending JPS63239297A (ja) 1981-03-24 1987-11-11 新規な拮抗剤

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP62283225A Pending JPS63239297A (ja) 1981-03-24 1987-11-11 新規な拮抗剤

Country Status (5)

Country Link
US (1) US4367225A (enExample)
JP (2) JPS5849352A (enExample)
CS (1) CS262407B2 (enExample)
IN (1) IN156510B (enExample)
ZA (1) ZA821422B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61172898A (ja) * 1985-01-23 1986-08-04 メデイカル　カレツジ　オブ　オハイオ アルギニンバソプレツシン拮抗薬の新規誘導体類

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4491577A (en) * 1981-11-16 1985-01-01 The Medical College Of Ohio Antagonists of the antidiuretic action of arginine vasopressin
US4504469A (en) * 1982-12-21 1985-03-12 Ferring Ab Vasotocin derivatives
US4469679A (en) * 1983-02-16 1984-09-04 Smithkline Beckman Corporation Octapeptide vasopressin antagonists
US4587045A (en) * 1983-02-16 1986-05-06 Smithkline Beckman Corporation Intermediates for preparing octapeptide vasopressin antagonists
US4469680A (en) * 1983-07-06 1984-09-04 Smithkline Beckman Corporation Iodinated vasopressin antagonists
US4551445A (en) * 1983-10-14 1985-11-05 The Medical College Of Ohio Derivatives of arginine vasopressin antagonists
US4714696A (en) * 1984-01-26 1987-12-22 Medical College Of Ohio Novel derivatives of arginine vasopressin antagonists
US4481194A (en) * 1984-03-07 1984-11-06 Smithkline Beckman Corporation Des-proline-des-glycine vasopressin antagonists
CA1249397A (en) * 1984-03-07 1989-01-24 Fadia E. Ali Process for preparing des-proline vasopressin antagonists
US4481193A (en) * 1984-03-07 1984-11-06 Smithkline Beckman Corporation Des-proline vasopressin antagonists
US4597901A (en) * 1984-12-14 1986-07-01 Smithkline Beckman Corporation β-indolylalanyl or β-indolylglycinyl vasopressin antagonists
US4719199A (en) * 1984-12-14 1988-01-12 Smithkline Beckman Corporation Diuretic compositions and methods of producing diuresis
US4684716A (en) * 1984-12-14 1987-08-04 Smithkline Beckman Corporation Polypeptide intermediates
US4624943A (en) * 1985-03-20 1986-11-25 Smithkline Beckman Corporation Aromatic basic-tailed vasopressin antagonists
US4656248A (en) * 1985-04-23 1987-04-07 Smithkline Beckman Corporation Cupric oxidation of 1,6-dimercapto-containing peptides
US4711877A (en) * 1985-09-18 1987-12-08 Smithkline Beckman Corporation 6-pen-vasopressin compounds
US4826813A (en) * 1987-05-21 1989-05-02 Smithkline Beckman Corporation 4'-Methyl-β-mercapto-β,β-cyclopentamethylenepropionic acid vasopressin antagonists
US5055448A (en) * 1987-06-25 1991-10-08 Medical College Of Ohio Linear derivatives of arginine vasopressin antagonists
US5225528A (en) * 1990-02-27 1993-07-06 Merck & Co., Inc. Cyclic hexapeptide oxytocin antagonists
US20030103983A1 (en) * 2002-05-09 2003-06-05 Pressler Milton Lethan Ace inhibitor-vasopressin antagonist combinations
US8168592B2 (en) * 2005-10-21 2012-05-01 Amgen Inc. CGRP peptide antagonists and conjugates

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1193509B (de) * 1960-06-02 1965-05-26 Hoechst Ag Verfahren zur Herstellung eines neuen Oktapeptids mit vasopressorischer Wirksamkeit
CH426861A (de) * 1963-06-06 1966-12-31 Sandoz Ag Verfahren zur Herstellung eines bisher unbekannten Polypeptids
CH442342A (de) * 1964-07-17 1967-08-31 Sandoz Ag Verfahren zur Herstellung eines neuen Polypeptids
CH460039A (de) * 1965-04-15 1968-07-31 Sandoz Ag Verfahren zur Herstellung eines neuen Polypeptids
CH495957A (de) * 1966-09-15 1970-09-15 Ceskoslovenska Akademie Ved Verfahren zur Herstellung eines antidiuretisch wirksamen Polypeptids
US3691147A (en) * 1970-06-05 1972-09-12 Medical College Of Ohio The (4-l-threonine)-oxytocin
US3700652A (en) * 1970-08-31 1972-10-24 Medical College Of Ohio At Tol (4-l-threonine)-mesotocin
ZA72790B (en) * 1971-03-12 1972-10-25 Kloeckner Werke Ag Conveyor trough for scraper chain conveyors,particularly twin chain conveyors
US4148787A (en) * 1976-05-24 1979-04-10 Ferring Ab Antidiuretically effective polypeptide and a process for preparing the same

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JOURNAL OF MEDICAL CHEMISTRY=1978 *
JOURNAL OF MEDICAL CHEMISTRY=1980 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61172898A (ja) * 1985-01-23 1986-08-04 メデイカル　カレツジ　オブ　オハイオ アルギニンバソプレツシン拮抗薬の新規誘導体類

Also Published As

Publication number Publication date
IN156510B (enExample) 1985-08-17
CS262407B2 (en) 1989-03-14
CS201782A2 (en) 1988-08-16
ZA821422B (en) 1983-04-27
JPH0325439B2 (enExample) 1991-04-05
JPS63239297A (ja) 1988-10-05
US4367225A (en) 1983-01-04

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