JPS58146855A - 免疫検定法 - Google Patents
免疫検定法Info
- Publication number
- JPS58146855A JPS58146855A JP8483A JP8483A JPS58146855A JP S58146855 A JPS58146855 A JP S58146855A JP 8483 A JP8483 A JP 8483A JP 8483 A JP8483 A JP 8483A JP S58146855 A JPS58146855 A JP S58146855A
- Authority
- JP
- Japan
- Prior art keywords
- fragment
- fragments
- specific
- immunogen
- aggregated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 title claims description 28
- 238000012360 testing method Methods 0.000 title claims description 6
- 239000012634 fragment Substances 0.000 claims description 98
- 210000002966 serum Anatomy 0.000 claims description 31
- 238000003556 assay Methods 0.000 claims description 29
- 108060003951 Immunoglobulin Proteins 0.000 claims description 25
- 102000018358 immunoglobulin Human genes 0.000 claims description 25
- 241001465754 Metazoa Species 0.000 claims description 23
- 239000002245 particle Substances 0.000 claims description 21
- 230000002163 immunogen Effects 0.000 claims description 15
- 238000003018 immunoassay Methods 0.000 claims description 14
- 229940072221 immunoglobulins Drugs 0.000 claims description 12
- 239000011541 reaction mixture Substances 0.000 claims description 9
- 238000006243 chemical reaction Methods 0.000 claims description 7
- 239000013060 biological fluid Substances 0.000 claims description 6
- 239000000126 substance Substances 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 5
- 210000001124 body fluid Anatomy 0.000 claims description 3
- 239000010839 body fluid Substances 0.000 claims description 3
- 230000003053 immunization Effects 0.000 claims description 3
- 238000002649 immunization Methods 0.000 claims description 3
- 239000000376 reactant Substances 0.000 claims description 3
- 239000007787 solid Substances 0.000 claims description 3
- 102000006395 Globulins Human genes 0.000 claims description 2
- 108010044091 Globulins Proteins 0.000 claims description 2
- 239000010419 fine particle Substances 0.000 claims 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 23
- 239000000427 antigen Substances 0.000 description 14
- 102000036639 antigens Human genes 0.000 description 14
- 108091007433 antigens Proteins 0.000 description 14
- 241000894007 species Species 0.000 description 13
- 238000007818 agglutination assay Methods 0.000 description 8
- 239000004816 latex Substances 0.000 description 8
- 229920000126 latex Polymers 0.000 description 8
- 238000004220 aggregation Methods 0.000 description 7
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 6
- 230000002776 aggregation Effects 0.000 description 6
- 238000003127 radioimmunoassay Methods 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 102100023635 Alpha-fetoprotein Human genes 0.000 description 4
- 230000004520 agglutination Effects 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 102000004506 Blood Proteins Human genes 0.000 description 3
- 108010017384 Blood Proteins Proteins 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 239000004471 Glycine Substances 0.000 description 3
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 3
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 3
- 108010026331 alpha-Fetoproteins Proteins 0.000 description 3
- VHJLVAABSRFDPM-QWWZWVQMSA-N dithiothreitol Chemical compound SC[C@@H](O)[C@H](O)CS VHJLVAABSRFDPM-QWWZWVQMSA-N 0.000 description 3
- 230000006862 enzymatic digestion Effects 0.000 description 3
- 241000283707 Capra Species 0.000 description 2
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 description 2
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 239000007853 buffer solution Substances 0.000 description 2
- 239000007975 buffered saline Substances 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 102000053391 human F Human genes 0.000 description 2
- 108700031895 human F Proteins 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 230000004936 stimulating effect Effects 0.000 description 2
- GZCWLCBFPRFLKL-UHFFFAOYSA-N 1-prop-2-ynoxypropan-2-ol Chemical compound CC(O)COCC#C GZCWLCBFPRFLKL-UHFFFAOYSA-N 0.000 description 1
- 102000013563 Acid Phosphatase Human genes 0.000 description 1
- 108010051457 Acid Phosphatase Proteins 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- XUIIKFGFIJCVMT-GFCCVEGCSA-N D-thyroxine Chemical compound IC1=CC(C[C@@H](N)C(O)=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-GFCCVEGCSA-N 0.000 description 1
- 102000008857 Ferritin Human genes 0.000 description 1
- 108050000784 Ferritin Proteins 0.000 description 1
- 238000008416 Ferritin Methods 0.000 description 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
- 102000018071 Immunoglobulin Fc Fragments Human genes 0.000 description 1
- 108010091135 Immunoglobulin Fc Fragments Proteins 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 229920002684 Sepharose Polymers 0.000 description 1
- 102000009488 Thyroxine-Binding Proteins Human genes 0.000 description 1
- 108010048889 Thyroxine-Binding Proteins Proteins 0.000 description 1
- 241000190020 Zelkova serrata Species 0.000 description 1
- 239000012491 analyte Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 229940098773 bovine serum albumin Drugs 0.000 description 1
- 230000003196 chaotropic effect Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000007429 general method Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000000415 inactivating effect Effects 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000003169 placental effect Effects 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 210000001685 thyroid gland Anatomy 0.000 description 1
- 229940034208 thyroxine Drugs 0.000 description 1
- XUIIKFGFIJCVMT-UHFFFAOYSA-N thyroxine-binding globulin Natural products IC1=CC(CC([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-UHFFFAOYSA-N 0.000 description 1
- 230000009261 transgenic effect Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/563—Immunoassay; Biospecific binding assay; Materials therefor involving antibody fragments
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8200189 | 1982-01-05 | ||
| GB8200189 | 1982-01-05 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS58146855A true JPS58146855A (ja) | 1983-09-01 |
| JPH0467150B2 JPH0467150B2 (enExample) | 1992-10-27 |
Family
ID=10527451
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP8483A Granted JPS58146855A (ja) | 1982-01-05 | 1983-01-05 | 免疫検定法 |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0083869B1 (enExample) |
| JP (1) | JPS58146855A (enExample) |
| AU (1) | AU567486B2 (enExample) |
| CA (1) | CA1185175A (enExample) |
| DE (1) | DE3266967D1 (enExample) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6215464A (ja) * | 1985-07-13 | 1987-01-23 | Fujirebio Inc | 逆受身凝集反応用非特異反応吸収剤 |
| JPS63292062A (ja) * | 1987-05-08 | 1988-11-29 | デイド・ベーリング・マルブルク・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング | 体液中の血清タンパク質の定量的測定法およびそれに用いられる試薬 |
| JPH01254869A (ja) * | 1988-03-03 | 1989-10-11 | Boehringer Mannheim Gmbh | 免疫的に結合可能の物質の測定法及び診断剤 |
| JPH08505220A (ja) * | 1992-07-14 | 1996-06-04 | パチョルニック，アブラハム | 万能標準試薬と、その調製及び使用方法 |
| JP2008106610A (ja) * | 2006-10-23 | 2008-05-08 | Mahle Filter Systems Japan Corp | 蒸発燃料処理装置 |
| WO2025047641A1 (ja) * | 2023-08-25 | 2025-03-06 | 積水メディカル株式会社 | 免疫学的測定方法、免疫学的測定用試薬、免疫学的測定用検体前処理液、及び免疫学的測定用試薬キット、非特異反応抑制剤 |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3366740D1 (en) * | 1982-08-06 | 1986-11-13 | Int Inst Cellular Molecul Path | Particle agglutination assay of antigens |
| ZA855031B (en) * | 1984-08-31 | 1986-02-26 | New York Blood Center Inc | Assay for simultaneous detection of antigen and antibody in given serum |
| DE3717401A1 (de) | 1987-05-23 | 1988-12-08 | Behringwerke Ag | Einschritt-immuntest zur bestimmung von antigen-spezifischen antikoerpern aus einer der immunglobulin-klassen a, m, d oder e und dazu geeignetes mittel |
| CA2697656C (en) * | 2007-08-23 | 2017-10-03 | Mitsubishi Chemical Medience Corporation | Non-specific reaction inhibitor |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS579723A (en) * | 1980-06-20 | 1982-01-19 | Mitsubishi Chem Ind Ltd | Stabilizing agent for immunological reaction and measuring method of antigen-antibody reaction |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4184849A (en) * | 1977-12-05 | 1980-01-22 | Technicon Instruments Corporation | Mixed agglutination |
| GB2013211B (en) * | 1978-01-26 | 1982-06-30 | Technicon Instr | Immunoassays using f(ab')2 fragments |
| AU543007B2 (en) * | 1980-04-15 | 1985-03-28 | Technicon Instruments Corportion | Agglutination immunoassay |
| DE3168691D1 (en) * | 1980-11-07 | 1985-03-14 | Technicon Instr | Immunoassay of proteins |
| AU557731B2 (en) * | 1981-03-05 | 1987-01-08 | Westinghouse Electric Corporation | Catalytic gas turbine combustor |
| SE461726B (sv) * | 1989-02-06 | 1990-03-19 | Rolf Arne Larsson | Anordning foer fasthaallning av knivblad foer skaerning av en pappersbana |
-
1982
- 1982-12-23 DE DE8282306917T patent/DE3266967D1/de not_active Expired
- 1982-12-23 EP EP19820306917 patent/EP0083869B1/en not_active Expired
-
1983
- 1983-01-04 CA CA000418851A patent/CA1185175A/en not_active Expired
- 1983-01-05 JP JP8483A patent/JPS58146855A/ja active Granted
- 1983-01-05 AU AU10036/83A patent/AU567486B2/en not_active Ceased
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS579723A (en) * | 1980-06-20 | 1982-01-19 | Mitsubishi Chem Ind Ltd | Stabilizing agent for immunological reaction and measuring method of antigen-antibody reaction |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6215464A (ja) * | 1985-07-13 | 1987-01-23 | Fujirebio Inc | 逆受身凝集反応用非特異反応吸収剤 |
| JPS63292062A (ja) * | 1987-05-08 | 1988-11-29 | デイド・ベーリング・マルブルク・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング | 体液中の血清タンパク質の定量的測定法およびそれに用いられる試薬 |
| JPH01254869A (ja) * | 1988-03-03 | 1989-10-11 | Boehringer Mannheim Gmbh | 免疫的に結合可能の物質の測定法及び診断剤 |
| JPH08505220A (ja) * | 1992-07-14 | 1996-06-04 | パチョルニック，アブラハム | 万能標準試薬と、その調製及び使用方法 |
| JP2008106610A (ja) * | 2006-10-23 | 2008-05-08 | Mahle Filter Systems Japan Corp | 蒸発燃料処理装置 |
| WO2025047641A1 (ja) * | 2023-08-25 | 2025-03-06 | 積水メディカル株式会社 | 免疫学的測定方法、免疫学的測定用試薬、免疫学的測定用検体前処理液、及び免疫学的測定用試薬キット、非特異反応抑制剤 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA1185175A (en) | 1985-04-09 |
| EP0083869B1 (en) | 1985-10-16 |
| AU1003683A (en) | 1983-07-14 |
| JPH0467150B2 (enExample) | 1992-10-27 |
| DE3266967D1 (en) | 1985-11-21 |
| EP0083869A1 (en) | 1983-07-20 |
| AU567486B2 (en) | 1987-11-26 |
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