JPS58174319A - 薬剤組成物 - Google Patents

薬剤組成物

Info

Publication number
JPS58174319A
JPS58174319A JP58049677A JP4967783A JPS58174319A JP S58174319 A JPS58174319 A JP S58174319A JP 58049677 A JP58049677 A JP 58049677A JP 4967783 A JP4967783 A JP 4967783A JP S58174319 A JPS58174319 A JP S58174319A
Authority
JP
Japan
Prior art keywords
iron
hydroxypyrid
aliphatic hydrocarbon
hydroxy
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP58049677A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0460987B2 (enExample
Inventor
ロバ−ト・チヤ−ルズ・ハイダ−
ジヨ−ジ・コントギオルゲス
ジヤツク・シルバ−
マイケル・ア−サ−・ストツクハム
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Research Development Corporation
Original Assignee
National Research Development Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Research Development Corporation filed Critical National Research Development Corporation
Publication of JPS58174319A publication Critical patent/JPS58174319A/ja
Publication of JPH0460987B2 publication Critical patent/JPH0460987B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/69—Two or more oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Pyrane Compounds (AREA)
JP58049677A 1982-03-24 1983-03-24 薬剤組成物 Granted JPS58174319A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB8208608 1982-03-24
GB8208608 1982-03-24
GB8230148 1982-10-22

Publications (2)

Publication Number Publication Date
JPS58174319A true JPS58174319A (ja) 1983-10-13
JPH0460987B2 JPH0460987B2 (enExample) 1992-09-29

Family

ID=10529232

Family Applications (3)

Application Number Title Priority Date Filing Date
JP58049677A Granted JPS58174319A (ja) 1982-03-24 1983-03-24 薬剤組成物
JP58049676A Granted JPS58174318A (ja) 1982-03-24 1983-03-24 医薬用組成物
JP4030887A Expired - Lifetime JPH0757749B2 (ja) 1982-03-24 1992-02-18 医薬用組成物に用いる化合物

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP58049676A Granted JPS58174318A (ja) 1982-03-24 1983-03-24 医薬用組成物
JP4030887A Expired - Lifetime JPH0757749B2 (ja) 1982-03-24 1992-02-18 医薬用組成物に用いる化合物

Country Status (8)

Country Link
US (1) US4840958A (enExample)
EP (1) EP0093498B1 (enExample)
JP (3) JPS58174319A (enExample)
CY (1) CY1502A (enExample)
DE (2) DE19975062I1 (enExample)
GR (1) GR78491B (enExample)
HK (1) HK6190A (enExample)
NL (1) NL990031I2 (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8308055D0 (en) * 1983-03-24 1983-05-05 Hider R C Pharmaceutical compositions
EP0305646B1 (en) * 1983-03-24 1996-11-13 Btg International Limited 3-Hydroxypyrid-4-ones and pharmaceutical compositions
GB8308054D0 (en) * 1983-03-24 1983-05-05 Hider R C Pharmaceutical compositions
GB8325494D0 (en) * 1983-09-23 1983-10-26 Hider R C Pharmaceutical compositions
USRE34313E (en) * 1983-09-23 1993-07-13 National Research Development Corporation Pharmaceutical compositions
US4912118A (en) * 1983-09-23 1990-03-27 National Research Development Corporation Pharmaceutical compositions
EP0335745A1 (en) * 1988-03-31 1989-10-04 The Royal Free Hospital School Of Medicine Process for producing pyrid-4-ones
GB8910521D0 (en) * 1989-05-08 1989-06-21 Nat Res Dev The stabilization of organic compounds
US5298525A (en) * 1992-11-23 1994-03-29 University Technologies International, Inc. Diabetes prevention and treatment
US6046219A (en) * 1995-01-20 2000-04-04 Cornell Research Foundation, Inc. Method for the treatment of conditions mediated by collagen formation together with cell proliferation by application of inhibitors of protein hydroxylation
US5849587A (en) * 1995-06-09 1998-12-15 Cornell Research Foundation, Inc. Method of inhibiting viral replication in eukaryotic cells and of inducing apoptosis of virally-infected cells
EP0833627B1 (en) 1995-06-10 2004-08-18 Vitra Pharmaceuticals Ltd. Iron compounds, compositions, methods of making the same and uses thereof
US6004986A (en) * 1997-05-08 1999-12-21 The University Of Virginia Patent Foundation Method for treating cerebral vasospasm and cerebral ischemia using iron chelators and pharmaceutical compositions therefor
US6767741B1 (en) * 1999-08-27 2004-07-27 Invitrogen Corporation Metal binding compounds and their use in cell culture medium compositions
IL135884A (en) * 2000-04-30 2005-08-31 Yissum Res Dev Co Method for measuring non-transferrin bound iron
CA2421410C (en) * 2000-09-19 2009-11-10 Vitra Pharmaceuticals Limited Iron compositions
US6426418B1 (en) 2001-11-02 2002-07-30 Apotex, Inc. Processes for the manufacturing of 3-hydroxy-N,1,6-trialkyl-4-oxo-1,4-dihydropyridine-2-carboxamide
GB0211500D0 (en) 2002-05-18 2002-06-26 Vitra Pharmaceuticals Ltd Method of forming iron hydroxypyrone compounds
WO2004040252A2 (en) 2002-10-30 2004-05-13 Yissum Research Development Company Of The Hebrew University Of Jerusalem Molecules and methods using same for measuring non-transferrin bound iron
US8058442B2 (en) 2002-11-07 2011-11-15 Technion Research And Development Foundation Ltd. Neuroprotective iron chelators and pharmaceutical compositions comprising them
CA2488034C (en) * 2004-11-19 2009-10-06 Apotex Inc. Process for the manufacture of 3-hydroxy-n-alkyl-1-cycloalkyl-6-alkyl-4-oxo-1,4-dihydropyridine-2-carboxamide and its related analogues
US9309199B2 (en) * 2010-03-04 2016-04-12 Merck Sharp & Dohme Corp. Inhibitors of catechol O-methyl transferase and their use in the treatment of psychotic disorders
GB201007209D0 (en) 2010-04-29 2010-06-16 King S College London Compound
WO2012137202A1 (en) 2011-04-05 2012-10-11 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Composition comprising an iron indicator attached to a microparticle and uses of same for quantifying non-transferrin bound iron (ntbi) and cellular labile iron (lci)
JP7113009B2 (ja) 2016-11-07 2022-08-04 アービュタス バイオファーマ コーポレイション 置換ピリジノン含有三環式化合物およびそれを使用する方法
TWI801517B (zh) 2018-03-12 2023-05-11 加拿大商愛彼特生物製藥公司 經取代的2-吡啶酮三環化合物、其類似物及其使用方法
TW202010499A (zh) 2018-04-12 2020-03-16 加拿大商愛彼特生物製藥公司 經取代的吡啶酮之三環化合物的製備方法

Also Published As

Publication number Publication date
JPH0757749B2 (ja) 1995-06-21
NL990031I1 (nl) 1999-12-01
JPH0680636A (ja) 1994-03-22
EP0093498A3 (en) 1984-07-11
EP0093498A2 (en) 1983-11-09
JPS58174318A (ja) 1983-10-13
DE19975062I1 (de) 2003-09-04
JPH0460987B2 (enExample) 1992-09-29
US4840958A (en) 1989-06-20
EP0093498B1 (en) 1986-11-26
GR78491B (enExample) 1984-09-27
CY1502A (en) 1990-08-03
HK6190A (en) 1990-02-02
NL990031I2 (nl) 2000-04-03
JPH0515693B2 (enExample) 1993-03-02
DE3367849D1 (en) 1987-01-15

Similar Documents

Publication Publication Date Title
JPH0460987B2 (enExample)
US4587240A (en) Pharmaceutical compositions
US6048851A (en) Solid pharmaceutical compositions for the oral administration of gallium
US4834983A (en) Pharmaceutical compositions
US4666927A (en) Pharmaceutical compositions of hydroxypyridones
US5028411A (en) Pharmaceutical compositions
US5258376A (en) Pharmaceutical compositions of gallium complexes of 3-hydroxy-4-pyrones
DK162840B (da) Zink(ii)-komplekser af substituerede 3-hydroxypyroner eller 3-hydroxypyridoner, anvendelse af disse samt farmaceutiske praeparater indeholdende disse
US5104865A (en) Iron complexes of hydroxypyridones useful for treating iron overload
US4550101A (en) Iron complexes of hydroxy pyridones useful for treating iron deficiency anemia
US5574027A (en) Pharmaceutical compositions of gallium complexes of 3-hydroxy-4-pyrones
JPH0625120B2 (ja) 医薬用組成物
US5177068A (en) Pharmaceutical compositions
US5281578A (en) Gallium compounds
GB2117766A (en) Pharmaceutical compositions
USRE34313E (en) Pharmaceutical compositions
EP0612246B1 (en) Pharmaceutical compositions of gallium complexes of 3-hydroxy-4-pyrones
USRE37534E1 (en) Pharmaceutical compositions
JPH01501387A (ja) ２―メチルメルカプト―３―シアノ―４―（０―ジフルオロメトキシフェニル）―６―フェニル―１，４―ジヒドロピリジン