DE3367849D1 - Pharmaceutical compositions containing n-substituted-3-hydroxypyrid-2-one or -4-one derivatives - Google Patents

Pharmaceutical compositions containing n-substituted-3-hydroxypyrid-2-one or -4-one derivatives

Info

Publication number
DE3367849D1
DE3367849D1 DE8383301659T DE3367849T DE3367849D1 DE 3367849 D1 DE3367849 D1 DE 3367849D1 DE 8383301659 T DE8383301659 T DE 8383301659T DE 3367849 T DE3367849 T DE 3367849T DE 3367849 D1 DE3367849 D1 DE 3367849D1
Authority
DE
Germany
Prior art keywords
hydroxypyrid
derivatives
substituted
pharmaceutical compositions
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8383301659T
Other languages
English (en)
Inventor
Robert Charles Hider
George Kontoghiorghes
Jack Silver
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BTG International Ltd
Original Assignee
National Research Development Corp UK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Research Development Corp UK filed Critical National Research Development Corp UK
Application granted granted Critical
Publication of DE3367849D1 publication Critical patent/DE3367849D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/69—Two or more oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Pyrane Compounds (AREA)
DE8383301659T 1982-03-24 1983-03-24 Pharmaceutical compositions containing n-substituted-3-hydroxypyrid-2-one or -4-one derivatives Expired DE3367849D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8208608 1982-03-24

Publications (1)

Publication Number Publication Date
DE3367849D1 true DE3367849D1 (en) 1987-01-15

Family

ID=10529232

Family Applications (2)

Application Number Title Priority Date Filing Date
DE8383301659T Expired DE3367849D1 (en) 1982-03-24 1983-03-24 Pharmaceutical compositions containing n-substituted-3-hydroxypyrid-2-one or -4-one derivatives
DE1999175062 Pending DE19975062I1 (de) 1982-03-24 1983-03-24 Pharmazeutische Zusammensetzungen die N-substituierte 3-Hydroxypyrid-2-on-oder-4-on-Derivate enthalten

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE1999175062 Pending DE19975062I1 (de) 1982-03-24 1983-03-24 Pharmazeutische Zusammensetzungen die N-substituierte 3-Hydroxypyrid-2-on-oder-4-on-Derivate enthalten

Country Status (8)

Country Link
US (1) US4840958A (de)
EP (1) EP0093498B1 (de)
JP (3) JPS58174319A (de)
CY (1) CY1502A (de)
DE (2) DE3367849D1 (de)
GR (1) GR78491B (de)
HK (1) HK6190A (de)
NL (1) NL990031I2 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8308055D0 (en) * 1983-03-24 1983-05-05 Hider R C Pharmaceutical compositions
EP0305646B1 (de) * 1983-03-24 1996-11-13 Btg International Limited 3-Hydroxypyrid-4-one und pharmazeutische Zusammensetzungen
GB8308054D0 (en) * 1983-03-24 1983-05-05 Hider R C Pharmaceutical compositions
GB8325494D0 (en) * 1983-09-23 1983-10-26 Hider R C Pharmaceutical compositions
US4912118A (en) * 1983-09-23 1990-03-27 National Research Development Corporation Pharmaceutical compositions
USRE34313E (en) * 1983-09-23 1993-07-13 National Research Development Corporation Pharmaceutical compositions
EP0335745A1 (de) * 1988-03-31 1989-10-04 The Royal Free Hospital School Of Medicine Verfahren zur Herstellung von Pyridin-4-onen
GB8910521D0 (en) * 1989-05-08 1989-06-21 Nat Res Dev The stabilization of organic compounds
US5298525A (en) * 1992-11-23 1994-03-29 University Technologies International, Inc. Diabetes prevention and treatment
US6046219A (en) * 1995-01-20 2000-04-04 Cornell Research Foundation, Inc. Method for the treatment of conditions mediated by collagen formation together with cell proliferation by application of inhibitors of protein hydroxylation
US5849587A (en) * 1995-06-09 1998-12-15 Cornell Research Foundation, Inc. Method of inhibiting viral replication in eukaryotic cells and of inducing apoptosis of virally-infected cells
ES2230564T3 (es) 1995-06-10 2005-05-01 Vitra Pharmaceuticals Ltd. Compuestos ferricos, composiciones, metodos de fabricacion de estos y sus utilizacioneds.
US6004986A (en) * 1997-05-08 1999-12-21 The University Of Virginia Patent Foundation Method for treating cerebral vasospasm and cerebral ischemia using iron chelators and pharmaceutical compositions therefor
US6767741B1 (en) * 1999-08-27 2004-07-27 Invitrogen Corporation Metal binding compounds and their use in cell culture medium compositions
IL135884A (en) * 2000-04-30 2005-08-31 Yissum Res Dev Co Method for measuring non-transferrin bound iron
ES2236300T3 (es) * 2000-09-19 2005-07-16 Vitra Pharmaceuticals Ltd. Composiciones de hierro.
US6426418B1 (en) 2001-11-02 2002-07-30 Apotex, Inc. Processes for the manufacturing of 3-hydroxy-N,1,6-trialkyl-4-oxo-1,4-dihydropyridine-2-carboxamide
GB0211500D0 (en) 2002-05-18 2002-06-26 Vitra Pharmaceuticals Ltd Method of forming iron hydroxypyrone compounds
EP2295980A1 (de) 2002-10-30 2011-03-16 Yissum Research Development Company, of The Hebrew University of Jerusalem Moleküle und diese verwendende Verfahren zur Messung von nicht-transferringebundenem Eisen
EP1565185A4 (de) 2002-11-07 2011-01-05 Technion Res & Dev Foundation Neuroprotektive eisenchelatoren und pharmazeutische zusammensetzungen damit
CA2488034C (en) * 2004-11-19 2009-10-06 Apotex Inc. Process for the manufacture of 3-hydroxy-n-alkyl-1-cycloalkyl-6-alkyl-4-oxo-1,4-dihydropyridine-2-carboxamide and its related analogues
EP2542077A4 (de) * 2010-03-04 2013-08-21 Merck Sharp & Dohme Hemmer der catechol-o-methyl-transferase und ihre verwendung bei der behandlung psychotischer störungen
GB201007209D0 (en) 2010-04-29 2010-06-16 King S College London Compound
WO2012137202A1 (en) 2011-04-05 2012-10-11 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Composition comprising an iron indicator attached to a microparticle and uses of same for quantifying non-transferrin bound iron (ntbi) and cellular labile iron (lci)
CN116751200A (zh) 2016-11-07 2023-09-15 爱彼特生物制药公司 含有取代的吡啶酮的三环化合物以及使用其的方法
US11702427B2 (en) 2018-03-12 2023-07-18 Arbutus Biopharma Corporation Substituted 2-pyridone tricyclic compounds, analogues thereof, and methods using same
US11505551B2 (en) 2018-04-12 2022-11-22 Arbutus Biopharma Corporation Methods for preparing substituted pyridinone-containing tricyclic compounds

Also Published As

Publication number Publication date
EP0093498B1 (de) 1986-11-26
NL990031I1 (nl) 1999-12-01
CY1502A (en) 1990-08-03
JPH0757749B2 (ja) 1995-06-21
GR78491B (de) 1984-09-27
NL990031I2 (nl) 2000-04-03
HK6190A (en) 1990-02-02
JPS58174318A (ja) 1983-10-13
JPH0515693B2 (de) 1993-03-02
JPH0680636A (ja) 1994-03-22
JPH0460987B2 (de) 1992-09-29
EP0093498A3 (en) 1984-07-11
DE19975062I1 (de) 2003-09-04
JPS58174319A (ja) 1983-10-13
EP0093498A2 (de) 1983-11-09
US4840958A (en) 1989-06-20

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: BRITISH TECHNOLOGY GROUP LTD., LONDON, GB

8328 Change in the person/name/address of the agent

Free format text: KRAUS, W., DIPL.-CHEM. DR.RER.NAT. WEISERT, A., DIPL.-ING. DR.-ING., 80539 MUENCHEN SPIES, J., DIPL.-PHYS., PAT.-ANWAELTE, 81545 MUENCHEN

V448 Application of spc

Free format text: PRODUCT NAME: DEFERIPRON/FERRIPROX (3-HYDROXY-1,2-DIMETHYLPYRIDIN-4-ON); REGISTRATION NO/DATE: EU/1/99/108/001, 19990825

Spc suppl protection certif: 199 75 062

Filing date: 19991004

8327 Change in the person/name/address of the patent owner

Owner name: BTG INTERNATIONAL LTD., LONDON, GB

V457 Spc granted

Free format text: PRODUCT NAME: DEFERIPRON/FERRIPROX (3-HYDROXY-1,2-DIMETHYLPYRIDIN-4-ON); REGISTRATION NO/DATE: EU/1/99/108/001, 19990825

Spc suppl protection certif: 199 75 062

Filing date: 19991004

V464 Spc expired

Free format text: PRODUCT NAME: DEFERIPRON/FERRIPROX (3-HYDROXY-1,2-DIMETHYLPYRIDIN-4-ON); REGISTRATION NO/DATE: EU/1/99/108/001, 19990825

Spc suppl protection certif: 199 75 062

Filing date: 19991004